FOOD CHEMISTRY
·
2019
·
IF 5.399
Hui Shen,Mouming Zhao,Weizheng Sun
The influence of pH-induced structural modifications of myofibrillar proteins (MPs) on their interaction mechanisms with pyrazine compounds was investigated. At a lower pH (4.9, 5.5), MPs aggregated to larger particle sizes due to enhanced the protein–protein interactions. The binding with pyrazine compounds was strongly affected by pH and the nature of flavor compounds. MPs exhibited flavor releasing behavior, probably due to protein–protein interactions and surface tension. Fluorescence analysis revealed that the interaction of pyrazine compounds with MPs followed a combination of static and dynamic quenching. The changes in quenching constant ( K sv ) might be attributed to a dynamic quenching, probably due to protein aggregation. The percentages of free 2,5-Dimethylpyrazine (2,5-DMP) were similar to K sv . Thermodynamic parameters indicated that electrostatic interactions and hydrophobic interactions were the major acting forces in the binding of MPs to 2,5-DMP. The binding of 2,5-DMP increased the α-helix content of MPs.
研究领域:
食品科学
·
蛋白质化学
·
风味化学
·
分子互作
·
生物物理化学
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NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 33
·14103-14107
·
IF 3.288
Chanchan Xu,Le Lv,Dawei Luo,Wei Liu
By using pyrazine derivatives, three different types of copper(I) iodide based inorganic–organic hybrid structures, 1D-CuI(2-mo-pz) (1, 2-mo-pz = 2-methoxy-pyrazine), 2D-CuI(2,3-dm-pz)0.5 (2, 2,3-dm-pz = 2,3-dimethyl-pyrazine), and 2D-Cu2I2(2,5-dm-pz)2 (3, 2,5-dm-pz = 2,5-dimethyl-pyrazine), have been obtained by using a slow-diffusion method. Single crystal and powder X-ray diffraction analyses reveal that these hybrid structures are a one-dimensional (1D) staircase chain based structure, two-dimensional (2D) staircase-chain based structure, and 2D rhomboid dimer based structure, respectively. All of the three compounds show photoluminescence, with the internal quantum yield (IQY) as high as 88.2% for 1. This work provides evidence that for this type of hybrid materials, the structure of the inorganic module could be determined by the selection of the organic ligands and that the substituted group on the organic ligands can influence the luminescence efficiency of the hybrid structures.
研究领域:
无机化学
·
材料化学
·
配位化学
·
光物理
·
功能材料
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ADVANCED MATERIALS
·
2026
·
IF 29.1
Da-Shuai Huang,Yi Tang,Pei-Qin Liao,Xiao-Ming Chen
Electrochemical CO 2 reduction must move beyond purified CO 2 to use real-world sources like flue gas or captured CO 2 . But such low-concentration feeds pose two problems: residual O 2 poisons the reaction, triggering competing oxygen reduction reaction, cutting carbon efficiency, and degrading the catalyst, while low CO 2 concentration limits mass transfer and conversion. We solve both with a kinetic molecular sieve: polyethylene glycol-coated bismuth nanoparticles (Bi@PEG). Under simulated flue gas (15% CO 2 , 5% O 2 , 80% N 2 ), Bi@PEG demonstrates record-breaking performance for CO 2 electroreduction to formate, achieving a Faradaic efficiency of 94.1 ± 0.6%, a current density of 0.91 A·cm −2 , and a single-pass CO 2 conversion of 72.5%, and maintains this performance even at 8% O 2 . Mechanism studies show the PEG layer selectively admits CO 2 (small size, quadrupole moment, strong Lewis acid, base interaction with ether oxygens; binding energy −27.4 kJ mol −1 ; diffusion barrier 0.57 eV), resulting in interfacial CO 2 enrichment. In contrast, O 2 transport is significantly impeded due to a higher diffusion barrier (0.83 eV), weak binding affinity (−3.0 kJ mol −1 ), and steric hindrance. By overcoming the dual challenges of low CO 2 concentration and oxygen interference, this work establishes “armored catalysis” as a universal approach for electrochemical CO 2 conversion using realistic, low-concentration, oxygen-containing carbon sources.
