INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Huayong Luo,Xueyang Zeng,Peng Liao,Hongwei Rong,Tian C. Zhang,Z. Jason Zhang,Xiangchao Meng
Currently, there is a growing trend in employing natural biomaterials (e.g., alginate) to prepare a novel bead adsorbent for phosphorus (P) elimination. However, the utilization of alginate beads to remove and recover P from effluents possesses limitations associated with its physical characteristics such as a dense gel layer, poor mechanical strength and low stability. To overcome the limitations and improve the adsorption performances, we synthesized a novel alginate-derived bead constituted of PNIPAM network interpenetrated in alginate-Zr 4+ network (PNIPAM/SA-Zr) decorated with polyethylene glycol as a pore-forming agent, and then investigated its ability to remove and recover P from effluents. The morphology, functional groups, surface area, and mechanical strength of the beads were evaluated by SEM, FTIR , BET, and swelling analysis. The adsorption of P was investigated by varying various factors. The adsorption kinetics , isotherms, and thermodynamics were studied. Particularly, the P-loaded beads exhibited a faster desorption rate under thermal stimulus, and remained good desorption efficiency and reusability within five consecutive cycles. Zeta-potential and XPS results revealed that the adsorption mechanisms were related to electrostatic interactions, ligand exchange, and the formation of inner-sphere complexes. The beads possessed favorable fixed-bed column operation performances for P removal and recovery from real wastewater.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
·
2013
·Vol. 102
·期 7
·2408-2416
·
IF 2.834
Li Chen,Ying Zhang,Shen Li,Xiuli Wang,Na Li,Yu Wang,Xin Guo,Shan Zhao,Weiting Yu,Guangwei Sun,Yang Liu,Xiaojun Ma
Immobilization of hepatocytes in microcapsules has been a potentially alternative methodology for bioartificial livers (BALs). Moreover, the stability and permeability are the key parameters of these microcapsules. However, these alginate-based microcapsules are unstable if the surrounding medium disrupts the ionic interactions between alginate and the polycation. As hundreds of components are included in human plasma, the stability and permeability in plasma of microcapsules need to be sufficiently investigated. In the present study, the stability of three kinds of alginate-based microcapsules was evaluated when they were immersed in plasma. Our results showed that stability of alginate-α-poly ( l -lysine)-alginate (α-APA) microcapsules was well maintained, better than those of alginate-ε-poly ( l -lysine)-alginate (ε-APA) and alginate–chitosan–alginate (ACA) microcapsules. Also, factors affecting the stability of microcapsules in plasma were analyzed and it showed that heparin was the key factor that affected the stability of α-APA microcapsules, whereas heparin and low molecular electrolytes such as HCO 3 − and H 2 PO 4 − /HPO 4 2− were the factors to ε-APA and ACA microcapsules. In addition, the permeability evaluation showed no decrease in permeability of microcapsules after incubation in plasma. Our study might provide a foundation for the selection and modification of materials for microcapsule-based BAL devices. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2408–2416, 2014.
研究领域:
生物材料
·
组织工程
·
再生医学
·
肝病学
·
药物递送系统
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2018
·
IF 2.829
Rongli Zhang,Jingjing Lv,Cuige Zhang,Renchun Yang,Xingchen Sun,Bo Song,Ching-Ping Wong
A new kind of dopamine modified alginate colloid particles (DA-ALG CPs) was prepared via the direct chemical self-assembly triggered by the amidation reaction between dopamine and alginate in aqueous solution. The structure and morphology of the DA-ALG CPs were characterized by infrared spectroscopy , Zeta PALS and scanning electron microscope . The prepared DA-ALG CPs were then used as particulate emulsifier to prepare Pickering emulsions . The properties of the emulsion were characterized by optical microscope . The results revealed that the prepared DA-ALG CPs exhibited good emulsifying property at a wide pH value range, which will endow the potential application of the Pickering emulsions stabilized by DA-ALG CPs in food and biological medicine fields.
