ACS Applied Materials & Interfaces
·
2026
·Vol. 18
·期 30
·40273-40290
·
IF 7.8
Qian Huifeng,Pan Xiaoyu,Liang Shujie,Wang Sheliang,Yu Debao,Lu Jinyun,Li Shunchang,Jin Xinyi,Tong Haijiang,Yu Zhangsen
Burn wounds are highly susceptible to bacterial colonization, particularly by multidrug-resistant pathogens, which often result in refractory infections, excessive inflammation, and delayed healing. Herein, we report the rational design and construction of a multifunctional nano-antimicrobial agent, designated mPB@PHMB, through the co-assembly of mesoporous Prussian blue (mPB) with the polymer polyhexamethylene biguanide (PHMB). The resultant nanocomposite integrates potent antibacterial activity with the capacity to modulate the inflammatory microenvironment. Notably, mPB@PHMB exhibited pronounced bactericidal efficacy against methicillin-resistant Staphylococcus aureus (MRSA). Benefiting from the intrinsic multi-enzyme-mimetic activities of mPB, the nanocomposite efficiently scavenged intracellular reactive oxygen species, thereby alleviating oxidative stress-induced cellular injury. Transcriptomic profiling and protein analyses revealed that mPB@PHMB markedly suppressed the NF-κB pathway activation, attenuated lipopolysaccharide-induced M1 macrophage polarization, and reduced the production of pro-inflammatory cytokines. Biocompatibility assessments demonstrated negligible acute cytotoxicity toward skin fibroblasts and no overt toxicity in healthy C57BL/6 mice, underscoring the favorable safety profile of mPB@PHMB. Furthermore, in a murine model of MRSA-infected burn wounds, topical treatment with mPB@PHMB reduced the bacterial burden by approximately 90%. Concurrently, treatment with mPB@PHMB substantially decreased the proportion of M1-polarized macrophages, suppressed the expression of inflammatory cytokines, and alleviated the inflammatory milieu within the wound bed, thereby accelerating tissue repair and wound closure. Collectively, these findings establish mPB@PHMB as a promising nano-therapeutic platform that synergistically couples antimicrobial action with immunomodulatory functions, offering a robust and translatable strategy for the management of burn wounds complicated by multidrug-resistant bacterial infection.
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DESALINATION
·
2026
·
IF 9.9
Yiyang Zhang,Xiaoming Hu,Fangrong Tian,Dinghe Yan,Yutong Cao,Chun Wang,Jingjing Yan,Dawei Ji,Haolong Xue,Changfa Xiao
Controllable design of ternary PNIPAM-PEGMA-PEI microgel with enhanced hydrophilicity and covalent anchoring • Direct embedding of microgels into polyamide Layer via interfacial polymerization • Long-Term anti-scaling performance with thermally triggered self-cleaning and permeance enhancement As a cutting-edge intelligent membrane material, temperature-responsive composite membranes can reversibly regulate the surface properties and pore size structure of the membrane according to changes in ambient temperature, demonstrating unique application potential in the field of high-temperature separation. In this study, we used fully rigid aromatic poly ( p -phenylene terephthamide) (PPTA) as the porous base membrane and designed a temperature-resistant macromolecule. By introducing hydrophilic poly(ethylene glycol) methacrylate (PEGMA) monomers into the PNIPAM-PEI system, we synthesized the PNIPAM-PEGMA-PEI ternary copolymer microgel, and directly embedded it into the surface separation layer of positively charged polyamide using interfacial polymerization to obtain high-temperature resistant PPTA/PA@[PNIPAM-PEGMA-PEI] nanofiltration membranes, achieving significant reduction in membrane surface contamination rates while maintaining temperature-sensitive regulation of membrane pore size. The membrane exhibited a 57.9% increase in pure water flux at 60 °C and achieved salt rejections above 97% for Na 2 SO 4 , CaCl 2 , and MgSO 4 (5 g/L) at 25 °C. During a 180 h test with periodic thermal transitions, permeance rose from 9.8 to 16.4 L·m −2 ·h −1 ·MPa −1 while retention remained above 89%. This heat-triggered cleaning and reversible pore-size regulation originate from the reversible chain collapse of PNIPAM above its LCST, providing a new strategy for designing highly permeable, regenerable, and anti-scaling nanofiltration membranes for high-temperature desalination and high-salinity wastewater treatment.
