Advanced Healthcare Materials
·
2025
·
IF 9.6
Tianlong Wang,Zhiqing Liu,Xinhui Wu,Lei Zhang,Yan Chen,Yixing Chen,Yiping Luo,Yaqi Liu,Zeeshan Waheed Muhammad,Jinhui Zhao,Duolikun Dilixiati,Zifei Zhou,Long-po Zheng
Biomimetic mineralization as a promising method offers a bottom-up strategy for creating new organic-inorganic hybrid materials for treating bone defects. However, it is insufficient for bone regeneration, a complex biological procedure involving an interaction between osteogenesis and microenvironment. Herein, a biomimetic mineralized scaffold derived from decellularized adipose tissue modified with polyphenol tannic acid (TA@mDAT) is developed, drawing inspiration from the regulation of the microenvironment and the biomimetic strategy. Besides its enhanced mechanical properties by mineralization, the shape-memory effect of the biomimetic mineralized decellularized adipose tissue (mDAT) is also improved, due to the crosslinking structure between decellularized adipose tissue (DAT) and tannic acid (TA). Besides, the TA@mDAT scaffold exhibits excellent biocompatibility and immunomodulation effect, high efficacy in guiding bone regeneration via intramembranous and endochondral ossification, and enhanced H-type vessel formation. Furthermore, the enhanced expression of Dll4 and Hey1 involving the Notch1 signaling pathway is detected in the regenerated bone, indicating that the Dll4-Notch1 signaling pathway may play an important role in bone regeneration. Thus, this work provides a promising method for bone regeneration by triggering periosteal osteogenesis and H-type vessel formation and revealing a potential mechanism in the osteogenic process.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Yingying Li,Guangyao Zhang,Deqi Fan,Zongze Li,Yi Lu
Achieving efficient and selective solar-driven CO2 reduction remains a grand challenge due to sluggish proton–electron transfer kinetics and limited reactant availability at catalytic interfaces. Herein, we present a hierarchically structured aerogel integrating triazine-based covalent organic frameworks (TCOF) with Nb2CTx MXene nanosheets embedded in a poly(vinyl alcohol)/sodium alginate (PVA/SA) matrix. The aerogel leverages broadband light harvesting, hierarchical water regulation, and localized photothermal activation to enhance multielectron CO2 conversion. The hydrophilic–hydrophobic PVA/SA scaffold promotes rapid water uptake and vapor-phase transport, while Nb2CTx enables efficient near-infrared-induced heating to establish a proton-rich interfacial microenvironment. Simultaneously, the porous TCOF network offers abundant CO2 adsorption and activation sites. This synergistic architecture facilitates stable proton-coupled electron transfer (PCET) pathways and C–C coupling. In situ spectroscopic analyses reveal enhanced formation and stabilization of *COOH, *CH3, and *OCCHO intermediates under photothermal conditions, evidencing facilitated C–C coupling for C2 product generation. Under 3-sun irradiation for 3 h, the optimized TCOF/Nb2CTx aerogel delivers exceptional yields of 119.3 μmol·g–1 CH4 and 94.9 μmol·g–1 C2H4, which is 2-fold higher than powder analogues and surpassing previous COF/MXene systems. This work demonstrates a generalizable strategy to engineer carbohydrate polymer-based aerogels with integrated light-to-heat conversion, vapor regulation, and catalytic site accessibility for efficient solar-to-chemical fuel generation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2025
·
IF 12.4
Senlin Shao,Lei Zhu,Weiyi Li,Hongting Wan,Fanxi Zeng,Huarong Yu,Fangshu Qu
