INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Zhanwei Yang,Jin Wang,Hualei Chen,Hecheng Meng,Xiaobing Guo,Shujuan Yu
Two low-methoxy pectins (LMPs) were obtained by local electrochemical pH modification using an H-type double-layer water bath sealed electrochemical cell at the voltage of 180 V for 3 h. The weight-average molecular weight (Mw) of citrus peel pectin (CPP) prepared in the anodic part at room temperature (CPP-A 5/RT ) and in the cathodic part at 5 °C (CPP-C 5/RT ) were 346 kDa and 328 kDa, respectively, and the degrees of methylation (DM) were 36.8 % and 11.9 %. Moreover, the second-order kinetic model was most appropriate for the degradation processes, as free radicals were generated in the anodic part and β -elimination occurred in the cathodic part. Subsequently, CPP-A 5/RT and CPP-C 5/RT were utilized to fabricate food packaging film blending with polyvinyl alcohol (PVA), bcZnO (ZnO coupled with bentonite and colophony) nanorods , and Ca 2+ ions by casting method. Then the prepared films were studied for their ability to maintain the freshness of strawberries. The addition of Ca 2+ ions and bcZnO nanorods increased the thickness, water contact angle (WCA), and mechanical properties of the composite films, while decreased water vapor permeability (WVP). Therefore, the CPP-based films, supplemented with bcZnO nanorods and crosslinked with Ca 2+ ions by “egg-box” model, can serve as an antibacterial food packaging material for food preservation.
研究领域:
食品科学
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高分子材料
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食品包装
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电化学改性
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纳米复合材料
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农产品保鲜
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Lele Chen,Shaofei Zhang,Tingyu Liang,Xu Ding,Ling Ding,Jipeng Shi,Ji Zhang,Jianping Wu
The therapeutic potential of essential oils in feed and medicine is limited by their volatility, degradation, and poor bioavailability. To overcome these challenges, a novel colon-targeted microsphere was engineered for the controlled delivery of tea tree essential oil (TEO), as illustrated in Scheme 1 . A critical component of this system is a pH-responsive coating composed of pectin and starch, which acts as a colon-specific polymeric barrier. This coating demonstrated precise pH-responsive release, with minimal leakage in simulated gastric fluid (SGF) (only 10.87 % release over 4 h) and sustained, colon-specific release in simulated intestinal fluid (SIF) (79.77 % over 14 h). The core of the system, designated TEOCMT, was fabricated through the modification of montmorillonite (MMT) with cetyltrimethylammonium bromide (CTAB), resulting in organo-montmorillonite (CMT). Tea tree essential oil was then encapsulated within the interlayer spaces of CMT, forming an effective sustained-release system (TEOCMT). Compared to raw MMT (5.63 %), the TEO loading capacity of CMT increased 8.3-fold, reaching 46.79 %. Furthermore, the antibacterial activity of PS/TEOCMT microspheres was triggered in alkaline media, where they dissolved and released the TEOCMT core. This resulted in enhanced efficacy, particularly against S. aureus (MIC = 1.25 mg mL −1 ), which was superior to that of pure TEO (MIC = 2.5 mg mL −1 ). The PS/TEOCMT microspheres also exhibited excellent biocompatibility. This work presents a robust and effective strategy for unlocking the full potential of essential oils in colon-specific applications.
