INDUSTRIAL CROPS AND PRODUCTS
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2026
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IF 6.4
Yongliang Ding,Bingbing Shi,Siyu Liu,Jindong Li,Fang Wu,Qingmin Yang,Yuhong Wang,Mengjie Li,Zhongkai Wang,Xiankun Wu
H 2 O 2 -assisted cleavage converts non-edible tung oil into bio-based azelaic acid for polyamide synthesis. • Programmable crystallinity transforms rigid PA69 into tough elastomers with good melt processability. • Crystallinity-engineered polyamide elastomers show strong, reprocessable adhesion on metals. Transforming non-edible plant oils into high-performance engineering polymers offers a promising route toward sustainable materials, yet remains challenged by the inefficient upgrading of structurally complex feedstocks and the difficulty of simultaneously controlling crystallinity, toughness, and processability in the resulting polymers. Tung oil, a renewable resource rich in conjugated polyunsaturated fatty acids, is particularly attractive but has been underutilized because selective conversion into well-defined monomers remains difficult. Here we report an integrated strategy that links feedstock upgrading with molecular structure programming to create bio-based polyamides with designer crystallinity. Through hydrogen peroxide-assisted oxidative cleavage, tung oil is selectively converted into high-purity azelaic acid (AA), which is subsequently copolymerized with hexamethylenediamine and poly(propylene glycol) bis(2-aminopropyl ether) (D400) to construct a family of random copolyamides (PA69 X ). The incorporation of flexible ether-containing segments disrupts chain regularity and hydrogen-bond organization, enabling precise modulation of crystalline order, melting behavior, and lamellar structure while preserving excellent thermal stability. As a result, the materials undergo a transition from rigid semicrystalline polyamides to highly tough elastomers with programmable crystallinity. The optimized copolyamide exhibits a fracture toughness of 141 MJ m −3 together with continuous melt-fiber processability, stretch-induced crystallization behavior, and robust reprocessable adhesion to metal substrates with lap shear strengths exceeding 9 MPa. This work establishes a general framework that integrates renewable feedstock valorization, crystallinity engineering, and multifunctional performance, providing a pathway for converting underutilized plant oils into sustainable engineering polymers. Download: Download high-res image (240KB) Download: Download full-size image Description: A sustainable pathway from tung oil to high-performance polyamide elastomers is established via bio-based azelaic acid, enabling programmable crystallinity, exceptional toughness, stretch-induced crystallization, and multifunctional applications in fibers and reprocessable adhesives
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Cell Metabolism
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2026
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IF 37
Mingyuan Wei,Xinzhu Yi,Zhuandi Lin,Jingjing Cai,Shanze Chen,Fang Zhou,Hanqin Cai,Xinfeng Lu,Juan Tang,Yunfeng Shi,Liping Cui,Lei Yang,Xinru Jing,Yunong Zeng,Rong Wu,Tingting Shu,Yuanyuan Li,Fangyuan Yang,Yi He,Zhibin Zhao,Yuqiong Yang,Wenjiao Zhu,Qiong Jiang,Weiwei Zhang,Xiang Tan,Zhuo Ma,Xiaoying Fan,Wei Ma,Sheng Li,Wensheng Shu,Hong Wei,Zhiming Xiang,Jack A. Gilbert,Shenhai Gong,Zhang Wang
Sepsis is characterized by impaired immunity to infection, leading to multi-organ dysfunction, with the lung being the most vulnerable organ. Here, we show that ketogenic diet (KD) alleviates sepsis-induced lung injury through a microbial-gut-lung axis. KD alters the gut microbiota in mice and humans, enriching Limosilactobacillus reuteri and Lactiplantibacillus plantarum . Specific strains of these species produce a flavin-dependent monooxygenase (FMO) that converts oleic acid in KD into azelaic acid (AZA). During sepsis, AZA translocates to the lung, where it promotes neutrophil apoptosis and expands MerTK + alveolar macrophages (AMs) via PPAR-γ activation, enhancing efferocytosis and resolution of lung injury. In patients with sepsis, elevated AZA correlates with improved clinical outcomes, including survival rates, ventilation-free days (VFDs), and pulmonary function, along with increased MerTK + AMs and apoptotic neutrophils in patient lungs. These findings uncover a pathway of gut-lung crosstalk mediated by diet-microbiome interactions, highlighting the therapeutic potential of KD and microbiome modulation in sepsis.
