CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jie Zhou,Jingyi Zhu,Zhaozhong Yang,Yuqi Sun,Shuang Wang,Jiayu He,Xiaogang Li,Liangping Yi
The failure of traditional acid systems to retard reaction rates has posed challenges for acid fracturing in ultra-deep carbonate reservoirs. Microencapsulated acid can address the retardation issue by targeting release at distal fractures, but existing formulations lack sufficient pressure resistance to meet operational demands, and their controlled-release mechanisms in complex environments remain unclear. This study employed emulsion polymerization to prepare high-temperature and high-pressure resistant microencapsulated acid, incorporating benzene rings via the addition reaction of N -hydroxymethyl acrylamide with isocyanate monomers containing aromatic rings to enhance thermal and pressure resistance. Trimethylolpropane tri-acrylate was used as a trifunctional crosslinker to simultaneously improve thermal stability. The effects of varying benzene ring content on the microcapsules' morphology, thermal resistance, pressure tolerance, load rate, and shear resistance were investigated, leading to the optimal product MA-TDI-2. It exhibited the highest sphericity and smoothness, with a thermal resistance of 199.4 °C, pressure resistance of 69 MPa, and shear tolerance of 170 s −1 . These properties ensure targeted release in distal fractures, occurring only at 180–200 °C and 55.2–69 MPa. Post-release, the point etching exhibited greater non-uniformity compared to the planar etching of gelled acid. Finally, the hierarchical influence of environmental factors on controlled release was determined as pressure > temperature > salinity, where high pressure directly crushes the shell to promote release, high temperature softens and enlarges shell pores to accelerate release, and high salinity causes shell shrinkage to inhibit release. The developed product and elucidated release mechanisms can advance the application of microencapsulated acid in ultra-deep acid fracturing.
✓ 已验证
产品关联
DOI
高影响因子
DRUG DELIVERY
·
2025
·
IF 8.1
Liqing Chai,Xiaomin Niu,Xiaoning Li,Jingjing Han,Fugui Guo,Rongrong Wang,Xiaohui Zhou,Xiaozhou Dong,Guoshun Zhang,Ruili Wang,Guolian Ren
Malaria remains a global health crisis, with Plasmodium resistance underscoring the urgent need for advanced drug delivery strategies. To overcome the limitations of oral antimalarials, such as hepatic first-pass metabolism and insufficient drug accumulation in parasites, intestinal M cell-mediated lymphatic transport and Plasmodium-triggered drug release are effective strategies. Plasmodium parasites maintain a weakly acidic intracellular environment with high levels of glutathione (GSH). Polydopamine (PDA) remains stable in the gastrointestinal tract and degrades in the parasite’s weakly acidic, GSH-rich environment, making PDA nanoliposomes (PNLs) a promising oral delivery system for Plasmodium-responsive drug release. Additionally, cyclic arginine–glycine–aspartic acid (cRGD) can specifically target intestinal M cells, promoting lymphatic transport and thereby reducing the first-pass effect. We developed cRGD- and PDA-modified nanoliposomes (cRPNLs) to address the challenges associated with oral administration and loaded them with a disulfide bond (–SS–)-modified dihydroartemisinin (DHA) prodrug (DSSC) to simultaneously deplete GSH and induce lethal oxidative stress, thereby offering an enhanced antimalarial mechanism. In vitro, cRPNLs exhibited pH- and GSH-responsive DHA release. Ex vivo fluorescent imaging confirmed that cRPNLs targeted Peyer’s patches with minimal distribution in the liver. Crucially, both PNLs and cRPNLs reduced GSH levels in infected erythrocytes and elevated ROS by 2.0-fold, outperforming unmodified DHA. Pharmacokinetic and in vivo antimalarial pharmacodynamic studies revealed that cRPNLs exhibited significantly higher exposure and Plasmodium inhibition rates compared to PNLs and free DHA. These results highlight cRPNLs as a potent oral nanoplatform that combines M cell-mediated lymphatic uptake with parasite-triggered drug release, significantly improving antimalarial efficacy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Jingyi Zhu,Yuzhi Tang,Jie Zhou,Zhaozhong Yang,Jiayu He,Jin Zhang
