POLYMER COMPOSITES
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2026
·
IF 4.9
Chunying Min,Yijie Yang,Hongyu Liang,Fan Ye,Amna Siddique,Zhiwei Xu
The effectiveness of carbon fiber reinforced polymers (CFRPs) is frequently limited by stress concentration, which arises from the substantial modulus disparity between the reinforcing fibers and the polymer matrix. To overcome this limitation, a modulus gradient interphase was designed by constructing a zinc oxide nanosheet@zeolitic imidazolate framework-8 (ZnO-Ns@ZIF-8) nanoarray on the fiber surface. This interphase not only alleviated the modulus gap between carbon fibers and the polymer matrix but also increased fiber surface roughness and chemical activity. Furthermore, an electron-rich indole group was incorporated as a π-system into the PHT resin (In-PHT), enabling cation–π interactions with Zn 2+ in ZIF-8 and thus synergistically enhancing interfacial adhesion. As a result, CF@ZnO-Ns@ZIF-8/In-PHT exhibited a tensile strength improvement of 62% and a wear rate decrease of 41% relative to the untreated control sample. Additionally, the acid-degradable In-PHT matrix allowed closed-loop recycling of the fibers without substantial performance loss. This study presents a novel approach for fabricating durable, wear-resistant, and sustainable CFRPs, with a focus on achieving significantly improved interfacial bonding. Highlights ZnO-Ns@ZIF-8 hierarchical architecture was constructed on carbon fibers. Continuous modulus gradient was designed to mitigate stress concentration. Cation–π interactions between ZIF-8 and In-PHT enhanced interfacial bonding. The composite exhibited 41% lower wear rate over the original sample. Recycled composites still maintain high performance.
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Cell Reports Medicine
·
2026
·
IF 14
Shan Zhang,Fang Li,Xiaoqiang Xu,Tianze Yu,Yang Liu,Xiaokai Fang,Yuan Zhou,Beilei Xu,Yu Zhang,Yang Luo,Qianjin Lu,Xiaochun Liu,Wei Li,Xu Yao
Skin microbial dysbiosis is a key characteristic of atopic dermatitis (AD). Although Cutibacterium acnes ( C. acnes ) is the most abundant bacterium in the skin microbiota, its precise functions in AD remain unclear. Here, whole-genome sequencing of C. acnes isolates reveals strain-level genomic and functional heterogeneity between AD patients and healthy individuals. Metabolomic profiling identifies reduced indolelactic acid (ILA), a tryptophan metabolite, in AD skin and in cultures of AD-associated C. acnes strains . In murine models of epidermal-barrier-damaged and AD-like dermatitis, topical ILA application activates the aryl hydrocarbon receptor (AhR) pathway in keratinocytes, upregulating tight junction proteins and suppressing interleukin (IL)-33 to restore barrier integrity and mitigate dermatitis. A proof-of-concept clinical trial confirms ILA’s efficacy in reducing transepidermal water loss and alleviating AD symptoms. Our study establishes C. acnes -derived ILA as a crucial regulator of skin barrier repair via AhR signaling, offering therapeutic potential for AD. Clinical trial registration: ChiCTR2400090988.
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PubMed
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DESALINATION
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2026
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IF 9.9
Ping Keung Wong,Lok Wan Ng,Wei Han,Matthew Y. Lui
Natural deep eutectic solvents are used as novel media for extractive desalination. • Achieves among the lowest salinity and dissolved organics for similar process. • Solvent components create synergic effects to enhance water yield. Extractive desalination is a low-cost, membrane-free process for desalination that can be applied in the presence of low-grade heat sources, such as industrial waste heat and solar thermal energy. However, the solvents previously proposed for extractive desalination of water for human usage are relatively toxic and unsustainable, causing health and environmental concerns. Thus, the use of greener, but still effective, extractants is critical to the viability of this process. In this study, the use of natural deep eutectic solvents (NADESs) for extractive desalination of simulated brackish water, seawater and brine was investigated. Menthol/decanoic acid NADESs demonstrated the most effective desalination performance, producing freshwater with relatively low salinity (140–700 ppm from seawater) compared to other extractants. Moreover, the quantity of these food-based solvents discharged into the water phase was relatively low (around or less than 120 ppm). Consequently, the produced freshwater generally meets international standards and regulations, which is not commonly reported for extracts produced by this process. The presence of menthol enhanced water yields by over threefold, achieved by breaking the strong dimeric hydrogen bonds in decanoic acid molecules that hinder water absorption, and by extending the hydrogen-bond lifetimes between extractant and water. Moreover, the water yield improved with decreasing salinity of the water source, making brackish water and seawater particularly attractive for this process.