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
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2026
·Vol. 34
·期 4
·80
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IF 5.6
Zhou Xiaorui,Yang Ying,Lv Chang,Cheng Xinru,Hao Wenbo,Su Tingting,Huang Chenhao,Hu Bing
To adjust and optimize the structure and characteristics of biodegradable poly (butylene succinate) (PBS)-type polyesters, seven aliphatic polyesters with different chain lengths were synthesized by introducing azelaic acid. It can be finded that the melting points of the six polyesters gradually rise with increasing carbon chain length, with the exception of poly(propylene azelate) (PPAz). The XRD analysis reveals that the odd–even effect exerts a certain influence on the diffraction peaks. Specifically, the diffraction angles of odd-odd carbon polyesters demonstrate a systematic shift in comparison to those of odd–even carbon polyesters. Except for PPAz and poly(hexylene azelate) (PHAz), the hydrophilicity of the polyesters decreases with increasing chain length, with PHAz being the most hydrophilic polyester. The thermal decomposition temperatures of the seven polyesters exceed 315.0 °C, indicating good thermal stability. Among them, poly(decylene azelate) (PDAz) exhibits the highest thermal decomposition temperature, reaching as high as 358.1 °C. Enzyme hydrolysis studies show that poly(pentylene azelate) (PPeAz) has the best biodegradability, with the polyester experiencing 100% weight loss after 12 h of enzymatic degradation. Graphical
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REACTIVE & FUNCTIONAL POLYMERS
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2026
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IF 5.4
Shibo Pei,Yanli Xiang,Peng Zhang,Xv Meng,Chenyi Wang,Qiang Ren
A kind of epoxy-functionalized flexible graft polyesters containing pendant polydimethylsiloxane short chains (ADSE) as novel tougheners for epoxies were developed. The polyesters with varying compositions were synthesized using dodecanedioic acid and azelaic acid as diacids, diethylene glycol and a Y-shaped mono-terminal bis‑carbon hydroxyl polydimethylsiloxane (PDMS) as diols, and two epoxy compounds as capping agents. Chemical structure and crystallization property of ADSE were well characterized by 1 H NMR, FTIR, GPC and DSC. Viscosity testing revealed a higher content of PDMS resulted in a lower viscosity of ADSE. Polyester containing 50% of PDMS in diols (ADSE50) showed best toughening and strengthening performance for epoxies. The epoxy thermosets containing 2% of ADSE50 exhibited the maximum impact strength of 40.42 kJ/m 2 and tensile strength of 103.25 MPa, which increase of 94.14% and 34.21% compared with that of neat epoxy. The introduction of ADSE50 also increased the glass transition temperature ( T g ), initial thermal decomposition temperature, hydrophobicity and maintain high transparency of epoxy thermosets. The polyester of ADSE 50 was demonstrated to be a versatile toughener, capable of fabricating high-performance epoxy thermosets.
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POLYMER BULLETIN
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2025
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IF 4
Wang Guoqiang,Yu Yiheng,Zhang Mengke,Shi Longqing,Hu Hongliang,Jin Yujie,Hu Jing
1,4-Cyclohexanedimethanol-based polyesters were synthesized from 1,4-cyclohexanedimethanol (CHDM) and a variety of aliphatic diacids with odd carbons. Differential scanning calorimetric analyzer (DSC), wide angle X-ray diffraction (WXRD), thermogravimetric analyzer (TGA), universal testing machine, dynamic mechanical analysis (DMA), and rotational rheometer were used for the characterization. Number-average molecular weight of CHDM-based polyesters is 12,000–37,000 g/mol. All polyesters can crystallize. All CHDM-based polyesters have good thermal stability. The polyesters from aliphatic diacids with long chains (azelaic acid, undecanedioic acid, and tridecanedioic acid) have better crystallization ability and good toughness (elongation at break > 300%). CHDM-based polyesters are potentially bio-based materials with great potential and promise.
