CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2016
·Vol. 32
·期 6
·943-946
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IF 1.086
Li Min,Jin Yongri,Wang Xiaozhong,Wu Qian,Liu Ying,Li Peng,Li Xuwen
A new triterpenoid glycoside( 1 ) and seven known triterpenoid glycosides, pseudoginsenoside RT 2 ( 2 ), yesanchinoside R 2 ( 3 ), vinaginsenoside R13( 4 ), vinaginsenoside R8( 5 ), notoginsenoside E( 6 ), 6′′′- O -acetylginsenoside Re( 7 ), 6″- O -acetylginsenoside Rb 1 ( 8 ), were isolated from the rhizomes of Panacis majoris . The new triterpenoid glycoside was elucidated as 3- O -[ β - D -glucopyranosyl-(1→2)- β - D -(6′- O -ethyl)-glucuronopyranosyl]-oleanolic acid-28- O - β - D -glucopyranoside by extensive spectroscopic and phytochemical methods. Compounds 2 ― 8 were obtained from the plant for the first time. Compounds 3 and 4 displayed good activities against adenosine diphosphate (ADP)-induced platelet aggregation, and compounds 1, 5, 6 and 8 showed moderate activities. Compound 6 exhibited moderate antiplatelet aggregation activity induced by arachidonic acid(AA).
研究领域:
天然产物化学
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药用植物学
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心血管药理学
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药物代谢
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分子药理学
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Petroleum Science
·
2021
·Vol. 19
·期 2
·608-618
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IF 4.09
Jin-Sheng Sun,Zong-Lun Wang,Jing-Ping Liu,Kai-He Lv,Fan Zhang,Zi-Hua Shao,Xiao-Dong Dong,Zhi-Wen Dai,Xian-Fa Zhang
The demand for non-toxic and biodegradable shale inhibitors is growing in the drilling industry. In this paper, the effect of notoginsenoside (NS) as a new, environmentally friendly inhibitor of shale hydration is systematically studied for the first time. The inhibition performance of NS was evaluated via inhibition evaluation tests, including mud ball immersion tests, linear expansion tests, shale rolling recovery tests, and compressive strength tests. The inhibition mechanism of NS was analyzed using Fourier transform infrared spectroscopy (FTIR), contact angle measurements, particle size distribution determination, thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). The experimental results demonstrate that NS is able to adhere to the clay surface, forming a hydrophobic film that prevents the entry of water molecules and inhibiting the hydration dispersion of the clay. Because of this, NS can maintain the original state of bentonite pellets in water, which can effectively reduce the swelling rate of bentonite, increase the recovery rate of shale drill cuttings, maintain the strength of the shale, and therefore maintain the stability of the borehole wall during drilling. In addition, NS is non-toxic, degradable, and compatible with water-based drilling fluids. The above advantages make NS a promising candidate for use as an environmentally friendly shale inhibitor.
研究领域:
石油工程
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钻井液化学
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环境材料科学
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胶体与界面化学
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可持续能源技术
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Journal of Integrative Neuroscience
·
2026
·Vol. 25
·期 7
·
IF 3.3
Wenyu Yan,Xianyue Meng,Yan Wang,Chuanfei Wei,Fabin Han,Xueli Li
Background: Parkinson’s disease (PD) is a neurodegenerative disorder marked by motor dysfunction. No definitive methods exist to repair damaged neurons. Vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) are two neuroprotective agents that work synergistically. However, these large molecular proteins have difficulty crossing the blood–brain barrier (BBB). Extracellular vesicles (EVs) offer superior targeting and low immunogenicity, making them excellent carriers. In this study we examined the protective effects of VEGF and NGF in a cell model and evaluated the therapeutic potential of VEGF–NGF contained within EVs in PD rats. Methods: EVs were isolated using sequential differential centrifugation and characterized using transmission electron microscopy, nanoparticle tracking analysis, and western blotting (WB). VEGF and NGF were loaded into the EVs using a saponin-assisted method to create VEGF@EVs, NGF@EVs, and VEGF/NGF@EVs. The viability of 6-hydroxydopamine hydrochloride (6-OHDA)-induced SH-SY5Y cells was measured using the cell counting kit-8 assay before and after treatment with VEGF and NGF. Autophagy levels were assessed using WB, and the role of autophagy was further explored using the autophagy inhibitor chloroquine. Unilateral PD rat models were established via stereotactic injection of 6-OHDA into male Sprague–Dawley rats. Behavioral changes were monitored before and after treatment. Neuronal recovery, neurotransmitter levels, and autophagy levels in the rat brains were evaluated using immunohistochemistry, enzyme-linked immunosorbent assay, and WB. Results: VEGF/NGF@EVs significantly enhanced the viability of 6-OHDA-induced SH-SY5Y cells. A complete autophagic process was identified as essential for this protective effect. The intranasal administration of VEGF/NGF@EVs improved motor behavior in PD rats, with performance better than that of single growth factor treatments. The number of tyrosine hydroxylase (TH)–positive neurons, TH protein expression, and dopamine content were significantly increased. In addition, the level of autophagy in the rat substantia nigra was elevated. Conclusions: VEGF/NGF@EVs exert protective effects in both in vitro and in vivo 6-OHDA-induced PD models by promoting autophagy, demonstrating greater efficacy than either growth factor alone. By transplanting VEGF/NGF@EVs into PD rats, we showed that these vesicles can effectively cross the BBB and deliver targeted therapy to the central nervous system. This study highlights the significant potential of EV-mediated protein transplantation strategies for treating neurological disorders.