Organic fouling poses a primary barrier to the widespread application of membrane distillation (MD), an emerging technology for treating high‑salinity and chemically complex wastewaters. Despite its importance, quantitative insight into fouling dynamics remains limited, hindering the development of effective mitigation strategies. Here, we monitored the fouling dynamic using optical coherence tomography (OCT) and quantified this dynamic with an extended collision–attachment model. Results indicated that the model showed excellent agreement with experimental observations ( R 2 = 0.95), accurately capturing the kinetics of both foulant deposition and flux loss. With the model, we successfully identified and quantified the key factors governing the fouling dynamics. Notably, our analysis reveals that, in contrast to pressure-driven membrane processes where hydraulic resistance dominates, flux loss by organic fouling in MD is primarily governed by cake-enhanced temperature polarization. Based on these findings, we proposed a framework that enabled both qualitative analysis of organic fouling control strategies and quantitative description of their effects on fouling dynamics, and identified a self‑limiting regime in fouling dynamics, which was attributed to the feedback between collision-attachment kinetics and cake-enhanced temperature polarization effects. This work offers a theoretical basis for the optimization of MD processes and the development of fouling mitigation strategies.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Like Wang,Peiyan Feng,Bo Liu,Shuheng Wei,Peng Tang,Shouwei Yin
Novel phase-change Pickering emulsion microcapsules (PCPEs) were constructed using tannic acid (TA)-modified zein nanoparticles (T-zein) and a lauric acid/stearic acid eutectic (LS) to encapsulate β-carotene. The grafting of TA tuned the wettability of zein nanoparticles, enabling stable emulsification at 50 °C. Subsequent cooling resulted in microcapsules with a T-zein shell and crystalline core (LS), achieving an encapsulation efficiency of 88.15 %. The solidified oil phase restricted molecular migration, while interfacial T-zein provided dual protection, reducing β-carotene degradation under UV irradiation and auto-oxidation by 57.19 % and 67.88 %, respectively, compared with liquid-core emulsions. In vitro digestion studies showed that phase change triggered by physiological temperature enabled controlled release. PCPEs displayed superior gastric stability and resistance to coalescence in the intestine, enhancing the bioaccessibility of β-carotene to 42.57 % (36 % higher than liquid-core emulsions and 298 % of the free control). Overall, this solid-core engineering strategy presents a novel platform for the rational design of emulsion for targeted delivery of lipophilic bioactives.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Acta Pharmaceutica Sinica B
·
2025
·
IF 14.6
Fangke Zhang,Tao Ding,Jiancheng Zheng,Nan Li,Zechuan Li,Xuefei Wang,Yawei Du,Weiguo Hu,Wenguo Cui,Weisheng Guo
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that requires long-term pharmacological management. Melittin, a peptide derived from bee venom, has shown promising therapeutic efficacy for RA by modulating immune balance. Given the critical role of the gut in immune regulation, oral administration of melittin could have significant clinical implications. However, this approach faces substantial challenges, including degradation by gastric fluids and off-target adverse effects, which compromise its efficacy and safety. To address these limitations, we developed an innovative orally administered, gut-targeted micro-nano system (SPM/AlgL) inspired by bacterial colonies. This system employs gas-shearing microfluidic technology to encapsulate sialic acid-modified peptide nanomedicines within calcium alginate hydrogel microspheres. These microspheres are then coated with probiotic biofilms, leveraging their acid resistance and intestinal adhesion properties. The biofilm coating effectively protects melittin from gastric degradation and enhances its accumulation in the mesenteric lymph nodes, thereby improving its targeting ability to inflammatory sites and reducing adverse effects. By modulating the Th1/Th2 and Th17/Treg ratios in the mesenteric lymph nodes and spleen tissues, this system successfully alleviates immune responses and efficiently mitigates the progression of arthritis. Overall, this oral therapeutic strategy demonstrates significant potential for advancing the immunotherapy of RA and other systemic autoimmune diseases.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2025
·
IF 6.5
