JOURNAL OF MATERIALS SCIENCE
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2026
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IF 4.4
Zhang Xing,Xia Dan,Ding Shaochun,Wu Yihui,Xu Yahai
Electrolysis of seawater presents a sustainable pathway to green hydrogen production, utilizing both the abundant source of seawater and from renewable energy. Yet, the slow anode oxygen evolution reaction (OER) necessitates alternative, where urea oxidation reaction (UOR) intermediate shows promise due to its favorable thermodynamic potential. In this work, we report a simple synthetic method to prepare an iron-cobalt (Fe–Co) electrocatalyst directly onto Ni foam via cyclic voltammetric (CV) electrodeposition. The catalyst demonstrates outstanding UOR activity in 1 M KOH + 0.33 M urea seawater, achieving low potentials of 1.335 V and 1.458 V at 10 and 100 mA·cm −2 , respectively, a Tafel slope of 133.8 mV·dec −1 , and a charge-transfer resistance (Rct) of 0.81 Ω. It exhibits a high mass activity of 13.24 mA·mg −1 at 1.45 V and maintains stable operation for over 70 h at 10 mA·cm −2 . The excellent UOR performance, coupled with the electronic structure reconstruction induced by Co doping, suggests the formation of more active sites with optimized electronic configurations, which favors the key steps of urea oxidation. Additionally, the superhydrophilic surface of the electrocatalyst Fe–Co permits quick and complete electrolyte infiltration, which creates a highly accessible reaction interface and therefore increases catalytic activity. Given its low-cost synthesis, simple preparation method, remarkable UOR activity, and long-life operation stability, the electrocatalyst Fe–Co is one of the most promising candidates to enhance urea-assisted, sustainable electrolytic hydrogen production technologies.
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JOURNAL OF MICROELECTROMECHANICAL SYSTEMS
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2026
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IF 3.5
Haoran He,Wanli Ma,Zhiqiang Fan,Kai Xu,Zhiqiang Kang,Wei Zhao,Le Zhang,Xiaojun Qiao,Wenping Geng
With the advancement of micro-nano manufacturing technologies, microheaters have demonstrated significant application value in fields such as sensing, ignition, and self-destruction systems. This paper designs and fabricates a parallel necked Ni microbridge microheater based on microelectromechanical systems (MEMS), employing a Ti/Cu/Ni metal multilayer structure on a SiO2/Si/SiO2 substrate to achieve a compact, integrable device configuration. Finite element simulations revealed the temperature distribution and evolution patterns under different current conditions, which were subsequently validated experimentally. Test results demonstrated that the device rapidly heats up under constant current drive, reaching a maximum temperature exceeding 600°C at 1.8 A drive conditions, exhibiting excellent electrothermal response characteristics. Further integrated validation demonstrates that the proposed microheater structure can achieve stable and controllable triggering under system-level packaging conditions. Under a driving current of 3 A, the device completes the self-destruction process within 1 s, accompanied by pronounced current drop and voltage surge characteristics, indicating that the designed electrothermal structure can satisfy the ignition requirements of porous silicon energetic chips at the system level, thereby reflecting favorable structural compatibility and design rationality. [2025-0234]
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Brazilian Journal of Pharmaceutical Sciences
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2023
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IF 1.3
Yang Xintong,Chen Yang,Qiao Ning
In this study, we investigated the effects of polymers on the pharmaceutical cocrystal formation process. Ibuprofen (IBU) was selected as the active pharmaceutical ingredient (API), nicotinamide (NIC) and saccharin (SAC) as the cocrystal coformer (CCF), ethanol/water as the solvent, polyvinylpyrrolidone (PVP) and poly (ethylene glycol) (PEG) as the representative polymers. We prepared IBU-NIC and IBU-SAC cocrystals in ethanol-water cosolvent in the absence or presence of polymers. Cocrystal screening products were characterized by FTIR, DSC, PXRD, and HPLC. The results showed that the mixture of IBU and IBU-NIC cocrystal can be prepared in ethanol-water cosolvent without polymers. The addition of PVP facilitates the formation of pure IBU-NIC cocrystal; however, no cocrystal was formed in PEG solutions. SAC could not cocrystallize with IBU in the ethanol-water solvent in the absence of polymers. Neither PVP nor PEG could facilitate the formation of the IBU-SAC cocrystal.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Jiahui Chen,Minshan Guo,Runhui Fan,Yayun Peng,Ting Cai
