CERAMICS INTERNATIONAL
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2026
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IF 6
Shuan Tang,Jiawen Luo,Yulu Zhao,Kehao Zhang,Cheng Fang,Mingliang Li,Gang Shao,Hailiang Wang,Hongliang Xu,Hongxia Lu
In this study, a novel medium-entropy perovskite Cs(Pb 1/4 Yb 1/4 Mn 1/4 Ca 1/4 )Cl 3 quantum dots (QDs) were successfully synthesized via high-energy ball milling method. By introducing equimolar amounts of Mn 2+ , Yb 3+ and Ca 2+ cations, the lead content was reduced to 25%. This design of a medium-entropy structure not only preserves the fundamental perovskite lattice framework of CsPbCl 3 , but also introduces abundant intrinsic defects and localized structural distortions. The synthesized medium-entropy QDs exhibit unique dual-band luminescence properties at room temperature: a visible emission centered at ∼600 nm and a near-infrared (NIR) emission at ∼980 nm, attributed to the 4 T 1 → 6 A 1 transition of Mn 2+ and the f-f transition of Yb 3+ , respectively. The entropy-increasing strategy effectively suppresses non-radiative recombination, stabilizes the crystalline structure of the QDs, thereby significantly enhances both the luminescence properties and stability. Specifically, the QDs achieve a photoluminescence quantum yield (PLQY) of 13.22%, a visible fluorescence lifetime of 108.01 μs, and an outstanding NIR fluorescence lifetime of up to 2.20 ms. After 80 days of storage in ambient air at room temperature and atmospheric pressure, the QDs. still retain 77% and 86% of their initial visible and NIR luminescence intensities, respectively. This work provides a feasible new strategy for developing highly efficient and stable multispectral luminescent medium-entropy perovskite materials, expanding their application potential in biomedical and sensor fields.
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高影响因子
ChemistrySelect
·
2026
·Vol. 11
·期 28
·e73876
·
IF 2.3
Tao Liu,Huichao Zhang,Bo Huang,Shitong Li,Bin Liu
Mn 2+ -doped perovskite nanocrystals (NCs) have attracted extensive research interest and have been synthesized with sizes in the strong confinement regime. Nevertheless, the size of the doped NCs is still not as small as that of undoped perovskite NCs. To address this, we develop a ligand-assisted reprecipitation method incorporating ultrasonication to synthesize Mn 2+ -doped CsPb(Cl/Br) 3 NCs. The obtained spherical NCs have an average size of 3.1 nm and exhibit orange photoluminescence originating from the 4 T 1 to 6 A 1 transition of Mn 2+ . The luminescent properties correlate with the volume ratio of MnCl 2 to PbBr 2 precursors. Increasing the ratio enhances the Mn 2+ -related emission, while excessive doping leads to photoluminescence quenching. When the precursor ratio is reduced to 1:1, the NCs exhibit both intrinsic exciton and Mn 2+ -related emission, with some particles adopting cubic or rod-like morphologies. Prolonged ultrasonic treatment does not significantly shift the emission peak of the NCs, but promotes superlattice assembly in small-sized NCs, showing a center-to-center separation of 4.2 nm. Subsequently, altering the precursor addition sequence to introduce MnCl 2 last during ultrasonic preparation yields simultaneous formation of spherical and cubic NCs. Finally, post-synthesis doping of Mn 2+ is achieved. Formation of small spherical NCs confirms hypothesis that MnCl 2 induces morphological transformation of NCs. Graphical Ultrasonication-assisted ligand-assisted reprecipitation delivers 3.1 nm Mn 2+ -doped CsPb(Cl/Br) 3 nanocrystals with orange emission from the Mn 2+ 4 T 1 → 6 A 1 transition.
