RSC Advances
·
2014
·Vol. 4
·期 48
·25183-25188
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IF 3.708
Meihua Wang,Weifen Niu,Xin Wu,Lixia Li,Jun Yang,Shaomin Shuang,Chuan Dong
3-Mercaptopropionic acid (MPA)-capped ZnS:Cu/ZnS core/shell quantum dots (QDs) have been synthesized via a facile aqueous coprecipitation method and characterized by fluorescence, UV-Vis absorption, infrared spectroscopy and transmission electron microscopy. The fluorescence of ZnS:Cu/ZnS could be increased in the presence of uric acid (UA). The affecting factors for the fluorescence of ZnS:Cu/ZnS were examined including pH, temperature and reacting time. Under the optimized conditions, the fluorescence intensity of the ZnS:Cu/ZnS QDs against the UA concentration showed a linear response in the range of 0.66 μM to 3.3 μM with the correlation coefficient (R2) 0.9973 and the limit of detection 0.044 μM. Most relevant molecules and physiological ions had no effect on the detection of UA. The feasibility of the developed method was further demonstrated by determining the concentration of uric acid in human urine samples and the recoveries were 95% ∼ 103%. Our work provides a sensitive, selective and convenient fluorescence method to determine UA in real samples.
研究领域:
分析化学
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纳米医学
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生物传感器
·
临床检验
·
分子诊断
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2019
·
IF 3.218
Zhiwei Qiu,Tao Yang,Rui Gao,Guifen Jie,Wanguo Hou
In this study, a novel Cu-based metal−organic frameworks (Cu-MOFs) composite material was prepared, and used to develop a sensitive and efficient electrochemical ratiometric sensor for dopamine detection. Gold nanoparticles (NPs) and the conductive poly(xanthurenic acid) p(XA) were assembled on the Cu-tetrakis (4-carboxyphenyl) porphyrin (TCPP) surface by electrodeposition and cyclic voltammetry (CV) method, which greatly improved the electrocatalytic performance of the Cu-MOF modified electrode . Two substances (dopamine/DA, paracetamol/PA) with different electrochemical peaks were added to the electrolyte solutions , where DA was the analyte and PA was as a reference. The ratiometric value of differential pulse voltammetry (DPV) oxidation current (I DA /I PA ) linearly increased with the increasing concentration of DA with low detection limit. This electrochemical ratiometric approach based on the metal−organic framework composites is expected to be a valuable strategy for detection of other analytes.
研究领域:
分析化学
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生物传感器
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神经化学
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电分析化学
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纳米材料
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药物分析
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Qian Bi,Hongmei Zhang,Han He,Qian Li,Baoting Dou
Doxorubicin (DOX) is a frequently prescribed chemotherapy medication for a range of cancers. It is essential to monitor the levels of doxorubicin in human biological fluids to ensure effective treatment. An efficient electrochemical sensor for amplified detection of DOX is developed in this work. The strand displacement reaction is initiated when the blocking probe, which attaches to the terminal toehold sequence of the immobilization probe, is released due to the selective recognition of DOX with the aptamer probe. The secondary toehold region is then available for hybridization with the methylene blue (MB)-labeled signal probe, causing the blocking probe to be displaced and activating the molecular machine. Consequently, the blocking probe is reused in a cyclical manner, with numerous signal probes being attached to the sensor surface, resulting in a significant increase in current for quantitative analysis. This technique successfully detected DOX in human serum samples with high selectivity and sensitivity, reaching a detection limit of 670 fM. The proposed research offers a novel approach to identifying various biomarkers, with the potential to significantly advance clinical diagnosis and drug research.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Rui Yao,Zhenyu Wu,Olanrewaju Yaasir Olatunji,Khaydar E. Yunusov,Fozil Mamarayim Ugli Turakulov,Jing Chen,Guohua Jiang
Although subcutaneous implanted continuous glucose monitoring (CGM) systems have proven effective in promoting diabetes management, their adoption has been limited because of high production costs and reduced accuracy and precision resulting from their invasive nature. In this research, a biosensor based on a minimally invasive solid microneedle array for continuous glucose monitoring was introduced. The device was consisted of solid metal microneedles integrated with polydopamine (PDA) and reduced graphene oxide (rGO) to immobilize platinum nanoparticles (Pt NPs)s. The geometric features of these microneedles allowed them to penetrate dermal tissue without the need for an applicator. The as-fabricated biosensor has been used for blood glucose detection as a non-enzymatic electrochemical biosensor with a wide detection range of 2–38 mM, high sensitivity of 0.48 μA/mM/cm 2 and low detection limit of 0.18 mM. To assess its practical applicability, the efficacy of the biosensor was evaluated on in vivo animal assessment. The results demonstrated a high degree of consistency in blood glucose levels between those detected by the developed microneedle biosensor and the conventional glucometer.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Lin Jiang,Liting Yao,Fan Wu,Chenjiang Liu,Weiwei Jin,Qi Ao,Maofeng Wang
Glucose offers basic power for the daily activities of human beings, and the concentration of glucose in serum influences health. At present, the main problems faced by nanogel glucose detection include: the sensitivity and selectivity need to be further improved, and the long-term in vivo stability is insufficient. Here, a cyclodextrin-based multi-functional nanogel was synthesized for glucose detection. In such a nanogel, glucose oxidase (GOx), chitosan (CS) and β-cyclodextrin (β-CD) were cross-linked in the nanogel net and Fe ions coordinate with multiple groups and cyclodextrin lumen. A cascade catalysis of GOx and Fe nanoparticle could enhance the detection sensitivity for better sensitivity. 1 H nuclear magnetic resonance result confirmed that β-CD has a host-guest interaction with the substrate glucose for better catalysis with GOx for selectivity. Moreover, the Fe coordination with nanogel make the structure stable for long-term detection. Overall, the Fe-based nanogel strategy provides a new glucose detection method.