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PubMed
高影响因子
MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Ying-Fang Jian,Mei Li,Hai-Sha Liu,Jin-Kuang Jiang,Dong-Mei Chen,Xiu-Fang Yan,Chao Kang,Ya-Juan Liu
Apple branch canker, caused by Botryosphaeria dothidea , poses a serious threat to apple production worldwide. Despite its economic importance, current understanding and analysis techniques of the infection dynamics and host defense responses remains limited. Here, an in situ , label-free, high-throughput, and precise imaging method based on confocal Raman microspectroscopic imaging coupled with chemometrics was developed to characterize key defensive constituents, including lipids, lignin, phenols, cellulose, hemicellulose, and pectin, within the cuticle and cell wall, and to monitor their spatiotemporal dynamics across the epidermis and cortex. During infection, lignin of the cuticle in epidermis initially decreased while lipids and phenols increased; Defensive components of cell wall in the cortex decreased and then increased by 3 days; All these constituents decreased by 5 days, leading to disease symptoms. Furthermore, to gain a systems-level understanding, untargeted metabolomics using UPLC–Q–Orbitrap–MS and machine learning screened 2090 differential metabolites (including phenylpropanoids and polyketides, organic heterocyclic compounds, lipids, and lipid-like molecules), and revealed significantly enriched metabolic pathways associated with defense activation ( e.g. , isoquinoline alkaloid biosynthesis, flavonoid biosynthesis). Additionally, a rapid, non-destructive diagnostic platform integrating Raman spectroscopy with machine learning achieved early detection of apple branch canker with an overall accuracy of 97.2%. Collectively, this integrated multi-technology strategy provides new insights into the pathogenicity and defense responses of fruit trees and establishes a non-destructive tool for early disease diagnosis.
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高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
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IF 4.9
Pei-Ling Liu,Jia-Lin Wang,Yi-Ying Dong,Hong Liu,Jin-Ju Lei,Bin Xu,Xin-Ru Liao,Di Han,Zi-Hao He,Si-Xue Cheng
Epidermal growth factor receptor (EGFR) targeted cancer therapy offers high selectivity and reduced toxicity. However, the therapeutic efficacy is compromised by the poor bioavailability of hydrophobic drugs such as gefitinib (GEF), and the acquired resistance. Curcumin (CUR) can sensitize tumor cells toward EGFR inhibitors and reverse drug resistance, but its application is also hindered by low solubility. To address these limitations, we developed a zein-based drug delivery system for the co-delivery of GEF and CUR. The dual-drug loaded zein-based nanoparticles (GEF/CUR@ZNP) decorated by pectin were prepared by self-assembly. GEF/CUR@ZNP exhibited a mean diameter less than 300 nm, featuring a narrow size distribution and an encapsulation efficiency higher than 80 %. The therapeutic efficacy was evaluated in vitro using PC-9 cells. Compared with free drugs, GEF/CUR@ZNP led to significantly enhanced cellular uptake, resulting in improved induction of cancer cell apoptosis and higher efficiency in downregulation of proteins promote cancer progression (e.g., Sp1, Bcl-2, VEGF, Snail, and CD44). To evaluate the efficacy of the drug delivery system in a context more relevant to clinical settings, we evaluated the EGFR inhibition efficacy by using the blood samples containing circulating tumor cells (CTCs) from non-small cell lung cancer (NSCLC) patients, and immunofluorescence labeling confirmed that GEF/CUR@ZNP achieved most effective suppression of EGFR expression. These findings demonstrate that zein-based co-delivery of GEF and CUR can overcome multiple barriers to targeted cancer therapy, and offer a clinically relevant strategy for enhancing antitumor efficacy and personalizing cancer treatment.
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高影响因子
FOOD CHEMISTRY
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2026
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IF 9.8
Yin-Yin Lv,Xian-Hao Zhang,Jia-Ni Zhou,Ying-Rui Wang,Zhu-Jun Zhang,Jia-Nan Yan,Bin Lai,Ce Wang,Hai-Tao Wu
The effects and mechanisms of four polysaccharides (xanthan gum (XG), pectin (PE), curdlan (CUR), and chitosan (CS)) at 2 % ( w /w) concentrations on the gelation of Spanish mackerel surimi were investigated. The gel strength, hardness and chewiness of surimi added with XG and PE decreased by 33.6 %–84.9 %, while those of the CUR and CS groups increased by 6.2 % to 38.9 %. Additionally, the incorporation of PE reduced water holding capacity and increased cooking loss. According to the International Dysphagia Diet Standardization Initiative framework, gels supplemented with XG and PE met levels 5 and 6 standards, respectively. Through strong electrostatic repulsion and steric hindrance, XG and PE impeded the approach and cross-linking of myofibrillar proteins and competed for water binding, which collectively weakened hydrophobic interactions, inhibited the formation of a dense gel network, and resulted in a soft and porous weak gel structure. This research provides insights into the development of dysphagia-friendly foods.