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ACS Food Science & Technology
·
2026
·
IF 3
Jiayi Chen,Dandan Zhang,Lu Liu,Xiaoli Wu,Meihan Guo,Hong Yan Zou,Xi Yang
Herein, a cost-effective, naked-eye-readable platform for on-site biogenic amines (BAs) detection and shrimp freshness monitoring was developed based on a ratiometric fluorescent CDs–RhB hybrid nanosystem that was constructed by integrating carbon dots (CDs) with rhodamine B (RhB). Biogenic amines induced a significant enhancement in the green fluorescence emission of CDs, while the red fluorescence emission of RhB remained unchanged, enabling an instant self-calibration during detection. Loaded on filter paper to form disposable test strips, the nanosystem enabled a visible color transition from orange to green with increasing BAs concentration. Readable via a smartphone RGB app, the paper-based assay showed a linear response of 5.0–250 μM with a limit of detection (LOD) of 3.56 μM using histamine as the model analyte. Validated through on-site shrimp quality evaluation, the paper-based sensor established a reliable “nanoprobe–paper–phone” strategy, facilitating on-site and quantitative freshness assessment in real-world demand scenarios.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Yanan Liu,Yuhao Huang,Qileng Aori,Yu Wang,Sai Zhao,Zhen-Lin Xu
Antibacterial hydrogel packaging often adheres poorly to hydrophobic prefabricated meat surfaces. Metal-polyphenol networks, combining metal ion antibacterial properties with polyphenol adhesion, offer promising preservation potential. In this study, tannic acid -Fe III metal polyphenol network-coated gallic acid -loaded ovalbumin/chitosan nanoparticles with adhesion and sustainable antibacterial properties were prepared and embedded into the gelatin hydrogel to elongate the shelf life of prefabricated meat. The composite hydrogel exhibited high adhesion, with an average adhesion force of 1.4-fold ∼1.9-fold larger than the other groups. It also exhibited good antibacterial properties, the colony-forming units (CFU) of 4 type of bacteria was reduced by 0.69, 0.34, 1.05 and 0.90 log 10 (CFU/mL). The composite hydrogel delayed pH, total volatile basic nitrogen (TVB-N), microorganism growth, and the marginally acceptable limit was delayed by 4 days compared with the other groups in applications. These results demonstrate the composite hydrogel's significant potential as a preservation material for prefabricated meat.
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PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2023
·
IF 7.4
Yuze Li,Ke Jia,Yixin Pan,Jing Han,Junyu Chen,Yiran Wang,Xiaobing Ma,Hongwei Chen,Shengjie Wang,Dongcheng Xie,Caiqiao Xiong,Zongxiu Nie
Analysis of volume-limited biological samples such as single cells and biofluids not only benefits clinical purposes but also promotes fundamental research in life sciences. Detection of these samples, however, imposes strict requirements on measurement performance because of the minimal volume and concentrated salts of the samples. Herein, we developed a self-cleaning nanoelectrospray ionization device powered by a pocket-size “MasSpec Pointer” (MSP-nanoESI) for metabolic analysis of salty biological samples with limited volume. The self-cleaning effect induced by Maxwell–Wagner electric stress helps with keeping the borosilicate glass capillary tip free from clogging and thus increasing salt tolerance. This device possesses a high sample economy (about 0.1 μL per test) due to its pulsed high voltage supply, sampling method (dipping the nanoESI tip into analyte solution), and contact-free electrospray ionization (ESI) (the electrode does not touch the analyte solution during ESI). High repeatable results could be acquired by the device with a relative standard deviation (RSD) of 1.02% for voltage output and 12.94% for MS signals of caffeine standard. Single MCF-7 cells were metabolically analyzed directly from phosphate buffered saline, and two types of untreated cerebrospinal fluid from hydrocephalus patients were distinguished with 84% accuracy. MSP-nanoESI gets rid of the bulky apparatus and could be held in hand or put into one’s pocket for transportation, and it could operate for more than 4 h without recharge. We believe this device will boost scientific research and clinical usage of volume-limited biological samples with high-concentration salts in a low-cost, convenient, and rapid manner.