Deep carbonate reservoirs are rich in oil and gas reserves, but high-temperature and deep-burial conditions may cause conventional retarded acid to fail, thereby reducing acid stimulation efficiency. To address these challenges, microcapsule acids with high thermal stability, strong acid resistance, and delayed release capability were prepared. Methyl methacrylate and N-methylolacrylamide copolymer were selected as the shell material, and microcapsule acids capable of withstanding temperatures up to 180°C were synthesized via the interfacial polymerization method. Optimized parameters for mini-emulsion preparation and the interfacial polymerization process improved the uniformity of microcapsule particle size. The particle size and its distribution, micro-morphology, and shell material properties of the microcapsule acids were characterized by laser particle size analysis, infrared spectroscopy, scanning electron microscopy, differential scanning calorimetry, and thermogravimetric analysis. The experimental results showed that the average particle size of the microcapsule acids prepared by the interfacial polymerization method was 321.7 μm, with most particles distributed between 200 μm and 400 μm, exhibiting uniformity and good dispersibility. Thermal analysis indicated that the shell material maintained its structural integrity under high-temperature conditions of 180°C. Suspension tests demonstrated that the microcapsule acids could achieve long-distance transport in clear water and be evenly distributed in the formation. Acid release experiments confirmed that these microcapsule acids could achieve delayed release. These results further indicate that the microcapsule acids have broad application potential in acid fracturing of deep carbonate reservoirs.
✓ 已验证
产品关联
DOI
高影响因子
Innovative Food Science & Emerging Technologies
·
2026
·
IF 6.8
Wenjuan Qu,Tongtong Shen,Cunshan Zhou,Haile Ma,Qunhui Jiang,Yicheng Huang
To achieve efficient lipoxygenase (LOX) inactivation, this study developed an innovative catalytic infrared (IR) method using natural gas as an alternative to conventional electric heating. The activity, deactivation kinetics, structure, and catalytic kinetics of LOX were evaluated following IR treatment. Molecular dynamics and docking simulations were employed to assess the inactivation effects of both thermal and radiation components. Both temperature and wavelength effects contributed significantly to LOX denaturation, with an inactivation rate of 95.83% after 9 min at 130 °C. This was evidenced by the disruption of hydrogen bonds and various interactions, the disordering of LOX's secondary structure, and a reduction in LOX-substrate binding energies. The deactivation kinetics followed a Weibull distribution. The catalytic reaction efficiency of LOX decreased 177-fold. The temperature effect was stronger than the wavelength effect. This study provides a quantified mechanism for LOX inactivation by IR, highlighting IR as a promising alternative to conventional methods, offering both energy savings and efficient enzyme deactivation.
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2026
·Vol. 42
·期 35
·25844-25855
·
IF 4.4
Gao Qiulong,Han Jiangxue,Hu Jinxia,Huang Yan,Li Zhangpeng,Wang Jinqing,Yang Shengrong
Liquid
lubricants are crucial for advanced bearing equipment, as
they help mitigate key tribological issues including friction and
wear, thereby reducing the risk of failure and extending service life.
Herein, a low-viscosity, high-affinity deep eutectic solvent (TB-C 12 OH DES) was synthesized by blending tetrabutylammonium chloride
with 1-dodecanol using a simple heating-stirring method, and it was
used as a high-performance lubricant for steel substrates. The as-synthesized
TB-C 12 OH DES showed favorable physicochemical properties.