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PubMed
高影响因子
APPLIED SURFACE SCIENCE
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2026
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IF 6.6
Zhao Li,Liang Tang,Xiangying Chen,Zhongjie Zhang
A synergistic interfacial reinforcement strategy combining KH560 grafting and pectin-Ca 2+ crosslinking is developed. • Multi-scale interfaces (covalent/ionic/hydrogen bonds and entanglement) enhance filler-matrix compatibility. • The modified BF-K-P-Ca filler achieves a water contact angle of 120°, indicating effective hydrophobization. • The composite film exhibits tensile strength of 24.35 MPa and elongation at break of 593%. • The modification strategy enables industrial-scale film blowing for green biodegradable composites. In this study, PBAT, bamboo flour (BF), KH560, pectin, and calcium ions were used as starting materials to prepare PBAT/modified BF composites through chemical modification, melt blending, and blow molding processes. The effects of key process parameters such as pectin dosage and calcium ion dosage on the structure and properties of the products were systematically investigated. When the pectin dosage was 3%, calcium ion dosage was 2%, and BF dosage was 10%, the composite material achieved a transverse tensile strength of 24.35 MPa, a transverse elongation at break of 593%, a longitudinal tensile strength of 23.46 MPa, and a longitudinal elongation at break of 530%. The comprehensive properties were superior to those of composites prepared by traditional processes. The research results indicate that bamboo flour sequentially modified with KH560, pectin and calcium ions can effectively enhance the compatibility between the filler and the PBAT matrix, thereby significantly improving the overall performance of PBAT/BF composites. The PBAT/modified BF composites prepared in this study, due to their excellent mechanical properties, demonstrate broad application prospects in fields such as packaging, daily necessities, membrane materials, and disposable products. Download: Download high-res image (73KB) Download: Download full-size image
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高影响因子
Food Bioscience
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2026
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IF 6.2
Kaiyuan Su,Haoqian Chen,Zhuoran Guo,Yikai Song,Lin Yang,Jun Liu,Jianlong Wang,Wentao Zhang,Shuo Shi
Natural photosensitizers are promising for postharvest fruit preservation, but their antibacterial efficacy is often limited by weak visible-light responsiveness. Based on the natural photosensitizer quercetin, this study prepared an Fe-quercetin coordination complex (QF), which was subsequently incorporated into an edible coating with a pectin matrix for the preservation of strawberries. DRS-Tauc analysis showed that iron coordination reduced the bandgap of quercetin from 2.64 eV to 1.86 eV, and EPR analysis confirmed the generation of 1 O 2 , •O 2 − , •OH, and HO 2 • under illumination. Under visible-light irradiation, QF completely inactivated Staphylococcus aureus at 0.2 mg/mL within 10 min and Escherichia coli at 0.3 mg/mL within 5 min, whereas free quercetin was markedly less effective under the same conditions. In strawberries stored at 25 °C for five days, the QF-P coating delayed spoilage, reducing weight loss from approximately 16.63% to approximately 7.95%, while maintaining a firmness of approximately 242 g. QF-P coating also better preserved the pH, total soluble solids and color of strawberries during storage. These results show that iron coordination is an effective way to improve the visible-light-driven antibacterial activity of quercetin and support the use of QF-based edible coatings for preserving perishable fruits under mild conditions.
