MATERIALS RESEARCH BULLETIN
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2022
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IF 5.6
Min Yang,Yujia Yan,Enzhou Liu,Qian Sun,Jun Fan
In recent years, all-inorganic perovskite has been extensively studied due to its excellent photoelectric properties, but the application of Cs n PbBr 2+ n perovskite with excellent stability in the field of chemical sensing has yet to be developed. Herein, Cs 4 PbBr 6 /CsPbBr 3 with good stability was successfully prepared by controlling the synthesis temperature to 100 ° C. The fluorescence intensity of Cs 4 PbBr 6 /CsPbBr 3 exhibited 2,4-dinitriphenylhydrazine (DNPH) concentration-dependent characteristics and could be used for sensing DNPH based on the dynamic quenching process triggered by the collision between Cs 4 PbBr 6 /CsPbBr 3 and DNPH. A good linear model was established based on the detection signal and DNPH concentration in the range of 0.05∼30 mg/L and the detection limit was 0.033 mg/L. This method was applied to detect DNPH in soil and tap water samples with satisfactory results obtained. Therefore, this research broadens the application of Cs n PbBr 2+ n in the field of quantitative detection and is expected to be developed into a fluorescent sensor for the detection of hydrazine substances.
研究领域:
分析化学
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材料科学
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环境监测
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传感器技术
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光电子学
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JOURNAL OF CONTROLLED RELEASE
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2026
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IF 11.5
Dingfu Wang,Dan Li,Xiaolin Liu,Shixin Wang,Yile Fan,Ling Lu,Chuanbin Shen,Chunxia Li
Thrombosis remains a leading cause of cardiovascular and cerebrovascular mortality worldwide. Plasminogen activators, notably urokinase and alteplase, have been established as standard thrombolytic agents in clinical practice. However, their therapeutic potential is severely compromised by rapid metabolic clearance, non-specific biodistribution, and associated hemorrhagic complications. Here, we designed a dual-functional nano drug delivery platform that leverages P-selectin overexpression on activated platelets and the characteristic hypoxic microenvironment at thrombotic sites for precision thrombolytic intervention. Specifically, we developed a hypoxia-responsive block (PAC) by conjugating polyguluronate sulfate (PGS, P-selectin targeting motif) with azobenzene-modified cholesterol, enabling urokinase encapsulation within PAC@UK liposomes. Under hypoxic conditions that mimic the thrombotic microenvironment, the reductive cleavage of azobenzene moieties initiated sustained urokinase release (96.41% cumulative release), while maintaining exceptional biocompatibility and demonstrating preferential targeting of activated platelets. Comprehensive in vivo validation across zebrafish, murine mesenteric, and carotid artery thrombosis models revealed markedly enhanced thrombolytic efficacy compared to free UK. This biomimetic nanoplatform represents a paradigm shift toward intelligent, site-specific thrombolytic intervention, offering substantial clinical promise for safer and more effective treatment of thrombotic disorders.
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Journal of Water Process Engineering
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2026
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IF 6.7
Tianyuan Xu,Nanxi Zhu,Ruina Yuan,Yaowen Xing,Xiahui Gui
Carbon-driven persulfate (PS) activation is promising for antibiotic degradation, but conventional carbon catalysts often require thermal/acid-base modification or metal doping, suffering from low yields and high costs. Herein, we innovatively employed unmodified low-rank coals from Shengdong (LC SD ) and Sujiagou (LC SJG ) as cost-effective PS activators for sulfamethazine (SMZ) degradation. Characterizations including Raman, 13 C nuclear magnetic resonance, and electron paramagnetic resonance (EPR) revealed distinct structural-chemical features. LC SJG had more structural defects, –OH, and –COOH groups, while LC SD showed higher persistent free radical and C O group concentrations. LC SJG exhibited superior performance (99.3 % SMZ removal in 120 min) versus LC SD (84.2 %) and good tolerance to coexisting ions, indicating practical application potential. Possible degradation pathways of SMZ, as revealed by high-performance liquid chromatography-mass spectrometry, were proposed involving sulfonamide cleavage and pyrimidine ring opening. Mechanistic investigations via EPR, radical quenching, and electrochemical analysis revealed that 1 O 2 dominated SMZ degradation (59.3 %) in the LC SD /PS system via C O groups. Conversely, • OH and SO 4 •− contributed 62.7 % to degradation in the LC SJG /PS system through structural defects and –COOH groups. Overall, this study provides a novel strategy for developing low-cost, high-performance PS activators tailored for wastewater treatment.
