DRUG DELIVERY
·
2019
·
IF 3.829
Guofei Li,Limei Zhao
Tumor microenvironment is closely related to the occurrence and development of liver cancer. Tumor-associated macrophages (TAMs) are an important part of tumor microenvironment promoting tumor deterioration and metastasis by inhibiting immune cells. Previous studies showed that PI3Kγ inhibitor could reverse the phenotype of TAMs, relieve immunosuppression and sensitize chemotherapy drugs, suggesting that the combination of PI3Kγ inhibitor and chemotherapeutics is likely to bring new breakthroughs in the treatment of liver cancer. Based on it, this paper builds HES-TG100-115-CDM-PEG micelles with tumor microenvironment responsiveness that simultaneously loaded sorafenib and TG100-115 to synergistically treat liver cancer. Pharmacokinetic study showed that the prepared micelles had longer half-life than that of the free drug solutions, which was favorable for high propensity of extravasation through tumor vascular fenestrations. Under low pH and high α-amylasereductive conditions, micelles could depolymerize quickly due to the sensitivity of bonds and enhance significantly cytotoxic activity against Hep-3B liver cancer cell. Additionally, micelles demonstrated higher levels of antitumor efficiency and better tolerance against nude mouse with Hep-3B cell than the free drug solutions. These findings reveal that HES-TG100-115-CDM-PEG micelles are a promising drug delivery system in clinical comprehensive therapy of liver cancer.
研究领域:
药学
·
肿瘤学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
International Journal of Minerals Metallurgy and Materials
·
2019
·Vol. 26
·期 12
·1512-1522
·
IF 1.221
Zhao Jun,Zuo Hai-bin,Wang Jing-song,Xue Qing-guo
The high-value utilization of low-rank coal would allow for expanding energy sources, improving energy efficiencies, and alleviating environmental issues. In order to use low-rank coal effectively, the hypercoals (HPCs) were co-extracted from two types of low-rank coal and biomass via N-methyl-2-purrolidinone (NMP) under mild conditions. The structures of the HPCs and residues were characterized by proximate and ultimate analysis, Raman spectra, and Fourier transform infrared (FT-IR) spectra. The carbon structure changes within the raw coals and HPCs were discussed. The individual thermal dissolution of Xibu (XB) coal, Guandi (GD) coal, and the biomass demonstrated that the biomass provided the lowest thermal dissolution yield Y 1 and the highest thermal soluble yield Y 2 at 280°C, and the ash content of three HPCs decreased as the extraction temperature rose. Co-thermal extractions in NMP at various coal/biomass mass ratios were performed, demonstrating a positive synergic effect for Y 2 in the whole coal/biomass mass ratios. The maximum value of Y 2 was 52.25wt% for XB coal obtained with a XB coal/biomass of 50wt% biomass. The maximum value of Y 2 was 50.77wt% for GD coal obtained with a GD coal/biomass of 1:4. The difference for the optimal coal/biomass mass ratios between XB and GD coals could be attributed to the different co-extraction mechanisms for this two type coals.
研究领域:
能源化学
·
煤化工
·
生物质转化
·
热化学转化
·
资源综合利用
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 41
·19642-19650
·
IF 3.5
Chu Yican,Yao Zhendong,Liu Min,Li Wenqing,Gu Jing,Huang Zhenguang,Xie Jiaxing,Li Chao,Cui Yongfu,Li Yun,Fan Meiqiang
The hydrolysis of silicon and its compounds to produce hydrogen for fuel cell remains a major problem. The main obstacle is the weak hydrolytic activity and slow kinetics of silicon. In this work, the alloying properties of Si and Ca to improve its hydrolytic activity, and studied the film breaking effect of different metals and halogen ions on its passivation layer. The results show that the hydrogen production of the alloy is still determined by its phase composition. Among the common metal (Ni, Bi, Sn) and halogen ions (F – , Cl – ) catalyzed by hydrolysis, Ni and F – showed a good synergistic effect, resulting in a hydrogen yield of 269 mL/g at room temperature without alkali. Graphical
The effects of metal ions and halogens on the hydrolytic properties of Ca–Si alloy were investigated, and Ni 2+ and F — showed good synergistic effect.
