Journal of Marine Science and Engineering
·
2026
·Vol. 14
·期 14
·1311
·
IF 3.2
Daping Zhou,Shuye Xue,Ye Qiu,Xiangming Zeng,Haijun Wei,Shen Wu
The instability of marine low-sulfur fuel oil caused by asphaltene precipitation poses significant operational challenges in the shipping industry. This study systematically investigates the dispersing effects of biodiesel derived from three different feedstocks—palm oil, waste cooking oil (WCO), and microalgae oil—and their individual fatty acid methyl ester components on asphaltenes extracted from VLSFO. Biodiesel was selected as a dispersant due to its renewable nature, polar ester functional groups, and variable unsaturation levels, which enable favorable interactions with asphaltene molecules through hydrogen bonding and π-π stacking. Using UV–Visible spectrophotometry, the dispersion performance was quantitatively evaluated under various conditions including dispersant concentration, temperature, storage time, and molecular structural characteristics. The results demonstrate that microalgae oil biodiesel exhibits the most superior asphaltene dispersion capability among the three biodiesels, with a dispersion improvement index of 35% at 12 g/L, compared to 28% and 22% for waste cooking and palm oil biodiesels. Optimal performance is achieved at 80 °C, where the asphaltene concentration increases by 68% relative to the control, and remains stable within the first 10 days of storage but deteriorates significantly after 30 days due to oxidative degradation. Among individual FAME components, the dispersion effectiveness increases with alkyl chain length from C10 to C20, with the latter reaching a 30% improvement index. Functional group polarity plays a critical role, with carboxylic acid exhibiting a 45% improvement at 14 g/L, substantially outperforming alcohol at 32% and ester at 28%. The degree of unsaturation further enhances dispersion, as the improvement index rises progressively from 20% for saturated methyl stearate to 42% for tri-unsaturated methyl linolenate, representing a 2.1-fold increase. Dynamic light scattering (DLS) measurements confirm that biodiesel addition reduces asphaltene particle size from the micrometer range of 2 to 5 μm down to submicron levels of 200 to 500 nm, while microscopic observations reveal inhibited aggregation. These findings provide theoretical foundations for biodiesel application in marine fuel systems.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Jingyi Zhang,Tian Liu,Yaqiao Li,Lurong Zhang,Chengde Jiang,Hongying Xiao,Mengyuan Duan,Jingzhe Sheng,Yingjie Zhao,Hao Zhang,Qing Wang,Zhonggui He,Jin Sun,Xianbao Shi,Bingjun Sun
Nanodrug delivery systems show great potential in cancer therapy. However, conventional spherical nanoparticles are rapidly recognized and cleared by the mononuclear phagocyte system (MPS). This results in shortened circulation and inadequate tumor accumulation, which ultimately compromises the therapeutic efficacy. Previous studies have suggested that anisotropic morphologies, such as rod-like or worm-like nanostructures, can prolong blood circulation and promote tumor tissue-specific distribution. Nevertheless, controlling the morphology of nanoparticles without altering their chemical composition remains a significant challenge. In this study, we report a novel strategy for physical morphology regulation using prodrug nanoassemblies as a model. Specifically, this process refers to a noncovalent, energy-driven structural reorganization that proceeds without chemical bond cleavage or formation. An ultrasound-assisted one-step nanoprecipitation method is employed to controllably transform thioether-linked SN38 prodrugs (SN38-S-OA) from spherical nanoassemblies into highly uniform nanorods (NRs) with aspect ratios (AR) of 5 or 8. In contrast, the disulfide linkage provides more structural defects, which hinders similar structural reorganizations. Biological evaluations demonstrated that SN38-S-OA NRs AR5 achieved reduced macrophage uptake, prolonged blood circulation, enhanced tumor accumulation, and superior antitumor efficacy compared with those of SN38-S-OA NPs and SN38-SS-OA NPs. Additionally, an optimal aspect ratio is identified, as overly elongated SN38-S-OA NRs AR8 exhibited reduced tumor cell uptake due to increased steric hindrance. This study establishes purely physical morphology regulation as an independent design principle that prolongs circulation, enhances tumor targeting, and improves the therapeutic efficacy in nanomedicine.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Boyu Chen,Jinghao He,Qingqing Wang,Jianjun Wang,Piaoping Yang