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JOURNAL OF HAZARDOUS MATERIALS
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2022
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IF 14.224
Lei Yang,Zifei Wei,Zihan Guo,Mengfang Chen,Jingchun Yan,Linbo Qian,Lu Han,Jing Li,Mingyue Gu
CoFe 2 O 4 /hydrochar composites (FeCo@HC) were synthesized via a facile one-step hydrothermal method and utilized to activate peroxymonosulfate (PMS) for simultaneous degradation of monochlorobenzene (MCB) and p-chloroaniline (PCA). Additionally, the effects of humic acid , Cl - , HCO 3 - , H 2 PO 4 -, HPO 4 2- and water matrices were investigated and degradation pathways of MCB and PCA were proposed. The removal efficiencies of MCB and PCA were higher in FeCo@HC140–10/PMS system obtained under hydrothermal temperature of 140 °C than FeCo@HC180–10/PMS and FeCo@HC220–10/PMS systems obtained under higher temperatures. Radical species (i.e., SO 4 • - , •OH) and nonradical pathways (i.e., 1 O 2 , Fe (IV)/Co (IV) and electron transfer through surface FeCo@HC140–10/PMS* complex) co-occurred in the FeCo@HC140–10/PMS system, while radical and nonradical pathways were dominant in degrading MCB and PCA respectively. The surface functional groups (i.e., C-OH and C O) and Fe/Co redox cycles played crucial roles in the PMS activation . MCB degradation was significantly inhibited in the mixed MCB/PCA solution over that in the single MCB solution, whereas PCA degradation was slightly promoted in the mixed MCB/PCA solution. These findings are significant for the provision of a low-cost and environmentally-benign synthesis of bimetal-hydrochar composites and more detailed understanding of the related mechanisms on PMS activation for simultaneous removal of the mixed contaminants in groundwater.
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高影响因子
Foods
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2022
·Vol. 11
·期 9
·1176
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IF 5.561
Wenjie Wang,Zhiwen Zhang,Xiaoying Liu,Xiaoji Cao,Lianzhu Wang,Yuting Ding,Xuxia Zhou
Malondialdehyde (MDA) is one of the representative end products under lipid peroxidation, indicating the degree of lipid oxidation in foods. However, compounds in pickled products, especially the nitrite in salted lean pork can react with MDA under the acidic condition, leads to the loss of MDA and an underestimation on lipid oxidation through the conventional assay. In this study, the quantification for MDA in the sample containing sodium nitrite were found lacking accuracy by the thiobarbituric acid (TBA) assay and chromatography assay based on alkaline hydrolysis as the reaction between them were difficult to be completely inhibited. Among other trials, the improvement GC-MS analysis utilizing deuterium substituted MDA (MDA-d2) as an internal standard and applying perfluorophenylhydrazine (PFPH) as a derivative reagent can reduce the deviations from the presence of nitrite in the salted lean pork meat and the recovery is between 93.9% and 98.4% and coefficient of variation for the intermediate precision is between 1.1 and 3.5% using the method. The advanced gas chromatograph mass spectrometer (GC-MS) assay also has a very low detection limit (0.25 ng/mL) with both hydrolysis types.Keywords:malondialdehyde;lipid peroxidation;pickled products;nitrite;GC-MS
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BIOMEDICINE & PHARMACOTHERAPY
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2022
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IF 7.419
Yule Wang,Huimin Wu,Hongda Sheng,Yingchao Wang,Xuecai Li,Yi Wang,Lu Zhao
