Advanced Healthcare Materials
·
2025
·
IF 9.6
Huanhuan Wu,Haoyu Wang,Jinwen Wei,Gang Shu,Shao-kai Sun,Cai Zhang,Dong Li
Acquiring multidimensional tumor and tumor-associated vascular information is essential for accurate diagnosis and treatment planning of glioma, yet effective imaging methods are still lacking. Here, ultrasmall manganese ferrite nanoparticles (UMFNs) are developed as a dual contrast-enhanced T 1 -weighted imaging (T1WI) and susceptibility-weighted imaging (SWI) probe for multidimensional diagnosis of glioma. The UMFNs are synthesized through thermal decomposition and functionalized with polyethylene glycol, ensuring excellent water dispersibility and biocompatibility. Characterization studies confirm the nanoparticles’ uniform size (3.8 nm) and high stability in various media. High r 1 (6.8 m m −1 s −1 ) and r 2 * (95.1 m m −1 s −1 ) values demonstrate the superior T 1 and T 2 * enhancement capabilities of UMFNs. In vivo imaging on a 3.0 T magnetic resonance imaging (MRI) scanner demonstrates that UMFN-enhanced SWI clearly delineates tumor margins and provides sustained tumor enhancement in ultrasmall orthotopic glioma (<2 mm). Besides, UMFN-enhanced SWI reveals distinct vascular structures associated with the glioma, including tortuous, thickened vessels indicative of tumor-induced angiogenesis. Whole-brain histological analysis corroborates these findings, demonstrating dense tumor proliferation and vascular remodeling. These results highlight the potential of UMFNs as a dual-enhanced agent for the early detection and high-resolution vascular mapping of glioma, providing an advanced multidimensional method for precise diagnosis of brain tumors.
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ACS Nano
·
2026
·
IF 17.3
Zhang Huan,Liu Minrui,Zhou Zhongqin,Ye Pengfei,Wen Lingyi,Feng Quanqing,Song Ningning,Wang Yanyun,Ma Guohang,Sun Ran,Zhang Kun,Wu Qihong,Zhang Meng,Wang Yining,Guo Yingkun,Fan Haiming
Accurate
magnetic resonance imaging (MRI) of microvascular
occlusive
diseases, exemplified by subsegmental pulmonary embolism (SSPE), remains
a clinical challenge because of the intrinsic limitations of clinically
available Gd-based small molecular contrast agents (CAs). Ultrasmall
iron oxide nanoparticles (USIOs)-based CAs have emerged as promising
alternatives, offering adjustable MRI T 1 relaxivity, favorable pharmacokinetics, and high biocompatibility;
however, their performance is critically hampered by inefficient atomic
utilization for MR T 1 relaxivity enhancement.
Herein, we report Mg-doped USIOs MRI CAs with high atomic utilization
efficiency, where incorporating a biocompatible Mg dopant into surface
octahedral-site Fe vacancies substantially boosts the T 1 relaxivity, enabling accurate detection of SSPE-associated
structural and perfusion abnormalities. The Mg 0.03 -USIOs
exhibit a 261-fold enhancement of T 1 relaxivity
contribution by the Mg dopant, achieving an exceptionally high T 1 relaxivity of 12.6 mM −1 s −1 . Such a high atomic utilization efficiency could
stem from the promoted spin polarization and ferromagnetic spin alignment
through the surface Mg doping, which considerably boosts the magnetic
moment and outer-sphere relaxation contribution. Further in vivo MRI studies in a pig SSPE model demonstrated that the
Mg 0.03 -USIOs enabled visualization of structural and perfusion
abnormalities in SSPE, far surpassing the capabilities of Gd-based
CAs. In vivo biosafety assessment in the pig model
confirmed the high biocompatibility of Mg 0.03 -USIOs. Our
findings provide a highly efficient doping strategy to construct high-performance
USIOs-based T 1 CAs for sensitive MRI of
microvascular structural and functional abnormalities.