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Cancer Medicine
·
2026
·Vol. 15
·期 8
·e72212
·
IF 3.5
Yanmin Zhang,Yaxi Shi,Wenlong Bai
Advanced epithelial ovarian cancer responds poorly to current treatments, creating an urgent need for novel therapeutic strategies. 1,25-dihydroxyvitamin D 3 (1,25D 3 ) exerts potent anti-proliferative effects on ovarian cancer cells in vitro, but the concentrations required for growth suppression in cell culture are not readily achievable in vivo, and higher doses induce hypercalcemia, which hinders its clinical translation. Sodium selenite (Na 2 SeO 3 ) has been identified as a chemopreventive agent that inhibits the growth of multiple cancer types. In this study, we demonstrated that combined treatment with Na 2 SeO 3 and 1,25D 3 exerts enhanced anti-proliferative efficacy against ovarian cancer cells both in vitro and in vivo. Specifically, 1,25D 3 upregulated the expression of vitamin D receptor (VDR) and Selenoprotein-P1 (SEPP1), and this effect was further enhanced by Na 2 SeO 3 co-treatment. Consistently, Na 2 SeO 3 augmented the suppressive effect of 1,25D 3 on ovarian cancer cell proliferation, demonstrating synergistic inhibitory activity. Notably, knockout (KO) of either VDR or SEPP1 abrogated this synergistic effect. Mechanistic investigations confirmed that SEPP1 is a direct target gene of VDR, and functional vitamin D response elements (VDREs) are present within its genomic locus. In vivo, low-dose 1,25D 3 (0.3 μg/kg) combined with Na 2 SeO 3 outperformed 1,25D 3 monotherapy, with no significant hypercalcemia, ascites formation, or metastasis observed throughout the treatment period. These findings indicate that Na 2 SeO 3 acts in combination with 1,25D 3 to induce SEPP1 expression, thereby enhancing the antitumor efficacy of low-dose 1,25D₃ against ovarian tumors. This study provides a promising strategy for the safe and effective application of 1,25D 3 in ovarian cancer therapy.
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Foods
·
2025
·Vol. 14
·期 12
·2116
·
IF 5.1
Xianghui Yan,Ting Peng,Zheling Zeng,Pengbo Wang,Yifang Gao,Xuefang Wen,Jiaheng Xia,Deming Gong,Ping Yu
Medium chain triglycerides (MCTs) are regarded as an important ingredient for functional foods and nutraceuticals.Cinnamomum camphoraseed kernel oil (CCSKO) contains more than 95% medium chain fatty acids (MCFAs), which is a significantly higher level than palm kernel oil (62%) and coconut oil (55%). However, the safety assessment of CCSKO, as the only natural MCT oil rich in capric acid and lauric acid found so far in the world, has not been fully verified. The study aimed to investigate the 90-day sub-chronic oral toxicity and teratogenicity of CCSKO. In the sub-chronic oral toxicity study, no clinically significant adverse events occurred in male or female Sprague–Dawley (SD) rats with CCSKO daily administration for 13 weeks. Moreover, there were no dose–response relationships between CCSKO and body-weight gain, food intake and food utilization in male or female SD rats. No significant differences (p> 0.05) were found in the hematological properties or organ weights between the male and female SD rats. In the teratogenicity test, no toxicological signs were observed in either Wister pregnant rats or fetuses. The no-observed-adverse-effect level of CCSKO was determined to be more than 4 mL/kg body weight. These results suggested that CCSKO may be an excellent edible oil with high oral safety.
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Molecular & Cellular Toxicology
·
2026
·
IF 1.4
Lan Xinpeng,Li Ji,Zhang Peiqing
Background Chronic renal failure (CRF) is characterized by progressive renal function decline, oxidative stress (OS), inflammation, and fibrosis, with a current lack of effective treatments. This study investigates the interventional effects of Epimedium extract (EPE) on CRF and focuses on the elucidation of its potential mechanisms of action. Methods In vivo and in vitro experiments were conducted using a CRF rat model and a TGF-β1-induced fibrosis model in human renal tubular epithelial cells (HK-2). Rats were randomly assigned to control, model, low/high-dose EPE, and EPE combined with Mdivi-1 experimental groups. HK-2 cells were grouped into control, TGF-β1, EPE-treated, and STING overexpression groups. Renal function parameters (SCR, BUN, UPR), OS markers (ROS, MDA, GSH, SOD), inflammatory cytokines (IL-1β, IL-6, TNF-α), fibrosis markers (Hyp, MMP2/9, α-SMA, Col-1, FN), autophagy-related proteins (LC3B, Beclin1, ATG5, p62), and key molecules of the cGAS-STING pathway were assessed to explore the protective effects and underlying mechanisms of EPE in CRF. Results EPE significantly improved renal function, reduced OS and inflammatory responses, alleviated pathological damage and fibrosis in renal tissues, and promoted the expression of autophagy-related proteins in CRF rats. Mdivi-1 partially reversed the protective effects of EPE, suggesting autophagy-dependent mechanisms. Mechanistically, EPE inhibited cGAS-STING pathway activation and reduced the phosphorylation of downstream TBK1 and IRF3. In HK-2 cells, EPE mitigated TGF-β1-induced apoptosis, OS, inflammation, and fibrosis, while promoting mitophagy. However, STING overexpression attenuated these protective effects. Conclusion EPE ameliorates renal dysfunction, OS, inflammation, and fibrosis in CRF by suppressing cGAS-STING signaling activation and enhancing autophagy activity. This study provides experimental evidence supporting EPE as a potential therapeutic agent for chronic kidney disease and highlights the regulatory role of the cGAS-STING pathway in renal fibrosis. Graphical abstract