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ANALYTICAL LETTERS
·
2025
·
IF 1.8
Ping Li,Yuan Lv,Sainan Yang,Keqian Xu,Haiyong Luo,Qian Liu,Bin Dai
A novel smartphone-based dry assay was developed for quantitative determination of hemoglobin concentration ([Hb]) in blood. Hemoglobin ((Hb) test strips and smartphone imaging enabled analysis of multiple color parameters, with the G value providing the highest sensitivity (slope = 3.36). Analytical models based on the G value showed that the G0–G model was most robust to variations in light intensity and color temperature (maximum deviations: −48% and −7.76%, respectively). Optimal sensitivity was achieved at +1 EV exposure compensation. The regression equation was y = 4.33[Hb] − 12.3 (R² = 0.995, n = 3), and the detection limit was 0.62 g/dL. The assay exhibited good repeatability at low, medium, and high [Hb] levels (RSDs: 4.8%, 1.3%, 2.1%; n = 10) and strong agreement with a commercial HemoCue analyzer (R² = 0.910, n = 30). This method offers a cost-effective tool for on-site Hb testing.
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JOURNAL OF FOOD SCIENCE
·
2023
·Vol. 88
·期 2
·825-836
·
IF 3.9
Jie He,Youfa Xie,Junzhen Zhong,Wenrong Chen,Suqiong Fang,Xing Chen,Shengfeng Peng,Wei Liu,Chengmei Liu
It is significant to develop a colloidal delivery system to improve the water solubility, stability, and bioavailability of shikonin, which is a hydrophobic plant polyphenol with a variety of physiological activities. In this study, three kinds of natural surfactants (saponin, sophorolipid, and rhamnolipid) were used to prepare shikonin nanoparticles by the pH-driven method. The physicochemical and structural properties of the shikonin nanoparticles were characterized, including particle size, zeta potential, and morphology. The encapsulation efficiencies of shikonin nanoparticles coated with saponin and sophorolipid were 97.6% and 97.3%, respectively, which were much higher than that of rhamnolipid-coated shikonin nanoparticles (19.0%). Shikonin nanoparticles coated with saponin and sophorolipid showed good resistance to heat and light and maintained long-term stability during storage. Moreover, shikonin nanoparticles coated with saponin and sophorolipid improved their in vitro-bioavailability. Practical Application These article results are of great importance for improving the stability and bioavailability of shikonin in functional foods, dietary supplements, or pharmaceutical preparations. Moreover, this study provided theoretical and practical guides for further research of shikonin nanoparticles and may promote the development of natural colloidal delivery systems.
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Acta Pharmaceutica Sinica B
·
2022
·
IF 14.903
Xiaonan Chen,Yiqing Zou,Shuqi Zhang,Pengchao Fang,Shuxuan Li,Pengyu Li,Yingying Sun,Gang Yuan,Haiyan Hu
Helicobacter pylori ( H. pylori ), creating a global infection rate over 50%, presents great challenges in clinical therapies due to its complex pathological microenvironment in vivo . To improve the eradication efficacy, herein we fabricated a pharmaceutical vesicle RHL/Cl-Ch-cal where cholesterol-PEG, calcitriol and first-line antibiotic clarithromycin were co-loaded in the rhamnolipid-composed outer lipid layer. RHL/Cl-Ch-cal could quickly penetrate through gastric mucus layer to reach H. pylori infection sites, and then effectively destroyed the architecture of H. pylori biofilms, killed dispersed H. pylori and inhibited the re-adhesion of residual bacteria (called biofilms eradication tetralogy). Moreover, RHL/Cl-Ch-cal activated the host immune response to H. pylori by replenishing cholesterol to repair lipid raft on the cell membrane of host epithelial cells. Finally, RHL/Cl-Ch-cal killed the intracellular H. pylori through recovering the lysosomal acidification and assisting degradation. In experiments, RHL/Cl-Ch-cal demonstrated prominent anti- H. pylori efficacy in the classical H. pylori -infected mice model. Therefore, the study provides a “comprehensive attack” strategy for anti- H. pylori therapies including biofilms eradication tetralogy, immune activation and intracellular bacteria killing.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Datong Liu,Sijie Lei,Yang Hu,Zhanguo Li,Hailing Xi,Xiaoyan Lin