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Applied Sciences-Basel
·
2026
·Vol. 16
·期 15
·7453
·
IF 2.9
Qian Zhang,Xianrui Chen,Yatao Wang,Li Hou,Bin Zhang
Ruthenium-based catalysts have attracted considerable attention owing to their excellent activity in the selective hydrogenation of benzene to cyclohexene. Their catalytic performance is primarily governed by the electronic structure of metallic active sites and the interfacial interaction between the metal and the support. In this work, three types of TiO2support, including nanosheet flowers (TNSFs), elongated bipyramids (TNEBs), and tetragonal bipyramids (TNQBs), were successfully synthesized via a solvothermal route, which predominantly expose the (001), (010), and (101) crystal facets, respectively. Subsequently, ruthenium nanoparticles were deposited onto the support surfaces by means of chemical reduction, yielding three supported catalysts. The exposed (101) crystal facets of TNQBs induce the strongest electronic metal–support interaction (EMSI). Abundant Ti3+defects and oxygen-containing species on the surface endow the catalyst with superior hydrophilicity, enhancing the contact between the reaction medium and active sites as well as the desorption of cyclohexene. Meanwhile, the supported Ru species exhibit the highest fraction of electron-deficient states, with the proportion of Ruβreaching up to 82.22%. As a result, the catalyst exhibits outstanding catalytic performance, achieving a benzene conversion of 42.8%, a cyclohexene selectivity of 82.27%, and a cyclohexene yield as high as 53.22%.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Guoyong Liu,Yanrui Xie,Yanzhen Cao,Yingying Jing
Under the catalysis of MnO 2 , TBHQ can react with Cys to generate fluorescent CDs. • A fluorescence turn-on sensor for detection of TBHQ is proposed based on in-situ formation of fluorescent CDs. • This sensor is capable of quantitatively measuring the concentration of TBHQ in edible oils. Excessive intake of the food additive tert -butylhydroquinone (TBHQ) causes potential hazards to the human body. Designing an easy-to-fabricate and efficient TBHQ sensor is of great research significance. We found that in the presence of MnO 2 , TBHQ can react with cysteine (Cys) to generate fluorescent carbon dots (CDs). Inspired by this simple fluorogenic reaction, a turn-on sensor for TBHQ detection is proposed based on in-situ formation of fluorescent CDs. The sensor offers a linear range of 1–200 μM and a detection limit as low as 0.06 μM. Due to its simple reaction precursors and unambiguous reaction mechanism, this sensor demonstrates good practicability for TBHQ measurement in edible oils. This fluorescence turn-on in-situ sensor, which does not require pre-synthesized materials, offers considerable potential for on-site detection of TBHQ. Download: Download high-res image (122KB) Download: Download full-size image
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WATER RESEARCH
·
2026
·
IF 12.8
Yue Wang,Jingyi Lin,Yonghuan Zhao,Weiguang Lv,Bo Liang,Peihua Li,Kaisheng Zhang,Xing-jiu Huang
Tetracycline (TC) is widely detected in natural waters, yet its transformation under environmentally relevant oxidative conditions remains poorly understood, because most previous studies have focused on engineered oxidation systems employing strong oxidants or external energy input. Here we show that humic-like phenolic moieties can act as active mediators to redirect δ-MnO 2 -driven TC transformation from slow direct oxidation to a phenoxy-radical-mediated coupling pathway. Screening of 18 humic-acid model compounds identified acetosyringone (AS) and syringaldehyde (SyrA) as the most effective co-reactants, increasing the apparent rate constants ( k obs ) of TC by about 8.5- and 5.9-fold, respectively. Analyses indicate that TC transformation is governed by syringyl-type phenoxy radicals generated via surface-mediated one-electron transfer on δ-MnO 2 , with reactivity controlled by the fraction of deprotonated phenolic precursors (ArO − ) over a near-neutral pH range. The structure-activity analysis further revealed that ortho‑methoxy and para-carbonyl functionalities favor radical stability and cross-reactivity, whereas para-carboxyl substitution biases the mediator toward self-coupling and unproductive oxidant consumption. These substituent-dependent trends provide molecular-level insight into how humic-like phenolics regulate TC transformation at Mn oxide interfaces.
