Additive Manufacturing
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2022
·
IF 11.632
Yan Li,Shuqiang Peng,Kunrong Li,Dan Qin,Zixiang Weng,Jiangwei Li,Longhui Zheng,Lixin Wu,Chang-Ping Yu
3D printing provides a new way of microbial immobilization technology and creates innovative designed bioactive structures containing microorganisms for remediation of environmental pollution. However, the bio-ink design remains a critical challenge due to the difficulty in creating a durable and bio-friendly material. Here, a novel dual-crosslinking PEGDA-Alginate-PVA-Nanoclay (PAPN) bio-ink containing one heterotrophic bacterium is reported for 3D printing functional biomaterial with the capabilities of ammonia removal. The results showed that PAPN 3D printed bio-scaffolds could effectively remove 96.2 ± 1.3% ammonia within 12 h, and the removal rate increased within repeated use owing to the growth of bacteria inside the bio-scaffolds. Preservation of the bio-scaffolds under room temperature without a culture medium for 168 h still maintained the microbial activity for ammonia removal. It is demonstrated that visible-light-based 3D printing procedures could maintain high cell viability for the majority of bacteria, and the porous structures of 3D bio-scaffolds could allow the permeability of nutrients for the growth of bacteria. This work demonstrates the potential of the dual crosslinked PAPN 3D bio-scaffold for the production and application of immobilized functional bacteria in wastewater treatment .
研究领域:
环境科学
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生物技术
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2022
·Vol. 23
·期 22
·13817
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IF 6.208
Zhuojun Zhang,Jiasen Bu,Biyun Li,Hongyun Xuan,Yan Jin,Huihua Yuan
In this study, a hydrogel composite wound dressing with antibacterial and self-healing ability was prepared using cysteine-modified carboxymethyl chitosan, sodium oxidized alginate, and but-3-yn-2-one base on Schiff base and thiol-alkynone double cross-links. The structure and properties of the hydrogel were characterized by scanning electron microscope, Fourier-transform infrared, and rheological test, followed by antibacterial and in vivo biocompatibility tests. The results showed that the hydrogel exhibited good self-healing, mechanical properties, good antibacterial effect, and in vivo biocompatibility, and can inhibit inflammation and promote skin tissue regeneration in mice. This novel self-healing hydrogel dressing has a broad application prospect in skin tissue engineering.Keywords:wound dressing;skin repair;antibacterial;hydrogel;double cross-links
研究领域:
生物材料学
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医学
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组织工程学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2019
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IF 2.121
Yufan Zhang,Xian Li,Nan Zhong,Yuanlin Huang,Kewen He,Xu Ye
A series of injectable in situ dual-crosslinking hydrogels (HA/ALG) based on oxidized sodium alginate (oxi-ALG) and hyaluronic acid modified with thiol and hydrazide (HA-SH/CDH) were prepared via hydrazone bonds and disulfide bonds. The chemical structures, morphologies, rheological properties, gelling time, swelling ratio, degradation rate and drug release behavior of hydrogels were investigated. HA/ALG hydrogels exhibited tunable gelling time, rheological properties, swelling ratio and degradation rate with varying precursor concentrations. The gelling time of HA/ALG hydrogels ranged from 157 s to 955 s, the values of yield stress of HA2/ALG2, HA3/ALG3 and HA4/ALG4 hydrogels were 1724, 4349 and 5306 Pa, and the degradation percentage of HA2/ALG2, HA3/ALG3 and HA4/ALG4 hydrogels were about 64%, 51% and 42% after incubating 35 days, respectively. Bovine serum albumin (BSA) was used as a model drug to investigate the drug controlled release properties, and the in vitro cumulative release percentage of BSA from HA2/ALG2, HA3/ALG3 and HA4/ALG4 drug-loaded hydrogels were about 79%, 72% and 69% after 20 days. The series of injectable in situ dual-crosslinking HA/ALG hydrogels could be an attractive candidate for drug delivery system, tissue engineering and regenerative medicine.