Yawen Peng,Wenjuan Du,Yating Cui,Chenri Su,Yuyu Liu,Yang Bai,Wen Li,Juan Zhang,Xianhua Wang,Shihui Fu,Haiyan Zhu
Purpose: Treatment of bacterial-infected diabetic wounds is still challenging due to the susceptibility to bacterial infection and oxidative stress. Therefore, a novel multifunctional platform was established for accelerating the healing of bacterial-infected diabetic wounds.Methods: PtPdNi trimetallic-doped MIL-88 (PPNM) was fabricated and anchored to polyvinyl alcohol/sodium alginate (PVA/SA) matrix for constructing PPNM-containing hydrogel (PPNM-Gel). The basic properties of PPNM were characterized by TEM, SEM, XPS, FT-IR spectra, and UV-vis spectra. Adhesive, swelling, and degradation properties of PPNM-Gel were also analyzed. In vitro biocompatibility of PPNM-Gel was determined using L929 and HUVEC-SV40 cells. In vitro antimicrobial effects of PPNM-Gel were evaluated with E. coli and S. aureus. In vivo antibacterial and wound healing evaluation of PPNM-Gel was performed in the STZ-induced diabetic SD rats, which were established by intraperitoneal injection of STZ, followed by full-thickness skin wound preparation and bacterial infection. Histological and immunofluorescence staining were used to evaluate the status of epithelization, collagen deposition and inflammation response.Results: PPNM exhibited multienzyme-like activity including POD-like, OXD-like, CAT-like, SOD-like, and NAD-like activities. PPNM-Gel demonstrated excellent tissue adhesive activity, water absorption ability, biodegradability, and biocompatibility. In vitro testing, PPNM-Gel showed obvious antibacterial ability against E. coli and S. aureus in a PPNM dose-dependent approach, and its antibacterial ability against E. coli was stronger than that against S. aureus. In the STZ-induced diabetic SD rats, PPNM-Gel effectively accelerated wound remodeling by killing pathogenic bacteria, reducing inflammation, and promoting collagen deposition.Conclusion: PPNM-Gel significantly accelerated the healing of bacterial-infected diabetic wounds in the rat model. Therefore, PPNM-Gel showed great promise for the treatment of diseases affected by bacterial infections and high ROS levels.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Zhijin Wang,Qiongfen Yu,Ming Li,Fen Jiang,Lei Shu,Shengnan Sun,Danya Zhan,Zhongfan Mo,Zhihao Song,Runfang Ma,Meidi Ding,Hui Yao
Sorption-based atmospheric water harvesting (SAWH) offers a solution to global freshwater shortages that is not restricted by geographical conditions. However, in the current research, there are still problems such as the excessively high cost of adsorbents and the fact that photothermal materials only increase the desorption temperature during the desorption stage, without playing a role in the adsorption stage or even having a negative impact on it. This paper choses to use low-cost materials: renewable polysaccharides, potato starch (PS), bulk polymers, polyethylene glycol (PEG) as the framework, low-cost hygroscopic agent (CaCl 2 ) was employed as the moisture sorbing component, and MXene as the photothermal component to prepare high-performance sorbents materials (PPMC) through freeze-drying. MXene integration enabled dual functionality. During adsorption, it simultaneously enhanced kinetics and saturated capacity PPMC. Compared to PPC without MXene, PPMC's initial adsorption rate increased from 6.2 mg/g·min to 13.93 mg/g·min, representing an increase of 125 %, its saturated adsorption capacity increased substantially from 0.93 g/g to 1.47 g/g (59 % enhancement). During desorption, MXene's surface plasmon resonance confers exceptional photothermal conversion capability. Under 0.5 sun illumination (500 W/m 2 ), the material reaches 47 °C within 10 min and stabilizes at 71.1 °C after 2.5 h, enabling rapid vapor liberation. Water production validation using a compact system in arid environments (avg. 34.78 % RH, 19.7 °C) demonstrates successful freshwater harvesting. Post-collection analysis confirms compliance with WHO drinking water standards, which establish a cost-effective strategy for atmospheric water harvesting in resource-constrained scenarios.