Reciprocating friction tests demonstrated that TB-C 12 OH
DES achieved low friction coefficients (0.081–0.090) and ultralow
wear rates (3.02–4.75 × 10 –9 mm 3 N –1 m –1 ) under high-load
conditions (2.16–3.12 GPa). These results are attributed to
the formation of stable adsorption film and tribofilms consisting
of carbonaceous compounds and iron oxides at the tribointerface through
adsorption and tribochemical reactions. This straightforward preparation
strategy not only meets specific lubricant requirements but also paves
the way for the development of eco-friendly DES-based lubricants with
high lubricating performance to address friction and wear challenges
under complex operating conditions.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOM
·
2026
·
IF 2.3
Xiang Zhe,Xu Chengjin,Yu Haiyin,Wang Zhimei,Sun Guoxin,Cui Yu,Peng Xiujing
Titanium white waste acid contains economically recoverable concentrations of scandium (25 mg/L); however, the high acid content and presence of multiple impurity ions present significant challenges for scandium separation. In this study, a novel monoalkyl phosphate extractant, PC68, consisting of 1-hexadecyl phosphate and 1-octadecyl phosphate, was synthesized. The effects of extraction time, sulfuric acid concentration, and temperature on scandium extraction were systematically investigated using a simulated titanium white waste acid solution. The results demonstrated that equilibrium was reached within 50 min at 298 K, and that the extraction efficiency of scandium with 0.1 mol/L PC68 was 99%. Analytical techniques, including the Equimolar Series Method, FT-IR, and XPS, confirmed that PC68 extracts scandium through coordination with P-O − and P=O groups. The separation performance of scandium from titanium white waste acid was evaluated, yielding high separation factors of 1093 for Sc/Fe and 733 for Sc/Mn, which demonstrates excellent separation efficiency. The addition of 1% H 2 O 2 followed by three-stage countercurrent extraction enabled effective separation of scandium and titanium. These results provide new insights and practical approaches for scandium separation from titanium white waste acid.
✓ 已验证
产品关联
DOI
高影响因子
Theranostics
·
2025
·Vol. 15
·期 14
·6768
·
IF 13.3
Li He,Jiao-Jiao Ma,Yi-Qun Wu,Chen-Guang Wang,Tong Lan,Lu Su,Lin Zhu,Shi-Wen Huang,Kai Deng,Yong-Chang Wei
Background: Immunogenicity activation is vital for radioimmunotherapy, but the short-term oxidative damage caused by precise radiation planning limits this effect. Chemodynamic therapy (CDT) with prolonged generation of hydroxyl radical (•OH) can initiate immunogenicity in combination with X-rays, however, its performance is constrained by tumor insufficient H2O2. Methods: Here, we propose to construct β-lapachone-based nanoparticles (β-Lap/Fe NPs) which initiate cascade reactions to generate high levels •OH for an extended period in tumor following X-ray irradiation. Results: β-Lap/Fe NPs, constructed by co-encapsulation of β-Lap and Fe3O4 nanoparticles in reactive oxygen species (ROS) responsive C16-S-mPEG2000 micelles, remain stable under normal conditions but rapid decompose and release β-Lap and Fe2+ when exposed to high level ROS. Upon X-ray irradiation, the upregulation of ROS and NAD (P) H: quinone oxidoreductase-1 (NQO1) in tumor cells accurately triggers β-Lap/Fe NPs to persistently generate high levels H2O2 and •OH for 12 hours, ultimately causing strong immunogenic cell death effects. Moreover, β-Lap/Fe NPs with excellent T2-weighted magnetic resonance imaging provide imaging reference for guiding precise X-ray radiation and predicting •OH generation. β-Lap/Fe NPs mediated radio-chemodynamic-immunotherapy remarkably against primary tumor growth, and further shows effective suppression on untreated distant tumors via the abscopal effect. Conclusions: In a word, this work proposed the simple but powerful strategy for cancer radio-chemodynamic-immunotherapy that combines X-ray and CDT to remote locally and visually actuated long-time production of H2O2 and subsequently persistent generation of •OH for initiating strong antitumor immune responses.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2023
·
IF 6
Qihui Dong,Huimin Wang,Rong Wu,Jun Cao,Fuliang Cao,Erzheng Su
For the quantification of ginkgolic acids (GAs) within ginkgo products, a very effective liquid–liquid microextraction pretreatment method based on hydrophobic deep eutectic solvent (HDES) was created. The HPLC detection conditions for GAs were optimized before establishing the pretreatment method. Then, the DES composition, DES volume, sample amount, extraction temperature and time were investigated to obtain the optimal pretreatment conditions. This developed method had satisfactory analytical performance, the linearity was r 2 = 0.9997, and its low limit of detection (LOD) was 0.81 mg/kg. The recovery value ranged from 95.10 % to 98.75 %. When compared with the Ch.P.2010 and EP10.0 recommended methods, this developed method gave a higher efficiency and showed obvious advantages. Furthermore, the developed method was effectively used to identify GAs in a variety of Ginkgo biloba medications, Ginkgo biloba leaves from various cultivars and collection times. These results highlighted the superiorities of the HDES-based liquid–liquid microextraction pretreatment technique for the measurement of GAs, providing insights for future development of efficient methods in active ingredients analysis.
