JOURNAL OF NANOPARTICLE RESEARCH
·
2017
·Vol. 19
·期 12
·1-11
·
IF 2.02
Chen Daquan,Song Xiaoyan,Wang Kaili,Guo Chunjing,Yu Yueming,Fan Huaying,Zhao Feng
In this article, in order to enhance the bioavailiability and tumor targeting of curcumin (Cur), the oligosaccharides of hyaluronan conjugates, folic acid-oligosaccharides of hyaluronan-acetal-menthone 1,2-glycerol ketal (FA-oHA-Ace-MGK) carried oHA as a ligand to CD44 receptor, double-pH-sensitive Ace-MGK as hydrophobic moieties, and FA as the target of folate receptor. The structure characteristics of this smart response multifunctional dual-targeting nano-sized carrier was measured by fourier-transform infrared (FT-IR) and nuclear magnetic resonance ( 1 H–NMR). Cur, an anticancer drug, was successfully loaded in FA-oHA-Ace-MGK micelles by self-assembly. The measurement results of transmission electron microscopy (TEM) presented that the Cur-loaded micelles were spherical in shape with the average size of 166.3 ± 2.12 nm and zeta potential − 30.07 mV. Much more encapsulated Cur could be released at mildly acidic environments than at pH 7.4, from the Cur-FA-oHA-Ace-MGK micelles. Cytotoxicity assay indicated that non-Cur loaded micelles mostly had no cytotoxicity to MCF-7 cells and A549 cells, and Cur-loaded micelles had significantly lower survival rate than Cur suspension in the same concentration, which proved that the drug-loaded micelles can effectively inhibit tumor cell growth. The targeting of CD44 receptors and folate receptors was proved in vitro cellular uptake assay. These results showed the promising potential of FA-oHA-Ace-MGK as an effective nano-sized carrier for anti-tumor drug delivery.
研究领域:
药学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Jie Mao,Yang Li,Tong Wu,Conghui Yuan,Birong Zeng,Yiting Xu,Lizong Dai
To precisely deliver drug molecules at a targeted site and in a controllable manner, there has been great interest in designing a synergistical drug delivery system that can achieve both surface charge-conversion and controlled release of a drug in response to different stimuli. Here we outline a simple method to construct an intelligent drug carrier, which can respond to two different pH values, therefore achieving charge conversion and chemical-bond-cleavage-induced drug release in a stepwise fashion. This drug carrier comes from the self-assembly of a block copolymer-DOX conjugate synthesized through a Schiff base reaction between poly(2-(diisopropylamino)ethyl methacrylate-b-poly(4-formylphenyl methacrylate-co-polyethylene glycol monomethyl ether methacrylate) (PDPA-b-P(FPMA-co-OEGMA)) and DOX. The surface charge of the BCP-DOX micelles reversed from negative to positive when encountering a weakly acidic environment due to the protonation of PDPA segments. In vitro cellular uptake measurement shows that the cellular uptake and internalization of the BCP-DOX micelles can be significantly enhanced at pH ∼ 6.5. Moreover, this drug carrier exhibits a pH-dependent drug release owing to the cleavage of the imine bond at pH < 5.5. With this dual-pH responsive feature, these micelles may have the ability to precisely deliver DOX to the cancer cells.
研究领域:
生物材料
·
药剂学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Kunjie Wang,Xianrong Liu,Yanan Li,Yunsi Wang,Riming Hu,Bingxin Liu,Peng Zhang,Benhua Xu,Yongcheng Li
Ensuring Ruthenium-based (Ru) catalysts with high metal utilization is a potential and challenging strategy for designing and constructing high catalytic activity electrocatalysts for hydrogen evolution reaction (HER). Herein, Ruthenium single atoms (SA) and Ruthenium nanoparticles (NPs) are simultaneously anchored on hierarchically porous carbon via the self-templates method for the first time. Benefiting from the synergetic effect of hierarchically porous carbon and the coexistence of Ru SA and Ru NPs, the Ru/C-800 shows attractive HER catalytic activity in acidic and alkaline solutions, with low overpotentials to drive the current density of 10 mA cm −2 and the smallest Tafel slope. Density functional theory (DFT) results reveal that the coexistence of Ru SA and Ru NPs can positively affect charge distribution and charge transfer kinetics, and reduce the hydrogen adsorption and water dissociation free energy. This work provides a novel self-templating strategy for synthesizing high catalytic activity catalysts in a wide pH range.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2015
·Vol. 17
·期 10
·1-10
·
IF 2.184
Chen Daquan,Wang Guohua,Song Weiguo,Zhang Qiang