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PubMed
高影响因子
Materials Today Bio
·
2026
·
IF 11
Aiyang Tong,Yang Zhou,Yang Ding,Yuelin Zhao,Changna Han,Linlin Wei,Jian Zhao
PANoptosis, a newly characterized form of inflammatory programmed cell death that integrates multiple cell death modalities, offers distinct advantages in both potent tumor cell killing and activation of antitumor immunity. However, strategies that can effectively induce PANoptosis in tumor cells remain scarce. Herein, we constructed a tumor microenvironment-responsive nanoplatform (HA-MnO 2 -FTY720@CaO 2 , HMFC) comprising a CaO 2 core and a MnO 2 shell, loaded with fingolimod (FTY720) and surface-functionalized with hyaluronic acid (HA) for CD44-mediated targeting. Under the mildly acidic and glutathione (GSH)-rich conditions of the tumor microenvironment (TME), the MnO 2 shell degrades, liberating FTY720 and exposing the CaO 2 core. The CaO 2 subsequently decomposes to release Ca 2+ and H 2 O 2. FTY720 inhibits Transient Receptor Potential Melastatin 7 (TRPM7) channels, disrupting Ca 2+ /Mg 2+ homeostasis and thereby provoking severe calcium overload. Simultaneously, MnO 2 depletes GSH and, together with CaO 2 -derived H 2 O 2 , promotes a Fenton-like reaction that generates abundant reactive oxygen species (ROS), thereby disrupting intracellular redox homeostasis. In addition, Mn 2+ released from MnO 2 degradation activates the cGAS–STING pathway, further contributing to DC maturation and antitumor immunity. This orchestrated immune response markedly suppresses tumor growth and when combined with anti-PD-L1 therapy, induces a pronounced abscopal effect. Together, our results indicate that calcium overload, FTY720-mediated TRPM7 inhibition, and MnO 2 -induced redox imbalance can drive PANoptosis, offering a new concept for enhancing cancer immunotherapy.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Jin Li,Bin Zhang,Bingxin Wang,Xiaoxiao Zhang
ZDHHC15 regulates YAP localization and YAP/CYR61 signaling in OSCC. • PA supports OSCC migration through lipid metabolism-linked signaling. • R-LPA@siZDHHC15 enables targeted siRNA delivery and photothermal response. • The nanoplatform suppresses OSCC growth and lung colonization in models. This study aimed to elucidate the molecular mechanism by which ZDHHC15 promotes oral squamous cell carcinoma (OSCC) progression through regulation of the YAP/CYR61 signaling axis. Metabolomic and transcriptomic analyses revealed prominent lipid metabolic reprogramming in OSCC cells, with palmitic acid (PA) driving activation of the YAP transcriptional program and promoting cell migration and lung colonization. Functional experiments showed that ZDHHC15 enhanced YAP nuclear localization and transcriptional activity, leading to increased CYR61 expression and establishment of the ZDHHC15/YAP/CYR61 signaling axis. In addition, we developed a novel nanoplatform, R-LPA@siZDHHC15, which exhibited photothermal responsiveness and tumor-targeted delivery in vivo . When combined with photothermal therapy, this platform suppressed OSCC cell proliferation and tumor growth under the tested conditions. Collectively, these findings provide mechanistic insight into OSCC progression and support targeting the ZDHHC15/YAP/CYR61 axis as a potential therapeutic strategy, while further control and thermal-monitoring studies are needed to fully define the nanotherapeutic contribution. Schematic representation of the molecular mechanism by which R-LPA@siZDHHC15 modulates the YAP/CYR61 axis, thereby achieving combined photothermal and gene therapy to suppress OSCC progression. Download: Download high-res image (152KB) Download: Download full-size image
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Yuxin Xie,Jingjing Zhao,Jingyi Peng,Shubin Li,Xiaojun Han
V 4 C 3 T x MXene/GCE for highly sensitive detection of Cd 2+ , Pb 2+ , and Cu 2+ in water. • LODs of Cd 2+ , Pb 2+ , and Cu 2+ were 2.18 μg/L, 2.02 μg/L and 1.85 μg/L, respectively. • The electrodes possess good reproducibility, storage stability, and selectivity. Water pollution induced by heavy metal ions is growing increasingly severe and endangers human health significantly. Here, a high-performance electrochemical sensor for Cd 2+ , Pb 2+ and Cu 2+ detection in aqueous samples was fabricated by modifying V 4 C 3 T x MXene on a glass carbon electrode (GCE). V 4 C 3 T x was prepared through selective etching, and its structure and chemical compositions were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy. The