SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Dalong Hu,Dan Cao,Rui Li,Xintong Li,Peng Zhao,Yaohong Yu,Yajuan Li,Zhengjiang Wang,Runfang Fu,Gongyan Liu
Membrane fouling, particularly that induced by microbial and organic contaminants, severely limits the efficiency and lifespan of reverse osmosis (RO) membranes in surface water treatment. Herein, a sequential covalent post-modification strategy is developed by exploiting the native carboxyl groups of a commercial RO membrane to fabricate a novel dual-defense RO membrane. Specifically, sulfaguanidine (SG) and poly(glycidyl methacrylate- co -sulfobetaine methacrylate) (PGS) are sequentially immobilized on the polyamide layer via amidation and epoxy ring-opening reactions, with SG and PGS serving as the bactericidal and antifouling components, respectively. Benefiting from this interfacial structure, the resulting membrane (ROSP) achieves a 2.4-fold higher water flux of 34.04 L·m −2 ·h −1 than that of the pristine membrane while maintaining a high NaCl rejection of 98.47%. Furthermore, the ROSP membrane exhibits low irreversible fouling ratios (< 8.27%) during 11 h cyclic fouling filtration tests, displays over 99% bactericidal efficiency against both E. coli and S. aureus , and enhances the tolerated chlorine exposure by 42.9% to 10,000 ppm·h. More importantly, during 144 h of continuous filtration using real surface water, the ROSP membrane maintains stable separation performance and a bactericidal efficiency of 92.63% against native microorganisms. This work offers an effective covalent surface-modification strategy for developing durable RO membranes for surface water treatment.
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Huiting Feng,Yuxin Yang,Ruiling Li,Yuting Yang,Zongwen Wang,FengFu Fu,Yue Lin
A variety of sulfonamides (SAs) are extensively utilized in animal husbandry and aquaculture, necessitating the development of high-throughput methods for the rapid screening and accurate determination of multiple, ideally all commonly-applied SAs, in animal-derived foodstuffs. We herein developed a paper-based colorimetric aptasensor for the detection of eight different SAs employing a mixture of two broad-specific aptamers as bio-receptor, ascorbic acid (AA)-mediated gold nanobipyramids (AuNBPs) growth for generating color signals, and a paper-based analytical device (PAD) for stabilizing and enhancing color signals. The aptasensor exhibits target SAs concentration-corresponding multiple color changes and has excellent specificity. It can be used to visually screen eight SAs (either individually or collectively) with a visual detection limit (LOD) of 4.0 μM, and quantitatively detect these SAs (either individually or collectively) with a spectrometry LOD of 0.2 μM. Importantly, the signals of the aptasensor can be stably stored for one month for later verification, and the spectrometry LOD is lower than the maximum residue limit (MRL) of total SAs in animal-derived foodstuffs. The aptasensor was successfully applied to detect eight SAs (either individually or collectively) in milk samples with a recovery of 89% - 95% and a relative standard deviation (RSD, n = 5) < 8%. The results obtained with the aptasensor were consistent with those obtained using commercial ELISA kit. These findings demonstrated that the aptasensor simultaneously meets the requirement of instrument-free screening and quantitative determination of eight SAs in animal-derived foods, making it a promising approach for ensuring the consumption safety of animal-derived foodstuffs.
✓ 已验证
产品关联
DOI
高影响因子
AQUACULTURE
·
2026
·
IF 3.9
Jian-Fei Wang,Wei-Dan Jiang,Pei Wu,Yao-Bin Ma,Hong-Yun Zhang,Yang Liu,Lu Zhang,Hai-Feng Mi,Lin Feng,Xiao-Qiu Zhou
Nitrite is a toxic substance widely present in aquaculture water environments. This study explored the impact of vitamin K on liver pathology in grass carp ( Ctenopharyngodon idella ) challenged with nitrite. Grass carp received diets with six vitamin K concentrations (0 + sulfamethoxazole, 0, 1, 2, 3, and 4 mg/kg) for 60 days, then endured a 96-h nitrite stress test. Our results showed that vitamin K enhanced growth performance and reduced damage indicators in adult grass carp, including weight gain percentage (PWG), glutamic-pyruvic transaminase (GPT), and methemoglobin (MetHB). At the cellular level, vitamin K upregulated the expression of Golgi apparatus matrix protein 130 (GM130) and acid sphingomyelinase (ASM) in hepatocytes, increased sphingomyelin and ceramides levels, and repaired stress-damaged cell membranes. At the tissue level, vitamin K promoted liver regeneration by upregulating repair markers α-smooth muscle actin (α-SMA) and transforming growth factor-β (TGF-β) and boosting collagen deposition via growth arrest-specific 6 (GAS6) and its receptor AXL. Additionally, vitamin K alleviated nitrite-induced hepatocyte apoptosis, potentially through upregulating the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway to maintain mitochondrial homeostasis. With PWG and GPT as indicators, the optimal vitamin K requirements for normal and nitrite resistance of adult grass carp were 1.88 and 1.94 mg/kg, respectively. This study assessed the effects of nitrite exposure on grass carp liver, elucidated the potential mechanism by which vitamin K mitigates such damage, and provided novel insights for alleviating nitrite stress in fish.