Most anticancer drugs cannot kill cancer stem cells (CSCs) effectively, which lead to the failure of anticancer chemotherapy, such as relapse and metastasis. In this study, we prepared a multifunctional oligosaccharides of hyaluronan (oHA) conjugates, oHA-histidine-menthone 1,2-glycerol ketal (oHM). The oHM conjugates possess pH-sensitive menthone 1,2-glycerol ketal (MGK) as hydrophobic moieties and oHA as the target of CD44 receptor. Anticancer drugs, curcumin(Cur) and paclitaxel(PTX), were loaded into oHM micelles via self-assembly. Then, oHM micelles were mineralized through controlled deposition of inorganic calcium and phosphate ions on the nanoparticular shell via a sequential addition method to fabricate the “nano-eggs.” The formed nano-eggs had a smaller size (120.6 ± 4.5 nm) than oHM micelles (158.6 ± 6.4 nm), indicating that mineralization made the appearance of compact nanoparticles. Interestingly, when the nano-eggs were put into the acidic conditions (pH 6.5), their outer shell(inorganic minerals) will be destroyed with the larger size, while the “nano-eggs” were stable under pH 7.4. For both nano-eggs and oHM micelles, the Cur and PTX were released in a sustained manner depending on the pH of the solution. However, the nano-eggs showed much lower released than the oHM micelles due to the dissolution of the inorganic minerals and pH-sensitive ketal at mildly acidic environments (pH 6.5). In vivo study, the nano-eggs could get to the tumor site more effectively than oHM micelles. CSCs were sorted by a side population assay from MDA-MB-231 breast cancer cell lines over-expressing CD44 receptors. Antitumor activity was also evaluated on MDA-MB-231 xenografts in nude mice. The antitumor efficacy indicated that nano-eggs with co-delivery of Cur and PTX produced the strongest antitumor efficacy, and nano-eggs showed strong activity against cancer stem cells. These double pH-sensitive nano-eggs may provide a promising strategy for drug delivery to both cancer cells and cancer stem cells.
研究领域:
药学
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2024
·
IF 5.5
Kunjie Wang,Yanan Li,Dongxu Yang,Yunsi Wang,Fuan Wei,Bingxin Liu,Peng Zhang,Benhua Xu,Yongcheng Li
Coupling noble metals on molybdenum disulfide (MoS 2 ) has emerged as a promising strategy for triggering inert basal plane and boosting hydrogen evolution reaction (HER) performances. Herein, ultrafine Ru nanoparticles (NPs) are decorated on vertical 2H MoS 2 nanosheets via a facile hydrothermal method. Benefiting from new active site centers triggered by ultrafine Ru NPs and vertically grown 2H MoS 2 nanosheets on carbon cloth (CC), Ru 0.15 @2H MoS 2 exhibits impressive HER performances in dual pH media, with low overpotentials of 20 and 111 mV and small Tafel slope of 67.6 and 76.3 mV dec ‑1 in alkaline and acid solutions to drive a current density of 10 mA cm -2 . DFT calculation results prove that ultrafine Ru NPs decorated on 2H MoS 2 nanosheets endow Ru 0.15 @2H MoS 2 with low hydrogen adsorption free energy and fast charge transfer kinetics. This work provides an effective and simple method for designing MoS 2 -based catalysts with high catalytic activity to decorate precious metal in a wide pH medium.
研究领域:
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2021
·Vol. 13
·期 4
·621
·
IF 4.329
Xiao Wang,Shi Li,Yuanyuan Tu,Jiwen Hu,Zhenzhu Huang,Shudong Lin,Xuefeng Gui
The pH-responsive membrane is a new wastewater treatment technology developed in recent years. In this paper, a novel film with intelligent pH-responsiveness was first prepared by blending functional gates comprised of hydrolyzed aramid nanofibers (HANFs) into aramid nanofiber (ANF) membranes via a vacuum filtration method. Those as-prepared membranes exhibited dual pH-responsive characteristics, which were featured with a negative pH-responsiveness in an acidic environment and a positive pH-responsiveness in basic media. These dual pH-responsive membranes also exhibited a high tensile strength which could still reach 55.74 MPa (even when the HANFs content was as high as 50 wt%), a high decomposition temperature at ~363 °C, and good solvent resistance. The membranes described herein may be promising candidates for a myriad of applications, such as the controlled release of drugs, sensors, sewage treatment, etc.Keywords:aramid nanofiber;hydrolyzed aramid nanofiber;vacuum filtration;dual pH-responsive characteristic;high strength
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Shunyu Shen,Qian Zhang,Weijia Guo,Gaojie Jiao,Yawen Wang,Han Wang,Kai Shao,Zhenjie Wang,Caicai Li,Xianyun Peng,Qingfeng Sun