✓ 已验证
产品关联
DOI
高影响因子
Metabolic Engineering Communications
·
2022
·
IF 0
Yushi Liu,Wan-Qiu Liu,Shuhui Huang,Huiling Xu,Haofan Lu,Changzhu Wu,Jian Li
Fatty acid-derived products such as alkanes, fatty aldehydes, and fatty alcohols have many applications in the chemical industry. These products are predominately produced from fossil resources, but their production processes are often not environmentally friendly. While microbes like Escherichia coli have been engineered to convert fatty acids to corresponding products, the design and optimization of metabolic pathways in cells for high productivity is challenging due to low mass transfer, heavy metabolic burden, and intermediate/product toxicity. Here, we describe an E. coli -based cell-free protein synthesis (CFPS) platform for in vitro conversion of long-chain fatty acids to value-added chemicals with product selectivity, which can also avoid the above issues when using microbial production systems. We achieve the selective biotransformation by cell-free expression of different enzymes and the use of different conditions (e.g., light and heating) to drive the biocatalysis toward different final products. Specifically, in response to blue light, cell-free expressed fatty acid photodecarboxylase (CvFAP, a photoenzyme) was able to convert fatty acids to alkanes with approximately 90% conversion. When the expressed enzyme was switched to carboxylic acid reductase (CAR), fatty acids were reduced to corresponding fatty aldehydes, which, however, could be further reduced to fatty alcohols by endogenous reductases in the cell-free system. By using a thermostable CAR and a heating treatment, the endogenous reductases were deactivated and fatty aldehydes could be selectively accumulated (>97% in the product mixture) without over-reduction to alcohols. Overall, our cell-free platform provides a new strategy to convert fatty acids to valuable chemicals with notable properties of operation flexibility, reaction controllability, and product selectivity.
✓ 已验证
产品关联
DOI
PubMed
COMPOSITES PART B-ENGINEERING
·
2022
·
IF 11.322
Weijuan Zou,Longchen Wang,Junnian Hao,Lixian Jiang,Wenxian Du,Tao Ying,Xiaojun Cai,Haitao Ran,Jianrong Wu,Yuanyi Zheng
Insufficient concentrations of intracellular substrates such as hypoxia and H 2 O 2 considerably reduce the effectiveness of reactive oxygen species (ROS)-associated cancer therapy. Modulating the tumor microenvironment (TME) for augmenting efficacy has become a promising strategy. Herein, a phase-change cascaded nanomedicine (Lap-IrO x @PCM) was constructed via co-encapsulation of iridium oxide nanozyme (IrO x ) and β-lapachone (Lap) by using thermal-responsive phase-change materials (PCMs). After photothermal activation, the protective PCM layer was melted, causing the rapid release of IrO x and Lap. Simultaneously, the peroxidase-like nanozyme IrO x reacted with endogenous H 2 O 2 to liberate highly toxic hydroxyl radicals (•OH) for inducing tumor cell death. Meanwhile, IrO x as another glutathione peroxidase nanozyme also consumed glutathione (GSH) to protect ROS from scavenging. Importantly, the released Lap efficiently generated H 2 O 2 for facilitating the catalytic efficacy of IrO x and provoke the cleavage of heat shock protein 90 (Hsp90) for overcoming tumor heat tolerance in photothermal therapy (PTT). As systematically demonstrated both in vitro and in vivo , this well-defined system achieved a superior antitumor effect via mild photothermal-enhanced nanocatalytic therapy. Our findings have provided the proof of concept of the phase change-mediated, in vivo catalytic activity of nanozymes that can be customized for intensive, TME-mediated, self-enhanced nanocatalytic cancer therapy.
