INDUSTRIAL CROPS AND PRODUCTS
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2018
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IF 3.849
Shujie Ma,Leilei Fu,Siqi He,Xiaopeng Lu,Yuanyong Wu,Zhiqing Ma,Xing Zhang
The evaluation of herbicidal activity and the isolation of plant allelopathic substances can lead to the discovery of new herbicide. This study has confirmed that the ethanol extract of S. mukorossi leaves was inhibitory to growth of Avena fatua L. and Amaranthus retroflexus L. both in petri dish experiment and pot culture assay, with the fresh weight inhibition varied between 47.60% and 62.05% at a concentration of 40 g/L of the leaf extract, being comparable to that of a commercialized natural product herbicide pelargonic acid at a concentration of 4 g/L. Five herbicidal compounds, oleanolic acid (1) , lupeol (2) , d-pinitol (3) , hexadecanoic acid (4) and octadecanoic acid (5) were isolated from the most active fraction, petroleum ether extract. D-pinitol (3) showed the highest growth inhibitory activity against both the shoot and root of A. fatua , with the half maximal inhibitory concentration (IC 50 ) values of 53.61 and 56.43 μg/mL, respectively. Furthermore, oleanolic acid (1) and d-pinitol (3) also inhibited the growth of A. retroflexus with the IC 50 value of 56.05 and 61.89 μg/mL against shoot growth, and 58.07 and 66.70 μg/mL against root growth, respectively. Thus, oleanolic acid (1) and d-pinitol (3) are the main phytotoxin constituents of S. mukorossi , and these compounds have the potential for further development as a botanical herbicide.
研究领域:
植物生理学
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化感作用
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天然产物化学
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杂草科学
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农药学
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DOI
高影响因子
ELECTROCHIMICA ACTA
·
2026
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IF 5.8
Ruipeng Hao,Fangyuan He,Xuwen Gao,Wenbo Lu,Sumin Bian,Hugo Vankelecom,Chenzhong Li
Myricetin is a naturally occurring flavonoid found in various fruits and medicinal plants, possessing significant antioxidant and pharmacological activities. Accurate determination of myricetin is crucial for food quality control and pharmaceutical analysis. In this work, we synthesized a hierarchical composite consisting of cobalt-based Prussian blue analogue grown on Ni-MOF nanosheets supported on nickel foam (Co-PBA@Ni-MOF/NF) and employed it as a sensitive electrochemical sensor for myricetin detection. The composite combines the high conductivity and large surface area of Ni-MOF with the uniform catalytic sites of Co-PBA, significantly enhancing the electrocatalytic oxidation of myricetin. The as-prepared myricetin electrochemical sensor exhibited a wide linear range of 0–500 μM, a low detection limit of 0.168 μM, and high sensitivity of 1126 μA·mM⁻ 1 ·cm⁻ 2 . Furthermore, this sensor demonstrated excellent selectivity, stability, and reproducibility. Importantly, the sensor was successfully applied for the quantitative detection of myricetin in juice samples, achieving a satisfactory recovery rate of 98.15%–101.37%, demonstrating its practical utility for myricetin detection in real food samples.
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高影响因子
Frontiers in Immunology
·
2026
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IF 7
Gaohua Li,Lingping Zhao,Jingzhi Shen,Haiyang Wang,Jinru He,Yiming Liu,Ruge Zang,Tiantian Cui,Quan Zeng,Junnian Zhou,Wen Yue,Yanan Wang,Jiafei Xi
BackgroundCarcinoembryonic antigen (CEA) is overexpressed in most colorectal cancers (CRC) and serves as a promising immunotherapeutic target. However, current immune cell therapies against CRC show limited clinical efficacy, and the lack of renewable, standardized cell sources hampers broader application. The present study aimed to establish a scalable source of CEA-targeted natural killer (NK) cells from engineered human embryonic stem cells (hESCs).MethodshESCs were genetically engineered to express a CEA‑specific chimeric antigen receptor (CAR). The modified hESCs were subsequently differentiated into NK cells, yielding a homogeneous population of CAR hESC-NK cells. In vitro cytotoxicity against CEA-high CRC cell lines was evaluated using LDH and IFN-γ release assays. For in vivo assessment, we established a xenograft mouse model bearing CEA-positive CRC tumors. Following adoptive transfer of CAR-hESC-NK cells, tumor growth was monitored by bioluminescence imaging, overall survival was recorded for Kaplan–Meier analysis, and the persistence of transferred cells in peripheral blood was examined by flow cytometric analysis at serial time points.ResultsIn vitro, CAR hESC‑NK cells demonstrated potent and specific cytotoxicity against CEA-high CRC cell lines, along with significantly enhanced cytokine secretion compared to unmodified NK cells. In the xenograft model, adoptive transfer of CAR hESC‑NK cells resulted in marked tumor growth inhibition and prolonged survival, with no observable off‑target toxicity. Importantly, the CAR CEA‑ESC line maintained stable transgene expression and could serve as a renewable seed cell source.ConclusionWe have established a scalable platform for producing CEA‑targeted NK cells from engineered hESCs, providing an off‑the‑shelf, homogeneous cell product with robust antitumor activity. This strategy provides effective and specific immunotherapy against CEA-positive colorectal cancer and holds potential for other CEA-expressing malignancies.