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Materials Today Chemistry
·
2026
·
IF 7.4
Lin Zhang,Hai-Yan Guo,You-Qiang Yao,Lu Zhang
Pyrazine-modulated PdCu electronic structure enables selective EGOR and HER • Bimetallic synergy and N-coordination boost EG adsorption and *OH generation. • The assembled-cell achieves > 97.77% GA selectivity at ultra-low voltage. • The system requires only 2.89 kWh per m 3 for H 2 , coupled with GA upgrading. Electrocatalytic ethylene glycol oxidation (EGOR) represents a promising route for co-producing value-added chemicals and hydrogen, yet achieving high selectivity and efficiency remains challenging. Herein, we report a bifunctional N-PdCu@Ni(OH) 2 nanosheet catalyst that exhibits exceptional performance for both EGOR and the hydrogen evolution reaction (HER). The material features pyrazine-N-coordinated Pd–Cu dual-sites, where Pd serves as the main active center for EG and *OH adsorption, while Cu doping electronically modulates Pd to enhance glycolic acid (GA) selectivity and promote *H adsorption for improved HER kinetics. In a membrane-free flow cell, the catalyst enables current densities of 100 mA cm −2 at only 1.20 V, with GA selectivity exceeding 97.77% and hydrogen Faradaic efficiency near 100%. The system requires only 2.89 kWh per m 3 H 2 produced, demonstrating a viable strategy for electronic modulation in multifunctional electrocatalysis and advancing low-energy hydrogen production coupled with sustainable biomass upgrading. Download: Download high-res image (525KB) Download: Download full-size image
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 4
·268
·
IF 5.4
Liu Yan,Yin Zhaojiang,Wang Xin,Li Binghui,Chen Quan,Chen Yuqiang,Tu Peng,You Mei,Li Han,Zhong Zubin,Liao Fusheng,Fan Hao,Zhang Jing
A chiral ruthenium probe (Ru-phe) for determination of amino acids was constructed by conjugating L-phenylalanine to a Ru-MOF precursor via EDC/NHS activation. The stereogenic center and aromatic side chain of L-Phe establish a chiral microenvironment that facilitates π–π stacking and hydrophobic interactions with tryptophan, thereby enabling efficient enantioselective recognition. The Ru-phe electrochemiluminescence (ECL) sensing platform achieved broad linear quantification ranges—0.1 nM – 1 mM for L-Trp and 10 nM – 1 mM for D-Trp. The detection limits were 0.06 nM for L-Trp and 13 nM for D-Trp. Moreover, the method showed strong reproducibility in human serum samples, with relative standard deviations (RSDs) of 0.9–1.8% for L-Trp. Machine-learning-assisted classification further improved enantiomer discrimination accuracy to 96%. Overall, this work introduces an efficient and highly sensitive ECL approach that enables practical enantiomeric determination of tryptophan, offering strong potential for clinical monitoring.
Section
Graphical abstract
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ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Wang Juan,Zhang Hengqian,Hao Lilin,Hou Jingyu,Guo Yangyang,Dong Shaojun,Fan Daoqing
Nanozyme-based biosensors have aroused
much attention
in recent
decades and were broadly applied to multifarious areas. Whereas, the
inferior reliability and high cost/complexity induced by the limited-modal
outputs and commonly used multicomponent nanozymes in existing works
are still drawbacks that cannot be ignored. Herein, taking galactose
(Gal)/xanthine oxidase (XOD) as typical metabolic biomarkers and the
facilely obtained ZnTcPP(Fe) MOF as a representative single-component
nanozyme, we constructed a universal fluorescent-colorimetric-photothermal
trimodal platform that seamlessly integrates high sensitivity, visual
readouts, and POCT capability through the rational fusion of target-responsive
enzyme/nanozyme tandem catalysis and efficient catalytic oxidation
of optical substrates. Collaborative results of spectroscopic experiments,
EPR, and DFT calculations manifested the strong electron-transfer
ability of Fe-sites within the single-component nanozyme, wherein
•OH and O 2 •– that generated
via H 2 O 2 dissociation worked as the pivotal
ROS. Noteworthy, the trimodal outputs could achieve multitrack cooperative
sensing via their complementary advantages, which evidently improved
cost-effectiveness, reliability, and compatibility. The LODs for Gal
and XOD were satisfactory in all three modes, which could compete
with many previous works. Moreover, this platform demonstrated acceptable
adaptability in human serum samples. This work not only provides a
canonical paradigm for the accurate analysis of metabolic markers
and diagnostics of related diseases but also paves unique pathways
for the exploration of economical and robust nanozyme-based multimodal
sensors.