Currently, bare silica nanoparticles with low surface activity and weak stabilizing foam ability have restricted applicability in treating surface radioactive pollutants. To address potential issues with SiO 2 as a foam stabilizer , a highly efficient foam stabilizer was fabricated by compounding silica with hydroxylated graphene oxide (GO-OH), which was prepared by hydrothermal modification of graphene oxide (GO). Then, an environmentally friendly foam detergent with high stability and high decontamination efficiency was developed using the natural surfactant tea saponin (TAS) as a foaming agent and a composite of silica and GO-OH (GO-OH/SiO 2 ) as a foam stabilizer, which is named tea saponin foam detergent. For different types of surfactants, the structural and morphological characteristics of GO-OH, such as hydrophilic and surface oxygen groups, as well as the synergistic influence of GO-OH with SiO 2 on foamability, foam stability, and detergency of the foam detergent, were studied. As a consequence, the TAS foam detergent has good stability with a drain half-life of 68 min. By hydrothermal modification of GO, the contact angle of water on GO-OH in air dropped to 63.2°, which was lower than that (73.0°) on GO. Furthermore, the hydrophilicity of GO-OH increased, and more oxygen-containing groups on GO-OH enhanced its absorption and enrichment of the radionuclide uranium and improved the decontamination rate of the TAS foam detergent. Moreover, when GO-OH was combined with SiO 2 , the dispersion and stability of SiO 2 in the foam detergent improved, and the foam stability of the detergent subsequently further improved. Adding 2 wt% SiO 2 and 0.1 wt% GO-OH to the detergent enhanced the foam drainage half-life of the detergent from 40 min to 68 min and improved the stability of the detergent by 70%. In addition, the synergistic action of GO-OH/SiO 2 with TAS surfactant increased the liquid film thickness of the foam and the airflow resistance to support the weight-bearing capacity of the foam skeleton. As a result, it slowed the rate of foam disproportionation , reduced the bubble size, increased the bubble number, and finally improved the foam stability of the detergent. For simulated radioactive uranium pollutants on the surfaces of glass, stainless steel , and tiles, the foam detergent with the synergistic action of GO-OH/SiO 2 and TAS surfactant had decontamination rates of 91.7%, 91.16% and 91.76%, respectively, which were 14.96%, 15.67% and 19.39% higher than that of TAS foam detergent without GO-OH/SiO 2 . The synergistic enhancement of GO-OH and SiO 2 on foam stability and its adsorption and combination action with uranyl ions would be the main reasons to improve the detergency of the TAS foam detergent. Therefore, TAS foam detergent stabilized synergistically by GO-OH/SiO 2 with high stability and efficient decontamination will be widely applied in nuclear emergencies and decommissioning decontamination of nuclear facilities.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2020
·Vol. 101
·期 7
·2930-2939
·
IF 2.614
Xi Yang,Yuan-Yuan Zang,Sha Yang,Zhi-Gang Chen
BACKGROUND Porphyra haitanensis now faces serious heavy metal pollution problems. Natural deep eutectic solvents (NADESs) have been recognized as a novel class of sustainable solvents, which can be used for heavy metal removal. In this study, 28 kinds of NADESs were prepared and investigated as eluent in the removal of lead (Pb), cadmium (Cd), chromium (Cr), arsenic (As), and copper (Cu) from P. haitanensis for the first time, and the adsorption mechanism of NADESs was also studied. RESULTS The removals were greatly improved by NADESs compared with control where the removal rates of Pb, Cd, Cr, As and Cu were 17.4–87.54%, 57.54–100%, 9.8–48.59%, 21.32–78.24% and 11.68–79.73%, respectively. The optimal condition was 10% water content and solid–liquid ratio of 1:20. Moreover, the addition of 20% natural surfactant arabic gum can further increase the heavy metals removal rates of NADESs. The adsorption mechanism experiments showed that the pseudo second-order model and the Freundlich adsorption model can better explain the adsorption mechanism of NADESs on heavy metals removal. CONCLUSION Taken together, a green and efficient method for removing heavy metals from P. haitanensis was established. © 2020 Society of Chemical Industry
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BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
·
2020
·
IF 1.186
Guosong Xin,Miao Yu,Yang Hu,Shiyong Gao,Zheng Qi,Yuan Sun,Wenjing Yu,Jiaxin He,Yubin Ji
Lycorine is an isoquinoline alkaloid in Amaryllidaceae with antitumor, antibacterial, antiviral, diuretic and cardiovascular effects. This study explored the antitumor mechanism of lycorine in vitro and in vivo by focusing on its effects on tumor cell membrane fraction and tumor cell membrane structure. The results showed that lycorine had antitumor effect on H22 tumor-bearing mice in vivo and could effectively prolong the survival time of H22 tumor-bearing mice. In vitro, lycorine inhibited the proliferation of HepG-2 cells and induced cell death significantly. Lycorine reduced the total protein content, sialic acid content and cholesterol content on the surface of tumor cell membrane, and reduced the content of some main components of tumor cell membranes. Lycorine reduced the membrane fluidity and cell membrane integrity of tumor cells. In addition, the ion channel (Na+, K+-ATPase, Ca2+, Mg2+-ATPase) activity on the surface of the tumor cell membrane decreased. This contributed to a significant antitumor effect in vitro and in vivo.