研究领域:
高分子材料学
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胶体与界面化学
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食品科学
·
生物医学工程
·
药物递送
·
纳米医学
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Lei Du,Amin GhavamiNejad,Zhi-Chao Yan,Chandra Sekhar Biswas,Florian J. Stadler
Here, we report on the effect of functional copolymer poly(N-isopropylacrylamide-co-4-vinyl-phenylboronic acid) (NIBA) on the rheology and network structure formed by sodium alginate (SA) through linear and nonlinear viscoelasticity measurements. The hydrogel moduli at pH 3 increased with increasing NIBA addition, while the yield point decreased. Furthermore, these hydrogels showed strain-softening behavior, weak G″-overshoot marking the onset of nonlinearity, and good self-healing properties after large deformation. The zero-strain nonlinearity parameter (Q 0 ) was found to be more sensitive to NIBA-addition than the linear viscoelastic properties. The blends showed a clear peak in the startup test except for SA alone and the peak intensity increased with increasing NIBA-concentration. Finally, based on all data, gelation mechanism and interaction of SA and NIBA will be clarified.
研究领域:
高分子材料科学
·
生物医学工程
·
软物质物理
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药剂学
·
组织工程
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Yurou Feng,Amatjan Sawut,Rena Simayi,Xieraili Maimaitiyiming,Xueying Jiao
With the advancement of science and technology, the issue of wastewater pollution has escalated, necessitating urgent attention to wastewater treatment . In this study, a highly efficient adsorbent for Cu 2+ was successfully synthesized through in situ self-assembly using Ca 2+ as the cross-linking agent in ZIF-8@ALG composite hydrogel. The results demonstrated that the incorporation of Ca 2+ as the cross-linker enhanced both adsorption capacity and swelling properties of ZIF-8@ALG composite hydrogel. Adsorption performance evaluation revealed that the hydrogel followed pseudo-second-order kinetic model for Cu 2+ adsorption and Freundlich isotherm model with a theoretical maximum adsorption capacity of 309.57 m g −1 . Thermodynamic analysis indicated that Cu 2+ adsorption onto the hydrogel occurred spontaneously with heat absorption. Furthermore, excellent reusability was observed after five cycles of usage without significant loss in adsorption efficiency. Overall, these findings highlight the potential application of ZIF-8@ALG composite hydrogel as an effective solution for wastewater remediation and recovery of heavy metal ions.
研究领域:
环境科学
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材料科学
·
化学工程
·
环境污染治理
·
重金属去除
✓ 已验证
DOI
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 65
·37417-37423
·
IF 2.936
Jihui Li,Kang Sun,Changyu Leng,Jianchun Jiang
Reasonable structure design and component selection are crucial to electrochemical performance of supercapacitor electrode materials. Sodium alginate (SA), with a novel structure which can immobilize multivalent metal cations, was used to coordinate with Fe3+ to fabricate a carbon and Fe3O4 composite by an easy sol–gel method. Due to the chelation effect between SA and Fe3+, the carbon composite was constructed into a two-dimensional sheet-like structure, and the Fe3O4 particles were nanosize and homogenously distributed on the surface of the carbon nanosheet. As an electrode material for supercapacitors, the composite electrode showed a high specific capacitance of 550 F g−1 at 1 A g−1 in the potential range from −1.1 to 0 V, and excellent cycling stability of 89% retention after 2000 cycles. The enhanced electrochemical performance could be attributed to the abundant exposed active sites, producing high pseudocapacitance, to the two-dimensional nanosheet structure, facilitating electrolyte transport and to the strong attachment strength, improving cycle life. This environmentally-friendly design can provide an alternative to existing methods, resulting in the development of a two-dimensional carbon/metal oxide composite for energy storage devices.