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Acta Biomaterialia
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2021
·
IF 8.947
Suleixin Yang,Ka Hong Wong,Peng Hua,Chengwei He,Hua Yu,Dan Shao,Zhi Shi,Meiwan Chen
Ferroptosis is a newly discovered non-apoptotic cell death form but its therapeutic efficacy triggered by traditional iron-based nanomaterials or classic drug inducers has been far from satisfactory due to the high glutathione (GSH) level in cancer cells and insufficient lipid peroxide production. Here we reported a ferroptosis/apoptosis combinational therapy by depleting GSH and downregulating GPX4 to disrupt redox homeostasis and amplify ferroptosis-related oxidation effect. In this study, we developed reactive oxygen species (ROS)-responsive serum-resistant nanoparticles with thioketal-crosslinked fluorinated polyethyleneimine 1.8K ( TK PF) as the core, which were wrapped with hyaluronic acid (HA) as the shell ( TK PFH NP) to co-deliver shGPX4 and shMTHFD2 plasmids for cancer treatment. The highly efficient and tumor-selective gene carrier TK PFH NPs revealed outstanding transfection efficiency (∼100 %) and sustained the efficiency (∼50 %) even in media containing 90 % FBS. Mediated by HA, TK PFH NPs actively targeted CD44 receptors, thus enabling efficient uptake by tumor cells and experiencing surface charge conversion to induce subsequent lysosomal escape. Then the TK PF NPs were effectively disintegrated by the abundant ROS in cancer cells, which facilitated the release of plasmids and avoided the cytotoxicity of cationic polymers. shGPX4 plasmid induced ferroptosis by producing ROS and lipid peroxides via downregulating GPX4, while shMTHFD2 triggered apoptosis by modulating NADPH/NADP and depleting GSH of the cancer cells. Moreover, GSH consumption caused by shMTHFD2 indirectly suppressed GPX4 and further augmented ferroptosis, showing synergistic anticancer effect against B16-F10 cells. Taken together, the rationally designed dual-gene loaded TK PFH NPs provided a safe and high-performance platform for enhanced ferroptosis-apoptosis combined anticancer efficacy based on gene therapy. Statement of significance The therapeutic efficacy of ferroptosis has been far from satisfactory due to high GSH level and insufficient lipid peroxide production in cancer cells. Herein, we reported a ferroptosis/apoptosis combinational therapy by depleting GSH and downregulating GPX4 to disrupt redox homeostasis and amplify ferroptosis-related oxidation effect. ROS-responsive serum-resistant nanoparticles were fabricated with thioketal-crosslinked fluorinated PEI 1.8K ( TK PF) as the core and hyaluronic acid (HA) as the shell ( TK PFH NP) to co-deliver shGPX4 and shMTHFD2 plasmids. The shGPX4 plasmid induced ferroptosis by producing ROS and lipid peroxides via downregulating GPX4, while shMTHFD2 triggered apoptosis by modulating NADPH/NADP and depleting GSH. The rationally designed dual-gene loaded TK PFH NPs provided a safe and high-performance platform aimed for enhanced ferroptosis-apoptosis combined anticancer efficacy.