Ischemic stroke is a leading cause of death worldwide, and it remains an urgent task to develop novel and alternative therapeutic strategies for the disease. We previously reported the positive effects of Guhong injection (GHI), composed of safflower extract and aceglutamide, in promoting functional recovery in ischemic stroke mice. However, the active substances and pharmacological mechanism of GHI is still elusive. Aiming to identify the active anti-stroke components in GHI, here we conducted a multi-phenotypic screening in zebrafish models of phenylhydrazine-induced thrombosis and ponatinib-induced cerebral ischemia. Peripheral and cerebral blood flow was quantified endogenously in erythrocytes fluorescence-labeled thrombosis fish, and baicalein and rutin were identified as major anti-thrombotic substances in GHI. Moreover, using a high-throughput video-tracking system, the effects of locomotion promotion of GHI and its main compounds were analyzed in cerebral ischemia model. Chlorogenic acid and gallic acid showed significant effects in preventing locomotor dyfunctions. Finally, GHI treatment greatly decreased the expression levels of coagulation factors F7 and F2, NF-κB and its mediated proinflammatory cytokines in the fish models. Molecular docking suggested strong affinities between baicalein and F7, and between active substances (baicalein, chlorogenic acid, gallic acid, and rutin) and NF-κB p65. In summary, our findings established a novel drug discovery method based on multi-phenotypic screening of zebrafish, provided endogenous evidences of GHI in preventing thrombus formation and promoting behavioral recovery after cerebral ischemia, and identified baicalein, rutin, chlorogenic acid, and gallic acid as active compounds in the management of ischemic stroke.
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WATER RESEARCH
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2021
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IF 11.236
Chenying Zhou,Peng Zhou,Minglu Sun,Yang Liu,Heng Zhang,Zhaokun Xiong,Juan Liang,Xiaoguang Duan,Bo Lai
The sluggish kinetics of Fe(II) recovery strongly impedes the scientific progress of Fenton reaction (Fe(II)/H 2 O 2 ) towards practical application. Here, we propose a novel mechanism that metal-free nitrogen-doped carbon nanotubes (NCNT) can enhance Fenton chemistry with H 2 O 2 as electron donors by elevating the oxidation potential of Fe(III). NCNT remarkably promotes the circulation of Fe(III)/Fe(II) to produce hydroxyl radical ( • OH) with excellent stability for multiple usages (more than 10 cycles) in the NCNT/Fe(III)/H 2 O 2 system. Although carbonyl on NCNT can act as the electron supplier for Fe(III) reduction, the behavior of NCNT is distinct from common reductants such as hydroxylamine and boron. Electrochemical analysis and density functional theory calculation unveil that nitrogen sites of NCNT can weakly bind with Fe(III) to elevate the oxidation potential of Fe(III) (named near-free Fe(III), primarily FeOH 2+ ) at pH ranging from 2.0 to 4.0. Without inputs of external stimulations or electron sacrificers, near-free Fe(III) can promote H 2 O 2 induced reduction of Fe(III) to initiate Fenton chain reactions for long-lasting generation of • OH. To our delight, it is a common property of N-doped carbon materials (e.g., graphene, carbon nanofibers, and acetylene black), our research thus provides a novel, sustainable, and green strategy for promoting Fenton chemistry.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2021
·
IF 8.128
Bo Kong,Tong Yang,Feng Cheng,Yan Qian,Chunmei Li,Lei Zhan,Yuanfang Li,Hongyan Zou,Chengzhi Huang
Aberrant reactive oxygen species (ROS) generation is one of the crucial mediators in the pathogenesis of inflammation. So, the development of nanocatalytic medicine to catalyze the ROS-scavenging reactions in pathological regions are promising for anti-inflammatory therapy. Herein, a type of biocompatible metal free carbon dots is prepared via a hydrothermal method which can exhibit peroxidase (POD)-like, catalase (CAT)-like and superoxide dismutase (SOD)-like activities. It has been found that the carbon dots have the capability to efficiently deplete the excessive ROS such as peroxide (H 2 O 2 ) , superoxide anion (O 2 − ) and hydroxyl radical ( OH) for their abundant functional groups. After the tail injection in mice with liver inflammation induced by lipopolysaccharide, the carbon dots efficiently reduced the excessive production of ROS and proinflammatory cytokines in vitro . Both in vitro and in vivo results endowed the biocompatible carbon dots with great potential in nanocatalytic medicine for the treatment of disease.