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Advanced Healthcare Materials
·
2026
·
IF 11
Xin Liu,Zifan Zhao,Liujixiang Wang,Lei Tan,Fengxiao He,Gufeng Liu,Yang Xie,Bin Shi,Tao Wu,Haibin Xia
Infectious jawbone defects, arising from open fractures, surgical contamination, or hematogenous pathogen spread, represent severe orthopedic complications characterized by concurrent bone loss and chronic infection. Precise control of pathogen colonization, effective modulation of local immune microenvironment, and activation of osteogenesis are spatiotemporal phases that pose significant clinical challenges. Here, we construct a multifunctional platform of copper-zinc bimetallic metal–organic nanosheets encapsulated in a polyvinylpyrrolidone-polyvinyl alcohol hydrogel (CuZn-MON@gel). Upon ultrasound irradiation, CuZn-MON produces singlet oxygen, achieving antibacterial efficiencies of 99.93% against Staphylococcus aureus and 99.78% against Porphyromonas gingivalis . In the absence of ultrasound, the nanozyme switches to SOD- and CAT-like activities, scavenging excess reactive oxygen species and downregulating pro-inflammatory pathways, including chemokine and NF-κB signaling pathway. Simultaneously, controlled release of osteogenic Cu 2+ and Zn 2+ ions activates AMPK and PI3K/Akt pathways, enhancing the expression of osteogenic markers Runx2, ALP, OCN, and OPN. This system promotes osteogenic differentiation and accelerates bone regeneration in an infected rat model, achieving robust repair of jawbone defects. By dynamically balancing bactericidal ROS generation and antioxidant protection, CuZn-MON@gel offers a spatiotemporal therapeutic strategy for reconstructing infectious bone defects.
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Materials Today Bio
·
2025
·
IF 10.2
Qifan Yang,Jing Liu,Yanwei Liu,Shun Liu,Xiaokang Wei,Yilin Yang,Weijie Zhang,Shuqi Zhang,Maosheng Zhang,Bin Liu,Xinyu Wang,Dong Zhu
Background Obesity-induced osteoporosis is a prevalent complication among obese individuals. Conventional anti-osteoporosis medications often lack therapeutic specificity and may exacerbate lipid metabolism disorders. Consequently, identifying suitable pharmacological interventions for obesity-induced osteoporosis, elucidating its underlying biological mechanisms, and developing nanodrug delivery systems with enhanced biocompatibility and targeted delivery remain significant challenges. Methods This study reveals that the pathogenesis of obesity-induced osteoporosis is primarily driven by excessive mitophagy. Notably, Exendin-4 (Ex-4) has been shown to ameliorate mitophagy and mitigate obesity-induced osteoporosis. The nanocomposite DSPE-PEG-ALN (DPA)@Neutrophil membrane (NM)@Cu-TCPP(Zn)/Ex-4 (CTZE), characterized by high biocompatibility and reactive oxygen species (ROS) responsiveness, effectively targets bone tissue, reduces ROS levels, and regulates the release of Cu 2+ , Zn 2+ , Ex-4, and Alendronate (ALN). This composite interferes with B-cell lymphoma-2 (BCL2)- Beclin-1 (BECN1) binding via the tet methylcytosine dioxygenase 2 (TET2)/ PTEN-induced putative kinase protein 1 (PINK1)/Parkin (E3 ubiquitin-protein ligase parkin) pathway, thereby promoting osteoblast differentiation and mineralization. The safety and efficacy of this nano-delivery platform were validated in a mouse model of obesity-induced osteoporosis. Conclusions In summary, our study illustrates that excessive mitophagy plays a crucial role in obesity-induced osteoporosis. Furthermore, DPA@NM@CTZE exhibits significant potential for the precise treatment of obesity-induced osteoporosis, mitigating the side effects of Ex-4, and enhancing the bone microenvironment.