Cocrystal engineering has become increasingly prevalent as an efficient and versatile route to overcome solubility limitations and improve the oral bioavailability of poorly soluble drugs. However, the unwanted solution-mediated phase transformation of cocrystals to less soluble parent drugs in the gastrointestinal tract may fail to deliver the drug in the body in a sufficient quantity. This study explores how bile salt sodium taurocholate (STC) affects the dissolution performance of indomethacin-saccharin (IMC-SAC) cocrystals. Fluorescence microscopy was used for in situ monitoring of the phase transformation of IMC-SAC cocrystals in the presence and absence of STC during dissolution. Intrinsic dissolution tests, atomic force microscopy and energy dispersive X-ray spectroscopy revealed that there was a significant relationship between the coformer release rate and the kinetics of the phase transformation of cocrystals. The addition of low-concentration STC in the buffer significantly inhibited the phase transformation of IMC-SAC cocrystals by retarding the release of SAC from cocrystals, leading to enhanced release rates of IMC. A molecular dynamics simulation revealed that preferential adsorption of STC molecules on the cocrystal surface may be responsible for the suppression of drastic release of SAC from the cocrystal lattice, thus preventing a rapid crystallization of IMC at the solid–liquid interface. The presence of STC in the buffer could also prolong the supersaturation of IMC, accounting for the overall improved in vitro and in vivo performance of IMC-SAC cocrystals. This study provides a deeper insight into the mechanisms of solution-mediated phase transformation of cocrystals in the presence of endogenous surfactant, which could also be used as an effective strategy to improve the absorption performance of pharmaceutical cocrystals by minimizing the risk of phase transformation during dissolution.
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RSC Advances
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2022
·Vol. 12
·期 14
·8317-8322
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IF 4.036
Qifei Chen,Huaming Hou,Dan Zheng,Xueming Xu,Xingjun Xi,Yisheng Chen
As a widely used artificially synthesized sweetener, saccharin faced numerous disputes associated with food safety. Therefore, its fast analysis in food is of crucial importance. In this study, an analytical method for the fast and reliable screening of saccharin in various beverages was established and validated, by combining HPTLC with densitometry and surface enhanced Raman spectroscopy. The diluted sample liquid was directly sprayed and separated on a silica gel plate using a mixture of ethyl acetate and acetic acid in the ratio of 9 : 1 (v/v) as the mobile phase. The separation realized full isolation of the analyte from background noises. Then, a densitometry analysis in the absorption–reflection mode (working wavelength 230 nm) was optimized to obtain quantitative data, showing a good linearity in the range of 40–200 ng per band (R2 = 0.9988). The limits of detection and quantification were determined to be 6 and 20 ng per band, respectively, which were equal to 6 and 20 mg kg−1. The quantitative results also displayed satisfactory accuracy and precision, with a spike-recovery rate within 87.75–98.14% (RSD <5.13%). As a cost-efficient tool for confirmation, surface enhanced Raman spectroscopy was employed to profile the molecular fingerprint of the analyte eluted from the plate layer. Under optimized conditions (785 nm laser as the excitation light and silver nanoparticle loaded glass fiber paper as the active substrate), the elution of the saccharin band exhibited stable and sensitive surface enhanced Raman spectroscopy signals. This study demonstrated that HPTLC could be a versatile platform for food analysis, with outstanding simplicity and cost-efficiency.
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CHEMICAL ENGINEERING SCIENCE
·
2022
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IF 4.889
Yuehua Deng,Wenhao Deng,Wenquan Huang,Zhiyong Zheng,Rui Zhang,Shiyuan Liu,Yanbin Jiang
Amorphization technology has been a promising strategy to improve the solubility and dissolution of drugs. This study aims to prepare norfloxacin (NFX) co-amorphous (CA) systems and evaluate the association between molecular descriptors and the formation and physical stability of NFX CAs. The molecular miscibility between NFX and 17 co-former candidates was firstly predicted using Hansen solubility parameters (HSPs) and six NFX CAs were successfully prepared by dry ball mill. Compared with crystalline NFX, four NFX CAs showed enhanced solubility (up to 2.50-fold) and dissolution rates. NFX CAs exhibited excellent physical stability under dry conditions. According to the quantitative calculations of Pearson correlation coefficient and Ridge regression, molecular descriptors have a great effect on NFX CA formation with structural parameters (Weight, VDW_vol, VDW_area, Rings) stronger than miscibility parameter Δ δ ¯ and p K a. These molecular descriptors corresponding to π···π interactions, molecular miscibility and ionic interactions are also responsible for physical stability. The results demonstrate that NFX CA can be stably formed if the co-former has more rings, smaller Δ δ ¯ (less than or close to 5 MPa 0.5 ) and larger Δp K a. This study offers a potential strategy to screen and design a CA system using multivariate data analysis based on theoretical considerations of molecular descriptors.
