INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2012
·
IF 3.35
Anning Wang,Hui Gao,Yanfang Sun,Yu-long Sun,Ying-Wei Yang,Guolin Wu,Yinong Wang,Yunge Fan,Jianbiao Ma
A series of temperature- and pH-responsive polyurethanes based on hexamethylene diisocyanate (HDI) and 4,4′-diphenylmethane diisocyanate (MDI) were synthesized by a coupling reaction with bis-1,4-(hydroxyethyl) piperazine (HEP), N -methyldiethanolamine (MDEA) and N -butyldiethanolamine (BDEA), respectively. The chemical structure , molecular weight, thermal property and crystallization properties were characterized by Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and X-ray diffraction (XRD) spectroscopy. The resulting polyurethanes were then used to prepare nanoparticles either by direct dispersion method or dialysis method. Their pH and temperature responsibilities were evaluated by optical transmittance and size measurement in aqueous media. Interestingly, HDI-based and MDI-based polyurethanes exhibited different pH and temperature responsive properties. Nanoparticles based on HDI-HEP and HDI-MDEA were temperature-responsive, while MDI-based biomaterials were not. All of them showed pH-sensitive behavior. The possible responsive mechanism was investigated by 1 H NMR spectroscopy. The cytotoxicity of the polyurethanes was evaluated using methylthiazoletetrazolium (MTT) assay in vitro . It was shown that the HDI-based polyurethanes were non-toxic, and could be applied to doxorubicin (DOX) encapsulation. The experimental results indicated that DOX could be efficiently encapsulated into polyurethane nanoparticles and uptaken by Huh-7 cells. The loaded DOX molecules could be released from the drug-loaded polyurethane nanoparticles upon pH and temperature changes, responsively.
研究领域:
生物材料学
·
药剂学
·
肿瘤学
·
高分子科学
·
纳米医学
✓ 已验证
DOI
高影响因子
IRANIAN POLYMER JOURNAL
·
2019
·Vol. 28
·期 2
·157-166
·
IF 1.707
Zhang Guangyan,Zhou Jun,Wang Peng
A novel cross-linkable polyaspartamide derivative-containing cinnamoyl pendant groups, P(HPA-Az)-CA, was designed and synthesized in this study. Chemical structures of the obtained polymers were confirmed by FTIR, UV, and 1 H NMR techniques. The transmittance measurement results showed that the prepared polymer P(HPA-Az)-CA displayed temperature and pH dual stimuli-responsive behaviors. The cloud point of P(HPA-Az)-CA could be tuned just by adjusting the introduced percentage of hydrophobic moieties or the pH of polymer aqueous solution. The effect of pH on the cloud point of P(HPA-Az)-CA was investigated by zeta potential, and the results showed that it may be related to the weakened electrostatic repulsion caused by decreased zeta potential with pH decreasing. Diamines (ethylenediamine or cystamine) were adopted to prepare cross-linked micelles using the mixture of P(HPA-Az)-CA aqueous solution and diamines just by one-step heating method. The cross-linked micelles were stable, even when the environmental temperature was below the cloud point of P(HPA-Az)-CA. The cross-linking mechanism between the diamines and α,β-unsaturated carbonyl moieties of P(HPA-Az)-CA was confirmed by 1 H NMR. In addition, the micelles cross-linked with cystamine could be disrupted in the presence of 10 mM glutathione. According to the results, the obtained polyaspartamide derivative P(HPA-Az)-CA may be a potential for facilitating drug loading.
研究领域:
高分子化学
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药物传递系统
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2014
·
IF 3.916
Jiachang Huang,Li Zhou
The hydrolyzed peach gum polysaccharide (HPGP) prepared at acidic condition is investigated as an anionic polyelectrolyte for the first time. A hydrolysis mechanism is proposed by monitoring the hydrolysis efficiency and morphological change of crude peach gum, and the intrinsic viscosity of resulted HPGP as a function of hydrolysis time. Fourier transform infrared (FTIR) spectroscopy and ζ-potential measurements reveal that HPGP with multiple carboxylic groups is negatively charged in water in the pH range 3–11. The HPGP exhibits remarkable pH and ionic strength responsiveness, as proven by dynamic light scattering (DLS) and atomic force microscopy (AFM) measurements. Moreover, the layer-by-layer (LbL) self-assembly experiments further confirmed that the HPGP can be utilized as an anionic polyelectrolyte . Considering the facile availability, favorable compatibility and intriguing functionality of HPGP, this study opens up enormous opportunities for the large-scale utilization of peach gum resource.