研究领域:
生物材料
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药物递送
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组织工程
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产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
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2024
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IF 4.4
Cuihong Sheng,Yufei Tang,Yijun Yao,Yani Sun,Yuanna Sun,Pengfei Zhang,Ying Xue,Kang Zhao
Ionic hydrogels can change the number of transient ions at low pressure to promote ion migration, similar to the sensory mechanism of human skin. Reported ionic hydrogel sensors have multiple ion migration characteristics, which is not conducive to the precise regulation of ion transport. In this paper, a double cross-linked anionic polyelectrolyte hydrogel (CPAM-IP6) with negative channels and internal cations was prepared with the main components of methacrylic acid (MAA), acrylic acid (AA), sodium carboxymethylcellulose (CMC), and inositol hexaphosphate (IP6). The prepared hydrogels show a unique interconnected porous structure due to the regular arrangement of chemical and hydrogen bonds. IP6 has high hydrogen bonding density, which provides the hydrogels with tunable mechanical properties and a large amount of dissociable proton H+. Optimized hydrogels exhibit excellent electrical conductivity (∼22 mS/cm), high tensile strength (∼0.56 MPa), and high strain at break (∼1030%). It has a modulus similar to that of human skin (E = 0.09–0.22 MPa) and has strain-hardening properties. In addition, the resistance changes and voltage signals of the hydrogel under different force modes (tension and compression) are monitored by dual-mode sensing with a high sensitivity and stability. Hydrogels are expected to be used for motion monitoring and energy collection and have broad application prospects in intelligent medical treatment.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
Soft Matter
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2019
·Vol. 15
·期 47
·9797-9804
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IF 3.399
Jin Zhang,Shengzhen Hou,Yanru Chen,Jing Zhou,Hao Chen,Yebang Tan
The strategy of dual cross-linking was investigated by enhancing the performance of dynamic hydrogels. To this end, phenylalanine modified ε-polylysine was synthesized and employed as the polymer backbone of hydrogels. The phenylalanine moieties and amine groups of the polymer could be cross-linked with cucurbit[8]uril (CB[8]) and the dialdehyde cross-linker, respectively. Single CB[8] linkage with fast dynamics led to an increase in the viscosity of the polymer solution, and single imine linkage with slow dynamics led to the formation of weak and brittle hydrogels. However, the two linkages were combined together to form a dual-cross-linked hydrogel and the performance of the hydrogel could be well enhanced. Compared with the single imine cross-linked hydrogel, the dual-cross-linked hydrogel demonstrated a higher mechanical strength, better extensibility and faster self-healing rate. It is anticipated that this line of research could provide a useful method to enhance the performance of dynamic hydrogels.
研究领域:
材料科学
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生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
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2024
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IF 6.5
Jingsong Zhang,Zhanpeng Jiang,Yajie Wang,Maolian Guo,Tao Ban,Yiyang Zhang,Xiuling Zhu
The abrasion of materials leads to huge economic losses and resource waste. It is a common measure to protect substrates with organic coatings. To obtain a type of waterborne polyurethane coating with excellent abrasion resistance, 6,6′-(1,4-butanediyl)-bis-(1,3,5-triazine-2,4-diamine) (BBTDA) was synthesized and employed to prepare crosslinked waterborne polyurethane (CWPU). The introduction of BBTDA allows the construction of covalent bonding crosslinking and hydrogen bonding crosslinking networks, which contribute to improving the mechanical properties and wear resistance of the CWPU coatings. The effects of BBTDA content on the mechanical properties, thermal stability, water resistance and wear resistance of CWPU were researched. The test result indicated that the addition of BBTDA improved the mechanical properties and wear resistance of the CWPU coatings significantly. When the BBTDA content was 0.5 %, the tensile strength of the film reached 26 MPa, the water absorption decreased to 4.7 %, the hardness of the coating was 4H, and the abrasion value was only 0.4 mg. CWPU-0.5 coating offered the optimum combination property.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
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2020
·Vol. 39
·期 3
·327-336
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IF 3.154
Shi Zhen,Wang Qi,Li Gui-Fei,Shou Yu-Feng,Zong Hong-Jie,Yan Shi-Feng,Zhang Kun-Xi,Yin Jing-Bo