results demonstrated that the distinctive two-dimensional lamellar architecture and multivalent vanadium of V 4 C 3 T x MXene provided an ideal platform for efficient heavy metal ion enrichment and electrochemical response. The limit of detection (LOD) was 19.4 nM for Cd 2+ , 9.7 nM for Pb 2+ , and 29.1 nM for Cu 2+ . Besides, the V 4 C 3 T x /GCE was utilized to detect Cd 2+ and Pb 2+ simultaneously, with the LODs to be 24.1 and 12.2 nM. Similarly, the V 4 C 3 T x /GCE was applied for the detection of Pb 2+ and Cu 2+ simultaneously, and the LODs were 12.6 and 34.5 nM, respectively. The V 4 C 3 T x /GCE exhibits excellent repeatability, reproducibility, anti-interference performance and stability, and demonstrates successful application to the analysis of actual water samples. Download: Download high-res image (226KB) Download: Download full-size image
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LUMINESCENCE
·
2026
·Vol. 41
·期 7
·e70559
·
IF 2.8
Huiping Zhou,Mingyi Kang,Zhifeng Hao,Xue Zhang,Peng Liu,Guangyou Zhang,Xueying Wang,Na Jiang
Two simple Schiff bases PHMP( (E)-2- ((2-(9H-purin-6-yl)hydrazono)methyl)phenol) and PHMEP( (E)-2- ((2-(9H-purin-6-yl)hydrazono)methyl)-6-ethoxyphenol) were designed and synthesized based on 6-hydrazine-purine with salicylaldehyde and 3-ethoxy-salicylaldehyde, respectively. Among them, both PHMP and PHMEP exhibit significant “turn-on” response characteristics when coordinating with Zn 2+ ions in an EtOH/H 2 O buffer solution, demonstrating remarkable selectivity and sensitivity, accompanied by a noticeable color change. Initially, neither probe exhibited significant fluorescence. However, upon forming complexes with Zn 2+ , PHMP and PHMEP exhibit bright blue and green fluorescence responses, respectively. In contrast, the ethoxy modification in PHMEP alters its steric hindrance and electron cloud density, resulting in fluorescence signals with both superior selectivity and sensitivity compared with PHMP . Additionally, the newly formed complex PHMEP -Zn 2+ can serve as a selective “turn-off” fluorescence probe for Cu 2+ ions. Experimental data indicate that the detection limits of PHMP and PHMEP for Zn 2+ ions are 1.08 × 10 −8 M and 8.85 × 10 −9 M, respectively; the detection limit of PHMEP -Zn 2+ for Cu 2+ ions is 1.79 × 10 −8 M. Job's plot analysis, ESI-MS titration, and theoretical calculations confirmed that the stoichiometric ratio of the probes to the target ions is 1:1. Additionally, PHMP and PHMEP demonstrate broad potential applications in quantitative detection, being suitable for both tap water and convenient test strips.
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高影响因子
Advanced Science
·
2026
·
IF 14.1
Bolun Xu,Xuan Lu,Yuquan Wang,Haihua Ji,Ying Zhang,Yiqun Wan,Hao Wan
Immunogenic cell death (ICD)-based whole-cell personalized cancer immunotherapies present full tumor antigens but suffer from poor immunogenicity, early clearance, and a glutathione (GSH)-rich immunosuppressive tumor microenvironment (TME). Here, we report a TME-responsive immunotherapeutic platform, DTBEI@CS@MnO 2 , which integrates immunogenicity-enhanced dead tumor cell bodies (DTBEI) with Mn 2 + -potentiated innate immunity. Tumor cells preloaded with indocyanine green (ICG) are sequentially functionalized with a chitosan (CS) interlayer followed by MnO 2 adsorption (CS@MnO 2 ) via electrostatic interactions. Upon near-infrared laser irradiation, ICG-mediated photodynamic/photothermal effect induces potent ICD, generating DTBEI. Within the acidic and GSH-enriched TME, the CS@MnO 2 coating disassembles to release DTBEI and MnO 2 . DTBEI provides endogenous antigens and ICD-associated danger signals, while MnO 2 is reduced by GSH to Mn 2 + . The resulting Mn 2 + amplifies DTBEI- and tumor-derived deoxyribonucleic acid-triggered cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) activation and downstream immune-stimulatory effects, thereby synergistically promoting dendritic cell maturation, antigen cross-presentation, and tumor-specific T-cell priming. Consequently, DTBEI@CS@MnO 2 elicits durable anti-tumor immunity, effectively inhibiting tumor growth and suppressing recurrence and metastasis, while establishing T-cell memory responses. Importantly, this strategy shows broad applicability in multiple tumor models, including CT26 colon cancer, 4T1 breast cancer, and B16F10 melanoma, while maintaining favorable biocompatibility. Overall, these findings highlight a materials-based approach for personalized cancer immunotherapy.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Jiahui Liu,Xiaorui He,Yue Wang