The exploration of non-Pt catalysts that are highly efficient, durable, and cost-effective for the hydrogen evolution reaction (HER) is crucial for enhancing the energy efficiency of water splitting technologies. In this study, we fabricated an electrocatalyst comprising RuP2 nanoparticles decorated on N, P codoped cellulose nanofibers (CNFs)-derived carbon networks (RuP2/NPC) through a simple mixing-pyrolysis strategy. Specifically, the CNFs, which are rich in oxygen-containing functional groups, not only serve as dispersants to prevent the restacking of graphene oxide (GO) and the aggregation of RuP2 nanoparticles, thereby exposing more active sites, but also form a conductive network with GO to facilitate electron transport. Moreover, density functional theory (DFT) calculations indicate that the integration of NPC regulates the electronic structure of RuP2, resulting in a nearly thermoneutral ΔGH* at the Ru site of RuP2/NPC and making the HER process more feasible. Consequently, the synthesized catalyst exhibits excellent catalytic activity, achieving low overpotentials of 41 mV in 0.5 M H2SO4 and 52 mV in 1.0 M KOH to drive a current density of 10 mA cm–2, while maintaining robust stability. Notably, RuP2/NPC also demonstrates promising performance in alkaline seawater electrolysis, requiring an overpotential of merely 108 mV to support the same level of current density. This research significantly advances the application of CNFs-derived carbon materials in hydrogen production and contributes to the high-value utilization of forestry resources, thereby providing an inspiring avenue for the advancement of efficient and sustainable energy conversion technologies.
研究领域:
材料科学
·
能源化学
·
理论计算
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Yihang Xue,Dahai Zeng,Yuying Meng,Bing Du,Haifang Xie,Lei Ma,Yufeng Wang,Qingsheng Gao
Atomic transition metal-nitrogen (M-N x ) active sites dispersed on carbon matrix have emerged as highly promising electrocatalysts for energy conversion systems, owing to their maximized metal center utilization and excellent conductivity of the carbon substrate. However, conventional symmetric M-N 4 configurations often exhibit limited hydrogen evolution reaction (HER) activity in alkaline due to the inferior water dissociation capacity. In this work, isolated Co single atoms anchored on N -doped hollow carbon substrates (Co SA /NHCs) are successfully fabricated by the pyrolysis of Co 2+ -containing polypyrrole (Co-PPY) precursor, and the subsequent removal of embedded Co particles. Thanks to the high density of atomically distributed asymmetric Co-N 4 moieties, which facilitate efficient water activation and optimal adsorption of the active hydrogen (H*), the synthesized Co SA /NHCs electrocatalysts show remarkable HER activity and stability in alkaline electrolyte. Besides, they can effectively electrolyze HER in acidic medium, undergoing the Volmer-Heyrovsky pathway. Remarkably, Co SA /NHC-800, pyrolyzed at 800 °C, requires small overpotentials of 230 and 228 mV to achieve the current density of −10 mA cm −2 in 1.0 M KOH and 0.5 M H 2 SO 4 solutions, respectively. Moreover, it displays small Tafel slopes, high Faradic efficiencies (∼100 %) and superior long-term stability. This study paves a strategic approach for designing high-performance single-atom electrocatalysts through asymmetric structural engineering.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2017
·
IF 3.684
Hongyao Ding,Xin Ning Zhang,Si Yu Zheng,Yihu Song,Zi Liang Wu,Qiang Zheng
As a promising structural material, various tough hydrogels have been developed in recent years by incorporating different kinds of noncovalent bonds as the energy-dissipating segments. Among these systems, it is challenging to use hydrogen bonds due to their instability in aqueous environment. Here we report a tough hydrogel of poly(1-vinylimidazole- co -acrylic acid) (P(VI- co -AAc)) reinforced by the robust hydrogen bonds between imidazole and carboxylic acid groups. The hydrogels with different composition possess excellent mechanical performances, with tensile breaking stress, breaking strain, Young's modulus , and tearing fracture energy being 0.3–1.8 MPa, 920–1400%, 0.1–0.7 MPa, and 0.7–5.6 kJ/m 2 , respectively, which are well maintained over a wide pH range (3 ≤ pH ≤ 10). The high stability of hydrogen bonds should be rooted in the strong proton donor-acceptor pair. However, when pH ≤ 2 or pH ≥ 11, the gels become highly swelled due to the dissociation of imidazole and carboxylic acid groups, respectively, accompanying with dramatic decrease in mechanical properties . The tough hydrogels also show temperature- and deformation rate-dependent mechanical properties , as well as shape memory and self-recovery abilities, due to the dynamic nature of noncovalent bonds. Such hydrogels with remarkable mechanical properties and dual pH-responsiveness should find applications in load-bearing soft actuators, flexible electronics, etc.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xinlong Wang,Huijie Zhou,Mengjiao Su,Yingxue Xu,Zhengxian Zhang,Haotian Peng,Huahui Zeng,Mingsan Miao,Xiangxiang Wu