Self-healing hydrogels with the shear-thinning property are novel injectable materials and are superior to traditional injectable hydrogels. The self-healing hydrogels based on 2-ureido-4[1 H ]-pyrimidinone (UPy) have recently received extensive attention due to their dynamic reversibility of UPy dimerization. However, generally, UPy-based self-healing hydrogels exhibit poor stability, cannot degrade in vivo and can hardly be excreted from the body, which considerably limit their bio-application. Here, using poly (l -glutamic acid) (PLGA) as biodegradable matrix, branching α-hydroxy- ω -amino poly(ethylene oxide) (HAPEO) as bridging molecule to introduce UPy, and ethyl acrylate polyethylene glycol (MAPEG) to introduce double bond, the hydrogel precursors (PMHU) are prepared. A library of the self-healing hydrogels has been achieved with well self-healable and shear-thinning properties. With the increase of MAPEG grafting ratio, the storage modulus of the self-healing hydrogels decreases. The self-healing hydrogels are stable in solution only for 6 h, hard to meet the requirements of tissue regeneration. Consequently, ultraviolet (UV) photo-crosslinking is involved to obtain the dual crosslinking hydrogels with enhanced mechanical properties and stability. When MAPEG grafting ratio is 35.5%, the dual crosslinking hydrogels can maintain the shape in phosphate-buffered saline solution (PBS) for at least 8 days. Loading with adipose-derived stem cell spheroids, the self-healing hydrogels are injected and self-heal to a whole, and then they are crosslinked in situ via UV-irradiation, obtaining the dual crosslinking hydrogels/cell spheroids complex with cell viability of 86.7%±6.0%, which demonstrates excellent injectability, subcutaneous gelatinization, and biocompatibility of hydrogels as cell carriers. The novel PMHU hydrogels crosslinked by quadruple hydrogen bonding and then dual photo-crosslinking of double bond are expected to be applied for minimal invasive surgery or therapies in tissue engineering.
研究领域:
生物材料学
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组织工程学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Meng Yu,Zhiming Wang,Renyan Huang,Zuwei Luo,Renchuan You,Ying Huang,Shuqin Yan,Qiang Zhang
Hydrogels are widely used due to their exceptional biocompatibility and adaptability, but their weak mechanical properties limit their application in biomedical engineering. Herein, we rapidly attained a comprehensive enhancement of silk fibroin hydrogels in mechanical properties by employing a physical-chemical double crosslinking strategy. The SF was ultrasonicated and simultaneously photo-crosslinked to form a di-tyrosine network interspersed with β -sheet blocks, resulting in a SF hydrogel network structure with both rigid and flexible domains. The SF hydrogels exhibited a maximum breaking strength of 59.7 kPa and a Young's modulus of 82.2 MPa, demonstrating significant rigidity and flexibility. Subsequently, the silk screws prepared by this double crosslinking strategy showed extraordinary compressive strength and Young's modulus of 41.8 MPa and 10.9 MPa, respectively. The silk screws cocultured with osteoblasts showed optimal biocompatibility, and the rate of biodegradation could be matched to the rate of osteogenesis. The screw also exhibited high adaptability in the requirements of bone screws. In this study, the SF hydrogels prepared by physical-chemical double crosslinking have extraordinary mechanical properties and biocompatibility, which provides a new avenue for the preparation of high-performance hydrogels and has great potential in bone tissue engineering.
研究领域:
生物医学工程
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材料科学
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组织工程
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2022
·
IF 10.383
Chenguang Jiang,Xuexue Ding,Wenyuan Xie,Defeng Wu
Building multiple cross-links or networks is a favorable way of diversifying applications of the hydrogels, which is also available for the organohydrogels prepared via the solvent replacement way. However, the situations become more complicated for organohydrogels due to the presence of replaced solvents. Therefore, the correlations between the multiple cross-links and final performance need to be better understood for the organohydrogels, which is vital for tailoring their inherent properties to expand final application scenarios. Polyacrylamide (PAM)/poly(vinyl alcohol) (PVA)/MXene composite organohydrogels with dual cross-links, namely, the covalently cross-linked PAM chains as the primary network and the physically cross-linked PVA/PAM chains with MXene particles as the secondary cross-links, were developed here for the study. The occurrence of the secondary cross-links plays multiple roles as sacrificial units endowing the system with ultrastretchability with an excellent strain–resistance effect and as temperature-sensitive units endowing the system with thermosensation ability with an outstanding temperature coefficient of resistance. Thus, the optimized sample can be used as a strain sensor with excellent environmental tolerance for detecting human motion as a pressure sensor to probe compression with weak deformation and as a thermal sensor to capture environmental temperature changes. This work provides valuable information on developing organohydrogels with superior performance for multimodal sensors.