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Chen-Ting Zhu,Kai-Yuan Huang,Qing-Lin Zhou,Xiang-Ping Zhang,Gang-Wei Wu,Hua-Ping Peng,Hao-Hua Deng,Wei Chen,Hamada A.A. Noreldeen
Sulfonamides (SAs) are widely used in many fields because of their advantages, including low price, wide antibacterial spectrum, and high stability. However, their accumulation in the human body leads to a variety of serious diseases. Therefore, it is necessary to design a convenient, effective, and sensitive method to detect SAs. Moreover, the fluorescence excitation spectrum has rich information characteristics, especially for the interaction between fluorophore and quencher via various mechanisms. However, the excitation wavelength-guided sensor array construction does not draw proper attention. To address these issues, we used BSA-AuNCs as a single probe to construct a sensor array for the detection of five SAs. The selected SAs showed different quenching effects on the fluorescence intensities of BSA-AuNCs. The changes in the fluorescence intensity at different excitation wavelengths (λ = 230, 250, and 280 nm) have been applied to construct our sensor array and address the distinguishability between the selected SAs. With helping of pattern recognition methods, five different SAs have been identified at three different concentrations. Additionally, qualitative analysis at different moral ratios and quantitative analysis at nanogram concentrations have been considered. Moreover, the proposed sensor array was successfully used to distinguish between different SAs in commercial milk with an accuracy of 100 %. This study provides a simple and powerful approach to SAs detection. Also, it shows a broad application prospect in the field of food and drug monitoring.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Chemosensors
·
2023
·Vol. 11
·期 7
·386
·
IF 4.2
Meiling Ping,Wenchao Lv,Chen Yang,Qian Chen,Zongwen Wang,Fengfu Fu
It is crucial that simple and high-throughput methods for determining multiple, or groups of, sulfonamides (SAs) be developed since they are widely used in animal husbandry and aquaculture. We developed a paper-based multicolor colorimetric aptasensor to detect 3 SAs: sulfaquinoxaline (SQ), sulfamethoxypyridazine (SMP) and sulfamethoxydiazine (SMD). Using a broad-specificity aptamer as a bioreceptor, we reduced the growth of nicotinamide adenine dinucleotide I (NADH)–ascorbic acid (AA)-mediated gold nanobipyramids (AuNBPs) to generate a multicolor signal. We also used a paper-based analytical device (PAD) system to deposit AuNBPs for a sensitive color signal read out. The aptasensor can detect more color changes corresponding to the concentrations of SQ, SMP and SMD and has higher sensitivity, better specificity and stability. It can also be used to determine SQ, SMP and SDM individually, or collectively, or any two together with a visual detection limit of 0.3–1.0 µM, a spectrometry quantification limit (LOQ) of 0.3–0.5 µM and a spectrometry detection limits (LOD) of 0.09–0.15 µM. The aptasensor was successfully used to determine SQ, SMP and SDM in fish muscle with a recovery of 89–94% and a RSDn= 5) < 8%, making it a promising method for the rapid screening of total SQ, SMP and SDM residue in seafood.Keywords:aptasensor;antibiotics residue;seafood;sulfonamides;visual detection
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2023
·
IF 7.4
Zongwen Wang,Xiating Li,Feng Zhang,Yu Gao,Jintian Cheng,FengFu Fu
It is an urgent need to develop simple and high-throughput methods for simultaneously screening and detecting multiple or groups of sulfonamides (SAs) in animal-derived foods since various SAs were alternately used in animal husbandry to avoid generating drug resistance. We herein developed a novel HCl-reduced nicotinamide adenine dinucleotide I (NADH)-ascorbic acid (AA)-mediated gold nanobipyramids (AuNBPs) growth system, which can precisely regulate the growth rate of AuNBPs, to generate two colorful and stable AA-corresponding multicolor signal channels with different sensitivities. Based on the HCl-NADH-AA-mediated AuNBP growth system, we further developed a dual-channel multicolor immunoassay for simultaneously realizing rapid screening and detection of 5 SAs (sulfamethazine, sulfamethoxydiazine, sulfisomidine, sulfamerazine, and sulfamonomethoxine) by using a paper-based analytical device for sensitively and stably reading out the signal and a broad-specificity anti-SAs antibody as a bio-receptor. The developed immunoassay has more color changes, a wider linear range, excellent specificity and stability, and two multicolor signal channels (L-channel and H-channel) with different sensitivities. The H-channel exhibited 7–8 SAs-corresponding color changes and can be used to detect 5 target SAs with a visual detection limit of 0.1–0.5 ng/mL and a spectrometry detection limit of 0.05–0.16 ng/mL. The L-channel