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JOURNAL OF LUMINESCENCE
·
2022
·
IF 4.171
Fengchang Huang,Xiaoming Mo,Xuesong Li,Maolan Peng,Yulu Zhou,Xiaoma Tao,Yifang Ouyang,Jialong Zhao
Lead-free copper(I)-based halides have attracted tremendous attentions in producing optoelectronic devices due to their outstanding optical properties and low-cost synthesis. However, the low efficiency of copper(I)-based halides in the long-wavelength visible emissions (typically yellow- or red-light emissions) has hindered the use of such non-toxic halides in full-color displays and solid-state lighting applications. In this work, lead-free, air-stable and yellow-light emissive CsCu 2 I 3 microplatelets (MPs) with well-defined smooth surface were synthesized by a one-pot anti-solvent solution method at room temperature via surface functionalization with different long-chain surfactants . The results suggested that oleic acid (OA) was the most favorable surfactant for the CsCu 2 I 3 MPs with the best performance. Photoluminescence quantum efficiency of the yellow-emissive CsCu 2 I 3 MPs (centered at 580 nm) was dramatically enhanced fourfold by coordinating OA ligands during the synthesis to eliminate the surface pinholes of the CsCu 2 I 3 MPs. Notably, the CsCu 2 I 3 MPs showed ultra-high stability towards exposure of ambient air over 50 days. These findings may open new directions to synthetize high-efficiency copper(I)-based halides that generate long-wavelength visible emissions for lead-free nontoxic full-color optoelectronic devices.
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ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Jie Cheng,Yuling Li,Yunjun Wang,Jing Zhang,Tuanqi Sun,Li Zhang,Yinlong Guo
Accurate quantification of disease-related unsaturated fatty acids (UFAs) in biomedical samples plays an important role in clinical diagnosis. Here, we reported a quaterization derivatization-stable isotope labeling strategy for accurate quantitative analysis of UFAs by high-performance liquid chromatography-mass spectrometry. [d0]/[d10]-Bis(pyridine) iodine tetrafluoroboride ([d0]/[d10]-IPy2BF4) was employed as the carbon–carbon double bond derivatization reagent with high efficiency and high specificity, to introduce a charge tag on UFAs and avoid the interference of saturated fatty acids. After labeling, the detection sensitivity was significantly enhanced by up to three orders of magnitude compared to intact UFAs. The standard curves showed good linearity (R2 > 0.999) over a wide concentration range. This strategy was successfully applied to determine the content of 12 UFAs in human thyroid carcinoma and para-carcinoma tissues. A significant difference was found in the content of several UFAs between these two kinds of tissues (p < 0.05). These results indicated that the proposed strategy may be valuable for the discovery of abnormal UFA content in early clinical diagnosis.
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JOURNAL OF MOLECULAR LIQUIDS
·
2021
·
IF 6.165
Yuandong Yu,Guizhao Liang
Zein, a mixture protein existed in maize endosperm, has desirable biocompatibility and bioadhesion, which has been extensively applied as carrier materials in food and pharmaceutical industry. However, to the best of our knowledge, there is no published paper that has systematically explored the binding between phenolic acids and zein on the basis of the regression model. In this study, we investigated interaction behaviors of 19 phenolic acids with zein via fluorescence spectroscopy and partial least squares regression (PLS) modeling, among which trans -ferulic acid (hydroxycinnamic acid with the highest pK A values) and 3,5-dinitrosalicylic acid (hydroxybenzoic acid with the lowest pK A values) were selected to further investigate their interaction mechanisms based on molecular modeling methods. The fluorescence spectra results showed that these 19 phenolic acids can cause obvious fluorescence quenching of zein, and the binding capacities of hydroxycinnamic acid were generally better than those of hydroxybenzoic acid. Molecular modeling results exhibited that the hydrogen bonding interaction and van der Waal force played crucial roles in maintaining the stable binding of these complexes; the formation of hydrogen bonds between Tyr-192 and carboxyl group on hydroxycinnamic acid was suggested to be the critical interaction causing stronger fluorescence quenching. The PLS modeling revealed that molecular descriptors P1s, Ks, ASP, Km, L/BW, P1m, JGI7, P1e, P1v, X3A had positive effects to the pK A of 19 phenolic acids, while P2s, P2m, L2s, PW4, JGI3 had negative effects. These findings suggest that zein should have the potential application as the polyphenol delivery system, and provide information for engineering zein to become more efficiently polyphenol carriers.
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BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
·
2021
·
IF 1.632
Shuai Xiao,Hai-ou Li,Meng-wei Xu,Ke Huang,Zhou-fei Luo,Lang-tao Xiao
Fatty acids (FAs) in oilseeds are important for human health. Gas chromatography-mass spectrometry (GC-MS) is a popular analytical technology for FAs measurement. FAs need to be derivatized into fatty acid methyl esters (FAMEs), which is essential for GC-MS analysis. The previous methods for methylation of FAs usually include reaction at high temperature and need specific vessels, for which samples with a large scale cannot be analyzed in a short time, leading to low efficiency. Here we report a high-throughput method for profiling fatty acids in plant seeds based on one-step acid-catalyzed methylation followed by GC-MS. This method for FA methylation via derivatization by sulfuric acid with methanol (5%, v/v) and incubation at 64 °C for 4 h in a more convenient 2 mL tube, is efficient. Satisfactory methodological performance was achieved by optimization of the parameters. Only 5 mg seeds were needed as a microscale sample usage by this method. The method is a successful approach to increase the efficiency of sample preparation and analysis for large-scale experiments.
