BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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2018
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IF 2.559
Peng Zhang,Menghuan Tang,Qin Huang,Guanjian Zhao,Ning Huang,Xiang Zhang,Ying Tan,Yuan Cheng
Mesoporous silica nanoparticles (MSNPs) of a small diameter were loaded with the anticancer drug temozolomide (TMZ), coated with polydopamine (PDA), and conjugated with Asn-Gly-Arg (NGR) for use in the treatment of glioma. The accumulation of NGR-MSNPs in C6 cells was shown to be higher than that of unmodified MSNPs. Anticancer drugs can cause autophagy in tumor cells, whereas autophagy inhibitors can block this reaction and enhance the therapeutic effect of the drugs. In this study, we demonstrated that MSNP-TMZ-PDA-NGR had stronger autophagy- and apoptosis-inducing effects in C6 cells than TMZ alone, and its anticancer effect was further enhanced when combined with autophagy inhibition. These results demonstrate that the combination of targeting vehicles and autophagy inhibitors may have research value in the treatment of gliomas.
研究领域:
纳米技术
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药学
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肿瘤学
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细胞生物学
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Antioxidants
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2026
·Vol. 15
·期 8
·1015
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IF 8.2
Xinyu Heng,Shaohong Huang,Qingyao Luo,Ke Zhang,Pei Liu,Yanan Zhu,Ruoxuan Deng,Ning Sun,Chen Qian,Chao Ye,Hai Yang
Hyperuricemia (HUA) is a chronic metabolic disorder resulting from abnormal uric acid (UA) metabolism. Common clinical drugs for HUA have serious and inevitable adverse effects. Blue honeysuckle (Lonicera caeruleaL.), a traditional edible berry with antioxidant and anti-inflammatory properties, shows great potential for alleviating HUA. This study prepared blue honeysuckle extract (BHE) and identified its main components as chlorogenic acid, quercetin, kaempferol, anthocyanin, etc., using LC-MS analysis. After in vitro digestion, BHE at concentrations ≥ 10 mg/mL retained over 70% of active components and biological activities. In HUA mice, BHE reduced serum UA levels, alleviated oxidative stress and inflammation, decreased UA production by inhibiting xanthine oxidase activity, and promoted renal and intestinal UA excretion through dual regulation of urate transporters. Additionally, BHE repaired the intestinal barrier, remodeled the gut microbiota structure, and improved UA metabolism disorders. This study supports BHE as a potential functional food ingredient for alleviating HUA.
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ANALYTICA CHIMICA ACTA
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2026
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IF 6.1
Yali Yang,Hui Ding,Kaijun Quan,Hongwei Zhao,Mingxia Sun,Zhimin Yang,Xiuhui Liu,Hongdeng Qiu,Jia Chen
Background To address the limitations of traditional single-mode stationary phases in separating complex samples, mixed-mode or multi-mode chromatographic stationary phases, which can provide two or more interaction mechanisms, have attracted extensive research interest. Among them, sulfonated pyrene derivatives present a promising candidate ligand, as they synergistically retain the hydrophobicity and π-π interaction capability of the pyrene moiety along with the hydrophilicity and strong cation-exchange capacity provided by the sulfonic acid groups. This synergistic multi-mechanism design significantly enhances separation selectivity for diverse and complex components. Results A pyrene trisulfonic acid-functionalized silica stationary phase (Sil-PyTSa) was successfully prepared and evaluated. In hydrophilic interaction liquid chromatography (HILIC) mode, Sil-PyTSa could efficiently separate nucleobases and nucleosides, ginsenosides, and alkaloids. For nucleobases and nucleosides, it utilized hydrophilic, electrostatic, and π-π interactions, showing superior retention and selectivity over a control HILIC column. In reversed-phase liquid chromatography (RPLC) mode, favorable separation of PAHs was achieved via hydrophobic and π-π interactions, enabling faster analysis and lower solvent consumption than a C18 column. In ion-exchange chromatography (IEC) mode, baseline separation of 14 rare earth elements (REEs) and removal of Fe/U impurities were accomplished. The column efficiency reached 95,920 N/m for naphthalene. Additionally, Sil-PyTSa achieved effective separation for REEs and iron (Fe) in a simulated NdFeB leaching solution and detected nucleobases and nucleosides in Angelica, indicting promising potential for analyzing complex matrices. Significance and novelty This work developed a novel multi-mode chromatographic stationary phase with multiple interactions mechanisms to enable high-performance separations in HILIC, RPLC, and IEC modes. It demonstrates good separation efficiency and selectivity, low solvent consumption, and high stability. This offers a versatile and green solution for the separation of complex samples with diverse analytes.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Yue Zhao,Dong-Lei Wang,Xin-Ya Zhou,Da-Peng Wang,Zhi-Yong Sun,Zheng-Hui Qiu,Jin-Wei Zhang,Cun-Guo Lin
This work investigates the novel application of a metal-complex hydrogen-bonded framework HOF-21 as an intelligent, chloride-responsive material for superior corrosion protection. A cost-effective and streamlined synthesis of HOF-21 was developed using rapid stirring at ambient conditions, offering a practical alternative to conventional static interfacial method. When embedded in epoxy coatings on copper substrates, HOF-21 significantly enhances anti-corrosion performance, outperforming traditional materials like ZnAl-LDHs. The protection mechanism is tripartite: effective chloride ion capture, reinforcement of the coating’s mechanical properties, and active protection. Experimental analyses, including kinetic and isotherm model fitting, confirm the exceptional chloride adsorption capacity, best described by pseudo-second-order and Temkin models. Molecular dynamics (MD) simulations elucidate the atomic-level mechanism, revealing that a unique hydrogen-bonded cage structure facilitates chloride sequestration. Furthermore, MD simulations demonstrate strong epoxy-HOF-21 compatibility and the formation of an interlocked structure that enhances mechanical cohesion. The active protection is attributed to the ion-exchange of fluorosilicate anions with chlorides. This work establishes M-HOFs as a versatile platform for chloride capture and provides a universal strategy for designing active-intelligent anticorrosion coatings.