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SURFACE & COATINGS TECHNOLOGY
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2022
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IF 4.865
Shuhan Dong,Yang Yang,Ruina Ma,An Du,Mingxu Yang,Yongzhe Fan,Xue Zhao,Xiaoming Cao
A Cu/Ni–B 4 C superhydrophobic coating was fabricated on the surface of Q235 steel under different current density via electrodeposition . The distribution of electric field influenced by current density controls the growth of rough structure. Therefore, the effect of current density was measured by the morphology and wettability of coating and analyzed by Electric field distribution model. The coating surface demonstrates the most uniform and compact rough structure at a current density of 3 A/dm 2 (M C-3 ) obtaining contact angle 160 ± 2° after the surface energy reduced by stearic acid. The self-cleaning performance and mechanical stability of M C-3 coating were studied. The potentiodynamic polarization curve (PPC) and electrochemical impedance spectroscopy (EIS) were used to measure the anti-corrosion and protection performance of the coatings with different morphology and contact angle. The protective performance of M C-3 coating soaked in 3.5 wt% NaCl solution for different time was studied by EIS. The wetting stability of different coatings was studied by single frequency impedance spectroscopy. Then the double protective mechanism of superhydrophobic coating was described and the corresponding model was established.
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SURFACE & COATINGS TECHNOLOGY
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2022
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IF 4.865
Xiuhu Li,Rongrong Deng,Qibo Zhang
Cobalt-phosphorous (Co P) coatings are promising alternatives for hard chromium due to their outstanding corrosion protection . An excellent Co P coating can efficiently reduce the effects of a corrosive environment. Herein, Co P coatings with a tunable P content, ranging from 5.1 at.% to 20 at.%, are fabricated via a simple electrochemical deposition approach from choline chloride-ethylene glycol (Ethaline)-based deep eutectic solvent (DES) with saccharin (SA) as an additive. The rational introduction of SA induced the formation of close-growing Co P coatings rich in P on the substrate with reduced grain size and surface roughness . It turned out that the crystal structure of the deposited Co P coatings changed from a crystallized state to an amorphous state upon the addition of SA, which accelerated the nucleation rate of the nanocrystals and modified the nucleation model from progressive to instantaneous. The optimal Co P coating prepared exhibited excellent anti-corrosion and barrier protection properties for mild steel in corrosive NaCl solution, functioning up to 10 times better than its counterparts. Our work reveals the central role of additives in tailoring the structure and composition of the deposited Co P coatings in Ethaline-based DES and offers a new avenue for fabricating high-performance coating materials for anti-corrosion applications.
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JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
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2022
·Vol. 32
·期 5
·2237-2248
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IF 2.036
Liu Cansen,Zhen Haowen,Huang Qishan,Chen Wanlin,Mai Yongjin,Zhang Liuyan,Jie Xiaohua
The dispersity of incorporated particles is critical for the creation of composite coatings with enhanced performance. Here, we propose a mechanical agitation and ultrasound-assisted pulse electroplating technique for producing exfoliated MoS 2 reinforced cobalt-based composite coatings with improved tribological and electrochemical properties. The dispersity of exfoliated MoS 2 and its corresponding effect on the microstructure, microhardness, tribological and electrochemical behaviors of the resultant composite coatings are systematically investigated. The results reveal that the outstanding dispersity of exfoliated MoS 2 in electrolyte is beneficial to its even distribution and incorporation in the composite coating, endowing the resultant composite coatings with a smooth surface, compact structure, high hardness, remarkable antiwear and friction reduction performance as well as superior corrosion resistance. This study offers a strategy for producing high-performance composite coatings with promising practical applications. Graphical Abstract
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Journal of Materials Research and Technology-JMR&T
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2021
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IF 5.039
Hui Jin,Renjie Ji,Tiancong Dong,Shuo Liu,Fan Zhang,Lilong Zhao,Chi Ma,Baoping Cai,Yonghong Liu
Nickel-iron alloy is broadly utilized in the industrial field due to its fabulous mechanical properties. How to prepare nickel-iron alloy with better corrosion resistance more efficiently is an important concern. Based on this, the WC particles enhanced nickel-iron coatings were fabricated by jet electrodeposition (JED) at a high current density of 100A/dm 2 . It was found that increasing the deposition temperature appropriately during JED is beneficial to obtain Ni-Fe-WC coating with the higher number of hard particles. Specifically, the maximum WC particles proportion reaches 4.47 wt% at 55 °C. The electrochemical corrosion behavior of coating was measured by polarization curve and electrochemical impedance spectroscopy (EIS). The polarization curve test results displayed that the E corr positively shifted from −0.402 to −0.281 V and the i corr reduced from 25.13 to 7.05 μA/cm 2 with the increase of WC particles proportion. Meanwhile, the EIS test results exhibited that the impedance of coating enhanced from 12,720 to 59,140 Ω cm 2 . The neutral salt spray test (NSS) was used to simulate the corrosion of coating in a seawater environment. The NSS results showed that with the increase of WC particles, the corrosion products decreased gradually and the degree of corrosion decreased. The analysis showed that WC particles can help the grain growth and release the internal stress in the coating. Larger grain sizes reduces intergranular corrosion and smaller internal stress help to alleviate stress corrosion cracking. The above research can provide theoretical support for the efficient preparation of particle enhanced composite coating with strong corrosion resistance.
