FOOD CHEMISTRY
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2026
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IF 10.4
Yukun Yang,Jian Liu,Rong Guo,Baoqing Bai,Tao Bo,Jinhua Zhang,Ligang Yu,Huilin Liu,Ying Zhang,Shuo Wang
A three-channel sensor array based on Au@Pt NPs was constructed. • Au@Pt NPs with dual-function characteristics was designed. • Discrimination of light aroma-type Baijiu (LAB) was achieved. • Different years, production processes, price gradients, and adulterated were analyzed. • This method highlighted simple to operate, rapid in detection. The development of light aroma-type Baijiu (LAB) industry proposes a growing need for developing rapid and accurate discrimination method for the quality control of LAB. This study innovatively constructed a dual-mode three-channel sensor array based on the gold/platinum nanoparticles (Au@Pt NPs) with surface engineering. In this case, two colorimetric sensor channels based on ascorbic acid/para-aminophenol-chloroauric acid-nanozyme (AA/ pAP-HAuCl₄-Au@Pt NPs) and one fluorescent sensor channel based on nanozyme‑hydrogen peroxide- o -phenylenediamine (Au@Pt NPs-H₂O₂-OPD) were established. Experimental results demonstrate the colorimetric and fluorescence mode can accurately quantify four organic acids and three aldehydes in Baijiu, respectively. Samples including 17 different years and 9 different production processes of basic liquors of LAB, 48 different price gradients of commercial LAB, and adulterated LAB were analyzed. Discrimination with an accuracy exceeding 96% by Linear Discriminant Analysis, Hierarchical Cluster Analysis, and leave-one-out cross-validation was achieved. The dual-mode three-channel sensor array is characterized by simplicity, rapidity and accuracy, providing a new idea for the quality discrimination and market regulation of Baijiu.
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FOOD RESEARCH INTERNATIONAL
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2026
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IF 8.8
Lingjin Li,Mengyuan Qin,Zhiqiang Xu,Yuanteng Xu,Yan Hong,Li Cheng,Zhengbiao Gu
The esterase-mediated esterolysis is the key for specific butyrate production. • Carboxylesterase assay verified the involvement of esterases during the fermentation. • The classical metabolic pathway for nonspecific butyrate production is altered. Butyrylated starch is a special type-4 resistant starch with butyrate-carrying attribute. In this study, the unique butyrate-producing capability of butyrylated starch was deeply investigated by focusing on its specific and nonspecific butyrate-producing pathways, respectively, using specially designed substrates as controls. In vitro fermentation studies revealed that butyrylated and isobutyrylated starches generated high levels of butyrate and isobutyrate, respectively, highlighting the role of butyryl group metabolism in the specificity of butyrate production. Carboxylesterase assays have demonstrated that butyryl group metabolism is primarily facilitated by carbohydrate esterases expressed in the gut microbiota. Combined with 16S rRNA sequencing and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, it was found that butyrylated starch fermentation did not significantly enhance traditional butyrate synthesis pathways but modified the balance between the butyryl-CoA:acetyl-CoA transferase and butyrate kinase pathways by altering the gut microbiota composition, specifically by upregulating the relative abundance of indicator species such as Bacteroides , the Lachnospiraceae_NK4A136_group , and Parabacteroides . These insights offer theoretical guidance for designing butyrylated starch structures and regulating intestinal health. Download: Download high-res image (169KB) Download: Download full-size image
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FOOD RESEARCH INTERNATIONAL
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2026
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IF 8.8
Jing Wang,Jiaqi He,Silei Bai,Yixiong Wang,Hengbin Yao,Xuehui Liu,Junhui He,Anhong Liu,Chao Wang,Zhonghua Liu,Jianan Huang
Fresh leaves from seven regions were processed under identical conditions. • Processing reshaped aroma composition and amplified regional differences. • OAV and multivariate analysis identified 17 region-specific odorants. • Molecular docking suggested different receptor binding capacities among key odorants. Whether standardized tea processing homogenizes regional raw material differences or reconstructs them into distinct aroma profiles of raw Anhua dark tea (RADT) remains unclear. In this study, fresh leaves from seven regions were processed under identical manufacturing conditions to separate the effects of raw material origin from manufacturing process. Sensory evaluation showed that standardized processing did not eliminate regional aroma differences; instead, the resulting tea infusions retained distinct aroma attributes across regions, including roasty/smoky, stale/woody, floral, fruity, and green/fatty notes. GC-O/MS and quantitative analysis identified 48 odorants in fresh leaves and 82 odorants in RADT infusions, indicating that processing substantially reshaped the aroma composition. Alcohols, aldehydes, and terpenoids derived from fresh leaves generally decreased, whereas processing associated acids, phenols, lactones, and heterocyclics increased. Multivariate analysis identified 45 processing responsive odorants, including newly formed heterocyclics, ( E , E )-2,4-heptadienal, and ( E )- β -ionone. By integrating odor activity value with multivariate discrimination, 17 regional key odorants were identified, demonstrating that standardized processing reconfigured regional raw material differences into distinct aroma-active compound combinations rather than homogenizing them. Molecular docking revealed different predicted binding capacities between representative key odorants and selected olfactory receptors, with cedrol and ( E )- β -ionone showing stronger predicted receptor interactions than smaller linear aldehydes, suggesting that regional aroma differences in RADT may also involve receptor level recognition. Overall, these findings reveal that standardized processing acts as a transformative filter that reshapes regional raw material differences into distinct aroma profiles in RADT. Download: Download high-res image (184KB) Download: Download full-size image
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JOURNAL OF CHROMATOGRAPHY A
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2026
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IF 4
Mengting Fu,Huimin Zhang,Mengting Cui,Jinling Bai,Zhiyu Liu,Zhixin Ouyang,Liyun Kong
A green HDES-based TA-DLLME was developed for PAEs analysis in beverages. • Optimized method achieved high preconcentration factors and low detection limits. • COSMO-RS and DFT studies revealed strong hydrogen-bonding interactions. • Sample analysis detected PAEs in beverages meeting national food safety standards. The quantification of phthalic acid esters (PAEs) in food and beverages is crucial for assessing human exposure levels. In this study, an environmentally benign microextraction methodology was developed utilizing a thymol-butyric acid deep eutectic solvent (DES) for the sensitive determination of six PAEs in beverage samples. Through systematic optimization, the temperature-assisted dispersive liquid-liquid microextraction (TA-DLLME) protocol achieved high enrichment factors (82.01–112.39) and extraction recoveries (66.94%-91.75%). Low detection limits (1.14–4.85 μg/L) were achieved, when coupled with HPLC-PDA analysis. The validated method was successfully applied to commercial beverages, with PAEs detected in 78.6% of samples at concentrations ranging from 4.04 to 47.1 μg/L. Mechanistic investigations through COSMO-RS and DFT calculations revealed that strong hydrogen-bonding interactions between the DES components and PAEs (ΔE = -17.29 to -26.28 kcal/mol) are the primary driver of the high extraction efficiency. With the advantages of low solvent consumption (≤200 μL) and rapid processing (<15 min), this approach provides a sustainable and practical alternative for routine monitoring of PAEs in liquid food products. Download: Download high-res image (136KB) Download: Download full-size image
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INTERNATIONAL JOURNAL OF FOOD PROPERTIES
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2026
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IF 3.9
Nian Cao,Yubo Yang,Xiaoling Xiong,Bohan Zhang,Ping Xiang,Fan Yang
This pioneering study investigated the effects of sip volume on sensory perception and drinking comfort during the consumption of Jiangxiangxing Baijiu (JB). Six sip volumes (6, 9, 12, 15, 18, and 20 mL) were tested with 30 participants (15 males and 15 females). Results revealed gender-specific preferences: females tended to prefer sip volumes of 9–12 mL, while males were more likely to favor 18 mL. Using Temporal Dominance of Sensation (TDS) and Check-All-That-Apply (CATA) methods, it was found that oral sensations of sweetness and sauce flavor, as well as post-pharyngeal sensations of “smoothness,” “mellowness,” and “lingering aftertaste,” enhanced drinking comfort. In contrast, oral sensations of spiciness and bitterness, along with post-pharyngeal sensations of “pungency,” “thinness,” “blandness,” and “momentary aftertaste,” impaired comfort. Notably, females may place greater emphasis on oral perception, whereas males could focus more on post-pharyngeal sensations. A novel flavor analysis identified 20 key compounds that influence JB perception. The insights from this research provide valuable contributions to improving the drinking experience of JB.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Jinmei Lu,Jing Jin,Yufei Zhang,Mingming Zheng
Rational engineering of nanocarrier morphology is pivotal for enhancing both the activity and recyclability of immobilized lipases. Although zeolitic imidazolate framework-8 (ZIF-8) represents a leading scaffold for enzyme immobilization, its morphology-dependent conjugation behavior toward lipases remains unexplored. Herein, we prepared five distinct ZIF-8 nanostructures—rhombic dodecahedral (RD), truncated rhombic dodecahedral (TRD), rough rhombic dodecahedral (RRD), flower-like, and flake-like structures. Three lipases (PS, CALB, and AY400SD) were subsequently immobilized to generate a 15-member library. Systematic evaluation demonstrated that carrier morphology plays an important role in biocatalytic performance: PS@ZIF-8-RRD achieved >49% conversion with >99% ee s during the kinetic resolution of 1-phenylethanol; CALB@ZIF-8-TRD yielded 92% conversion in the solvent-free esterification between caproic acid and ethanol; AY400SD@ZIF-8-RD approached free enzyme activity levels in perilla seed oil hydrolysis within biphasic media. Such morphology–activity relationships arise from facet-dependent enzyme orientation and tailored microenvironments.