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FOOD CHEMISTRY
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2026
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IF 10.4
Tingyu Ye,Mingcong Fan,Tingting Li,Jiajia Zhao,Haifeng Qian,Yan Li,Li Wang
Adzuki beans are rich in nutrients but high in purines, limiting their intake for patients with hyperuricemia. This study employed acid-assisted hydrothermal treatment (AHT) to remove purines from adzuki beans. The lower purine contents were found in adzuki bean treated with hydrochloric acid (37.72 mg/100 g), phosphoric acid (42.22 mg/100 g), and citric acid (68.75 mg/100 g), representing removal rates of 72.26%, 70.43%, and 49.45% respectively, while their processing losses were acceptable. Furthermore, low-purine adzuki bean powder exhibited lower purine release rate during in vitro digestion. AHT has improved the purine adsorption capacity of insoluble dietary fiber and enhanced the inhibitory effect of polyphenols on xanthine oxidase in adzuki beans. It also reduces the glycemic index of starch and improves protein digestibility in these beans. These enhancements have direct or potential therapeutic effects for treating hyperuricemia. Overall, AHT represents an effective approach for the processing of low-purine adzuki bean powder.
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INORGANIC CHEMISTRY
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2025
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IF 4.7
Tao Cheng,Lu Liu,Jia Hui Chen,Pan Wang,Jian Ming Pan
Metal–organic frameworks (MOFs) exhibit a diverse array of applications in the fields of adsorption, catalysis, sensing, and separation. However, the limited water stability of MOFs poses challenges in the separation domain, particularly due to the structural similarities among water-soluble nucleoside compounds, which complicate the selective adsorptive separation of these compounds from complex mixtures. In this study, hydrophilic flower-like zirconium-based MOF nanosheets (Zr-FNSs) were prepared by a one-step hydrothermal method. The investigation focused on their adsorption capacity and the mechanism of action, with respect to various nucleosides. Adsorption experiments were conducted under varying pH conditions to identify the optimal pH and to assess the influence of phosphate number on the adsorption of adenosine compounds. The kinetic adsorption capacities of Zr-FNSs for adenosine monophosphate (AMP), adenosine diphosphate (ADP), and adenosine triphosphate (ATP) were determined to be 254.81, 211.35, and 182.97 μmol g–1, respectively, demonstrating a gradient decrease that may be attributed to increased spatial resistance or a limited number of available adsorption sites. Zr-FNSs have excellent regenerative properties. This work underscores the significance of functional group interactions in the selective adsorption of nucleoside and provides valuable insights for the design of MOF-based adsorbents for the selective separation and purification of nucleoside.
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Results in Chemistry
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2025
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IF 4.2
Yanhui Ge,Xinya Xu,Yubo Liu,Chengyu Huang,Jiajun Zhu
In this work, the functionalization of mesoporous carbon@silica nanoparticles was described for recognizing monocrotaline in vivo to reach the goal of develop a diagnostic framework for hepatic veno-occlusive disease (HVOD) that aligns with biochemical indicators. Initially, adenine was successfully immobilized on hollow mesoporous carbon using 3-aminopropyltriethoxysilane as a coupling agent. The structural and morphological properties of the adenine-coated carbon nanoparticles were systematically characterized using a combination of analytical techniques, including Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). The adsorption performance of the adenine-coated nanoparticles was thoroughly evaluated through adsorption isotherm and kinetics studies. Subsequently, nanoparticles were employed as solid-phase extraction adsorbents for the enrichment of potential hepatotoxic compounds in rat liver tissues. The concentrations of monocrotaline were meticulously correlated with pharmacological indices and biochemical indicators in a rat model, which provided novel insights into the diagnosis of HVOD.