A multifunctional nanozyme-based reactor (FDIG) was rationally constructed by integrating Fe 3 O 4 nanoparticles, Ir nanoparticles, and glucose oxidase (GOx) within the spatially confined framework of dendritic mesoporous silica nanoparticles (DMSN). The DMSN scaffold provides abundant mesochannels and silanol groups for the uniform co-immobilization of catalytic components, enabling efficient oxidase–peroxidase cascade catalysis through a proximity-driven mechanism. In this confined architecture, GOx catalyzes glucose oxidation to produce H 2 O 2 , which is subsequently decomposed by Fe 3 O 4 /Ir nanozymes to generate hydroxyl radicals ( OH) for TMB oxidation, leading to a strong blue colorimetric response. Benefiting from the synergistic interaction between Fe 3 O 4 and Ir and the spatial confinement effect of DMSN, the FDIG nanoreactor exhibits remarkably enhanced peroxidase-like activity, high substrate affinity, and excellent structural robustness. Through a simple one-step detection, the optimized FDIG system demonstrated outstanding glucose-sensing performance with a wide linear range (50–1000 μM), a low detection limit (0.34 μM), and excellent selectivity. Besides, FDIG can be easily separated and reused due to the magnetic Fe 3 O 4 nanoparticles, maintaining over 80% activity after five cycles. The sensor also showed reliable analytical performance in artificial saliva, achieving recovery rates of 95–96% with RSDs below 3.2%, confirming its applicability in complex biological environments. Moreover, the colorimetric response could be quantitatively analyzed via an RGB-based smartphone platform, allowing rapid and instrument-free glucose monitoring, thus demonstrating the potential of FDIG for noninvasive point-of-care testing.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Yan Zhang,Yaoli Wei,Cristiano Varrone,Seongbong Heo,Jiating Hao,Zhihong Liu,Aijuan Zhou,Senlin Shao,Xiuping Yue
Coupling membrane extraction with chain elongation enables in-situ recovery of medium-chain fatty acids (MCFAs) from waste activated sludge, but interfacial instability and phase breakthrough remain major obstacles to practical application. To address this challenge, a thin-film composite (TFC) membrane was fabricated on a hydrophobic polytetrafluoroethylene (PTFE) porous membrane substrate via a polydopamine/polyethyleneimine (PDA/PEI) co-deposition strategy. TFC membrane significantly increased breakthrough pressure from 13 kPa (pristine PTFE) to 164–288 kPa, effectively preventing phase breakthrough. Notably, during the reactive extraction of MCFAs, the dense films in the TFC membrane did not hinder mass transfer; instead, enhanced both extraction efficiency (from 71.0% to 95.9%) and selectivity. These improvements arise from the enlarged interfacial reaction area provided by the rough film surface and the stronger binding of short-chain fatty acids to hydrophilic functional groups of the film, as confirmed by density functional theory (DFT) calculations. When integrated into a real chain elongation system, the adoption of the TFC membrane increased caproate production by 50%, accompanied by clear environmental and economic benefits (indicating promising economic prospects, with a net profit of 0.795 USD m −3 ). To our knowledge, this represents the first demonstration of TFC membranes in membrane extraction, revealing their unique ability to couple stability, efficiency, and selectivity, and opening new opportunities for sustainable MCFAs bioconversion.