研究领域:
材料科学
·
电化学
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纳米科技
·
能源存储
·
功能材料
✓ 已验证
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2020
·
IF 5.88
Gang Tao,Rui Cai,Yejing Wang,Hua Zuo,Huawei He
Hydrogel-based wound dressings are ideal materials as they could provide a moist environment to promote wound healing. Silk sericin is a natural macromolecular protein produced by silkworms and has positive effects on fibroblasts and keratinocytes. Sodium alginate is a natural polysaccharide known as a mouldable matrix. To develop novel hydrogel wound dressings, sodium alginate was functionalized with silk sericin to yield an injectable and mouldable semi-interpenetrating network hydrogel (SA/Se) using calcium ions as the crosslinking agents. Meanwhile, silver nanoparticles (AgNPs) were synthesized in situ by the phenolic hydroxyl group of tyrosine in sericin to enhance the antibacterial activity of the hybrid hydrogel. UV–visible spectroscopy, fluorescence spectroscopy, transmission electron microscope, X-ray photoelectron spectroscopy and energy dispersive spectroscopy demonstrated the successful synthesis of AgNPs with average size of 15.7 nm in SA/Se-Ag0.2. Field emission scanning electron microscopy showed the macroporous structure of the hydrogel. The hybrid hydrogel had a swelling ratio of 32 and more than 5% of retention ratio after 50 h. It exhibited effective antibacterial activity through irreversibly disrupting bacterial membrane structure to result in bacterial lysis and death. Cell counting kit-8 assay suggested the hybrid hydrogel was highly cytocompatible. The animal experiment showed the wound contraction ratio in SA/Se-Ag0.2 group was 99% after 12 days, indicating it can effectively promote wound healing. This novel hydrogel is promising for wound healing and tissue engineering.
研究领域:
生物材料
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组织工程
·
再生医学
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创伤修复
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纳米医学
·
生物医学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2017
·Vol. 28
·期 5
·67
·
IF 2.325
Li Wenyan,Huo Mengmeng,Sen Chaudhuri Arka,Yang Chen,Cao Dazhong,Wu Zhenghong,Qi Xiaole
Currently, polysaccharide-based hydrogels are widely studied macromolecular networks to modify drug dissolution from controlled-releasing matrix tablets. Among them, polyelectrolyte complexes (PEC) films consisted of chitosan (CS) and sodium alginate (SA) could be obtained via spontaneously assembling under physiological gastrointestinal environment. Here, we utilized these self-assembled PEC films as an efficient coating materials to develop controlled-released matrix tablets through compression coating process, with paracetamol (APAP) as model drug. The constitutive and morphology characteristic studies on these PEC films illustrated that the mixture of CS and SA with the weight ratio of 1:1 would be an promising outer layer for compression-coating tablets. In addition, the in vitro drug releasing behavior experiments demonstrated that the optimized compression coating tablets displayed satisfied zero-order drug releasing profits. Furthermore, the in vivo pharmacokinetic studies of these APAP loaded compression-coated tablets in New Zealand rabbits gave that the T max (12.32 ± 1.05 h) was significantly prolonged ( p < 0.01), compared to that (0.89 ± 0.26 h) of common APAP tablets (Jinfuning ® ) after oral administration. These studies suggest that the compression-coated tablets with self-assembled PEC film as coating outer layer may be a promising strategy for peroral controlled release delivery system of water soluble drugs. Graphical
研究领域:
药剂学
·
生物材料
·
药物递送系统
·
药代动力学
·
胃肠药理学
✓ 已验证
DOI
高影响因子
POLYMER
·
2019
·
IF 3.771
Zongqian Wang,Haiwei Yang,Zun Zhu
Tremendous attention has been paid to the structure and properties of silk fibroin/sodium alginate (SF/SA) composite films . However, there is no report devoted to study the formation of hydrogen bonds and their effects on the structures and properties. Herein, SF/SA blends with different mass ratios were obtained and the technic of Gaussian multi-peaks-fitting of Fourier transform infrared spectrum (FTIR) was used to analyze their hydrogen bonds. From the results, the existence of the intermolecular and intramolecular hydrogen bonds was manifested, and the relative strength of the intermolecular hydrogen bond enhanced with the increase of SA content. The contribution of the intermolecular hydrogen bonding was as follows: OH⋯O (ether) > OH … π > OH⋯N. Meanwhile, the increase of intermolecular hydrogen bonding led to the increase of apparent viscosity of the SF/SA blend solutions. Moreover, the relationship between the hydrogen bond and properties (e.g, crystallinity , thermal stability, mechanical properties, morphology and etc.) of SF/SA composite films with different mass ratios were analyzed in detail.