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BIOMACROMOLECULES
·
2023
·
IF 6.2
Cong Wei,Peipei Li,Lixin Liu,Hong Zhang,Tianyu Zhao,Yongming Chen
Following brain trauma, secondary injury from molecular and cellular changes causes progressive cerebral tissue damage. Acute/chronic neuroinflammation following traumatic brain injury (TBI) is a key player in the development of secondary injury. Rapidly elevated cell-free DNAs (cfDNAs) due to cell death could lead to production of inflammatory cytokines that aggravate TBI. Herein, we designed poly(amino acid)-based cationic nanoparticles (cNPs) and applied them intravenously in a TBI mice model with the purpose of scavenging cfDNA in the brain and suppressing the acute inflammation. In turn, these cNPs could effectively eliminate endogenous cfDNA, inhibit excessive activation of inflammation, and promote neural functional recovery.
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高影响因子
JOURNAL OF FOOD SCIENCE
·
2023
·Vol. 88
·期 4
·1253-1267
·
IF 3.9
Cikun Liu,Ruonan Feng,Jun Li,Zhongliang Hu,Yanshun Xu,Wenshui Xia,Qixing Jiang
The freeze-thawing (FT) stability generally correlates well with the economic value and acceptability of frozen surimi-based products. However, quality changes of emulsified surimi gels under FT conditions are still unclear. Therefore, the gel properties of samples with different phase states of lipids (lard, lard + soybean oil, and soybean oil) were investigated at FT conditions. Results showed that the soybean oil evidently improved the rheological behaviors of sols/gels compared to the lard group. The moisture content of samples with different lipids decreased by 2.40%–2.71% after 4 FT cycles. With increasing FT cycles, the water-holding capacity decreased accompanied by the increase of cooking loss. Spin–spin relaxation spectra and hydrogen proton density images proved the occurrence of water migration of gels during these processes. Better gel integrity was observed in samples consisting of soybean oil, where the proportion of pores was lower than those with lard regardless of FT treatments. Additionally, the intermolecular forces of gels also changed under FT treatments. There results suggested that the lipids with different phase states affected the migration and loss of water in emulsified surimi gels under FT cycles. Practical Application The quality changes of heating-induced surimi gel products under frozen storage have been ignored, especially the emulsified surimi gels. This study discloses the changes of the gel properties in emulsified gel products with different phase states of lipids after FT treatments, which provides critical insights into the quality improvement of this novel emulsified surimi product during processing, storage, and transportation.
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高影响因子
ACS ES&T Engineering
·
2023
·
IF 7.1
Lingya Fei,Lun Lu,Cheng Chen,Liguo Shen,Bisheng Li,Mingzhu Zhou,Jiujing Xu,Boya Wang,Hongjun Lin
Intelligent and controllable water and molecule transport through a membrane is of crucial significance for broadening membrane applications in smart-gating filtration. Herein, inspired by the extensive redox reactions in living systems, we report a redox-responsive graphene oxide (GO) membrane assembled by introducing a supramolecular host–guest complex between ferrocene (Fc) and β-cyclodextrin (CD) into the interlayer of GO. The well-designed intelligent responsive membrane, which was composed of Fc-modified GO and CD-modified GO, possessed fascinating redox-response property. Utilizing the reversible deformation and restoration of the Fc/CD complex, the size of the interlayer nanochannel between adjacent GO nanosheets was tunable by changing the membrane redox state. The water permeance and molecular separation performance of the membrane could be reversibly regulated with a high gating ratio (5.6) by virtue of the redox-responsive interlayer nanochannel. In addition, the obtained membrane also demonstrated superior cyclic response performance, excellent antifouling ability, and satisfactory stability in harsh environments. This work provides an innovative strategy for the fabrication of redox-responsive membranes, showing promising applications in intelligent and controllable gating and controllable water-contaminant removal process.