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Foods
·
2026
·Vol. 15
·期 3
·479
·
IF 5.1
Baizhi Cen,Juge Liu,Mengyuan Tan,Bo Wang,Lu Gao,Zhenquan Yang,Genxi Zhang,Tao Zhang,Xuechao Xu
In this study, a silver-based metal–organic framework (Ag-MOF) nanozyme was synthesized for the synergistic eradication of drug-resistantSalmonellaenteritidisin food matrices. Ag-MOF exhibits multiple enzyme-like activities, namely oxidase (OXD)-, peroxidase (POD)-, and superoxide dismutase (SOD)-like activities. It demonstrated excellent antibacterial and antibiofilm activities against erythromycin- and chloramphenicol-resistantS. enteritidisstrains (N29 and P23). Specifically, treatment with 20 mg mL−1Ag-MOF resulted in nearly complete eradication ofS. enteritidisin in vitro suspension assays, including 1 × 107CFU mL−1N29 strain and 6 × 106CFU mL−1P23 strain. Moreover, treatment with 1 mg mL−1Ag-MOF led to 80~90% biofilm inhibition ofS. enteritidis. Mechanistic investigations revealed that Ag-MOF effectively interacted with amino-rich structures on the bacterial surface (such as membrane proteins and peptidoglycan components), generated abundant reactive oxygen species (ROS), released Ag+ions, and depleted intracellular glutathione, which collectively disrupted cell membrane integrity and induced severe leakage of intracellular proteins and nucleic acids. Importantly, Ag-MOF maintained high antibacterial efficacy in complex simulated food matrices (pork, milk, and egg shell). Overall, this study offers key insights into enzyme-mimicking antibacterial materials and a promising strategy to combat multidrug resistant foodborne pathogens.
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BMEMat
·
2025
·
IF 15.5
Wenkui Mo,Zeyu Liang,Bo Zhang,Lin Xiao,Xun Liu,Zhigao Yi,Shangzhi Xie,Qiyue Wang,Liang Shi,Taobo Luo,Feng Li,Leilei Wu,Yuanzhe Piao,Fangyuan Li,Jian Zeng,Daishun Ling
Early, non-invasive detection of esophageal cancer at sub-millimeter resolution is critical for tailoring precise therapeutic strategies. While ultra-high-field (UHF) magnetic resonance imaging (MRI) offers exceptional spatial resolution, the lack of optimized contrast agents capable of enhancing sensitivity for detecting microscopic tumors remains a significant challenge. Here, we report a cyclo-RGD peptide-conjugated antiferromagnetic nanoparticle (RANP) as a novel targeted T 1 contrast agent, specifically designed to improve in vivo imaging of esophageal tumors at the micrometer scale. The RANP integrates an antiferromagnetic core with low magnetization, minimizing T 2 decaying effects, while the cyclo-RGD peptide enhances its targeting ability by specifically binding to integrin α v β 3 , a biomarker highly expressed on tumor vasculature. This targeted conjugation improves the probe's selective accumulation at the tumor site and facilitates superior T 1 relaxation of water protons. Under 9 T MRI conditions, the RANP exhibits an r 1 value of 1.88 mM −1 s −1 and a low r 2/ r 1 ratio of 1.84, enabling the detection of primary esophageal tumors as small as 0.8 mm. This study significantly advances the sensitivity of current imaging techniques, pushing the detection limit of in vivo esophageal cancer diagnosis into the sub-millimeter range. Our results demonstrate the promising potential of RANP-enhanced UHF MRI for early detection, monitoring, and therapeutic intervention in esophageal cancer, offering a powerful tool for more effective clinical management.
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Advanced Healthcare Materials
·
2025
·
IF 9.6
Huanhuan Wu,Haoyu Wang,Jinwen Wei,Gang Shu,Shao-kai Sun,Cai Zhang,Dong Li
Acquiring multidimensional tumor and tumor-associated vascular information is essential for accurate diagnosis and treatment planning of glioma, yet effective imaging methods are still lacking. Here, ultrasmall manganese ferrite nanoparticles (UMFNs) are developed as a dual contrast-enhanced T 1 -weighted imaging (T1WI) and susceptibility-weighted imaging (SWI) probe for multidimensional diagnosis of glioma. The UMFNs are synthesized through thermal decomposition and functionalized with polyethylene glycol, ensuring excellent water dispersibility and biocompatibility. Characterization studies confirm the nanoparticles’ uniform size (3.8 nm) and high stability in various media. High r 1 (6.8 m m −1 s −1 ) and r 2 * (95.1 m m −1 s −1 ) values demonstrate the superior T 1 and T 2 * enhancement capabilities of UMFNs. In vivo imaging on a 3.0 T magnetic resonance imaging (MRI) scanner demonstrates that UMFN-enhanced SWI clearly delineates tumor margins and provides sustained tumor enhancement in ultrasmall orthotopic glioma (<2 mm). Besides, UMFN-enhanced SWI reveals distinct vascular structures associated with the glioma, including tortuous, thickened vessels indicative of tumor-induced angiogenesis. Whole-brain histological analysis corroborates these findings, demonstrating dense tumor proliferation and vascular remodeling. These results highlight the potential of UMFNs as a dual-enhanced agent for the early detection and high-resolution vascular mapping of glioma, providing an advanced multidimensional method for precise diagnosis of brain tumors.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Kunlin Li,Xueyan Chen,Jianghao Zhang,Min Chen,Xiaoxiao Qin,Fei Wang,Kai Li,Jinhou Fang,Changbin Zhang