研究领域:
高分子科学
·
生物材料
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纳米技术
·
药物递送
·
表面化学
✓ 已验证
DOI
高影响因子
MACROMOLECULAR MATERIALS AND ENGINEERING
·
2018
·Vol. 303
·期 9
·1800060
·
IF 2.69
Titao Jing,Tuanwei Li,Zheng Ruan,Quan Cheng,Lifeng Yan
A negatively charged polypeptide nanogel, near-infrared (NIR) cyanine dye (Cy5.5) conjugated and 2,3-dimethylmaleic anhydride (DMA) modified poly- l -lysine-co- l -cystine (CDPLC), is synthesized and is used as an imaging-guided sequential drug delivery system. The CDPLC nanogel can respond to two general stimulations in sequence: extracellular tumor acidic microenvironment pHe (6.8–6.5) and intracellular high concentration glutathione (GSH). Under pHe, the DMA shell of the nanogel is removed and a charge reversal takes place, resulting in positively charged nanogel which can be internalized by cancer cells easily. Once internalized into tumor cells, the increased intracellular GSH concentration further promotes DOX release from the nanogel and DOX is enriched to the nucleus. Cy5.5 is conjugated to the nanogel as an NIR fluorescent probe, making it possible for imaging-guided drug delivery, which is confirmed by the MTT and confocal laser scanning microscopy via in vitro experiments. The as-prepared nanogel is a potential theranostic for cancer therapy.
研究领域:
肿瘤学
·
药剂学
·
分子影像学
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生物材料
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纳米医学
·
药物递送系统
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2014
·
IF 2.354
Shangyang Li,Pengyao Xing,Lin Zhang,Feifei Xin,Jinhui Nie,Hailu Wang,Mingfang Ma,Yurong Wu,Aiyou Hao
Herein, we report a novel responsive assembly system consisting of an amphiphilic drug fenspiride and β-cyclodextrin in host–guest approach. Fenspiride molecules can self-assembled into vesicles in aqueous solution. The obtained vesicles were characterized in detail by transmission electron microscopy (TEM), scanning electron microscopy (SEM) and atomic force microscopy (AFM). Furthermore, such a vesicular structure will be destroyed upon the addition of β-cyclodextrin due to the formation of inclusion complexes by host–guest interactions. In addition, amylase is a digestive enzyme which can catalyze the breakdown of starch into sugars. Adding α-amylase into the system could release fenspiride molecules, and trigger the self-assembly of fenspiride molecules again. It is anticipated that this research will provide widespread applications in the fields of responsive materials and biochemistry related to enzyme-responsive model system and host–guest chemistry.
研究领域:
药物化学
·
纳米医学
·
分子药剂学
·
生物材料
·
酶学
·
超分子化学
✓ 已验证
DOI
高影响因子
Advanced Electronic Materials
·
2018
·Vol. 4
·期 7
·1800154
·
IF 5.466
Qiu Li,Aixiang Wei,Jianting Lu,Lili Tao,Yibin Yang,Dongxiang Luo,Jun Liu,Ye Xiao,Yu Zhao,Jingbo Li
Layered 2D semiconductors, such as graphene and transition-metal dichalcogenides (TMDs), are receiving intensive attention owing to their great performance in electronic and optoelectronic application during the past few years. Among them, SnS has similar anisotropy to black phosphorus and high photoresponse in the near infrared range, rendering it as an ideal candidate for infrared photodetectors. In this work, large-size (up to 330 µm) and high-quality single-crystalline SnS nanoplates are synthesized successfully via controlled chemical vapor deposition technique and characterized by field-emission scanning electron microscopy, X-ray diffraction, confocal Raman system, atomic force microscope, transmission electron microscopy, and photoluminescence spectroscopy. Photodetectors based on as-grown SnS nanoplates are fabricated with back-gated field effect transistors (FETs) configuration, exhibiting a high mobility of 17.1 cm 2 V −1 s −1 . Photodetectors based on the SnS FETs demonstrate excellent optoelectronic performance both in visible and near-infrared spectral range. Typically, photoresponsivity of 197.7 A W −1 , photoresponse time of 39 ms, and external quantum efficiency of 6.06 × 10 4 % are exhibited under the irradiation of 405 nm laser. The wide response range and ultrahigh sensitivity make the large-area single crystal SnS nanoplate a promising candidate for future application in optoelectronics.