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MATERIALS LETTERS
·
2023
·
IF 3
Lili Gao,Ping Hu,Yingzhen Hu,Yingjie Hu,Jing Zhang
Here, the crystal synthesis, crystal structures, optical band gaps and application in devices of (C 4 N 2 H 6 )PbI 3 and (C 4 N 2 H 6 )PbBr 3 are researched and discussed. Novel hybrid 1D perovskite single crystals based on pyrazine were obtained by reacting the organic cation C 4 N 2 H 6 with lead iodide and bromide. The band gaps of (C 4 N 2 H 6 )PbI 3 and (C 4 N 2 H 6 )PbBr 3 compounds are 2.71 and 2.82 eV, respectively, which consistent with the structure distortion. The 1D crystals of (Py)PbI 3 and (Py)PbBr 3 assisted the device efficiency from 20.15% to 22.12 and 22.38%, respectively.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-11
·
IF 16.6
Chen Zhe,Li Jili,Meng Lingshen,Li Jianan,Hao Yaming,Jiang Tao,Yang Xuejing,Li Yefei,Liu Zhi-Pan,Gong Ming
Simultaneously achieving abundant and well-defined active sites with high selectivity has been one of the ultimate goals for heterogeneous catalysis. Herein, we construct a class of Ni hydroxychloride-based inorganic-organic hybrid electrocatalysts with the inorganic Ni hydroxychloride chains pillared by the bidentate N-N ligands. The precise evacuation of N-N ligands under ultrahigh-vacuum forms ligand vacancies while partially retaining some ligands as structural pillars. The high density of ligand vacancies forms the active vacancy channel with abundant and highly-accessible undercoordinated Ni sites, exhibiting 5-25 fold and 20-400 fold activity enhancement compared to the hybrid pre-catalyst and standard β-Ni(OH) 2 for the electrochemical oxidation of 25 different organic substrates, respectively. The tunable N-N ligand can also tailor the sizes of the vacancy channels to significantly impact the substrate configuration leading to unprecedented substrate-dependent reactivities on hydroxide/oxide catalysts. This approach bridges heterogenous and homogeneous catalysis for creating efficient and functional catalysis with enzyme-like properties.
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ANALYTICAL CHEMISTRY
·
2023
·
IF 7.4
Rihui Su,Gongke Li,Xiaohua Xiao
In this work, Ag nanoparticles (AgNPs) were embedded into a poly(N-isopropylacrylamide)-laponite (Ag/PNIP-LAP) hydrogel membrane for highly sensitive surface-enhancement Raman scattering (SERS) detection. In situ polymerization was initiated by UV light to encapsulate AgNPs in a PNIP-LAP hydrogel to prepare a highly active SERS membrane with a three-dimensional structure. Due to the surface plasmon resonance and high swelling/shrinkage ratio of the Ag/PNIP-LAP hydrogel SERS membrane, its network structure has a “sieving” effect, which makes it easier for hydrophilic small-molecule targets to enter the sterically confined hydrogel, and the AgNPs are close to each other to form a Raman “hot spot” through the shrinkage of the hydrogel, at the same time, the analyte is enriched in the confined space and close to the AgNPs to form a stronger SERS signal. The characterization of the SERS activity of the Ag/PNIP-LAP hydrogel showed that the prepared three-dimensional membrane had high detection sensitivity for urotropine, 2,5-dimethylpyrazine, pyrazinamide, and pyrazine; the detection limits (S/N = 3) were 17.4, 31.0, 53.1, and 1.11 μg/L, and the analytical time was 35 min. Due to the hydrophilicity of the Ag/PNIP-LAP hydrogel membrane, the small molecules can easily enter the SERS membrane, and the hydrophobic macromolecules are blocked outside the SERS membrane. The SERS method has good selectivity, stability, and reproducibility. The SERS method was applied to the detection of urotropine in dried bean curd sticks, 2,5-dimethylpyrazine in nuts and potato chips, and pyrazinamide in human plasma with recoveries of 81.8–116.8% and the relative standard deviation within 4.9–9.9%. The results matched well with that found by the corresponding chromatographic methods. The proposed method has the advantages of simple sample pretreatment, speediness, high sensitivity, and good selectivity to hydrophilic compounds and has potential application in the rapid on-site detection.
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Catalysts
·
2023
·Vol. 13
·期 3
·640
·
IF 3.9
Cong Wang,Gang Li,Hongchen Guo
MOFs have attracted widespread attention in the field of catalytic ethylene dimerization. Compared with post-synthetic modification, ion exchange and other methods to introduce external active centers, the direct use of MOF materials as catalysts is still the most convenient and prospective. Herein, the NiBTCs are synthesized using a one-pot method in two kinds of solvent and characterized by XRD, FT–IR, ICP–OES, XPS, TGA and N2physical adsorption. After treatment at 150 °C, the catalytic activities of both materials in ethylene dimerization are up to 470.9, and 647.0 gpro./(gcat.·h) and the selectivity of 1-butene in all products could reach 83.2% and 81.7%, respectively. Stability testing of the catalysts demonstrated that they do not decompose during the reaction, but their reuse performance is degraded. In addition, a probable Cossee–Arlman–type mechanism is proposed. The NiBTCs are shown to have superior catalytic performance in ethylene dimerization compared to employing Ni(pyz)2Cl2or α–Ni(im)2as catalysts.Keywords:ethylene dimerization;NiBTCs;MOFs;1-butene
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