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APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Boxuan Yao,Ke Zhang,Xiaoyang Liu,Hua Wei,Zihan Li,Jiarui Zhou,Guangfei Yuan,Xin Wang,Shenghong Yang,Jian Liu
Pursuing special negatively charged adsorbents is critical to selectively removing cationic pollutants from effluent. Herein, we proposed a versatile preparation strategy of negatively charged saccharide-based polymers using easily available saccharides as building blocks and hexachlorocyclotriphosphazene as a linker in a facile “one-step” method. Because of the existence of numerous hydroxyl groups and phosphine nitrile units in the skeleton, these polymers show selective adsorption capacity towards cationic dyes and pharmaceuticals, but not for ionic dyes and uncharged bisphenol A. Notably, β-cyclodextrin-based polymers (β-CDPs) displayed remarkable adsorption towards methylene blue (Q m , 1563 mg g −1 ) and promethazine (Q m , 944 mg g −1 ). Systematic experiments revealed that the synergy of “host-guest” inclusion, electrostatic attraction, and π-π interaction promoted the selective and efficient adsorption of cationic pollutants. Given the efficiently selective adsorption of cationic dyes and pharmaceuticals, these negatively charged saccharide-based polymers should be candidates for the adsorption of other cationic pollutants, including heavy metal ions. This work expanded the scope of the special utilization of biomass-based adsorbents for water remediation.
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Nature Photonics
·
2023
·Vol. 17
·期 4
·346-353
·
IF 35
Liang Wenfei,Nie Chengming,Du Jun,Han Yaoyao,Zhao Guohui,Yang Fan,Liang Guijie,Wu Kaifeng
Near-infrared-to-visible photon upconversion holds great promise for a diverse range of applications. Current photosensitizers for triplet-fusion upconversion across this spectral window often contain either precious or toxic elements and have relatively low efficiencies. Although colloidal nanocrystals have emerged as versatile photosensitizers, the only family of nanocrystals discovered for near-infrared upconversion is the highly toxic lead chalcogenides. Here we report zinc-doped CuInSe 2 nanocrystals as a low-cost and lead-free alternate, enabling near-infrared-to-yellow upconversion with an external quantum efficiency reaching 16.7%. When directly merged with photoredox catalysis, this system enables efficient near-infrared-driven organic synthesis and polymerization, which in turn solves the issue of reabsorption loss for nanocrystal-sensitized upconversion. Moreover, the broadband light capture of these nanocrystals enables very rapid reactions under indoor sunlight. Extending the reach of ‘solar synthesis’ into the near-infrared may realize the century-long dream of conducting high-added-value chemical transformations using sunlight.
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高影响因子
LANGMUIR
·
2023
·
IF 3.9
Lei Tang,Tongchang Wang,Zhixiang Zeng
Materials require specific surface structures to achieve the best performance, but achieving an optimal structural design requires a systematic study of how structure affects performance. In this work, we comprehensively and systematically investigated the structure–activity relationship between the nanowire structure and the oil dewetting self-cleaning performance. It is easy for an oil droplet to enter this structure, but it is difficult for it to escape from the gaps between the structures even under the action of water. So, the oil dewetting ability is greatly reduced, showing that this “easy to enter and difficult to exit” mode is very disadvantageous for oil desorption. Moreover, if the structure is dissolved during the test, the oil dewetting ability will be restored. The desorption effect is affected by structural parameters and reaction conditions, which further verifies the negative effect of this structure. In contrast, copper(II) oxide nanowires completely lose their self-cleaning ability due to the enhancement of hydrophobicity and oleophilicity, and the larger-diameter copper(II) oxalate nanorods exhibit a “difficult to enter and difficult to exit” mode, leading to the partial recovery of the oil dewetting performance. This study helps us deeply understand the influence of the surface microstructure on the oil dewetting performance and lay a solid foundation for further appropriate structural design.
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Yanqing Xu,Guibing Peng,Wenfei Li,Yuying Zhu,Zhaohuan Mai,Natalie Mamrol,Junbin Liao,Jiangnan Shen,Yan Zhao
Kevlar aramid nanofibers (KANF) are formed by the nanoscale structure of poly (paraphenylene terephthalamide) chains and are the emerging candidate for organic solvent permeation. However, the KANF membranes have a highly ordered and compact structure with few nanofluidic channels, resulting in low-efficiency solvent transport and undesirable membrane filtration. Here, the aligned composite membranes were fabricated by assembling the amino-polystyrene nanospheres (APN) into the KANF matrix and finally obtained a series of the APN@KANF membranes. These APN disrupted the KANF chain packing and increased the fractional free volume (from 27.7 to 35.6%). The ethanol permeance of the APN@KANF membrane was six times higher than the KANF membrane and maintained its rejection performance. Experiments and molecular simulations indicated that these APN increased the pore interconnectivity, which enhanced solvent permeability and molecular sieving. In addition, these highly stable and rigid resulting APN@KANF composite membranes could be used in extreme polar aprotic and nonpolar environmental conditions. This work highlights a promising application of the APN@KANF membranes in organic solvent nanofiltration .
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