✓ 已验证
产品关联
DOI
高影响因子
FUEL
·
2022
·
IF 8.035
Lin Fu,Zhaoxin Liu,Xin Li,Yongfei Li,Houyi Yang,Yuejin Liu
Ni-catalysts usually experienced quick deactivation during bio-lipids deoxygenation due to metal sintering and coke. Here we prepared a series of Ni/CeO 2 -Al 2 O 3 catalysts, denoted as NiCeAl-EISA, NiCeAl-WI and NiCeAl-CP, prepared by evaporation-induced self-assembly (EISA), wetness impregnation (WI), co-precipitation (CP) methods, respectively, aiming at tuning metal-support interaction (MSI) in Ni/CeO 2 -Al 2 O 3 catalysts for the deoxygenation of bio-lipids to hydrocarbons. The porosity and surface properties of the catalysts are systematically studied by BET, XRD, H 2 -TPR, HR-TEM, FT-IR, O 2 -TPD, NH 3 -TPD, RPR, Py-FTIR, XPS and in situ XPS. The NiCeAl-EISA catalyst afforded 92.2% n-C 11 yield at full methyl laurate conversion, and efficiently deoxygenated different FAMEs, yielding corresponding alkanes yields of 97.8% (n-C 9 ), 96.4% (n-C 13 ), 94.3% (n-C 15 ) and 92.9% (n-C 17 ). The TOFs were calculated as 426–719, 241–343 and 148–243 h −1 for NiCeAl-EISA, NiCeAl-WI and NiCeAl-CP catalysts, respectively. Jatropha oil and waste cooking oil were also converted into liquid alkanes (C 13-18 ) with a total yield of 95.4% and 93.7%, respectively. The NiCeAl-EISA catalyst exhibits superior catalytic activity and remained stable with 92.2% n-C 11 yield after 11 consecutive runs, as compared with NiCeAl-WI and NiCeAl-CP. This significant increase in catalyst activity and stability is closely correlated with the tunable SMSI of Ni/CeO 2 -Al 2 O 3 catalyst, which facilely forms abundant oxygen vacancies and interfacial sites (Ni δ+ -O V -CeO x ). This suppresses strong Ni-Al interaction, thus exposing more active and robust Ni sites to promote R-COOH → R-CHO reduction to produce more alkanes. The weakened Ni-Al interaction also reduces the strong acidity and consequently inhibits the coke formation and simultaneously restrains C–C bond cleavage of hydrocarbons.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF SURFACTANTS AND DETERGENTS
·
2022
·Vol. 25
·期 5
·643-654
·
IF 1.972
Yu Zhao,Chenyu Liu,Hailiang Chen,Hengjun Zhou,Simiao Yu,Deze Mi,Shuli Yue,Weihong Qiao
Liposomes are the predominant drug delivery system widely used in the pharmaceutical industry, but rapid clearance and endosome degradation are the main barriers to improve the delivery efficiency of liposomes, especially for protein or genes. Simulating viral membrane fusion peptides, four asymmetrically dihydrophobic chain polyethylene glycol (PEG) lipids with long circulating and membrane fusion properties have been designed and synthesized with a high yield. The structure of synthetic PEG lipids is characterized by 1 H NMR and mass spectrometry. The critical micelle concentrations of PEG lipids are lower by one or two orders of magnitude compared with traditional surfactants such as SDBS or SDS, which show excellent self-assembly performance of lipids. The size and morphology of liposomes constituted with neutral lipid DOPC and PEG lipid are characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). In the conditions of 50% ethanol and 5–25 mmol L −1 Ca 2+ , the PEG neutral lipid complexes encapsulated pEGFP are almost neutral with a diameter below 300 nm.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）