exhibited 7–9 SAs-corresponding color changes and can be used to detect 5 target SAs with a visual detection limit of 2.0–6.0 ng/mL and a spectrometry detection limit of 0.40–1.47 ng/mL. The developed immunoassay was successfully used to simultaneously screen and detect low-concentration and high-concentration of target SAs in milk and fish muscle samples with a recovery of 85–110% and an RSD (n = 5) < 8%. The visual detection limit of our immunoassay is much lower than the maximum residue limit of total SAs in edible tissue. All above features make our immunoassay a promising assay for simultaneously realizing the rapid screening and quantitative determination of multiple SA residues in food by bare eye observation. It must be mentioned that our immunoassay may be expended as a general method for the simultaneous visual screening and detection of other drugs using the corresponding antibody as a recognition probe.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Rongfang Yan,Zhenhua Wen,Xuelian Hu,Wenxiu Wang,He Meng,Yang Song,Shuo Wang,Yiwei Tang
Various types of fluorescent nanoparticles have been proposed for the detection of veterinary drug residues in food. However, structure-induced fluorescence nanoparticles with biodegradability and the capacity to conjugate with molecular recognition elements are lacking. Here, a biodegradable tryptophan-phenylalanine dipeptide-based nanomaterial was assembled and modified with a sulfadimethoxine aptamer ( [email protected] ). Then, a novel and efficient fluorescence sensing strategy, based on [email protected] and BHQ1-labeled single-stranded DNA ( [email protected] ), was developed for sulfadimethoxine determination. Under optimal conditions, the fluorescence was linear in the range of 0–200 ng/mL sulfadimethoxine with a detection limit of 1.47 ng/mL (S/N = 3). Satisfactory recoveries of standard additions were found between 92.88 % and 114.15 % for water and milk samples with a relative standard deviation less than 5.0 %, suggesting that the proposed fluorescence sensing strategy can be applied reliably in sulfadimethoxine analysis of liquid foods.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Lixiang Zuo,Ran He,Li Wang,Yanli Wei
The fast and accurate detection of residual veterinary antibiotics in food has great significance for the ecological balance and human health. This study presents a room temperature phosphorescence aptasensing system for sulfadimethoxine (SDM) detection with sulfadimethoxine-aptamer (SDM-APT) modified manganese doped ZnS quantum dots (Mn-ZnS QDs) as the signaling and recognition unit. The signal amplification was achieved by petal-like molybdenum disulfide nano sheets (MoS 2 NS). As the selective adsorption of single-stranded DNA (ssDNA) on MoS 2 NS, SDM-APT-Mn-ZnS QDs are assembled on the surface of MoS 2 NS, and lead to the efficient phosphorescence quenching of Mn-ZnS QDs. Once SDM is brought in the sensing system, the specific interaction between SDM-APT and SDM will switch the conformation of SDM-APT from random coil to hairpin structure, resulting in the exfoliation of SDM-APT-Mn-ZnS QDs from MoS 2 NS, along with the phosphorescence recovery. This SDM detection system has a linear range from 2.0 ng/mL to 400 ng/mL with LOD as 0.91 ng/mL (S/N = 3) at the optimal experimental condition. The feasibility, specificity and recovery have been verified from the detection of real samples, interfering experiments and standard recovery experiments. The SDM detection system may also be applied to other residual veterinary drugs with different aptamers.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2021
·
IF 4.759
Changjun Hu,Zhenkun Mao,Zhentao Li,Qiaoyan Li,Zilin Chen
Hydrophilic column combined with mobile phase containing high content of water is a green method for the separation of polar compounds, but there are few related studies, and the separation efficiency and performance of existing columns still needs to be improved. In this work, a novel monolithic column for separation of hydrophilic compounds under both high water content and HILIC condition, was prepared by in-situ polymerization using 4-vinylbenzoic acid (VBA) and 1-(Acryloyloxy)-3-(methacryloyloxy)-2-propanol (AMAP) as functional monomers. The poly(VBA- co -AMAP) monolithic column showed good separation performance towards various polar compounds under different chromatographic conditions based on the π-interaction, hydrophobic and hydrogen bonding interactions provided by 4-vinylbenzoic acid functional monomer. The highest column efficiency for adenine was over 2.15 × 10 5 plates m −1 (theoretical plate, N). In addition, the monolith showed good stability and reproducibility, the relative standard deviations (RSDs) of retention times within days (n = 5), between days (n = 5), between columns (n = 3) and between batches (n = 3) were 0.47-1.13%, 1.20-2.68%, 0.59-1.78% and 1.54-3.60%, respectively. This novel type of monolith has great application potential in the separation of hydrophilic compounds.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Chemistry