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高影响因子
Advanced Optical Materials
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2026
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IF 7.2
Xuetao Yan,Lifei Chen,Yuze Ren,Kaixuan Cui,Tianliang Li,Lixing Lin,Zeyu Li,Haicheng Song,Yingying Chen,Zhenzhen Li,Lingyan Feng
Circularly polarized luminescence (CPL) materials are highly sought after for their unique chiroptical properties, but their rational design remains challenging. To address this, a machine learning (ML) platform that intelligently screens deep eutectic solvents (DES) for crafting G-quartet-based gels with tailored CPL is established. An ML classifier trained on experimental data predicts CPL activity with 0.916 accuracy. SHapley Additive exPlanations (SHAP) analysis identifies key DES molecular descriptors, guiding the discovery of novel materials that exhibit a record-high luminescence dissymmetry factor (g lum ) of 0.222 for nucleotide-based systems and achieve chirality inversion via DES modulation. The Sure Independence Screening and Sparsifying Operator (SISSO) algorithm further yields interpretable design formulas. Leveraging the distinct polarization of these gels, we demonstrate a fourth-level anti-counterfeiting strategy, decrypting concealed information via Morse and ASCII codes to enhance information security. This ML-driven methodology accelerates the discovery of high-performance CPL materials and opens new design avenues.
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JOURNAL OF CHROMATOGRAPHY A
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2026
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IF 4
Chenqing Zhang,Juan Zhang,Zhiyu Zhang,Jing Yan,Zhuoyue Hou,Shusheng Zhang,Kai Hu
Short-chain fatty acids (SCFAs) are key biomarkers of gut microbiota activity and are implicated in various metabolic, inflammatory, and neurological diseases. This study fabricated a phenothiazine-based hyper-crosslinked polymer (PTZ-HCP) and applied it as a solid-phase microextraction (SPME) fiber coating for the analysis of nine SCFAs in rat feces by gas chromatography with flame ionization detection (GC-FID). The prepared PTZ-HCP was characterized by scanning electron microscopy, X-ray photoelectron spectroscopy, N 2 adsorption-desorption measurements, and thermogravimetric analysis. These analyses confirmed its successful synthesis and revealed a porous structure, high specific surface area, and excellent thermal stability. Owing to these structural advantages and the capability for multiple functional groups, the PTZ-HCP coatings demonstrated outstanding extraction efficiency and high adsorption capacity for SCFAs. An SPME/GC-FID method using PTZ-HCP coated fibers were established and validated. The validation results demonstrated significant advantages, including a wide linear range (1.0 × 10 -3 -0.50 μg·mL -1 for 2-methylvaleric acid; 1.0 × 10 -3 -2.0 μg·mL -1 for 4-methylvaleric acid), low LODs (3.0 × 10 -4 μg·mL -1 for 2-methylvaleric acid and 4-methylvaleric acid), and good precision (≤ 9.5%). This work presents a novel SPME coating material that effectively addresses key challenges in the extraction and analysis of SCFAs in rat fecal samples. Moreover, it verifies that Coptis chinensis modulates gut microbiota by altering SCFA levels, thereby offering important insights for research on the pathological mechanisms and treatment of Parkinson’s disease.