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PubMed
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Food Science & Nutrition
·
2023
·Vol. 11
·期 5
·2277-2287
·
IF 3.9
Shuyuan Cao,Shengjie Hu,Ping Jiang,Zhan Zhang,Lei Li,Qian Wu
Sulforaphane (SFN) is a promising phytochemical with a wide range of antitumor activities. A comprehensive understanding of the effects of SFN on breast cancer based on the metabolome and microbiome is limited. Thus, we treated MCF-7 cell-transplanted nude mice with 50 mg/kg SFN. SFN inhibits breast cancer cell proliferation. SFN increased the levels of sulfate-related metabolites and glutathione-related metabolites and decreased tryptophan metabolites and methyl-purine metabolites in urinary metabolic profile. SFN indirectly affected the activation of aryl hydrocarbon receptor by tryptophan metabolism. The ratio of SAM to methionine was decreased by SFN while the global DNA methylation was downregulated in tumor tissue. SFN decreased the sulfate-reducing bacterium Desulfovibrio , which is related to reduced methylation capacity, and increased the genus Lactobacillus related to tryptophan metabolites with antitumor activities. In conclusion, we provide a perspective on the metabolome and microbiome to elucidate the antitumor activities of SFN.
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PubMed
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Food Analytical Methods
·
2023
·Vol. 16
·期 5
·909-917
·
IF 2.9
Xu Yanfen,Lu Ying,Yu Jianna,Liu Wen,Jing Guoxing,Li Wenshan,Liu Wenjie
Tuna is one of the most popular fish and therefore among the most commercially valuable seafood. However, inadequate refrigeration during the whole supply chain causes serious economic loss and food poisoning. One important result of tuna spoilage is the accumulation of biogenic amines such as histamine, which can be used as a sensitive indicator for Tuna freshness. Thus, the development of rapid, sensitive, and economic analytical methods for biogenic amines in Tuna is highly desired. This research developed a method that combines high-performance liquid chromatography (HPLC) and electrospray ionization ion mobility spectrometry (ESI-IMS) to detect 7 kinds of biogenic amines including tryptamine, tyramine, spermidine, cadaverine, β-phenylethylamine, putrescine, and histamine in tuna. The limit of detections (LODs) for 7 biogenic amines are 0.01, 0.02, 0.02, 0.17, 0.03, 0.04, and 0.15 mg L −1 respectively. The linear range of histamine and spermidine is 2–100 mg kg −1 , and the linear range of other biogenic amines is 0.5–10 mg L −1 . The recoveries of biogenic amines are between 69.39 and 112.65%. Compared to the traditional HPLC-based analytical method, the proposed method does not involve any derivatization steps, which greatly decreased the sample preparation time and cost. Another advantage of the developed method is the supplementary separation to the HPLC, in which coeluted biogenic amines can clearly be separated in the ion mobility dimension. The proposed method is applied to determining the concentration of biogenic amines in tuna storage, which showed that this method can quickly and accurately monitor the changes of biogenic amines in tuna during storage.
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NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 16
·7588-7594
·
IF 3.3
Jianfeng Yan,Quanbin Fu,Shikai Zhang,Xianbao Shi,Yuanhong Zhang,Juying Hou,Junling Duan,Shiyun Ai
As a kind of organic basic compound containing nitrogen, biogenic amine is released from food spoilage and considered as an indicator for monitoring food freshness. Herein, an excellent dual-emission ratiometric fluorescent sensor for eight kinds of biogenic amines was established via the facile mixing of pH-responsive carbon dots and Rhodamine B. The developed sensor shows a rapid response (10 s), low limit of detection (0.733–3.943 μM) and a wide linear range (0–150 μM). More importantly, a portable fluorescent filter paper was prepared by simple dispersing the filter paper in a solution mixture of carbon dots and Rhodamine B. The obtained fluorescent filter paper based sensor showed an obvious color change in the presence of biogenic amine vapor derived from shrimp and mushroom. The results revealed that this sensor could realize the on-site and visual detection of biogenic amines in real food samples, making it suitable for potential application in food safety monitoring.