研究领域:
材料化学
·
能源材料
·
无机化学
·
氢能源
·
金属合金
✓ 已验证
DOI
高影响因子
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
·
2020
·
IF 3.442
Deqiang Feng,Jie He,Lingcheng Zheng,Wenjun Jiang,Ce Zhang,Long Li,Jian Song,Wei Yao
Developing novel catalysts and catalysis processes are highly attractive in environmental protection and energy utilization. Photocatalysis-Fenton combinational process is an environmentally friendly technology and has broad application prospects. In this work, thin Fe@α-Fe 2 O 3 nanosheets with thickness of 2–5 nm were designed by oxidation of Fe metal nanostructure synthesized using a modified solution reaction method. The nanosheet structure with thin thickness has short diffusion distance for the photogenerated carriers and prolongs the carriers' life. Simultaneously, the presence of Fe can reduce the resistance of system and further promote the transport and transfer of photogenerated carriers from the bulk to the surface, causing less carrier recombination and better photocatalytic performance. What's more, the Fe@α-Fe 2 O 3 composite can induce the Fenton-like reaction to generate active • OH radicals, which significantly improve the degradation rate . The synergistic effect of photocatalysis and Fenton processes makes the system show an enhanced photodegradation performance: 96.5% of RhB is degraded after 60 min visible light irradiation , especially, 84.3% of RhB is degraded within the first 10 min, which are much higher than that of the pure α-Fe 2 O 3 sample. This work demonstrates that the conjunction of photocatalysis and Fenton processes based on the Fe@α-Fe 2 O 3 nanosheets provides a potential application for pollutants degradation.
研究领域:
环境化学
·
材料科学
·
催化化学
·
纳米科技
·
物理化学
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2016
·
IF 4.758
Jun Qin,Xiaomei Li,Yunfeng Bai,Feng Feng,Qiliang Pan,Jianguo Zhao
A novel mesoporous silica-deoxycholate (MS-NaDC) synergistic substrate was developed for room-temperature phosphorescence (RTP) sensing and analysis. The substrate exhibited rapid and strong RTP-inducing ability toward 9-bromophenanthrene (9-BrP). The formation mechanism of MS-NaDC synergistic substrate was analyzed and demonstrated. Five MSs with pore size range of 2.73–18.58 nm were synthesized and investigated, and the MS designated as LPMS2 was selected for its rapid RTP protection and good stability in dispersions. RTP in the presence of MS-NaDC substrate also shows good thermostability. Assistant inducers, such as cyclohexane, can be used together for further RTP enhancement. Finally, 9-BrP holds a fairly wide linear concentration range of 2 nM–3 μM, and a detection limit of 0.5 nM. All the results demonstrated the feasibility and application potential of the MS-NaDC substrate in RTP.
研究领域:
分析化学
·
材料科学
·
生物传感器
·
纳米医学
·
分子探针
·
环境监测
✓ 已验证
DOI
高影响因子
Small
·
2022
·Vol. 18
·期 48
·2205163
·
IF 15.153
Shuhao Tian,Juanjuan Huang,Hongcen Yang,Guo Liu,Qi Zeng,Di Wang,Xiao Sun,Kun Tao,Guohan Liu,Shanglong Peng
The low utilization rate of active materials, shuttle effect of lithium polysulfides (LiPSs), and slow reaction kinetics lead to the extremely low efficiency and poor high current cycle stability of lithium sulfur batteries (Li–S batteries). In this paper, a self-supporting multicomponent hierarchical network aerogel is proposed as the modified cathode (S/GO@MX@VS 4 ). It consists of graphene (GO) and MXene nanosheets (MX) loaded with VS 4 nanoparticles. The experimental results and first-principles calculations show that the GO@MX@VS 4 aerogel has strong adsorption and reversible conversion effects on LiPSs. It can not only inhibit the shuttle effect and improve the utilization rate of active substances by keeping the chain crystal structure of VS 4 , but also promote the reversibility and kinetics of the reaction by accelerating the liquid–solid transformation in the reduction process and the decomposition of insoluble Li 2 S in the oxidation process. The GO@MX@VS 4 aerogel modified cathode with a multicomponent synergy exhibits the capacity ratios (Q 1 /Q 2 ) at different discharge stages is close to the theoretical value (1:2.8), and the capacity decay per cycle is 0.019% in 1200 cycles at 5C. Also, a high areal capacity of 6.90 mAh cm −2 is provided even at high sulfur loading (7.39 mg cm −2 ) and low electrolyte/sulfur ratio (E/S, 8.0 µL mg −1 ).