Regenerable materials with abundant basic sites and sulfur storage space are highly desirable for the removal of H 2 S. In this work, we synthesized a flower-like MgO/Carbon material by one-step carbonization of magnesium gluconate and applied it for H 2 S oxidation at room temperature. The results demonstrate that the high content of MgO and super-hydrophilic surface of the MgO/Carbon provide abundant basic sites for the adsorption and dissociation of H 2 S. Moreover, carbon defects and a well‐developed pore structure offer active sites for the desulfurization reaction and large space for storage of sulfur products. Consequently, the MgO/Carbon materials exhibit excellent H 2 S oxidation performance, which is far superior to that of commercial activated carbon. In addition, the MgO/Carbon materials show extraordinary regeneration capacity and maintain their high performance even after 5 cycles of desulfurization/regeneration. Furthermore, mechanisms for the H 2 S oxidation process, deactivation and regeneration are proposed based on the experimental and characterization results. Considering the simple preparation process, excellent desulfurization and regeneration performance of as-prepared MgO/Carbon material, our findings provide a new strategy for the design of efficient desulfurizers.
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PEST MANAGEMENT SCIENCE
·
2023
·Vol. 79
·期 9
·3090-3102
·
IF 4.1
Jinlan Xin,Kangle Jia,Longfei Yu,Huanling Li,Junhua Ning,Xiaoshan Zheng,Haifu Wu,Xingxing Liu,Linjia Huang,Wu Wen
Background Efficient deposition of high-speed droplets on superhydrophobic leaf surfaces remains an important challenge. For anisotropic wired superhydrophobic leaf surfaces, the splashing phenomenon is especially serious because it leads to the low effective utilization of pesticides by biological targets. The lost pesticides cause serious ecological environment pollution, therefore there is an urgent need to develop a green and sustainable cost-effective strategy to achieve efficient deposition of high-speed droplets on anisotropic superhydrophobic leaf surfaces at low dosage. Results One type of green pseudogemini surfactant is constructed based on fatty acids and hexamethylenediamine by electrostatic interaction to control the splashing and spreading of high-speed droplets on superhydrophobic surfaces. The formed surfactant can not only achieve complete inhibition of the bouncing of droplets, but also promote rapid spreading on superhydrophobic leaf surfaces at very low usage. The efficient deposition and superspreading phenomenon are attributed to the rapid migration and adsorption of the surfactant from the dynamic spherical micelles at the newly formed solid–liquid interface, the network-like aggregated spherical micelles, and the Marangoni effect caused by the surface tension gradient. Moreover, the surfactant shows an excellent synergistic effect with herbicides to control weeds by inhibiting droplet splashing. Conclusion This work provides a simpler, more effective and sustainable approach to utilize aggregated spherical micelles rather than conventional vesicles or wormlike micelles to improve the droplet deposition on superhydrophobic leaf surfaces and reduce the impact of surfactants and pesticides on the ecological environment. © 2023 Society of Chemical Industry.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
·
IF 5.2
Asim Mushtaq,Xuehua Ma,Jabeen Farheen,Xiaoqing Lin,Muhammad Tayyab,M. Zubair Iqbal,Xiangdong Kong
Magnetic hydroxyapatite nanocomposites are promising candidates for various biomedical applications. However, the uncontrolled growth with the unfavorable size limits their widespread utilization in real-time applications. Herein, a facile method was utilized to fabricate uniform spherical-shaped nanocomposites of manganese oxide combined hydroxyapatite (Mn 3 O 4 -HAp) with an average size of about 28 nm. The structural characterization reveals the presence of Mn 3 O 4 in the crystalline phase, confined by HAp to give a composite structure. The biocompatibility and drug loading capability of Mn 3 O 4 -HAp nanocomposites are improved by surface modification using Food and Drug Administration-approved triblock copolymer Pluronic® F-127, followed by folic acid (FA) for targeting ability. Taking advantage of the surface properties of the polymer and the drug delivery potential of HAp, metformin was encapsulated in the prepared nanocomposites with a loading capacity of 98 %. The prepared nanocomposites indicate promising cell viability up to 87 % and an excellent drug release profile in an acidic atmosphere. Moreover, the magnetic component Mn 3 O 4 presents auspicious T 1 -Magnetic resonance imaging with notable r 1 relaxivity of 2.166 mM −1 s −1 . Further, the Mn 3 O 4 [email protected] nanocomposites demonstrate good cellular uptake and excellent reactive oxygen species (ROS) production under low-intensity UV irradiation , resulting in a remarkable photodynamic therapeutic effect. The results showed that the designed Mn 3 O 4 -HAp nanocomposites are promising targeted chemo-theranostic agents.