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Greenhouse Gases-Science and Technology
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2021
·Vol. 11
·期 5
·974-987
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IF 2.013
Shunji Kang,Zhi Shen,Xizhou Shen,Liuya Fang,Li Xiang,Wenze Yang
The carbon dioxide discharged from fossil fuels combustion products is considered as a major contributor to global warming. The current investigation aimed at CO 2 desorption kinetics in 3.25 mol L –1 methyldiethanolamine (MDEA)–0.1 mol L –1 piperazine (PZ) rich amine aqueous solution with thermo-gravimetric analysis (TGA) method under different heating rates of 2.5, 5, 10, and 20 °C min –1 . The kinetics parameters were determined by comparison of 40 mechanism functions with thermal analysis kinetic method. The average activation energy E was 59.16 kJ mol –1 , preexponential factor A was 5.54 × 10 8 , and the most probable mechanism function was G( α ) = [–ln(1 – α )] 3/2 . In addition, the kinetic parameters of CO 2 desorption process from three rich amine aqueous solutions (MDEA, MDEA + diethanolamine(DEA), MDEA + PZ) were compared and the influence of kinetic parameters was further discussed. The desorption rate models of three rich amine aqueous solutions were established and desorption rates were well predicted. The order of desorption rate inferred from desorption rate model was MDEA > MDEA + DEA > MDEA + PZ. The results indicated that TGA combined with thermal analysis kinetics was an effective and quick method with high accuracy, easy operation, and good repeatability for screening absorbents preliminarily in laboratory. © 2021 Society of Chemical Industry and John Wiley & Sons, Ltd.
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PHYTOMEDICINE
·
2021
·
IF 5.34
Li-Wei Wang,Xue-Ying Cui,Jiang-Feng He,Shen Duan,Chun-Rui Liu,Cheng-Bin Shan,Yu Wang,Chao-Mei Ma
Background Hydroxysafflor yellow A (HSYA) from the flower of Carthamus tinctorius (Safflower) has been reported to have various pharmacological effects. However, little is known about the bioactivities of other chemical constituents in Safflower and the relationship between enhancement of blood circulation and hepatoprotection by HSYA. Purpose The present research was to evaluate the antithrombotic and hepatoprotective activities of HSYA and C, examine their mechanisms of actions, including influence on the excretion velocity of acetaminophen, and the relationship between the antithrombotic, hepatoprotective, and other bioactivities. Methods The hepatoprotective activities were examined by acetaminophen (APAP)-induced zebrafish toxicity and carbon tetrachloride (CCl 4 )-induced mouse liver injury. The concentrations of APAP in zebrafish and APAP that was excreted to the culture media were quantified by UHPLC-MS. The anti-thrombosis effect of HSYA and C were examined by the phenylhydrazine (PHZ)-induced zebrafish thrombosis. Results HSYA and HSYC showed robust protection on APAP-induced toxicity and PHZ-induced thrombosis. The hepatoprotective effects of HSYA and C were more potent than that of the positive control, acetylcysteine (61.7% and 58.0%, respectively, vs. 56.9% at 100 µM) and their antithrombosis effects were more robust than aspirin (95.1% and 86.2% vs. 52.7% at 100 µM). HSYA and C enhanced blood circulation, rescued APAP-treated zebrafish from morphological abnormalities, and mitigated APAP-induced toxicity in liver development in liver-specific RFP-expressing transgenic zebrafish. HSYC attenuated CCl 4 -induced mouse liver injury and regulated the levels of HIF-1α, iNOS, TNF-α, α-SMA, and NFκB in liver tissues. HSYA was also protective in a dual thrombotic and liver toxicity zebrafish model. By UHPLC-MS, HSYA accelerated the excretion of APAP. Conclusion HSYA and C are the bioactive constituents of Safflower that are responsible for the herbal drug's traditional use in promoting blood circulation to remove blood stasis. Safflower and its chalcone constituents may protect from damage due to exogenous or disease-induced endogenous toxins by enhancing the excretion velocity of toxins.