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高影响因子
FOOD CONTROL
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2026
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IF 7
Jun Yang,Zhengke Zhang,Xiangbin Xu,Mohammad Rizwan Khan,Naushad Ahmad,Abdorreza Mohammadi Nafchi,Haiming Chen,Wanli Zhang
Sodium alginate/pectin (SP) composite film functionalized with Nano-selenium (SeNPs) stabilized with Dendrobium officinale polysaccharides (DOP) was developed to enhance its physicochemical and biological activity properties. The addition of DOP significantly improved the dispersibility and surface potential of SeNPs, and the nanoparticles stabilized with 100% DOP exhibited the smallest particle size (210.45 nm), highest zeta potential (-7.95 mV), and optimal superoxide dismutase (SOD) and catalase (CAT) -like activities. Adding 2% SeNPs to SP film improved UV-blocking performance, matrix density, and thermal stability, as well as extensibility and barrier performance. Among the various formulations, SPS-2 film (SP film ccontaining 2% SeNPs) exhibited the highest antioxidant and antibacterial activity, effectively inhibiting Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) . The high-concentration SeNPs composite film demonstrated high biocompatibility, exhibiting no hemolytic activity against red blood cells and minimal cytotoxicity against RAW 264.7 cells. In a postharvest strawberry preservation test, the SPS-2 coating effectively reduced weight loss and spoilage, maintained firmness and soluble solids, and significantly enhanced antioxidant activity by preserving total phenol and flavonoid content. These results demonstrate that 2% SeNPs-added SP films provide an integrated strategy combining enzyme-mimetic activity, enhanced film performance, and high biosafety, and show promising potential for postharvest fruit preservation.
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DOI
高影响因子
TALANTA
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2026
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IF 6.7
Peipei Xu,Junpeng Su,Junhua Zhan,Junbo Huang,Junjie Ren,Yu Chen,Lu Chen,Hanhao Lu,Jingbo Chen,Zhenhua Liu,Jing Zhuang,Yudong Lu
Therapeutic drug monitoring (TDM) of mitoxantrone (MIT) is essential for balancing efficacy and toxicity, yet current methods are limited by complex pretreatment, long turnaround times, and matrix interference. Herein, we developed a SERS sensor based on a pectin/AgNPs@CMC/CS/PAAM composite hydrogel for separation-free detection of cationic anticancer drugs in plasma. Fabricated via one-step UV photopolymerization, the hydrogel's dense network provides size-sieving to exclude plasma proteins, while abundant carboxyl groups confer a strong negative surface charge for selective electrostatic enrichment of positively charged drug molecules. This dual mechanism enhances specificity toward cationic analytes in complex matrices. Using MIT as a model, the sensor achieved 82.6%–101.7% recoveries in 10% plasma, a detection limit of 4.7 × 10 −10 M, and excellent reproducibility. Requiring only simple dilution, this platform offers a practical and ultrasensitive tool for TDM of cationic drugs in combination chemotherapy.
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PubMed
高影响因子
Current Research in Food Science
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2026
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IF 7.7
Donglei Zheng,Mengle Li,Ying Qian,Xiangsong Chen,Jianglin Chen,Long Jin,Lili Cao,Min Pang,Jiaying Huo
Sialic acid (Neu5Ac) possesses a wide range of bioactivities; however, its instability under acidic conditions prevents it from effectively reaching the intestine. This underscores the urgent need to develop a stable delivery system capable of protecting Neu5Ac from gastric degradation and achieving its controlled release in the intestine. To enhance the stability and achieve controlled release, Neu5Ac was encapsulated within water-in-oil-in-water (W1/O/W2) emulsion-based microcapsules in this work. S2 emulsions featured a “dual-chamber, tri-phase” structure, comprising a Neu5Ac-chitosan fluid gel (inner aqueous phase), maize oil (oil phase), and an external aqueous phase of 13% sodium starch octenyl succinate, 5% β-cyclodextrin, 1.5% sodium caseinate, and 0.5% carboxymethyl cellulose. Microstructural analyses confirmed spherical morphology with core-shell architecture and bimodal droplet distribution (1-10 μm). In addition, S2 emulsions exhibited an encapsulation efficiency (EE) of 92.44%, a zeta potential of −60.80 mV, a Sauter mean diameter (d 3 , 2 ) of 1.337 μm, shear-thinning behavior and weak gel network stability. S2 emulsions were spray-dried to obtain S2 microcapsules. S2 microcapsules exhibited an EE of 89.43% and a d 3 , 2 of 3.839 μm, while FT-IR and XRD verified physical encapsulation without covalent bonding. In vitro digestion, S2 microcapsules exhibited controlled release behavior during simulated intestinal digestion, with a Neu5Ac release rate of 85.61% after 120 min. In mice, microencapsulated Neu5Ac increased the relative abundance of Akkermansia , Lactobacillus , and Bifidobacterium . This system demonstrates promising potential for the co-delivery and controlled release of Neu5Ac, and shows great promise for expanding its applications in the food industry.