研究领域:
材料科学
·
纳米科技
·
半导体物理
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光电子学
·
凝聚态物理
✓ 已验证
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2016
·
IF 2.725
Jie Zhang,Ningyu Chen,Yuheng Cui,Liqun Zhang,Dongmei Yue
In this study, novel 1-methylpropargyl alcohol derivatives containing leucine side groups on their side chains were successfully synthesized and polymerized using (nbd)Rh + [η 6 -C 6 H 5 B − (C 6 H 5 ) 3 ] as catalyst. Circular dichroism (CD) and ultraviolet–visible (UV–Vis) spectra revealed that the polymers took predominantly one-handed helical structures that were stable under heat. Deprotection of the t-butyloxycarboryl (Boc) groups in the homopolymers under acidic conditions produced polymers with primary amine moieties on the side chains. The polymers were soluble in aqueous medium, and turbidity test revealed that they were pH-responsive. Amino acid-based polymers were further used in the enantionselective crystallization of alanine enantiomers and l -alanine was preferably induced to crystallize with the l -leucine-based polymer.
研究领域:
高分子化学
·
手性分离
·
药物结晶
·
功能材料
·
生物材料
·
有机合成
✓ 已验证
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2019
·
IF 4.959
Wanling Cai,Mengyu Guo,Xiulan Weng,Wei Zhang,Zuliang Chen
Since Fe 3 O 4 nanoparticles synthesized by plant extracts possess good bio-compatibility and superparamagnetic properties, the possibility of these could be used as a carrier in drug delivery. In this work, doxorubicin hydrochloride (DOX), an anti-cancer drug, loaded on glutaric anhydride-functionalized magnetic nanoparticles (Fe 3 O 4 @SiO 2 -Glu) was investigated at varying pH values for effective drug delivery. Various factors affecting the adsorption of DOX onto the Fe 3 O 4 @SiO 2 -Glu were examined, where the adsorption efficiency of DOX reached 92% at a concentration of 20 mg/L employing 10 mg of Fe 3 O 4 @SiO 2 -Glu at 303 K in pH 7.4. However, the adsorption efficiency of DOX was decreased to 18% at acidic pH value down to 3.0, implicating that the drug releasing process was controlled by pH. Adsorption kinetics was fitting to pseudo-second-order and the isothermal adsorption conformed to Freundlich isotherm. The morphology and surface composition of the synthesized Fe 3 O 4 @SiO 2 -Glu were characterized by SEM, TEM , and N 2 adsorption/desorption isotherms, revealing that the specific surface area being 62.6 m 2 /g and the size ranging from ~30 to 50 nm. The zeta potential results indicated that Fe 3 O 4 @SiO 2 -Glu were negatively charged in various pH from 3 to 8.5. Characterizations by FTIR and UV–Vis techniques suggested that the DOX was absorbed and it can be delivered by Fe 3 O 4 @SiO 2 -Glu.
研究领域:
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 89
·72444-72452
·
IF 3.84
Hui Liu,Si Chen,Huanqing Cui,Jin Hu,Hongyan Cai,Wenkai Deng
The uniformly dispersed and structured silica nanoparticles were prepared and functionalized by amino and 2-bromoisobutyrate successively. The random copolymer brushes of 2-(dimethylamino) ethyl methacrylate (DMAEMA) and 1′-(2-acryloxyethyl)-3′,3′-dimethyl-6-nitrospiro-(2H-1-benzopyran-2,2′-indoline) (SPMA) were synthesized from 2-bromoisobutyrate-functionalized silica nanoparticles by surface-initiated atom transfer radical polymerization (SI-ATRP). FT-IR, TGA, XPS, TEM, and EDS verified the successful immobilization of initiator and grafting of the random copolymer. Subsequently, the triple responsive behaviors including thermo-, pH- and photo-sensitivities were investigated using dynamic light scattering (DLS) as well as UV-Vis spectrometry. Furthermore, the active palladium was loaded into the hybrid silica nanoparticles and the catalytic performance was evaluated using a styrene hydrogenation reaction at different temperatures.