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高影响因子
JOURNAL OF CHROMATOGRAPHY A
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2026
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IF 4
Qiuyue Hu,Ruochen Qi,Xindi Feng,Dian Jin,Li Sun,Zuoxiang Zeng,Feng Liang,Zhongli Xiong,Zhen Liu
Deep eutectic solvents (DESs) have emerged as promising green alternatives to conventional organic solvents for the sustainable extraction of bioactive compounds from medicinal plants. In this study, a DES-based extraction system enhanced by ultrasound was employed to extract flavonoids from Scutellariae Radix (SR). A hybrid optimization strategy integrating Box-Behnken design (BBD), artificial neural network (ANN) modeling, and genetic algorithm (GA) was utilized to maximize the extraction efficiency. Under the optimized conditions, the predicted yield of flavonoids reached 194.58 mg/g, which was in close agreement the experimental value (194.03 mg/g). The purified DES extracts exhibited strong antioxidant activity. After five consecutive extraction cycles, the DES maintained its structure stability and retained a high extraction yield with only a 11.39% decrease. The characterization of the solid extraction residue indicated the microstructure of SR was disrupted by the DES, facilitating the release of flavonoids. In addition, mechanistic studies based on quantum chemical calculations revealed strong hydrogen bonding and orbital interactions between the DES and flavonoids as key contributors to the extraction process. These results demonstrate the potential of DESs as tunable and reusable media for the efficient extraction of natural products, supported by both experimental data and molecular-level insights.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
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IF 6.7
Ken Lu,Jiahui Zhang,Rui Ma,Min Li,Jiangfei Chai,Imre Blank,Yan Ping Chen,Yuan Liu
Aroma is a key attribute influencing the quality of fermented dairy products. Volatile and odor-active compounds of kefir (SN) and three yogurt samples (S1, S2, and S3) were analyzed using the Sensomics approach. Sensory results showed that kefir scored lower than yogurt in sweet, milky, and fermented odor attributes. Gas chromatography-time-of-flight mass spectrometry (GC-ToF/MS) detected 61 volatiles, and gas chromatography-olfactometry (GC-O) further identified 16 odor-active compounds, including three unknown compounds with notable sensory relevance. Based on odor activity value (OAV) calculations, aroma recombination, and omission tests, 2,3-butanedione, hexanal, acetoin, and butanoic acid were identified as key aroma compounds in the kefir sample (SN), contributing to buttery, grassy, creamy, and cheesy aromas. In the yogurt sample (S1), the key contributors were 2,3-butanedione, acetoin, and butanoic acid, imparting buttery, creamy, and cheesy attributes. These findings enhance the understanding of aroma profiles in fermented milks and support future product optimization.
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ADVANCED MATERIALS
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2026
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IF 29.1
Minglu Tang,Chenwei Jiang,Mingmei Guo,Qi Chen,Qi Shang,Lin Xiong,Wen Zhang,Liang Dong,Qi Yue,Xihui Gao,Feihu Wang
Personalized vaccines represent a promising approach for cancer treatment by eliciting tumor-specific immune responses. However, their development faces persistent challenges, including the laborious and costly process of neoantigen identification, which substantially delays vaccine production. Moreover, conventional platforms suffer from rapid systemic clearance and inefficient delivery to antigen-presenting cells (APCs), leading to only transient and weak immune activation. Here, we report a STING-agonist-integrated hydrogel system designed for localized delivery of tumor-derived extracellular vesicles (TEVs) to achieve robust and durable antitumor immunity. Upon subcutaneous administration, the in situ formed hydrogel vaccine acts as a depot for antigen-rich TEVs and STING agonists. We demonstrate that this vaccine promotes dendritic cells (DCs) recruitment and establishes an immune-permissive niche through spatiotemporal control over antigen-adjuvant distribution and prolonged APC-antigen engagement. Within this niche, DCs efficiently internalize and process TEVs under STING-mediated activation. These matured DCs subsequently migrate to draining lymph nodes, where they initiate potent and sustained tumor-specific T-cell responses. Our results show that rapidly producible personalized vaccines derived from melanoma TEVs effectively inhibit tumor growth. In a postoperative breast cancer model, patient-tailored TEV vaccines also markedly prevent tumor recurrence and metastasis. This readily customizable platform represents a robust and translatable strategy for personalized cancer immunotherapy.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Yan Zhang,Yaoli Wei,Cristiano Varrone,Seongbong Heo,Jiating Hao,Zhihong Liu,Aijuan Zhou,Senlin Shao,Xiuping Yue
Coupling membrane extraction with chain elongation enables in-situ recovery of medium-chain fatty acids (MCFAs) from waste activated sludge, but interfacial instability and phase breakthrough remain major obstacles to practical application. To address this challenge, a thin-film composite (TFC) membrane was fabricated on a hydrophobic polytetrafluoroethylene (PTFE) porous membrane substrate via a polydopamine/polyethyleneimine (PDA/PEI) co-deposition strategy. TFC membrane significantly increased breakthrough pressure from 13 kPa (pristine PTFE) to 164–288 kPa, effectively preventing phase breakthrough. Notably, during the reactive extraction of MCFAs, the dense films in the TFC membrane did not hinder mass transfer; instead, enhanced both extraction efficiency (from 71.0% to 95.9%) and selectivity. These improvements arise from the enlarged interfacial reaction area provided by the rough film surface and the stronger binding of short-chain fatty acids to hydrophilic functional groups of the film, as confirmed by density functional theory (DFT) calculations. When integrated into a real chain elongation system, the adoption of the TFC membrane increased caproate production by 50%, accompanied by clear environmental and economic benefits (indicating promising economic prospects, with a net profit of 0.795 USD m −3 ). To our knowledge, this represents the first demonstration of TFC membranes in membrane extraction, revealing their unique ability to couple stability, efficiency, and selectivity, and opening new opportunities for sustainable MCFAs bioconversion.
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危险品化学品经营许可证（带存储）