✓ 已验证
产品关联
DOI
高影响因子
Tungsten
·
2025
·
IF 11.2
Wang Xue,Zhang Li,Han Yu,Li Feng-Bo,Li Shao-Bin
Accurate non-invasive glucose monitoring is crucial for health diagnostics. However, the development of high-performance non-enzymatic electrochemical sensors for this application remains a significant challenge. To address this issue, a novel material, FeOOH encapsulated within zeolitic imidazolate framework-67 (ZIF-67)-derived copper-cobalt-layered double hydroxide (FeOOH@CuCo-LDH), was developed through a vapor-assisted deprotonation process for FeOOH encapsulation, followed by a hydrothermal reaction to synthesize the hollow composite. The synergistic interactions between the multi-metallic composition and the hollow structure significantly enhance glucose oxidation-reduction reactions. This enables the sensor to achieve a wide linear detection range (0.5–722 μmol·L −1 and 722–4222 μmol·L −1 ), high sensitivity (4.05 and 1.43 μA·L·μmol −1 ·cm −2 ), and a low limit of detection (0.83 μmol·L −1 ). The sensor demonstrated excellent performance in practical applications, accurately detecting glucose in saliva under physiological conditions. This study highlights the potential of FeOOH@CuCo-LDH as an excellent electrode material for non-enzymatic electrochemical glucose sensing, offering promising applications in diabetes prevention and diagnosis. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
Journal of Cleaner Production
·
2025
·
IF 10
Dongyu Chen,Meizhu Chen,Xiangming Zhou,Shouwei Jian,Jianwei Zhang,Xinkui Yang,Yuechao Zhao
Minimizing indoor temperature fluctuations reduces dependence on heating and cooling systems, thereby lowering building energy consumption and carbon emissions and subsequently helping tackle global climate challenges. In this study, phase change capsules (PCCs) based on waste cooking oil derivative, Ca-alginate and nano SiO 2 were developed for foamed concrete (FC). The effects of nano SiO 2 dosage on PCC morphology, durability, thermal stability, and heat storage performance were systematically investigated. The distribution of PCCs within FC and the mechanical and thermal regulation properties of FC containing PCC were evaluated. The experimental results indicate that PCCs with 2 wt% nano SiO 2 exhibit a compressive strength of 26.29 N at 15 °C, the thermal decomposition onset above 200 °C with a notable mass loss of 40 %, and phase change enthalpy and temperature are 68.86 J/g and 20.1 °C, respectively. Ca-alginate/nano SiO 2 PCCs were uniformly dispersed and structurally intact within the FC matrix. Incorporation of 3 wt% Ca-alginate/Nano SiO 2 PCCs led to a 10.8 % reduction in compressive strength while exceeding the minimum strength requirements (>8.13 MPa) and achieving a 3.6 °C reduction in FC temperature variation. This study offers a sustainable strategy for improving building energy efficiency while promoting the recycling of waste cooking oil.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2025
·
IF 2.8
Zhikun Li,Yuanyuan Li,Yulong Ma,Wenxin Ji,Yonggang Sun
The purification of biomacromolecules, particularly proteins, plays an increasingly vital role in the fields of medicine, biopharmaceuticals, and emerging technologies. Adsorbents with excellent adsorption capacity, superior cycling performance, and environmental compatibility are crucial for protein separation and adsorption. A temperature- and pH dual-stimulus responsive hydrogel material for the adsorption and separation of protein was successfully prepared by copolymerizing sodium alginate (SA) as the matrix with N-isopropylacrylamide (NIPAM), acrylic acid (AAC), and simultaneously introducing zirconium-based metal-organic frameworks (Zr-MOF). This hydrogel material exhibits excellent adsorption and controlled release properties for protein including bovine hemoglobin (BHB) and bovine serum albumin (BSA) with maximum adsorption capacities of 617.45 mg/g and 527.06 mg/g at 45 °C, respectively. Experimental results demonstrate that the adsorption and release behavior of the hydrogel toward proteins can be effectively regulated by adjusting environmental temperature or pH value in an aqueous medium without any acidic, alkaline, high-salt, or organic solvent. Additionally, the material exhibits good cyclic stability, maintaining more than 85 % of its initial protein adsorption capacity after five adsorption-desorption cycles. This study provides new insights into the development of smart responsive biomolecular adsorption materials and has significant application potential in the fields such as drug controlled release and biological separation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DENTAL MATERIALS
·
2025
·
IF 6.3
Jiajia Xu,Yanji Lu,Kai Zhang,Qiaojie Luo,Xiaodong Li