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TALANTA
·
2025
·
IF 6.1
Xiwang Hou,Tianhao Chen,Chunyan Wang,Fanyu Liu,Minggang Zhao,Ye Ma
The concentration range of uric acid (UA) varies significantly across different biological fluids, and therefore, highly sensitive and wide-range detection of UA is of great importance for the early diagnosis of UA-related diseases. Surface-enhanced Raman spectroscopy (SERS) offers high sensitivity and molecular fingerprint specificity; however, challenges remain regarding its signal uniformity and detection range. In this work, a uniform and stable two-dimensional metasurface is constructed via liquid–liquid interface (LLI) self-assembly of silver nanoparticles (NPs) functionalized with bis (p-sulfonatophenyl) phenylphosphine di-potassium salt (BSPP). UA is catalytically oxidized by uricase, which in turn oxidizes the BSPP ligands on the NP surface, inducing microstructural changes in the metasurface, which led to a decrease in the BSPP signal in the SERS mode at low UA concentrations and a reduction in reflectance in the reflectance mode at high UA concentrations. Using this dual-mode strategy, a detection limit (LOD) of 3.22 ± 0.10 nM for UA and a dynamic range of 0.100–1500 μM are achieved. The strategy enables rapid NPs assembly and complementary linear ranges, offering a versatile approach with potential for extension to diverse analytes and portable point-of-care applications, highlighting its potential significance for the early diagnosis of UA–related diseases.
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IEEE SENSORS JOURNAL
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2025
·
IF 4.5
Fengjuan Miao,Yanan Lu,Bairui Tao
Nanomaterial-based electrochemical sensors enable real-time detection of chemical and biological parameters, with advantages including cost-effectiveness, high selectivity, high sensitivity, and portability. However, their detection sensitivity is drastically reduced in liquids due to the Debye screening effect. This paper investigates a Co₃O₄/CuS/rGO electrode for glucose detection: Co₃O₄ is obtained via annealing, while CuS and 3D wrinkled graphene are synthesized by hydrothermal method. Polyvinylpyrrolidone (PVP) is used during reduced graphene oxide (rGO) preparation to prevent graphene oxide sheet aggregation. Additionally, adding a biomolecule-permeable, porous polymer layer to the sensor extends the effective screening length near the device surface, enabling real-time glucose detection in high-ionic-strength fluids. The sensor exhibits a glucose detection range of 0.10–500 μM, sensitivity of 84.18 μA·mM⁻¹·cm⁻², signal-to-noise ratio (SNR) of 3, and detection limit of 0.046 μM. This study provides a valuable insight for applying nanomaterial-based electrochemical sensors in sweat glucose detection, which could become a powerful tool for basic research and medical applications.
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Tungsten
·
2025
·
IF 11.2
Wang Xue,Zhang Li,Han Yu,Li Feng-Bo,Li Shao-Bin
Accurate non-invasive glucose monitoring is crucial for health diagnostics. However, the development of high-performance non-enzymatic electrochemical sensors for this application remains a significant challenge. To address this issue, a novel material, FeOOH encapsulated within zeolitic imidazolate framework-67 (ZIF-67)-derived copper-cobalt-layered double hydroxide (FeOOH@CuCo-LDH), was developed through a vapor-assisted deprotonation process for FeOOH encapsulation, followed by a hydrothermal reaction to synthesize the hollow composite. The synergistic interactions between the multi-metallic composition and the hollow structure significantly enhance glucose oxidation-reduction reactions. This enables the sensor to achieve a wide linear detection range (0.5–722 μmol·L −1 and 722–4222 μmol·L −1 ), high sensitivity (4.05 and 1.43 μA·L·μmol −1 ·cm −2 ), and a low limit of detection (0.83 μmol·L −1 ). The sensor demonstrated excellent performance in practical applications, accurately detecting glucose in saliva under physiological conditions. This study highlights the potential of FeOOH@CuCo-LDH as an excellent electrode material for non-enzymatic electrochemical glucose sensing, offering promising applications in diabetes prevention and diagnosis. Graphical abstract
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Yifan Zhu,Renjie Wang,Mengyao Ma,Hanyu Ji,Jinnan Gan,Xudong Song,Huijuan Ran,Qianqian Chen,Qiaohan Cheng,Hongyu Zhu,Qingsong Zhu
Uric acid (UA) concentrations serve as pivotal health indicators. This study developed a novel carbon paper (CP) and Fe-MOF composite and utilized it as an efficient electrochemical sensor for the detection of UA. SEM, XRD and FT-IR confirms the successful in-situ growth of Fe-MOF on the carbon paper substrate. The sensor exhibits a linear response to UA concentrations ranging from 3 to 400 μM, with a high correlation coefficient (R 2 = 0.998) and a LOD of 2.798 μM. The sensor demonstrates excellent reproducibility, with an RSD of less than 5%, and notable long-term stability, retaining 96.4% of its initial current response after one month. Furthermore, it exhibits selectivity in UA detection even in the presence of interfering species such as ascorbic acid and dopamine. The feasibility of using the CP/Fe-MOF sensor to detect UA in a typical biological fluid, bovine serum, was also evaluated by the standard addition method. The enhanced sensing performance can be attributed to the preservation of the carbon paper's superior electron transport properties within the composite material, combined with the increased specific active sites by the Fe-MOF components, which significantly boost the electrochemical sensing capabilities.