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产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
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2023
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IF 6
Shunjing Luo,Yaqin Hou,Liang Xie,Huibin Zhang,Chengmei Liu,Tingting Chen
Microwaving was used to improve the functional properties of dietary fibers. However, the effects of microwave on the fermentability of different fibers and their role in modulating the gut microbiota were not clear. Four agro-industrial by-product fibers were treated with microwave and their fermentability and microbiota-modulating effects on different inoculum sources were investigated. The microwave treated fiber had a looser microscopic structure and more soluble dietary fiber (SDF). Microwave treatment increased soluble fiber the most, short-chain fatty acid production the most, and altered the microbial community the most in soybean fiber, while it caused the least changes in fiber structure and fermentability in sweet potato fiber. Although fecal inocula and fiber source had a greater effect on fiber fermentation, microwave treatment had a small but significant effect on fiber fermentability. Microwave treatment decreased gas production and pH in all four fibers. The key bacteria that responded to microwave treatment were clustered into 25 co-abundance groups (CAGs). CAG10 consisting of Blautia spp. and Bifidobacterium spp. was affected by microwave treatment and positively associated with SDF in all donors. This study showed that the new niches created by microwave, including increased SDF and loosened fiber structure, both contributed to the improvement of the fermentability and microbiota modulating effects of the different fibers.
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DOI
高影响因子
Journal of Energy Storage
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2023
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IF 9.4
Xue-Feng Shao,Sheng Yang,Hong-Yi Shi,Li-Wu Fan,Yan-Ping Yuan
Sugar alcohols have been proposed as a class of potential phase change materials (PCMs) for medium-temperature latent heat storage . The present work investigated the cycling stability of four pure and three mixture sugar alcohols by a specially-designed test setup, followed by a comprehensive evaluation based on their phase change behaviors (reported in our previous publication) and stability. It was found that the latent heats of fusion/crystallization degrade upon consecutive melting-crystallization cycles, and a higher degree of superheat Δ T sh leads to a faster degradation. An extremely low level of only 10.5 % degradation was obtained for erythritol after 200 cycles at a relatively low Δ T sh of 20 °C. The corresponding degrees of supercooling Δ T sc become higher due to the remarkable reduction of crystallization temperatures . It was shown that introducing protective nitrogen gas could suppress oxidation and improve cycling stability. The cycles of half degradation on latent heat of fusion was ~3.6 times with nitrogen protection. A comprehensive evaluation identified that the crystallization-related issues and poor stability are the primary challenges for sugar alcohols. Nevertheless, other than common PCMs, some particular application scenarios like controllable latent heat retrieval and seasonal heat storage can be hopefully developed by virtue of the deep supercooling nature of sugar alcohols.
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高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2022
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IF 4.598
Youchi Ding,Lingling Xie,Yuwei Zhang,Xizhuo Chen,Yu Niu,Jing Xu,Qing Han,Xuejing Qiu,Yongxia Miao,Yongmei Xiao,Limin Zhu,Xiaoyu Cao
Organic compounds are considered auspicious due to their widespread presence in nature, low cost, and sustainability. However, the inherent drawbacks of these organics’ compounds, like low-conductivity and high-solubility, restrict their large-scale application. To solve these problems, we innovatively combined carbon quantum dots (CDs) with active substances (tetrahydroxybenzoquinone ortho -disodium salt ( o -Na 2 THBQ)) at different mass ratios. The optimized o -Na 2 THBQ/CDs-2 (the mass ratio of o -Na 2 THBQ to CDs is 10:2) exhibited excellent electrochemical performance, the first-cycle discharge specific capacity was 410 mAh g −1 and maintained 182 mAh g −1 after 500 cycles, and the Coulombic efficiency was nearly 100 %. After 1300 cycles, the o -Na 2 THBQ/CDs-2 composite demonstrated a high specific capacity of 63 mAh g −1 at 500 mA g −1 . This work provides a reference to design an optimal composite ratio of carbon dots (CDs) and organics to fabricate cathode materials for high-performance sodium-ion batteries.