研究领域:
电化学储能
·
材料科学
·
纳米材料
·
能源化学
·
电池技术
·
表面催化
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2018
·Vol. 44
·期 3
·1586-1596
·
IF 4.229
Tianyu Zhao,Zipeng Xing,Ziyuan Xiu,Zhenzi Li,Shilin Yang,Qi Zhu,Wei Zhou
TiO 2-x /g-C 3 N 4 /CdS ternary heterojunctions are fabricated through thermal polymerization-chemical bath deposition combined with in-situ solid-state chemical reduction approach. The prepared materials are characterized by X-ray diffraction, Fourier transform infrared spectra , scanning electron microscopy, transmission electron microscopy , nitrogen adsorption-desorption, and X-ray photoelectron spectroscopy. The results show that the ternary heterojunctions are formed successfully and CdS quantum dots (QDs) and TiO 2 are anchored on surface of g-C 3 N 4 nanosheets simultaneously. The visible-light-driven photocatalytic degradation ratio of Bisphenol A and hydrogen production rate are up to 95% and ∼254.8 μmol h −1 , respectively, which are several times higher than that of pristine TiO 2 . The excellent visible-light-driven photocatalytic activity can be ascribed to the synergistic effect of TiO 2−x , g-C 3 N 4 and CdS QDs which extend the photoresponse to visible light region and favor the spatial separation of photogenerated charge carriers.
研究领域:
材料科学
·
光催化
·
纳米材料
·
环境催化
·
能源化学
✓ 已验证
DOI
高影响因子
DRUG DELIVERY
·
2019
·
IF 3.829
Wenguang Gu,Tao Zhang,Junsheng Gao,Yi Wang,Dejian Li,Ziwen Zhao,Bo Jiang,Zhiwei Dong,Hui Liu
Protein-based nanocarriers with inherent biocompatibility have been widely served as building blocks to construct versatile therapeutic nanoplatforms. Herein, bovine serum albumin-iridium oxide nanoparticles (denoted BSA-IrO2 NPs) are successfully synthesized via one-step biomineralization approach. The BSA-IrO2 NPs exhibits uniform size (40 nm), superb biocompatibility and high drug loading capacity for doxorubicin (27.4 wt%). Under near-infrared (NIR) laser irradiation, the as-prepared BSA-IrO2 NPs exhibited high photothermal conversion ability (54.3%) and good photostability. The in vitro drug release experiments displayed pH and NIR laser -triggered DOX release profiles, which could enhance the therapeutic anticancer effect. By utilizing this DOX loaded nanoplatform, effective synergistic chemo-photothermal therapy against human osteosarcoma can be realized, which has been systematically verified both in vitro and in vivo. Notably, in vivo pharmacokinetics studies showed that BSA-IrO2@DOX had prolonged blood circulation time due to the BSA component can improve the stealthiness of the nanoparticles during the blood circulation. Meanwhile, in vitro and in vivo toxicity studies demonstrated that the BSA-IrO2 NPs can act as biocompatible agents for drug delivery and cancer therapy. Therefore, this work presents a biomineralized iridium-based NPs with remarkable features and be used as a very potential therapeutic nanoplatform for cancer treatment.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Zixiang Gao,Jun Liu,Ying Wang,Yuqiong Zhao,Guoqiang Li,Wenzhe Si,Yuefeng Liu,Guojie Zhang
Activated carbon (AC) adsorbents are extensively utilized for the adsorption and elimination of volatile organic compounds (VOCs), such as styrene, owing to their remarkable adsorption capacity and cost-effectiveness. However, the regeneration and reutilization of activated carbon face significant limitations due to incomplete cleavage of styrene and carbon accumulation during heated styrene cracking. This research focuses on the preparation of Ni-Fe bimetal-enriched adsorbent columns by successfully loading transition metals Ni and Fe onto activated carbon saturated with styrene adsorption using a simple impregnation method. A series of characterizations were conducted to unveil the formation process of active sites in the alloy phase and the mechanism behind the synergistic anti-accumulation effect of Ni and Fe on carbon deposits. Furthermore, the adsorption performance of the regenerated activated carbon for styrene was evaluated. The results revealed the formation of Fe 0.64 Ni 0.36 and Ni-Fe alloy (Kamacite) phases on the activated carbon carriers, which enhanced the cracking of styrene and exhibited superior anti-carbon accumulation properties. The styrene adsorption capacity of the synthesized bimetallic 2.5Fe-2.5Ni-900 regenerated sample reached 407.5 mg/g, approximately 1.5 times higher than that of the monometallic samples 5Fe-900 and 5Ni-900, and 1.6 times higher than that of the unmodified activated carbon RAC-900. Furthermore, kinetic studies indicated that the adsorption process of styrene by the samples followed a multilayer adsorption mechanism, predominantly governed by physical adsorption. Intra-pore diffusion was identified as the primary rate-determining step during the adsorption process. Moreover, after three regenerative adsorption cycles, the decrease in styrene adsorption capacity for the 2.5Fe-2.5Ni-900 sample was below 20 %. This study presents novel perspectives and methodologies for addressing the regeneration challenge of activated carbon saturated with styrene adsorption.