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Nature Chemistry
·
2023
·Vol. 15
·期 11
·1581-1590
·
IF 21.8
Chen Gaoyu,Liu Xiaoyu,An Jiakun,Wang Shibin,Zhao Xiaokun,Gu Zhongzheng,Yuan Caojin,Xu Xiangxing,Bao Jianchun,Hu Han-Shi,Li Jun,Wang Xun
Although their zero- to two-dimensional counterparts are well known, three-dimensional chiral hybrid organic–inorganic perovskite single crystals have remained difficult because they contain no chiral components and their crystal phases belong to centrosymmetric achiral point groups. Here we report a general approach to grow single-crystalline 3D lead halide perovskites with chiroptical activity. Taking MAPbBr 3 (MA, methylammonium) perovskite as a representative example, whereas achiral MAPbBr 3 crystallized from precursors in solution by inverse temperature crystallization method, the addition of micro- or nanoparticles as nucleating agents promoted the formation of chiral crystals under a near equilibrium state. Experimental characterization supported by calculations showed that the chirality of the 3D APbX 3 (where A is an ammonium ion and X is Cl, Br or mixed Cl–Br or Br–I) perovskites arises from chiral patterns of the A-site cations and their interaction with the [PbX 6 ] 4− octahedra in the perovskite structure. The chiral structure obeys the lowest-energy principle and thereby thermodynamically stable. The chiral 3D hybrid organic–inorganic perovskites served in a circularly polarized light photodetector prototype successfully.
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Journal of Cleaner Production
·
2022
·
IF 11.072
Bin Zhang,Meng Mei,Kaiwei Li,Jingxin Liu,Teng Wang,Si Chen,Jinping Li
Magnetic biochar adsorbents often suffer from the uneven distribution and shedding problems of nanoparticles . In this study, a one-pot sol-gel pyrolysis method was proposed to synthesize a MnFe 2 O 4 functionalized magnetic sawdust-based biochar (MnFe 2 O 4 @SBC) for efficient removal of diclofenac sodium (DCF). The MnFe 2 O 4 @SBC was characterized by XRD , Raman, VSM, TG-DSC, SEM, TEM, BET, FTIR and XPS . The results demonstrated that the combination of sol-gel and sawdust effectively led to a homogeneous distribution of MnFe 2 O 4 on biochar and the MnFe 2 O 4 @SBC possessed a much richer pore structure and functional groups than the original biochar. A systematic comparison of MnFe 2 O 4 @SBC with commercial activated carbon (CAC) was conducted by analyzing the effects of initial pH, adsorbent dosage, coexisting ions, contact time and temperature on their adsorption performance. Based on the adsorption isotherm study, the maximum adsorption capacity of MnFe 2 O 4 @SBC was predicted to be 352.17 mg/g, which was almost 3.5 times that of CAC. Selectivity adsorption study and real water-based removal experiment further demonstrated the satisfactory adsorption selectivity and applicability of MnFe 2 O 4 @SBC for DCF. This study reveals that the one-pot sol-gel pyrolysis is a promising method for synthesizing excellent magnetic biochar adsorbents.
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