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MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Nuo Duan,Kexin Ren,Mingqian Song,Xinyue Zhang,Zhouping Wang,Fei Jia,Shijia Wu
The presence of biogenic amines (BAs) in food is not only important from a toxicological view, but can also be used as an indicator of food spoilage. However, the design of biosensors for the detection of BAs is very limited. Hence, in this work, a dual-donor fluorescence resonance energy transfer (FRET) aptasensor was established for simultaneous determination of histamine (HIS) and tyramine (TYR) using dual-color quantum dots (QDs) as energy donors and two-dimensional molybdenum sulfide nanosheets (MoS 2 NSs) as energy acceptor. Specific aptamer for HIS (Apt 1) and TYR (Apt 2) were labeled with two fluorescence emission QDs (QD 530 and QD 625 ), respectively. On the basis of the excellent adsorption ability of MoS 2 NSs toward aptamer, the fluorescence quenching can be observed between MoS 2 NSs and QD 530 -Apt1 and QD 625 -Apt2. Upon the addition of HIS and TYR, the aptamer conformation switches induced by the target binding mitigate the interaction force of MoS 2 NSs and QD 530 -Apt1 and QD 625 -Apt2, resulting in the fluorescence recovery. The method displays good sensitivity with limit of detection (LOD) of 0.1 ng/mL for HIS and 0.25 ng/mL for TYR, respectively. It can also be applied to the HIS and TYR detection in spiked fish samples with recovery of 95.2%∼106.6%, demonstrating its prospect in the sensitive detection of BAs in animal-derived foodstuff.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Lin Pang,Tianshi Zhang,Yuan Liu,Dezhong Li,Jiguang Li,Ming Guan,Xincun Dou
Tryptamines , an important family of new psychoactive substances, have attracted special attention from the international community owing to their abuse and corresponding influence on human health and social stabilization. However, realizing the on-site analysis of tryptamines with rapid and precise responses remains a great challenge, especially if these are present in their disguised form. A highly sensitive and specific analytical method was developed herein, driven by a dual noncovalent interaction towards tryptamines. An optical probe was designed to specifically recognize tryptamines via π–π stacking and hydrogen bond effect to produce significant optical responses for both colorimetric and fluorescent modes. The detection limits were calculated as 4.1 nM (fluorescent mode) and 17.2 μM (colorimetric mode), respectively, with an excellent specificity towards 16 interfering substances within 0.6 s. Based on the excellent detection performances of the proposed probe, a portable and operable sensor was developed and demonstrated with the rapid and accurate analysis capability towards the controlled α -methyl-tryptamine in complicated scenarios. We expect the portable sensor equipped with this optical probe would provide a powerful tool for trace tryptamine detection and effective technical support for real-time monitoring of other new psychoactive substances in complicated media.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Qiuyang Huang,Xiaoling Zang,Zhiwei Zhang,Hang Yu,Baoyan Ding,Zhuangzhuang Li,Simin Cheng,Xin Zhang,Mustafa R.K. Ali,Xue Qiu,Zhihua Lv
The discovery of new anti-cancer drugs targeting the PD-1/PD-L1 pathway has been a research hotspot in recent years. In this study, biological affinity ultrafiltration (BAU), UPLC-HRMS, molecular dynamic (MD) simulations and molecular docking methods were applied to search for endogenous active compounds that can inhibit the binding of PD-L1 to PD-1. We screened dozens of potential cancer related endogenous compounds. Surprisingly, cyclic adenosine monophosphate (cAMP) was found to have a direct inhibitory effect on the PD-1/PD-L1 binding with an in vitro IC 50 value of about 36.4 ± 9.3 μM determined by homogeneous time-resolved fluorescence (HTRF) assay. cAMP could recover the proliferation of Jurkat T cells co-cultured with DU-145 cells and may suppress PD-L1 expression of DU-145 cells. cAMP was demonstrated to bind and induce PD-L1 dimerization by FRET assay, and also predicted by MD simulations and molecular docking. The finding of cAMP as a potential inhibitor directly targeting the PD-1/PD-L1 interaction could advance our understanding of the activity of endogenous compounds regulating PD-L1.
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危险品化学品经营许可证（带存储）