·
2021
·
IF 8.301
X. Lu,M. Yu,D. Wang,P. Xiu,C. Xu,A.F. Lee,X. Gu
A simple and environmentally benign synthetic route to lignin-based epoxy resins is highly desirable. Alkali lignin and glyoxal are promising renewable and sustainable alternatives to phenol and formaldehyde, respectively. Their use is demonstrated to produce lignin-phenol-glyoxal novolac epoxy resins (LPG-NERs) through a simple one-pot synthesis. Flame retardancy of LPG-NERs was improved by functionalization with a N, S modified 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) material (termed DBS) obtained via nucleophilic reaction between DOPO and a N, S containing intermediate. FTIR and 1 H NMR analyses confirmed the successful fabrication of LPG-NERs and SBD. The introduction of lignin and SBD reduced crosslinking of the epoxy network, weakening mechanical properties , but conferred excellent flame retardancy (including vapor and condensed phases) as determined by LOI (34.5%), UL-94 (V-0 rating), and cone calorimetry tests (lower heat release and smoke production, and higher char formation). The SBD structure imparted a desirable vapor mechanism (blowing out phenomenon caused by the fire quenching effect of PO•/PO 2 • radicals and dilution effect from non-condensable gases such as NH 3 , N 2 , SO 2 ), while lignin (a natural biochar precursor) in synergy with SBD imparted superior charring performance.
✓ 已验证
产品关联
DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2019
·
IF 3.78
Peng Wang,Lei Chen,Hang Xiao,Tonghui Zhan
Improving the flame retardancy of epoxy resin will greatly expand its application in the fields requiring flame retardancy. Herein, a nitrogen/sulfur-containing DOPO based oligomer (SFG) for highly efficient flame-retardant epoxy resin was successfully synthesized via a facile one-pot method with DOPO, sulfaguanidine and p -phthalaldehyde. The incorporation of SFG accelerated the cross-linking reaction of epoxy system and improved the tensile strength , flame retardancy and fire safety of epoxy thermoset . SFG showed high flame-retardant efficiency due to the synergism among nitrogen, sulfur and phosphorus. With only 0.38 wt% phosphorus content, the corresponding epoxy thermoset achieved an LOI value of 32.8%, passed UL-94 V-0 rating and possessed lower fire growth rate and total heat release in cone calorimeter test in comparison with neat thermoset. SFG exerted dual flame-retardant effect not only by diluting oxygen and combustible volatiles and quenching active radicals, but also by promoting the formation of thermal insulating char layer with honeycombed cavity inside. Moreover, the appearance of blowing out phenomenon during combustion was disclosed that the intensive release of gases blew out the flame based on the dilution and quenching effects when the inner gas pressure was sufficient to break through the char layer.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Dandan Qin,Wangyang Lu,Xiyi Wang,Nan Li,Xia Chen,Zhexin Zhu,Wenxing Chen
For powder catalysts to be recycled easily and to be applied in practical wastewater treatment, it is imperative to search suitable carriers that can be applied to support catalytic particles. Herein, we highlight a facile route to synthesize an easily recycled photocatalyst using polyethylene terephthalate (PET) to disperse graphitic carbon nitride (g-C3N4) via electrospinning and subsequent hydrothermal treatment. The resultant nanofiber is labeled T-g-C3N4/PET. The design concept is to expose the g-C3N4 on the PET surface and convert it from inactivation to re-emergence. g-C3N4 is embedded into the PET, which avoids the reunion and unrecyclable deficiencies of powder catalysts. T-g-C3N4/PET was characterized by field-emission scanning electronic microscopy, transmission electron microscopy, UV–vis diffuse reflectance spectra, two-dimensional X-ray diffraction, Fourier-transform infrared spectroscopy, and thermogravimetric analysis technologies. T-g-C3N4/PET showed a high photocatalytic activity for the degradation of antibiotics such as sulfaquinoxaline and sulfadiazine under solar irradiation, and the activity was almost unaffected in a high background. The as-obtained catalysts could be reused several times with no loss in performance in cycling photodegradation tests. Finally, a possible pathway and mechanism for degrading sulfaquinoxaline with T-g-C3N4/PET was proposed, respectively, in which holes and the superoxide radical were the predominant active species, and resulted in the oxidative degradation of antibiotics. These results demonstrate that the preparation method may provide a novel idea for supporting nanoscale catalysts for reuse.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）