研究领域:
高分子化学
·
纳米材料科学
·
催化化学
·
智能响应材料
·
表面功能化
·
有机合成
✓ 已验证
DOI
高影响因子
SOLID STATE SCIENCES
·
2018
·
IF 1.861
Jianyi Liu,Yan Liu,Dianxin Jin,Minjia Meng,Yinhua Jiang,Liang Ni,Zhanchao Liu
Tannic-acid-templated large pore mesoporous silica nanoparticle (LMSN) was synthesized using one-pot procedure and the external surface was further modified with APTES (LMSN-N) to immobilize trypsin. After modification, trypsin was difficult to be immobilized on the outer surface of the LMSN due to the electrostatic repulsion. Naturally, study of the trypsin immobilized in the interior pores could be implemented solely. Meanwhile, the activity of immobilized trypsin was optimized by response surface method (RSM), and the ANOVA was employed to explore the interaction between independent variables. The maximum enzyme activity (12.28 U/mg) was obtained under a certain condition that the quality of T-LMSN-N-272 was 153 μg, the pH was 7.9, and the temperature was 40.4 °C. Simultaneously, the immobilized enzyme was proved to possess better thermal stability, storage stability and recycling performance than free enzyme.
研究领域:
生物化学
·
材料科学
·
酶工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Yawei Shi,Guobin Song,Anqi Li,Jun Wang,Haonan Wang,Ya Sun,Guanghui Ding
A series of composite aerogels with different precursor mass ratios were prepared from graphene oxide (GO) and chitosan (CS) by conducting the crosslinking step after lyophilization, the method of which was recently found beneficial to enhance the adsorptive properties of aerogels . The composite aerogels were then employed for the adsorption of methyl orange (MO) and methylene blue (MB) from water, and the one prepared at GO:CS= 1:2 (w/w) was selected as the optimal compromising the adsorption and mechanical properties. The maximum adsorption amounts of MO and MB were calculated to be 543.4 and 110.9 mg/g at 25 °C. Especially, the effects of pH on adsorption of MO and MB in both single and binary systems were investigated in detail. The aerogel possessed pH-responsive feature for single dye adsorption, tending to adsorb MO at low pH while to adsorb MB at high pH. In the binary system, the pH-responsive feature remained and selective adsorption was observed at low initial dye concentration. In contrast, synergistic adsorption occurred instead at high initial concentration, and MB and MO could be efficiently removed simultaneously in the whole pH range of 3–11.
研究领域:
环境科学
·
材料科学
·
化学工程
·
水处理
·
吸附技术
✓ 已验证
DOI
高影响因子
JOURNAL OF ASIA-PACIFIC ENTOMOLOGY
·
2021
·Vol. 25
·期 1
·101859
·
IF 1.303
Jianyu Deng,Zhijie Shen,Fumin Wang,Tao Liu,Wenying Hong,Minghua Fang,Linfeng Wo,Sijie Chu
Grapholita molesta (Busck) (the oriental fruit moth; OFM) and Conogethes punctiferalis (Guenée) are both fruit and stem borers with overlapping habitats, occurrences, and outbreak cycles. These two species are in different families and they have completely different sex pheromone components. Here, the effects of the sex pheromone components of C. punctiferalis , ( E )-10-hexadecenal ( E 10-16:Ald) and ( Z )-10-hexadecenal ( Z 10-16:Ald) and their mixture, were evaluated on the sexual communication of OFM by examining electrophysiological (EAG) and behavioral responses. We found that a considerably large amount of E 10-16:Ald or Z 10-16:Ald and a tiny amount of OFM pheromone elicited comparable EAG responses in OFM males, indicating the low antennal olfactory sensitivity of OFM males to the heterospecific pheromone compounds. In two different peach orchard parcels, captures of OFM by their pheromone lures baited in delta traps were increased by at least 1.5 times when OFM pheromone lures were combined with lures that contained 1000 μg of either E 10-16:Ald, Z 10-16:Ald or their mixture. In two other pear orchard parcels, both E 10-16:Ald and Z 10-16:Ald increased captures of OFM in Unitraps in a dose-dependent manner with more than a four-fold increase. Therefore, the enhanced attractiveness of OFM lures by the two interspecific pheromones suggests their potential application to improve mass trapping, population monitoring and mating disruption of OFM.
研究领域:
昆虫学
·
化学生态学
·
农业昆虫学
·
害虫综合治理
·
行为生理学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）