The clinical use of chemotherapy alone has been restricted by its unsatisfactory curative effects and serious adverse effects. Chemotherapy combined with chemodynamic therapy (CDT) has recently emerged as an effective strategy for pancreatic cancer therapy. However, CDT needs to overcome insufficient intracellular iron ions, deficient endogenous hydrogen peroxide, and increased cellular antioxidant defense. Herein, we synthetized a novel organic iron-based polysaccharide nanocarrier (FDC) consisting of dextran, carboxymethyl chitosan and ferrocene. After encapsulating doxorubicin and palmitoyl ascorbate (VP), a charge reversal nanoparticle (VDF NPs) based on FDC was developed with high stability, allowing for enhanced tumor accumulation and prolonged retention in blood. VDF NPs are triggered to release drugs by the pH-responsive hydrolysis of Schiff-base group, and amplify intracellular hydrogen peroxide and iron levels to generate highly toxic reactive oxygen species (ROS) by Fenton reaction. In vitro and in vivo investigations showed that VDF NPs enhanced the synergistic antitumor efficacy through apoptosis mediated by both ROS and doxorubicin and the decrease of cellular antioxidant defense, and reduced doxorubicin-induced systemic toxicity via the nanoformulation and palmitoyl ascorbate. This work provided a promising strategy to develop organic iron-based polysaccharide nanocarrier with good biocompatibility and biodegradability for clinical applications.
研究领域:
肿瘤学
·
纳米医学
·
药剂学
·
生物材料
·
分子影像
·
转化医学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2015
·Vol. 11
·期 21
·2543-2554
·
IF 8.368
Shi-Song Han,Ze-Yong Li,Jing-Yi Zhu,Kai Han,Zheng-Yang Zeng,Wei Hong,Wen-Xin Li,Hui-Zhen Jia,Yun Liu,Ren-Xi Zhuo,Xian-Zheng Zhang
A novel dual-pH sensitive charge-reversal strategy is designed to deliver antitumor drugs targeting to tumor cells and to further promote the nuclei internalization by a stepwise response to the mildly acidic extracellular pH (≈6.5) of a tumor and endo/lysosome pH (≈5.0). Poly( l -lysine)- block –poly( l -leucine) diblock copolymer is synthesized and the lysine amino residues are amidated by 2,3-dimethylmaleic anhydride to form β-carboxylic amide, making the polypeptides self-assemble into negatively charged micelles. The amide can be hydrolyzed when exposed to the mildly acidic tumor extracellular environment, which makes the micelles switch to positively charged and they are then readily internalized by tumor cells. A nuclear targeting Tat peptide is further conjugated to the polypeptide via a click reaction. The Tat is amidated by succinyl chloride to mask its positive charge and cell-penetrating function and thus to inhibit nonspecific cellular uptake. After the nanoparticles are internalized into the more acidic intracellular endo/lysosomes, the Tat succinyl amide is hydrolyzed to reactivate the Tat nuclear targeting function, promoting nanoparticle delivery into cell nuclei. This polypeptide nanocarrier facilitates tumor targeting and nuclear delivery simultaneously by simply modifying the lysine amino residues of polylysine and Tat into two different pH-sensitive β-carboxylic amides.
研究领域:
药学
·
纳米技术
·
癌症治疗
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Zitian Zhuang,Yutong Gu,Wenjie Yang,Xianying Cao,Ling Zhang,Ke Jiang
Combination chemotherapy is a key strategy for improving cancer treatment efficacy and overcoming drug resistance, but it requires smart nanocarriers capable of codelivering multiple drugs and achieving precise release at the tumor site. Herein, we report a ZIF-90-based dual-drug delivery platform (NAR@ZIF-90-DOX) for synergistic cancer therapy. The natural product naringenin (NAR) was encapsulated within ZIF-90 pores via a “one-pot” method, while the chemotherapeutic drug doxorubicin (DOX) was covalently grafted onto the surface through a pH-sensitive Schiff base linkage. This dual-gated design leverages the acidic tumor microenvironment to trigger simultaneous ZIF-90 degradation and Schiff base cleavage. This enables the synchronous and targeted release of both drugs in 4T1 cells, leading to a significantly enhanced synergistic anticancer effect compared to single-drug administration. This work provides a strategy for designing multifunctional, intelligent Metal–Organic Frameworks (MOFs) nanoplatforms for combination chemotherapy.
研究领域:
纳米技术
·
药学
·
材料科学
·
生物化学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）