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JOURNAL OF CHROMATOGRAPHY A
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2025
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IF 4
Minyi Yuan,Zheng Zhao,Ji Wu,Sumin Bian,Yuling Liao,Ying Zhou,Huikai Shao,Zhengjin Jiang,Qiqin Wang
To meet the increasing demand for the separation of complex samples, a novel monolithic stationary phase with hydrophobic and hydrophilic functionalities was developed by using 3-(1-(4-vinylbenzyl)-1H-imidazol-3-ium) propane-1-sulfonate (VBIPS) as monomer, pentaerythritol triacrylate (PETA) as crosslinker. The optimized mixed-mode poly(VBIPS- co -PETA) monolith exhibited good mechanical strength, high permeability (K = 0.23 × 10 -14 m 2 in 100% ACN, 0.23 × 10 -14 m 2 in 100% MeOH, and 0.11 × 10 -14 m 2 in 100% H 2 O), and multiple interaction modes, including hydrophilic, hydrophobic, hydrogen, and electrostatic interactions. The highest column efficiency of 83,330 plates/m was achieved for thiourea at a linear velocity of 0.23 mm/s. Systematic evaluations confirmed strong retention and separation of polar substances (e.g., benzoic acids, nucleoside bases, phenols), primarily due to the sulfobetaine-derived hydrophilicity as well as effective separation of nonpolar substances (e.g., aniline, aryl ketones, polyaromatic hydroxy compounds), facilitated by π-π stacking interactions between analytes and benzene rings within the stationary phase. Overall, this zwitterionic imidazolium sulfonate-functionalized monolith successfully combines hydrophobic and hydrophilic groups in a single continuous bed, enabling efficient separation of both polar and nonpolar analytes under low backpressure. This work enriches the library of mixed-mode stationary phases, and broadens the detection scope for complex sample analysis.
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Frontiers in Nutrition
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2025
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IF 5.1
Xiujuan Yang,Hengxi Li,Daermu Qumu,Binhui Han,Mukaram Amatjan,Qiyao Wu,Lanting Wei,Bo Li,Mengxue Ma,Junjie He,San Wang,Yingzhi Yu,Xiaoni Shao
Background: Gut microbiota play a critical role in developing hyperuricemic nephropathy (HN). We previously found that sulfur-containing amino acid taurine (T) has nephroprotective effects in hyperuricemia (HUA) rats. However, the mechanism is still unclear. To investigate the underlying mechanism of T, rats were fed adenine and ethambutol hydrochloride for the introduction of HN.Methods: Pathological changes in the kidney were assessed using hematoxylin and eosin staining. 16S rRNA sequencing and metabolomics analyzed changes in the gut microbiota and fecal metabolism, and in vitro experiments were conducted to investigate the potential action and mechanism of T against HN.Results: In vitro results demonstrated that T could inhibit NF-κB, IL-1β, IL-6, TNF-α, and ROS in UA-induced HK-2 cells. It also improved renal function, ameliorated renal fibrosis, and reversed enteric dysbacteriosis in HN rats. These results showed that T protects against HN through the modulation of metabolites mediated by the gut microbiota. Meanwhile, gut microbiota included Lactobacillus and Lachnospiraceae NK4A136 group showed correlations with nephroprotective profiles of T. The combined analysis of 16S rRNA gene sequencing and untargeted metabolomics indicated that the anti-HN effects of T could be achieved through phenylalanine metabolism, caffeine metabolism, nicotinate and nicotinamide metabolism, retinol metabolism, and tryptophan metabolism.Conclusion: These findings suggest that the potential protective mechanism of T for HN is not only related to altered metabolic pathways and downregulation of inflammatory cytokines but also to the reciprocal regulation of microbiota structure and metabolism.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Chengwen Zhang,Zihan Li,Chengbo Qian,Ziyang Ye,Feifan Yu,Yuyuan Yao
Developing porous iron-based catalysts with high metal loading for highly efficient removal of the organic pollutants has been a challenge in environmental catalysis. In this work, the preparation of porous iron–nitrogen-co-doped carbon catalyst (pNC-Fe) innovatively utilized zinc nitrate (Zn(NO 3 ) 2 ) as a pore-forming agent and adenine for metal anchoring. The resulting catalyst possessed a high Fe loading (18.49 wt%) and a high specific surface area (395.69 m 2 /g), which enhanced the adsorption and degradation of pNC-Fe. As a demonstration, the maximum adsorption capacity of pNC-Fe for CBZ (389.7 mg/g) surpassed nearly all recently reported CBZ adsorbents. Additionally, pNC-Fe possessed an excellent adsorption regeneration capability even after 5 cycles, enhancing its reusability. Surprisingly, pNC-Fe in PMS system removed almost 100 % of 50 μmol/L carbamazepine (CBZ) in 15 min and performed an excellent k obs (0.5895 min −1 ), outperforming the majority of metal-based catalysts. Interestingly, the adsorption of CBZ by pNC-Fe also remarkably facilitated the degradation of CBZ. Notably, different from the free radical mechanism of most reported work, the quenching experiments and EPR detection demonstrated that the main reactive oxygen species (ROS) of the pNC-Fe/PMS system was singlet oxygen ( 1 O 2 ), endowing pNC-Fe with potential environmental anti-interference capability (less affected by common anions and pH variations). This work provides a valuable insight for the design of porous iron-based catalysts for wastewater remediation.