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JOURNAL OF SEPARATION SCIENCE
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2021
·Vol. 44
·期 7
·1552-1563
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IF 3.645
Rui-Jia Fu,Wen-Xiao Wang,Hui-Juan Tao,Mei Wang,Yan-Yan Chen,Huan Gao,Shi-Jun Yue,Yu-Ping Tang
Danqi tablet composed of the dried roots of Salvia miltiorrhiza and Panax notoginseng is a well-known Chinese patent medicine commonly used for the treatment of cardio-cerebrovascular diseases such as coronary heart disease and myocardial ischemia. Numerous chemical constituents belonging to S. miltiorrhiza and P. notoginseng were detectable in Danqi tablet. Here, we established and validated a rapid and sensitive ultra-performance liquid chromatography coupled with triple quadrupole mass spectrometry method for simultaneous quantification of 23 components in Danqi tablet and then successfully applied to assay 12 batches of samples from ten manufacturers. Our results demonstrated that the contents of 23 components in 12 batches of Danqi tablets varied significantly and their quality indeed existed differently based on the principal component analysis. According to the quantitative data and the loading plot of principal component analysis, five abundant compounds in Danqi tablet were selected as characteristic chemical markers possibly responsible for the quality assessment. Among them, salvianolic acid B and ginsenoside Rg 1 were further chosen to be combined at 2:5 ratio to evaluate the anti-thrombotic activity on phenylhydrazine-induced zebrafish heart thrombosis model. Expectedly, this component combination increased the heart red blood cells intensity compared with the model group and the median effective concentration was 123.4 µg/mL, suggestive of its well anti‑thrombotic effect. This study contributed to the quantitative evaluation of Danqi tablet and indicated the combination of salvianolic acid B and ginsenoside Rg 1 may be capable of reflecting the effect of Danqi tablet, thereby providing a reference for further investigations on the improvement of quality control and clinical application of Danqi tablet.
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Analytical Methods
·
2020
·Vol. 12
·期 6
·813-821
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IF 2.596
Junbo Liu,Wensi Zhao,Guangyu Wang,Shanshan Tang,Ruifa Jin
Using the density functional theory M062X/6-31G(d,p) method, a molecularly imprinted self-assembly system has been simulated with phenobarbital (PHN) as the imprinted molecule and 4-vinyl pyridine (4-VPY), acrylamide (AM), methacrylic acid (MAA), and itaconic acid (IA) as the functional monomers. The steric configuration, key cooperation binding site, imprinted ratio, and binding energy of the complex have been investigated to obtain the optimal functional monomer. The cross-linking agent was optimized by calculating its binding energy with PHN and IA. The theory of atoms in molecules was used to predict the molecular diagram and Laplace quantity contour map of the stable PHN–IA complex. The imprinting nature between PHN and IA was also discussed. Meanwhile, the selectivity property of PHN–IA stable complex was studied via barbiturate (BAR) and barbiturate acid (BA) as structural analogues. The results showed that, among the four functional monomers, IA is most suitable to form the complex with PHN through hydrogen bond interaction. When the molar ratio between PHN and IA was 1 : 7 and TRIM was the cross-linking agent, the formed complex had the lowest energy and best selectivity to PHN. The maximum apparent adsorption of PHN molecular imprinted polymer (PHN-MIPs) was 16.02 mg g−1 and the maximum dissociation equilibrium constant was 94.97 mg L−1. The selective identification of PHN-MIPs for PHN is higher than for BAR.
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危险品化学品经营许可证（带存储）