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Biology-Basel
·
2021
·Vol. 10
·期 6
·548
·
IF 5.079
Ferry Saputra,Yu-Heng Lai,Rey Arturo T. Fernandez,Allan Patrick G. Macabeo,Hong-Thih Lai,Jong-Chin Huang,Chung-Der Hsiao
Simple SummaryThe usage of artificial sweetener has been increased from year to year as the result of pursuing healthy lifestyle. However, ironically, several studies suggest that the consumption of artificial sweeteners cause sugar-related adverse effects (e.g., obesity, type 2 diabetes and cardiovascular disease). In this study, we explore the potential cardiovascular adverse effect of several artificial sweeteners using zebrafish as animal model. We found that artificial sweetener at the highest concentration found in nature only slightly alter the cardiovascular performance of zebrafish larvae. Furthermore, no alteration of cardiac performance showed after longer incubation which support the safety of artificial sweeteners.AbstractArtificial sweeteners are widely used food ingredients in beverages and drinks to lower calorie intake which in turn helps prevent lifestyle diseases such as obesity. However, as their popularity has increased, the release of artificial sweetener to the aquatic environment has also increased at a tremendous rate. Thus, our study aims to systematically explore the potential cardiovascular physiology alterations caused by eight commercial artificial sweeteners, including acesulfame-K, alitame, aspartame, sodium cyclamate, dulcin, neotame, saccharine and sucralose, at the highest environmentally relevant concentration on cardiovascular performance using zebrafish (Danio rerio) as a model system. Embryonic zebrafish were exposed to the eight artificial sweeteners at 100 ppb and their cardiovascular performance (heart rate, ejection fraction, fractional shortening, stroke volume, cardiac output, heartbeat variability, and blood flow velocity) was measured and compared. Overall, our finding supports the safety of artificial sweetener exposure. However, several finding like a significant increase in the heart rate and heart rate variability after incubation in several artificial sweeteners are noteworthy. Biomarker testing also revealed that saccharine significantly increase the dopamine level in zebrafish larvae, which is might be the reason for the cardiac physiology changes observed after saccharine exposure.Keywords:artificial sweeteners;zebrafish;cardiac performance
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CRYSTAL GROWTH & DESIGN
·
2021
·
IF 4.076
Xinyuan Wang,Lei Wang,Changlin Yao,Guanying Xie,Shuhong Song,Huimin Li,Yaqian Qu,Xutang Tao
Recently, favipiravir, as a broad-spectrum antiviral drug, has gain more attention because it might be a candidate to remedy the coronavirus disease 2019 (COVID-19). To improve its poor permeability and tabletability, four multicomponent crystals of favipiravir (FPV) were prepared by a slow evaporation or liquid-assisted grinding method, including three cocrystals (FPV-theophylline, 1:1; FPV-saccharin, 1:1; FPV-5-fluorouracil, 1:1) and one salt (FPV-piperazine, 2:1). All of the crystal structures were solved by single-crystal X-ray diffraction. Interestingly, FPV-theophylline has a crystal structure similar to that of FPV, leading to similar properties, such as solubility, permeability, and tabletability. Except for FPV-theophylline, all of the other multicomponent crystals exhibit an enhanced permeability and tabletability. Our studies provide a new insight in overcoming the shortcomings of the important antiviral drug FPV.
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危险品化学品经营许可证（带存储）