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PubMed
高影响因子
FOOD CHEMISTRY
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2026
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IF 10.4
Guangfan Qu,Yanxiang Gao,Shuguo Sun
QPI-TA-HMP particles formed a highly viscoelastic interfacial film. • Lutein-loaded Pickering HIPEs possessed controllable rheological properties. • Pickering HIPEs improved the encapsulation efficiency and bioavailability of lutein. • Pickering HIPEs enhanced the in vivo biodistribution of lutein. This study aimed to encapsulate lutein in high internal phase emulsions (HIPEs) stabilized by quinoa protein isolate (QPI), tannic acid (TA), and high-methoxy pectin (HMP) particles at varying concentrations to address its low delivery efficiency and bioavailability. High concentrations (3%–4%) of QPI-TA-HMP particles demonstrated strong interfacial adsorption, forming thick viscoelastic films around oil droplets. These interfacial properties imparted controllable rheological behaviors, textural characteristics, and stable 3D-printing scaffolds to the lutein-loaded HIPEs, achieving an encapsulation efficiency of 81.65 ± 2.36%. In vitro tests indicated that HIPEs enhanced lutein's resistance to storage, heat, and UV exposure while facilitating sustained intestinal release, resulting in a lutein bioaccessibility of 43.73 ± 1.44%. In vivo experiments further demonstrated that the HIPEs delivery system maintained high lutein concentrations in the small intestine, cecum, and colon, thereby significantly enhancing lutein accumulation in systemic circulation. These findings provide new insights into enhancing lutein's stability, delivery performance, and bioavailability. Download: Download high-res image (202KB) Download: Download full-size image
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高影响因子
Food Bioscience
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2026
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IF 6.2
Jiajun Huang,Yangnan Yan,Chun Li,Libin Ma,Zhehao Li,Xuan Wang,Shuwen Liu,Xianghong Xie
The synergistic use of carrier encapsulation and co-pigmentation to stabilize anthocyanins in food matrices remains challenging. Here, we propose a design-to-application strategy to improve the effectiveness of stabilization approaches for black wolfberry anthocyanins. After evaluating the feasibility of the carrier system using molecular dynamics (MD) simulations, we fabricated black wolfberry anthocyanin-loaded core–shell nanocapsules (ACN@PC–CS–BSA). In both the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays, ACN@PC–CS–BSA showed enhanced radical-scavenging capacity. Regarding stability, ACN@PC–CS–BSA significantly improved anthocyanin retention under stress conditions, including ultraviolet irradiation and thermal treatment. Notably, after 150 days of long-term storage, ACN@PC–CS–BSA retained 56.0% of the anthocyanins, which was 40.9% higher than that of free anthocyanins. Subsequently, the co-pigmentation effects between ACN@PC–CS–BSA and six phenolic compounds in a model wine matrix were evaluated using spectroscopic analysis and thermodynamic calculations. Among the compounds tested, gallic acid exhibited the strongest co-pigmentation effect. This work provides a transferable and comprehensive reference for constructing anthocyanin encapsulation systems and evaluating their synergistic stabilization under simulated food-processing conditions.
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高影响因子
危险品化学品经营许可证（带存储）