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DOI
高影响因子
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
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2022
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IF 3.388
Xinyue Pang,Yongshuai Jing,Pengyue Li,Xiaoyue Qiu,Yuguang Zheng,Qian Wang,Lanfang Wu
The study aimed to select the best extraction technology of Angelica dahurica polysaccharides (ADP), characterize its structure, and antioxidant activity. On the basis of the single-factor experiment result, the ultrasonic-assisted extraction (UAE) of ADP was ameliorate using the response surface method. The optimal conditions were: extraction time 32 min, extraction temperature 74°C, ratio of water to material 19 mL/g, extraction power 270 W. The practical extraction rate was 11.21 ± 0.12% (g/g). C-1: Not clear?? g/s??? ADP was purified by column chromatography, and then three polysaccharide fractions (ADP-H, ADP-0.1 and ADP-0.3) were obtained using DEAE-Cellulose 52. The ADP was mainly composed of D-Mannose, D-Glucose, D-Galactose, L-Arabinose, the ADP-H was mainly composed of D-Mannose, D-Glucose, D-Galactose, L-Arabinose, the ADP-0.1 was mainly composed of D-Mannose, D-Galacturonic acid, D-Glucose, D-Galactose, L-Arabinose, and the ADP-0.3 was mainly composed of D-Mannose, L-Rhamnose, D-Galacturonic acid, D-Galactoe, L-Arabinose. The molecular weights of ADP-H, ADP-0.1 and ADP-0.3 were 1.01 × 104 Da, 1.45 × 107 Da and 6.96 × 106 Da. In addition, the purified polysaccharides have certain scavenging ability of DPPH free radical, hydroxyl free radical and ferric reducing power, which can be used as natural products of antioxidants.
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高影响因子
Chemical and Biological Technologies in Agriculture
·
2023
·Vol. 10
·期 1
·1-12
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IF 6.6
Zheng Lei,Zhu XingYi,Wang Jialu,Su Weike
Mechanochemical-assisted extraction (MCAE) and mechanochemical-assisted enzyme catalysis (MCAEC) methods were developed for extraction and enzymatic hydrolysis of calcium phytate from defatted rice bran, respectively.The MCAE conditions were optimized by response surface methodology: 10% sodium carbonate as the solid reagent, 33 min grinding time, 18:1 ball–material ratio, 330 rpm ball milling speed, and pH 5.5 extraction. Under these conditions, the yield of calcium phytate was 97.0 mg/g. The MCAEC conditions were optimized as follows: 2% enzyme addition, MM400 milling time 36 min, PM400 milling speed 262 rpm, MM400 milling frequency 27 Hz, and the addition of pH 5.5 sodium acetate buffer 3 mL. Under these conditions, the hydrolysis rate of calcium phytate was 39.7%.Compared with traditional extraction and enzymatic hydrolysis methods, MCAE and MCAEC could obtain higher yields and hydrolysis rates, respectively.