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WATER AIR AND SOIL POLLUTION
·
2019
·Vol. 230
·期 6
·1-12
·
IF 1.774
Yang Min,Ke Junfeng,Zhang Qiwu,He Xiaoman
Surfactants are considered promising and practical substances for enhancing polycyclic aromatic hydrocarbon (PAHs) removal from contaminated soil. In order to explore the effects of single and mixed surfactants on the removal of high-concentration PAHs from soil, a series of experiments have been conducted. In this study, Tween80-saponin (a mixed surfactant), Tween80 (a nonionic surfactant), and saponin (a biosurfactant) were used to remove two typical and high concentration PAHs (anthracene and pyrene) from contaminated soil. Results showed that the mixed surfactant had better performance on the solubilization of anthracene and pyrene than Tween80, but its performance was worse than saponin. When the proportion and concentration of the mixed surfactant were 1:9 and 800 mg L −1 respectively, the elution rate of anthracene could reach 97.67%, it was better than that by Tween80 and saponin. In addition, the Tween80-saponin mixed surfactant had good performance on actual PAHs contaminated soil remediation. When the proportion and concentration of Tween80-saponin were 1:9 and 800 mg L −1 respectively, the PAHs elution rate of actual contaminated soil could reach 81.31%.
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FOOD CHEMISTRY
·
2017
·
IF 4.529
Yao Huang,Fang Feng,Zhi-Gang Chen,Tao Wu,Zi-Han Wang
Natural deep eutectic solvents (NADESs) constitute a novel class of biodegradable and inexpensive solvents. In this study, twenty choline chloride- and glycerol-based NADESs were prepared and investigated as washing agents in the removal of cadmium (Cd) from rice flour for the first time. Choline chloride-based NADESs demonstrated good Cd removal (51%–96%). A natural, biodegradable surfactant, saponin, was mixed with the NADESs to enhance their efficiency. No increase in Cd removal was observed when glycerol-based NADESs were combined with 1% saponin; however, synergistic effects between saponin and choline chloride-based NADESs were observed during the washing process and >99% Cd was removed using NADES-saponin mixtures. Moreover, NADESs washing process did not affect the main chemical components or structure of rice flour. The mechanism of Cd removal by NADESs and regeneration of Cd-contaminated NADESs were also explored. The study presents a green and efficient way of removing Cd from contaminated rice.
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Food & Function
·
2018
·Vol. 9
·期 3
·1829-1839
·
IF 3.289
Shengfeng Peng,Ziling Li,Liqiang Zou,Wei Liu,Chengmei Liu,David Julian McClements
Curcumin is a bioactive phytochemical that can be utilized as a nutraceutical or pharmaceutical in functional foods, supplements, and medicines. However, the application of curcumin as a nutraceutical in commercial food and beverage products is currently limited by its low water-solubility, chemical instability, and poor oral bioavailability. In this study, all-natural colloidal delivery systems were developed to overcome these challenges, which consisted of saponin-coated curcumin nanoparticles formed using a pH-driven loading method. The physicochemical and structural properties of the curcumin nanoparticles formed using this process were characterized, including particle size distribution, surface potential, morphology, encapsulation efficiency, and loading capacity. Fourier transform infrared spectroscopy and X-ray diffraction indicated that curcumin was present in the nanoparticles in an amorphous form. The curcumin nanoparticles were unstable to aggregation at low pH values (<3) and high NaCl concentrations (>200 mM), which was attributed to a reduction in electrostatic repulsion between them. However, they were stable at higher pH values (3 to 8) and lower NaCl levels (0 to 200 mM), due to a stronger electrostatic repulsion between them. They also exhibited good stability during refrigerated storage (4 °C) or after conversion into a powdered form (lyophilized). A simulated gastrointestinal tract study demonstrated that the in vitro bioaccessibility was around 3.3-fold higher for curcumin nanoparticles than for free curcumin. Furthermore, oral administration to Sprague Dawley rats indicated that the in vivo bioavailability was around 8.9-fold higher for curcumin nanoparticles than for free curcumin. These results have important implications for the development of curcumin-enriched functional foods, supplements, and drugs.
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危险品化学品经营许可证（带存储）