研究领域:
材料科学
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传感器技术
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
·
IF 5.518
Sirui He,Jia Liu,Shu He,An Liu,Wei Shao
In this work, a double crosslinking strategy comprising chemical crosslinking and physical crosslinking was applied to fabricate novel polyvinyl alcohol/gelatin/silver sulfadiazine (PGA) sponges. The morphology and chemical composition were characterized via Environmental Scanning Electron Microscopy and Fourier-transform infrared spectroscopy. The antibacterial activity of PGA sponges towards Escherichia coli, Candida albicans , and Staphylococcus aureus was evaluated via several methods: inhibition zone determination, plate counting, fluorescence staining of dead/live bacteria, bacterial morphology observation, and protein leakage determination. The PGA sponges exhibited excellent antibacterial performance owing to the silver sulfadiazine release from the sponges. Moreover, the sponges exhibited sustained sulfadiazine release, and the release profiles reasonably fitted the Higuchi model, indicating that the release was diffusion controlled. The improved mechanical properties and excellent antibacterial effect of the prepared PGA sponges demonstrate their potential as outstanding antibacterial materials.
研究领域:
材料科学
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生物学
·
医学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Yang He,Feng Zhou,Yingxi Zhang,Tuan Lv,Paul K. Chu,Kaifu Huo
Silicon (Si) is a promising anode material for next-generation lithium-ion batteries (LIBs), but the huge volume change of Si particles causes anode fracture and delamination from the current collector, thereby stifling practical implementation. Herein, a high-toughness and hierarchical stress-dissipating binder for Si anodes is prepared by the covalent and hydrogen bonding of poly(acrylic acid) (PAA) and a cross-linked polyurethane (CPU). The physicochemical dual-cross-linked CPU-PAA binder with high toughness, large tensile strength, and hierarchical stress dissipation improves the structural integrity of Si anodes and minimizes thickness swelling. Finite element analysis confirms that the CPU-PAA binder reduces and uniformizes the stress distribution within the Si anodes during cycling. As a result, the Si/CPU-PAA anode shows a high capacity retention of 82.3% after 150 cycles at a high current density of 5 A g–1. Moreover, the Si/CPU-PAA//LiNi0.5Co0.2Mn0.3O2 full cell delivers stable cycling performance, highlighting the great potential of the CPU-PAA binder in high-energy-density LIBs. This work provides insights into the design of high-strength, large-toughness, and efficient stress-dissipating binders for high-performance Si anodes.
研究领域:
材料科学
·
电池技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2025
·
IF 4.7
Ran Zong,Xinli Hu,Shuangyi Liu,Aosheng Zhong,Baoqing Shentu
Aiming to satisfy the requirements of pressure-sensitive adhesives (PSAs) for flexible displays, 2-[[[6-[3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureido]hexyl]carbamoyl] oxy]ethyl acrylate (Upy-HDI-HEA) was synthesized, and a series of dual cross-linking EHA-co-HEA copolymers with multiple hydrogen bonds were prepared. The effects of the Upy-HDI-HEA content on the EHA-co-HEA copolymers’ chemical structure, thermal properties, viscoelasticity, mechanical properties, and adhesion performance were comprehensively investigated via in situ Fourier transform infrared (FT-IR), differential scanning calorimetry (DSC), mechanical testing, and adhesion testing. The multiple hydrogen bonds acting as strong physical cross-linking enhance the deformation resistance of EHA-co-HEA copolymers. Moreover, compared to chemical cross-linking, the multiple hydrogen bonds allow for a certain degree of unhindered movement and energy dissipation, which benefits the flexibility and peel resistance of EHA-co-HEA copolymers. Consequently, relatively low storage moduli and glass transition temperatures were observed in all EHA-co-HEA copolymers. Young’s modulus, recovery rate, and cyclic stability of EHA-co-HEA copolymers increase with the rising Upy-HDI-HEA content. Also, the loop tack, 180° peel strength, and shear strength of EHA-co-HEA copolymers significantly improved, showing a better adhesion performance than commercial PSAs.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）