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DOI
高影响因子
Sustainable Energy & Fuels
·
2023
·Vol. 7
·期 16
·3981-3992
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IF 5.6
Yuanhong Li,Songping Mo,Junhao Chen,Bo Xiao,Lisi Jia,Ying Chen
The utilization of sugar alcohols as phase change materials (PCMs) in medium-temperature solar thermal applications has significant potential, yet their utilization is limited by their low thermal conductivity and potential leakage during the phase change process. In order to achieve greater thermal conductivity and higher photothermal conversion efficiencies, this study proposes the incorporation of MXenes within inositol nanocapsules. The structures and thermal properties of the resulting nanocapsules were methodically examined through Fourier transform infrared spectroscopy (FT-IR), ultraviolet-visible (UV-vis) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), thermo-gravimetric analysis (TGA), differential scanning calorimetry (DSC) and the Brunauer–Emmett–Teller (BET) method. The thermal conductivity of the nanocapsule suspension was measured using a hot disk thermal constant analyzer. Furthermore, the temperature variations of the nanocapsule suspension, subjected to simulated solar irradiation, were measured and the photothermal conversion efficiencies were calculated. The findings of the study reveal that MXene doping had negligible impact on the latent heat of the nanocapsules. However, it was found that the thermal conductivity of the nanocapsule suspension was enhanced by 76.0% in comparison to that of the inositol suspension that contained an equivalent mass fraction of 2.0%. Moreover, the photothermal conversion efficiency of the nanocapsule suspension exhibited a 67.3% increase relative to that of the inositol suspension. These results indicate that the MXene-doped sugar alcohol nanocapsules demonstrate promising potential for enhancing the efficacy of solar thermal utilization.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2022
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IF 7.425
Nawei Zhang,Yu Gao,Gang Fan,Wu Zhong,Xuanxuan Chen,Xiao Guo,Jeanett Hansen,Bodil Jørgensen,Erhu Li
There have been rare reports about the structure/composition of polymers in blueberry skin and their changes during fermentation for wine production. In this study, the compositional changes occurring in blueberry skin during fermentation were tracked by a combination of cell wall analysis techniques including infra-red spectroscopy, monosaccharide analysis, and comprehensive microarray polymer profiling (CoMPP). The cross-corroborating data revealed that blueberry skin cell wall is particularly rich in xyloglucan. Chemical fractionation analysis indicated that the KOH soluble fraction is a dominant fraction in fermented blueberry skin. Interestingly, the KOH soluble fraction contained abundant epitopes associated with pectin branch chains, indicating tight binding of some enzyme-resistant pectin polymers to hemicellulose. This study provides important implications for the development of effective strategies to extract beneficial substances (such as aromatics, tannins and pigments) from berry tissues during processing.
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DOI
PubMed
高影响因子
ANALYST
·
2022
·Vol. 147
·期 24
·5754-5763
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IF 5.227
Zizheng Shen,Huan Yao,Jinlei Yang,Xingyu Pan,Hansen Zhao,Guojun Han,Sichun Zhang,Xinrong Zhang
NK cell-mediated immunotherapy has received increasing attention in the past decade due to its efficacy and bio-safety. The composition and content of lipids in individual cells are closely related to NK cell-mediated cytotoxicity, especially polyunsaturated fatty acids (PUFA) which are oxidized during NK cell-mediated apoptosis. Here we investigated the changes of lipids in single HepG2 cells by label-free mass cytometry and obtained information on 53 lipids and 13 oxidized lipids after the interaction with NK92 MI cells. We found that the contents of lipids and oxidized lipids of HepG2 cells changed obviously during the NK cell-mediated apoptosis. The HepG2 cells could be classified into two phenotypes after co-culturing with NK92 MI cells based on the ratio of PC(38:6-2OH)/PC(38:6) in individual cells, which may serve as a feature to evaluate NK cell-mediated cytotoxicity. The present work used the lipids and oxidized lipids of individual cells to reveal the heterogeneity in NK cell-mediated apoptosis which would be a powerful method for evaluating the cytotoxicity of NK cells at the single-cell level.
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DOI
PubMed
高影响因子
ACS Applied Nano Materials
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2022
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IF 6.14
Fan Yang,Hongbo Yu,Chunzheng Wu,Shiwei Wang,Tong Li,Hongfeng Yin
Supported Rh nanoparticles (NPs) exhibit excellent activity for the chemoselective hydrogenation of halonitrobenzenes (HNBs), but their selectivity to aromatic amines is not satisfactory due to the side reaction on the carbon–halogen bonds, and their recycling stability is limited due to the aggregation and the leaching of active component during the long-term usage. Herein, we design a yolk–shell-structured catalyst that consists of RhCu alloy cores and hollow/microporous carbon shells (HCS) to overcome these problems. The obtained RhCu@HCS catalyst with a Rh/Cu ratio of 1:1 showed good activity, selectivity, and stability in the hydrogenation of p-CNB (p-chloronitrobenzene) to produce p-CAN (p-chloroaniline) due to the synergistic effect between Rh and Cu. The protective carbon shells not only prevented the aggregation of metal NPs but also allowed the reactants to diffuse freely across the shells. Therefore, our research provides a general strategy to design highly efficient and stable hydrogenation catalysts.
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高影响因子
危险品化学品经营许可证（带存储）