Objective To compare the bonding efficacy of one-step versus two-step calcium fluoride (CaF₂) nanoparticle deposition and to elucidate the underlying mechanisms. The null hypotheses tested are as follows: 1) Nanoparticles deposited via the one-step strategy are less uniformly distributed than those deposited via the two-step strategy; 2) The one-step strategy does not release more confined water compared to the two-step strategy; 3) The one-step strategy is inferior to the two-step strategy in enhancing dentin bonding durability. Methods A stable amorphous calcium fluoride (ACF) precursor solution was prepared by mixing 10 mM CaCl₂ and 10 mM NaF in 20 mM HEPES buffer for 20 s, enabling one-step CaF₂ nanoparticle deposition through the mineralization-regulating function of non-collagenous proteins acting as pseudonuclei. The two-step strategy consisted of sequentially applying 0.1 M CaCl₂ and 0.2 M NaF, each for 20 s. Neutralization of matrix negative charges, reduced hydration capacity, and confined water release were assessed via cationic dye adsorption, zeta potential, water contact angle, ATR-FTIR spectroscopy, and thermogravimetric analysis. Interface characteristics were evaluated using SEM, TEM, and XPS. Bonding effectiveness was determined by adhesive infiltration depth, micro-tensile bonding strength (μTBS), and nanoleakage expression, both initially and after aging. Results Our results demonstrate that the one-step strategy produces smaller, more homogeneous nanoparticles that penetrate collagen fibrils more effectively. We thus reject the null hypothesis 1. Compared to the unmodified demineralized dentin matrix (DDM), the DDM obtained with the two-step approach exhibits reduced interfacial water, which further reduced by the one-step strategy. The null hypothesis 2 is thus rejected. Compared to the conventional wet-bonding control (AW), bonding performed on these optimized DDM leads to enhanced adhesive infiltration. Both one-step (ACF) and two-step strategies (CW) improve the immediate bonding strength (43.00 ± 4.15 MPa and 36.81 ± 3.32 vs. 31.57 ± 2.02 MPa). after 12 months of storage in water at 37 °C, bonding strength of the AW group significantly decreased to 26.92 ± 2.35 MPa (p < 0.05), whereas the CW group decreased to 30.20 ± 4.66 MPa (p < 0.05) and the ACF group maintained a high level (39.22 ± 5.12 MPa, p > 0.05). Significance This novel one-step dentin bonding strategy effectively addresses the challenge of dentin bonding durability. By simultaneously reduced electronegativity, lower hydration capacity, decreased confined water, enhanced mechanical properties, and reinforcement at the basal level, adhesive infiltration was improved, clinical procedure was simplified, and bond durability was sustained provided. The one-step dentin bonding strategy offers a clinically practical, time-efficient, and superior alternative for durable resin-dentin bonds.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CELLULOSE
·
2025
·
IF 4.8
Li Xiaoqing,Chen Ruoxin,Ren Jiahao,Duan Qingfei,Liu Fengsong
This study investigated the enhancement of carboxymethyl cellulose (CMC)-based films through the incorporation of gelatin and alkyl ketene dimer (AKD), aiming to address inherent limitations in hydrophobicity, film-forming capability, and mechanical strength. To further optimize film properties, three plasticizers, citric acid, glycerol, and isosorbide, were systematically evaluated for their effects on film morphology and flexibility. Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analyses revealed extensive hydrogen bonding among CMC, gelatin, and AKD, evidenced by a marked reduction in free hydroxy groups, indicative of strong intermolecular interactions. Thermal and morphological characterizations further demonstrated that isosorbide promoted homogeneous film formation, while AKD increased surface roughness and improved water resistance. Among all tested formulations, the CMC–gelatin film incorporated with isosorbide and AKD (SCGI–AKD film) exhibited the most favorable hydrophobic performance, achieving a contact angle (CA) of 105.09°, a water solubility (WS) of 28.46%, and a reduced water vapor permeability (WVP) of 0.65 g m/m 2 s Pa. This formulation also displayed superior mechanical characteristics, including a tensile strength of 13.27 MPa, a Young’s modulus of 151.24 MPa, and an elongation at break of 38.71%. Optical measurements confirmed the compatibility of composite components, as all films maintained stable visible light transmittance. Notably, the SCGI–AKD film exhibited selective light-filtering capacity, transmitting only 29.59% for UV light at 300 nm while allowing 80.25% transmittance at 600 nm in the visible range. These findings underscore the potential of CMC–gelatin–AKD composite systems as sustainable, multifunctional packaging materials with tunable barrier, mechanical, and optical properties. Graphical Synopsis: The synergistic incorporation of AKD and isosorbide into CMC films significantly enhanced hydrophobicity, film-forming capability, and mechanical performance, underscoring their potential for application in sustainable packaging systems.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）