One-step MXene/CNTs-COOH/CS/IL sensing interface was constructed. • CNTs-COOH alleviated MXene restacking and promoted electron transport. • CS and ionic liquid enhanced metal-ion enrichment and ionic transport. • The sensor simultaneously determined Cd 2+ , Pb 2+ , Cu 2+ , and Hg 2+ . • Real-water results agreed well with ICP-MS measurements. Rationally coordinating ion accessibility, electron transport, metal-ion enrichment, and film stability within a facile electrode architecture remains challenging for multiplex electrochemical analysis. Herein, an MXene-based multicomponent sensing interface was constructed through the one-step integration of carboxylated carbon nanotubes (CNTs-COOH), chitosan (CS), and an ionic liquid (IL) with Ti 3 C 2 T x nanosheets. CNTs-COOH act as conductive nano-spacers that alleviate MXene restacking and improve electronic connectivity, while CS provides coordination-active amino and hydroxyl groups for metal-ion enrichment and contributes to film stability. The incorporation of IL improves component dispersion and ionic transport and partially mitigates the interfacial transport limitation associated with the CS-containing layer. Structural and electrochemical characterization results collectively support complementary roles of the four components in regulating interfacial accessibility, analyte accumulation, and charge-transfer behavior. Under the optimized conditions, the resulting electrode enabled the simultaneous determination of Cd 2+ , Pb 2+ , Cu 2+ , and Hg 2+ by differential pulse anodic stripping voltammetry over linear ranges of 0.5–22.5, 0.5–60, 0.5–87, and 0.5–62 μM, respectively. The corresponding detection limits were 0.1539, 0.0746, 0.2279, and 0.0931 μM. The sensor also exhibited satisfactory selectivity, reproducibility, and long-term stability, retaining approximately 92–95% of its initial response after 30 days. Recoveries of 92.2–96.0% were obtained in spiked tap-water and river-water samples, and the measured concentrations were consistent with those obtained by ICP-MS. These results demonstrate a functionally coordinated interface-engineering strategy for the simultaneous electrochemical determination of multiple heavy metal ions. Download: Download high-res image (139KB) Download: Download full-size image
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DESALINATION
·
2026
·
IF 9.9
Linkai He,Xingqiang Wu,Yun Tian,Yixin Pan,Faquan Wu
The release and dispersion of uranium during mining activities and fuel/waste management processes in nuclear power plants pose serious environmental risks, particularly in aqueous systems. In such environments, uranium exhibits high solubility and strong mobility, leading to severe radioactive contamination of groundwater, soil, and ecosystems. Therefore, remediating uranium-contaminated environments remains a significant scientific and technological challenge. To address this issue, the present study exploits the high specific surface area and tunable pore architectures/functional sites of metal-organic frameworks (MOFs). Using a controlled synthesis strategy, a core-shell (Fe-Ni) galvanic cell structure was constructed and integrated with MIL-100(Fe) to fabricate the Ni-Fe-MIL-100(Fe) composite, enabling highly efficient and synergistic removal of U(VI) via an “adsorption-reduction-complexation” mechanism. Experimental results demonstrate that the maximum uranium uptake capacity reached 3038.19 mg·g −1 at 303 K and pH = 5, with a significantly enhanced removal efficiency. The kinetic analysis indicates that the uranium adsorption process is well described by the pseudo-second-order model. Combined with density functional theory (DFT) calculations, the electronic transfer channels of the structure were elucidated, revealing that they drive the reduction of U(VI) and facilitate its coordination and immobilization at multi-metal and oxygen-containing sites. These findings confirm that U(VI) removal by the composite material proceeds via a coupled chemical reduction and complexation process, thereby clarifying the underlying adsorption mechanism. Moreover, in mixed-ion solutions and real seawater, the composite maintains high adsorption capacity and excellent selectivity, demonstrating strong potential for uranium immobilization and recovery in the remediation of radioactive wastewater.
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