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Nature Communications
·
2021
·Vol. 12
·期 1
·1-17
·
IF 14.919
Qi Jing,Jin Feiyang,You Yuchan,Du Yan,Liu Di,Xu Xiaoling,Wang Jun,Zhu Luwen,Chen Minjiang,Shu Gaofeng,Wu Liming,Ji Jiansong,Du Yongzhong
Some specific chemotherapeutic drugs are able to enhance tumor immunogenicity and facilitate antitumor immunity by inducing immunogenic cell death (ICD). However, tumor immunosuppression induced by the adenosine pathway hampers this effect. In this study, E-selectin-modified thermal-sensitive micelles are designed to co-deliver a chemotherapeutic drug (doxorubicin, DOX) and an A2A adenosine receptor antagonist (SCH 58261), which simultaneously exhibit chemo-immunotherapeutic effects when applied with microwave irradiation. After intravenous injection, the fabricated micelles effectively adhere to the surface of leukocytes in peripheral blood mediated by E-selectin, and thereby hitchhiking with leukocytes to achieve a higher accumulation at the tumor site. Further, local microwave irradiation is applied to induce hyperthermia and accelerates the release rate of drugs from micelles. Rapidly released DOX induces tumor ICD and elicits tumor-specific immunity, while SCH 58261 alleviates immunosuppression caused by the adenosine pathway, further enhancing DOX-induced antitumor immunity. In conclusion, this study presents a strategy to increase the tumor accumulation of drugs by hitchhiking with leukocytes, and the synergistic strategy of chemo-immunotherapy not only effectively arrested primary tumor growth, but also exhibited superior effects in terms of antimetastasis, antirecurrence and antirechallenge.
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JOURNAL OF HAZARDOUS MATERIALS
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2019
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IF 7.65
Jiujiang Ji,Guo Chen,Jun Zhao
To explore the effect of coexisted amino and thiol groups on adsorption of heavy metal, a novel magnetic nanoparticle was prepared by sequentially modification with (3-Chloropropyl) trimethoxysilan, polyetherimide, epichlorohydrin and thiourea. Subsequently, it was characterized by TEM, N 2 adsorption/desorption, FTIR Spectroscopy, zeta potential, and VSM. The maximum adsorption capacity for Pb 2+ , Cd 2+ and Cu 2+ reached 110.13 mg·g −1 , 40.23 mg·g −1 and 29.37 mg·g −1 , respectively. The adsorption of the magnetic nanoparticles with different surface group for heavy metals were compared, which indicated that the amino and thiol group played an important role in the adsorption of heavy metals. Especially, the adsorption capacity increased dramatically after modification with the thiol group, which was attributed to the synergistic coordination of −NH 2 and −SH. The adsorption kinetics is consistent with the quasi-second-order kinetics equation, and the adsorption thermodynamic process is consistent with the Langmuir isotherm equation. The effects of experimental conditions, such as pH, the concentration of metals, adsorption time and temperature, on adsorption of Pb 2+ were studied in detail. In addition, over 90% of removal rate was remained after 6 cycles. The magnetic nanoadsorbents was a promising nanoadsorbent with high adsorption speed, simultaneous adsorption of various heavy metals, strong anti-interference ability and reusability.
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BIOMATERIALS
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2018
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IF 8.806
Gang-Gang Yang,Hang Zhang,Dong-Yang Zhang,Qian Cao,Jing Yang,Liang-Nian Ji,Zong-Wan Mao
A promising theranostic nanosystem VK3-CPT@Ru-CD is designed and fabricated by the host-guest driven self-assembly between the fluorescent adamantine-functionalized Ru(II) complexes and the ROS-labile-cyclodextrin modified thioketal linkers, in which anticancer drug camptothecin (CPT) and vitamin K3 (VK3) are effectively co-encapsulated. On account of the generative feedback between the intracellular redox cycling of VK3 and the high degree of ROS-triggered collapse of nanoparticles , VK3-CPT@Ru-CD can facilitate cancer-specific ROS amplification and drug release selectively in cancer cells, thus realizing the selective killing of tumor with minimal side-effects both in vitro and in vivo , the therapeutic effect of which is more prominent than the free anti-cancer drugs. More interestingly, the menadione structure of encapsulated VK3 can effectively quench the inherent fluorescence of Ru-CD, and a fluorescence lightening up phenomenon is observed accompanied with the ROS-triggered drug release, which can be utilized for real-time tracking of drug release in vitro and in vivo.