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JOURNAL OF SUPERCRITICAL FLUIDS
·
2023
·
IF 3.9
Jie Wang,Yingxi Gao,Jiayi Shi,Shichao Tian,Zhiyong Zhou,Chencan Du,Zhongqi Ren
In this study, the kinetics, thermodynamics, and optimization of the subcritical butane extraction of Acer truncatum seed oil were investigated. The effects of experimental parameters on the extraction yield and efficiency was studied and optimized by response surface methodology, with the optimum time, temperature, and liquid/solid ratio (mL/g) of 44 min, 52 °C, and 3.4, respectively. The extraction efficiency could reach up to 94.50 % after twice extraction under optimized conditions. The extraction kinetics was determined by a modified Fick’s law model and the activation energy of the effective diffusion coefficient was obtained as 23.26 kJ/mol. The enthalpy change and the entropy change were both positive with values of 20.06 kJ/mol and 70.02 J/(mol·K), respectively, while The Gibbs free energy change was negative in the temperature range. Finally, the comparisons of extraction efficiency, fatty acid composition , and properties were made for subcritical extraction and other three methods.
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JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Xiangxin Xu,Xiaofang Liu,Shuai Wang,Yongping Zou,Jixian Zhang,Li Liang,Chaoting Wen,Youdong Li,Xiaowei Xu,Xudong He,Guoyan Liu,Xin Xu
Lipids are closely related to the generation of PAHs during food thermal processing. During heating, lipids mainly triglycerides undergo hydrolysis, oxidation and decomposition. The relationship between the various products and the formation of PAHs is still unclear. This paper investigated the effect of different lipid standards on PAH4 production, and explored their thermal stability and reaction products to delve into nature of the differences in PAH4 production. Fatty acids were more prone to generate PAH4 than glycerides. The higher the degree of esterification of glycerides, the higher its thermal stability and the lower the content of PAH4 generated, implying that hydrolysis of glycerides promoted the generation of PAH4. In addition, there was a positive correlation between unsaturation in lipids and the PAH4 production. After heat treatment, hydroperoxides, unsaturated fatty alcohols and aldehydes, alkenes and aromatic substances were abundant in oleic acid and linoleic acid which produced the most PAH4. Thermal decomposition of lipid hydroperoxides was the pathway for the generation of conjugated hydrocarbon radicals, alcohols, aldehydes, and alkenes . The intramolecular cyclization and Diels-Alder reaction acted as ring-forming reactions, with consequent dehydrogenation , decarboxylation , side-chain breaks and radical reorganization, ultimately facilitating the amplification of the aromatic rings and the formation of PAHs.
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ANALYTICA CHIMICA ACTA
·
2023
·
IF 6.2
Jiaqi Cui,Jianxun Zhang,Shihao Sun,Wu Fan,Hui Xi,Xiujuan Xu,Lingbo Ji,Shusheng Zhang,Dingzhong Wang,Wuduo Zhao
Accurate and sensitive measurements of free fatty acids (FFAs) in biological samples are valuable for diagnosing and prognosing diseases. In this study, an in-source microdroplet derivation strategy combined with high-resolution mass spectrometry was developed to analyze FFAs in lipid extracts of biological samples directly. FFAs were rapidly derivated with 2-picolylamine (PA) in the microdroplet which is derived by electrospray . With the proposed method, twelve typical FFAs were determined reliably with high sensitivity and acceptable linearities ( R 2 ≥ 0.94). The LODs and LOQs for the twelve FFAs were 9–76 pg mL −1 and 30–253 pg mL −1 , respectively. The developed method was applied to analyze the alteration of FFAs in liver and kidney samples of rats induced by perfluorooctane sulfonate (PFOS) exposure. The good results demonstrate that the established analysis technique is dependable and has promising applications in detecting FFAs associated with complex biological samples.