研究领域:
高分子材料
·
生物材料
·
纤维科学
·
光谱分析
·
材料物理
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS CHEMISTRY
·
2011
·Vol. 21
·期 40
·16028-16034
·
IF 5.101
Jun Shi,Zhengzheng Zhang,Gefei Li,Shaokui Cao
Alginate/CaCO3 hybrid beads with pH- and thermal-responsive drug release properties were prepared under compressed CO2 using aliphatic poly(urethane-amine)s (PU) as the thermal-responsive component. Polyacrylic acid (PAA) was used as a crystal growth additive to control the structure of the hybrid beads. The hybrid beads were characterized by using scanning electron microscopy, X-ray powder diffraction and thermogravimetric analysis. The interaction between PAA and aliphatic PU contributed to the formation of alginate beads with a compact CaCO3 shell. Indomethacin release behaviour was found to be pH- and thermal-responsive. The release profiles were sustained with CaCO3 microparticles, indicating that the compact CaCO3 shell could hinder the permeability of the encapsulated drug and reduce the drug release effectively. The results suggest that the hybrid alginate beads can be used as “smart” polysaccharide materials for sustained dual-responsive drug delivery.
研究领域:
生物材料
·
药物递送系统
·
高分子科学
·
纳米医学
·
药剂学
·
生物化学
·
组织工程
✓ 已验证
DOI
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 66
·38003-38012
·
IF 2.936
Xiuqiong Chen,Huiqiong Yan,Wei Sun,Guangying Chen,Changjiang Yu,Wen Feng,Qiang Lin
To achieve the dispersion of the hydrophobic graphene (GR), the amphiphilic alginate caprylamide (ACA) was synthesized to fabricate electroactive Nafion/Mb–ACA–GR/CILE for the accurate determination of trichloroacetic acid (TCA). SEM observation, FT-IR and UV-Vis spectroscopic analysis indicated that ACA could tightly immobilize Mb and GR on the electrode surface by constructing biointerfaces, which not only provided Mb a suitable microenvironment to maintain its biological activity, but also shortened the distances between the active centers of Mb with carbon ionic liquid electrode (CILE), thus promoting the electron transfer rate. The electrochemical characterization of Nafion/Mb–ACA–GR/CILE showed that the direct electron transfer of Mb was realized on the modified electrode, which was attributed to the high electrical conductivity and excellent electrocatalytic activity of GR and good biocompatibility of ACA. Moreover, Nafion/Mb–ACA–GR/CILE exhibited good electrocatalytic activity towards TCA with the linear range from 2.5 to 47.3 mmol L−1 and lower KMapp value of 8.3 mmol L−1. Moreover, the modified electrode also revealed good stability, reproducibility and accurate detection of tap-water, exhibiting great potential for the applications as the third-generation electrochemical biosensors.
研究领域:
生物医学工程
·
电化学传感
·
纳米生物技术
·
分子生物学
·
分析化学
·
生物传感器
✓ 已验证
DOI
高影响因子
OPTICAL FIBER TECHNOLOGY
·
2013
·Vol. 20
·期 1
·28-31
·
IF 1.187
Jiao-Yang Li,Xu-Guang Huang,Wei Xu,Dong-Rui Xiao,Ze-Bing Zhong
A biocompatible fiber-optic pH sensor based on Fresnel reflection technique and a sensing coating is presented. Sodium alginate and polyethylenimine are alternatively deposited on the sensing fiber end to form the sensing coating via a layer-by-layer electrostatic self-assembly technique. An optical switch is added to the measurement system for the convenience of fast calibration. A linear, monotonic and fast response in a large pH range (from pH 5.87 to pH 10.55) is obtained with the resolution of 0.01 pH unit. The sensitivity of the pH sensor is 0.018 R.I.U/pH. It is not influenced by fluctuations of light source.
研究领域:
生物医学工程
·
传感技术
·
分子生物学
·
转化医学
·
生物材料
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）