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Case Studies in Thermal Engineering
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2026
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IF 6.4
Lin Zhou,Zhe Wang,Qi Zhao,Wenwei Wang,Xianfeng Chen
Wheat dust poses a significant hazard to grain processing safety due to its high explosion sensitivity. To develop an inhibitor combining high-efficiency explosion suppression with environmentally friendly and edible properties, this study innovatively employed an aqueous phase condensation-freeze-drying method to successfully synthesize a phytic acid-adenine complex (PA-A) using naturally edible phytic acid (PA) and adenine as raw materials. Characterization analyses employing laser particle size analyzer, field-emission scanning electron microscopy with energy-dispersive X-ray spectroscopy (FE-SEM/EDS) confirmed the formation of a lamellar microstructure with highly dispersed phosphorus elements. The suppression effect of PA-A on a 300 g/m 3 wheat dust explosion was systematically investigated evaluated in a vertical tube combustion apparatus (1000 × 80 × 80 mm). Results demonstrated that increasing inhibitor concentration (0 vol%-12.5 vol%) progressively suppressed flame propagation, evidenced by color transition from bright yellow to dark red, morphological fragmentation, and discontinuity. Quantitative analysis revealed peak flame propagation velocity decreased from 27.6 m/s to 10.9 m/s (a reduction of 60.5 %), maximum temperature declined from 993 °C to 367 °C (a reduction of 63.1 %), and the maximum explosion pressure attenuated from 48.3 kPa to 20.1 kPa (a reduction of 59 %), with a significant delay (>80 %) in the time to reach these peak parameters. Comprehensive analysis based on Thermogravimetry-Differential Scanning Calorimetry (TG-DSC), X-ray Photoelectron Spectroscopy (XPS), and Fourier Transform Infrared Spectroscopy (FTIR) elucidated a multi-level synergistic suppression mechanism involving endothermic cooling, gas-phase dilution, surface isolation, and free radical quenching. This study provides a safe, environmentally friendly, and edible new strategy for controlling grain dust explosions.
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COMPUTATIONAL BIOLOGY AND CHEMISTRY
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2026
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IF 3.1
Zhichen Cai,Jia Xue,Yongyi Zhou,Haijie Chen,Jingjing Shi,Lisi Zou,Cuihua Chen,Xunhong Liu
Epimedii Folium (EF) is a widely used traditional Chinese drug that encompasses a variety of species. It has been reported that the active constituents in EF vary, leading to the uneven quality of commercial medicinal materials. To investigate the specific differences, we developed a comprehensive evaluation method to access the quality of EF from four species. First, UPLC-Triple TOF-MS/MS was used to generate characteristic fingerprints of Epimedium samples; second, adenine-induced Kidney Yang deficiency model was established to evaluate the quality of four Epimedium varieties by evaluating biochemical markers and morphology; third, multivariate statistical analysis, including gray correlation analysis and bivariate correlation analysis was combined; and finally, UPLC-QTRAP MS/MS identified a potential biomarker. The results showed that 12 common peaks were identified in 40 batches derived from four Epimedium species. The severity of kidney and testicular lesions in experimental groups of rats showed significant improvement compared with the model. GCA and BCA indicated that three ingredients, icariin, quercitrin, and epimedin B were potential biomarkers, confirmed using LC-MS. In addition, epimedin B and icariin were significantly higher in EBM compared to the other three species, consistent with the pharmacological tests. The quality and efficacy of EF from different origins were stable, and all of them had protective effects on Kidney Yang deficiency of rats. Especially, all data suggested that EBM possesses superior quality than the other three. Overall, our work offers fundamental data for the thorough assessment and a fresh viewpoint on the quality control of EF from several species.
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