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2015
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IF 1.098
Zhijuan Sun,Xiao Wang,Fei Guo,Chunyue Jiang,Qinmin Pan
Bio-sourced nylon 69, one of promising engineering plastics, has a great potential in developing sustainable technology and various commercial applications. Isothermal and nonisothermal crystallization kinetics of nylon 69 is a base to optimize the process conditions and establish the structure–property correlations for nylon 69, and it is also highly beneficial for successful applications of nylon products in industry. Isothermal and nonisothermal crystallization kinetics has been investigated by differential scanning calorimetry for nylon 69, bio-sourced even–odd nylon. The isothermal crystallization kinetics has been analyzed by the Avrami equation, the calculated Avrami exponent at various crystallization temperatures falls into the range of 2.28 and 2.86. In addition, the Avrami equation modified by Jeziorny and the equation suggested by Mo have been adopted to study the nonisothermal crystallization. The activation energies for isothermal and nonisothermal crystallization have also been determined. The study demonstrates that the crystallization model of nylon 69 might be a two-dimensional (circular) growth at both isothermal and nonisothermal crystallization conditions. Furthermore, the value of the crystallization rate parameter ( K ) decreases significantly but the crystallization half-time ( t 1/2 ) increases with the increase of the isothermal crystallization temperature. To nonisothermal crystallization, the crystallization rate increases as the cooling rate increases according to the analysis of Jeziorny's theory. The results of Mo's theory suggest that a faster cooling rate is required to reach a higher relative degree of crystallinity in a unit of time, and crystallization rate decreases when the relative degree of crystallinity increases at nonisothermal crystallization conditions.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
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2016
·
IF 2.933
Shuai Zhang,Na Sha,Zhe Zhao
Stereolithography of UV-curable ceramic suspensions can benefit from the preparation of stable, low viscosity and high solid loading ceramic suspensions without yield stress. Appropriately adding dispersants could optimize the rheological behavior to meet the requirements of stereolithography. In this work, short-chain dicarboxylic acids were utilized to modify the alumina particles and achieve well dispersed ceramic suspensions. The maximum adsorption capacities of dicarboxylic acids were determined by the method of High Performance Liquid Chromatography and the mechanism of surface modification and dispersion was also discussed. Dicarboxylic acids’ influence on the rheology behavior was systematically studied. When doses of dicarboxylic acids reach their maximum adsorption capacities, the alumina suspensions would achieve their lowest viscosities and yield stresses. 45 vol% alumina suspension with a viscosity ˂2 Pa s at shear rate 30 s −1 was successfully formulated. A sintering density of 96.5% can be achieved for the sebacic acid-modified alumina UV-curable suspension.
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ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Danqing Song,Qiqi Xie,Jiaying Zhang,Bing Wang,Yi Liu,Sheng Chen,Liuchun Zheng
The synthesis of traditional polyurea (PUR) involves toxic, hazardous, and harmful isocyanates. Sustainable biobased feedstocks are significant for future industrial development. A range of nonisocyanate poly(amide-urea) (NIPURs) are obtained by melt polycondensation from biobased dicarboxylic acids, urea, and diamines without catalysts and high pressure. Excessive hydrogen bonding in NIPURs leads to high crystallinity, which renders it difficult to obtain a polymer material with both high strength and satisfactory toughness. The hydrogen bonding content and distribution can be regulated by changing the molar ratio of dicarboxylic acids/urea and the structure of the dicarboxylic acids. It is remarkable that NIPURs exhibit excellent mechanical and thermal properties. Its yield strength is up to 61 MPa, tensile strength is as high as 7069 MPa, and it maintains an elongation at break of 241%; its melting point ranges from 166 to 200 °C and it maintains initial decomposition temperature (T5%) higher than 345 °C. The adjustable mechanical and thermal properties of NIPURs offer significant potential for various applications. This work could provide new insights into designing PUR with enhanced mechanical properties.
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危险品化学品经营许可证（带存储）