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BIOMEDICAL CHROMATOGRAPHY
·
2026
·Vol. 40
·期 3
·e70382
·
IF 1.7
Linghao Zhao,Wei Yang,Shengjin Cui,Jingang Luo,Yaxin Cao,Nan Yan,Hongying Wang
Interference is a significant source of laboratory errors that can cause erroneous measurement results. In clinical practice, all the measured results should exclude the influence of interference. In this study, the ion exchange high-performance liquid chromatography of hemoglobin A1c (HbA1c) was evaluated via three brands of HbA1c analyzers, and 12 endogenous and 24 exogenous substances were added to hemoglobin solutions with different HbA1c levels to simulate the corresponding clinical samples. After the potential interfering substances were screened via interference screening testing, the interference concentration thresholds of each potential interfering substance were determined on the basis of dose–response experiment. When these substances exceed the interference concentration thresholds, elevated HbA1c values are caused by endogenous cholic acid and low pH, whereas exogenous ethanol increases HbA1c measurements in samples with low values. However, HbA1c measurements decreased in samples with high values. Although there are some differences in the thresholds of interferent concentrations between different brands of analyzers, the differences are not significant. On the basis of the detailed interference concentration thresholds and interference substances, this evidence can be provided to clinical laboratory experts and help them interpret and determine the testing results of clinical laboratories.
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BIOSENSORS & BIOELECTRONICS
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2026
·
IF 11.8
Xue Wang,Lin He,Zihan Li,Zongqian Hu
In modern medicine, glycemic control is critical for the health of individuals with diabetes. Over decades of care, patients with diabetes have relied on glucose meters for monitoring and on insulin or adjunct hypoglycemic agents for glycemic control. Frequent blood sampling and injections increase infection risk, restrict patient mobility, and generate substantial single-use medical waste. We present a simple, user-friendly closed-loop blood-glucose management system. The system integrates a highly sensitive glucose sensor and a controllable drug-release module within a dual-mode microneedle array, coupled with a miniature electrochemical workstation, thereby enabling dynamic glucose monitoring, precise drug delivery, and stable glycemic control with minimal patient intervention. The system's design demonstrates potential for achieving closed-loop glucose management. Preliminary proof-of-concept studies in diabetic mouse models yielded positive trends in relevant data. This work establishes an engineering framework integrating dual-mode microneedle devices with portable bioelectronic devices, providing a technical foundation for future mid-to-long-term closed-loop glucose management.
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ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Jun Cao,Wen-Tao Yang,Dan Cao,Chang-Yi Wu,Peng-Cheng Zhou,Wei Zhu,Si-Jie Liao,Ji-Ming Hu,Ai-Guo Shen,Jürgen Popp
Excessive oxidative stress and chronic inflammation are key obstacles to diabetic foot ulcer (DFU) healing. However, indiscriminate scavenging of reactive oxygen species (ROS) can disrupt physiological redox signaling that supports tissue repair. Here, we present a flexible feedback-guided sensing-and-treating patch integrating a ratiometric surface-enhanced Raman scattering (SERS) probe for real-time H2O2 monitoring with a photothermal-triggered dimethylthiourea (DMTU) release system. The SERS probe enables quantitative detection of H2O2 through a phenylboronic acid reporter, while near-infrared (808 nm) irradiation precisely triggers on-demand antioxidant delivery to restore physiological H2O2 levels. In diabetic mouse models, this hybrid patch effectively reduced oxidative stress, modulated inflammatory cytokines, promoted angiogenesis and collagen deposition, and markedly accelerated wound closure without adverse systemic effects. This work establishes a monitoring-guided redox-regulation strategy for intelligent, responsive wound management and highlights the potential of SERS-based theranostic materials in advanced biomedical applications.
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