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Theranostics
·
2019
·
IF 8.063
Yuqing Miao,Qian Xie,Huan Zhang,Jing Cai,Xiaoli Liu,Ju Jiao,Shanshuang Hu,Anujit Ghosal,Yu Yang,Haiming Fan
The development of a highly efficient, low-toxicity, ultrasmall ferrite nanoparticle-based T 1 contrast agent for high-resolution magnetic resonance imaging (MRI) is highly desirable. However, the correlations between the chemical compositions, in vitro T 1 relaxivities, in vivo nano-bio interactions and toxicities remain unclear, which has been a challenge in optimizing the in vivo T 1 contrast efficacy. Methods : Ultrasmall (3 nm) manganese ferrite nanoparticles (Mn x Fe 3-x O 4 ) with different doping concentrations of the manganese ions (x = 0.32, 0.37, 0.75, 1, 1.23 and 1.57) were used as a model system to investigate the composition-dependence of the in vivo T 1 contrast efficacy. The efficacy of liver-specific contrast-enhanced MRI was assessed through systematic multiple factor analysis, which included the in vitro T 1 relaxivity, in vivo MRI contrast enhancement, pharmacokinetic profiles (blood half-life time, biodistribution) and biosafety evaluations ( in vitro cytotoxicity testing, in vivo blood routine examination, in vivo blood biochemistry testing and H&E staining to examine the liver). Results : With increasing Mn doping, the T 1 relaxivities initially increased to their highest value of 10.35 mM -1 s -1 , which was obtained for Mn 0.75 Fe 2.25 O 4 , and then the values decreased to 7.64 m M -1 s -1 , which was obtained for the Mn 1.57 Fe 1.43 O 4 nanoparticles. Nearly linear increases in the in vivo MRI signals (ΔSNR) and biodistributions (accumulation in the liver) of the Mn x Fe 3-x O 4 nanoparticles were observed for increasing levels of Mn doping. However, both the in vitro and in vivo biosafety evaluations suggested that Mn x Fe 3-x O 4 nanoparticles with high Mn-doping levels (x > 1) can induce significant toxicity. Conclusion : The systematic multiple factor assessment indicated that the Mn x Fe 3-x O 4 (x = 0.75-1) nanoparticles were the optimal T 1 contrast agents with higher in vivo efficacies for liver-specific MRI than those of the other compositions of the Mn x Fe 3-x O 4 nanoparticles. Our work provides insight into the optimization of ultrasmall ferrite nanoparticle-based T 1 contrast agents by tuning their compositions and promotes the translation of these ultrasmall ferrite nanoparticles for clinical use of high-performance contrast-enhanced MRI.
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Soft Matter
·
2019
·Vol. 15
·期 38
·7644-7653
·
IF 3.399
Yugui Han,Yefei Wang,Xianghai Meng,Qiuxia Wang,Xiaodong Han
Wormlike micelles (WLMs) have been successfully constructed from many different C22-tailed surfactants. Here, we creatively introduced a bulky piperazine group onto a C22-tailed zwitterionic surfactant, N-erucamidopropyl-N,N-piperazine-N-methyl ammonium propanesulfonate (EDPS), and investigated the micellar structure and properties of the EDPS WLMs via molecular dynamics simulation, cryo-TEM and rheological techniques. It was found that 25 mM EDPS increased the zero-shear viscosity to as high as ∼106 mPa s. Furthermore, abnormal rheological behaviors, such as an inflection in the shear thinning region of steady rheology and an abrupt decrease of the shear stress at a critical shear rate, were observed, which was attributed to the unique ladder shape micellar structure. The EDPS WLMs were superior to other C22-tailed surfactants in many aspects, such as a low overlapping concentration, higher viscosity, stable viscosity over the whole pH range, and great temperature and salt (NaCl, CaCl2 and MgCl2) tolerance.
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FUEL
·
2018
·
IF 4.908
Xuepeng Wu,Yue Zhang,Xin Sun,Yongping Huang,Caili Dai,Mingwei Zhao
Hydraulic fracturing is playing a more and more important role in rapid shale oil and gas recovery development. Meanwhile, damage to the reservoir fracture and environmental contamination caused by fracturing fluid flowback water has raised serious concerns. In this study, a CO 2 -responsive surfactant, erucamidopropyl dimethylamine (EA), was synthesized and used as the thickening agent to develop a novel viscoelastic surfactant (VES)-based fracturing fluid. This fluid was responsive to the presence and pressure of CO 2 . It was not only rock formation friendly and environment benign but also readily reusable attributed to a gelling-breaking process that can be easily controlled by manipulating CO 2 gas conditions. The viscoelastic behaviors of this VES fluid were investigated through rheological measurements under ambient and elevated temperature and pressure. The fluid-rock interaction was studied in core flooding tests. Results showed a good CO 2 -responsiveness, switchable viscoelastic performance, high shear tolerance, thermal stability, good salinity tolerance , and low core damage of the fluid. The switchable rheological behavior implies this fracturing fluid can readily be reused. It is expected that this fluid finds applications not only in enhanced oil and gas recovery, but also in other areas such as CO 2 sequestration reservoir leakage sealing.
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