研究领域:
环境化学
·
吸附科学
·
材料再生
·
大气污染控制
·
环境功能材料
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2022
·Vol. 47
·期 83
·35352-35364
·
IF 7.139
Zhichao Yu,Wei Zhang,Yongxi Zhang,Yaokun Fu,Ying Cheng,Sanyang Guo,Yuan Li,Shumin Han
Magnesium hydroxide (MgH 2 ) has excellent reversibility and high capacity, and is one of the most promising materials for hydrogen storage in practical applications. However, it suffers from high dehydrogenation temperature and slow sorption kinetics. Rare earth hydrides and transition metals can both significantly improve the de/hydrogenation kinetics of MgH 2 . In this work, MgH 2 –Mg 2 NiH 4 –CeH 2.73 is in-situ synthesized by introducing Ni@CeO 2 into MgH 2 . The unique coating structure of Ni@CeO 2 facilitates homogeneous distribution of synergetic CeH 2.73 and Mg 2 NiH 4 catalytic sites in subsequent ball milling process. The as-fabricated composite MgH 2 -10 wt% Ni@CeO 2 powders possess superior hydrogenation/dehydrogenation characteristics, absorbing 4.1 wt% hydrogen within 60 min at 100 °C and releasing 5.44 wt% H 2 within 10 min at 350 °C. The apparent activation energy of MgH 2 -10 wt% Ni@CeO 2 is determined to be 84.8 kJ/mol and it has favorable hydrogen cycling stability with almost no decay in capacity after 10 cycles.
研究领域:
材料科学
·
无机化学
·
能源化学
·
纳米催化
·
氢能源存储
✓ 已验证
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2020
·Vol. 31
·期 11
·2480-2491
·
IF 2.578
Po Hu,Xinyu Zheng,Jiwei Zhu,Baolin Wu
Chicken feather keratin (CK), a biomaterial that contains a large amount of nitrogen is extracted from chicken feathers and has significant potential for use as a flame retardant. In this study, CK and 9,10-dihydro-9-oxa-10-phosphenanthrene-10-oxide (DOPO) were added in different amounts to an epoxy resin (EP), and their flame retardancy and smoke suppression effects were studied. The results showed that CK exhibits a good flame-retardancy effect and better smoke suppression characteristics than those of DOPO when added to EP. Furthermore, it greatly reduces the CO yield in smoke. While the EP samples with DOPO showed better flame-retardancy properties than those of the samples with CK, they also produced more smoke, which had a higher CO content. Furthermore, when CK and DOPO were added to EP together, the flame-retardancy characteristics of the samples varied with the CK/DOPO ratio. Then the pyrolysis of all samples was divided into two stages based on thermokinetics analysis and the activation energies of these samples in the two stages were investigated. Finally, the flame-retardancy mechanism was discussed. When samples burn, the PO· free radicals derived from DOPO combine with H· and OH· to induce a quenching effect. In addition, the phosphate resulting from the decomposition of DOPO promotes the formation of the char layer. At the same time, the noncombustible gases generated during the pyrolysis of CK cause the char layer to expand and remove some of the heat. Thus, CK and DOPO synergistically improved the flame retardancy of EP.
研究领域:
高分子材料科学
·
阻燃化学
·
热分析
·
环境友好材料
·
生物基添加剂
✓ 已验证
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2020
·
IF 16.683
Hongguan Li,Jing Wang,Ruijuan Qi,Yongfeng Hu,Jing Zhang,Hongbin Zhao,Jiujun Zhang,Yufeng Zhao
Charge and spin manipulations of electrons are considered to be of great significance in boosting the catalytic activity of M N C electrocatalysts. However, to the best of our knowledge, most current studies focus only on the charge engineering, the interplay between spin and charge is not well understood, and the simultaneous manipulation of both charge and spin remains challenging. Herein, we show that the cooperative interplay between charge itineration and spin-polarization of electrons has a profound impact on the catalytic behavior through density functional theory (DFT) calculations for the first time. Following this concept, we report a Fe-Ni atomic pair as a superior bifunctional catalyst for high performance ORR and OER, with a very small potential difference (ΔE) of 0.691 V. We confirm that the coexistence of Fe 3d itinerant charge and moderate spin polarization (magnetic moment: 1.48 μ B ) is responsible for the superior functional catalytic activity for the Fe Ni atomic pairs.
研究领域:
电催化
·
材料化学
·
物理化学
·
纳米催化
·
能源材料
·
计算化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）