Chemistry-Switzerland
·
2025
·Vol. 7
·期 6
·173
·
IF 2.4
Yi Wang,Fuqiong Wang,Xiaoyang Zhao,Zhipeng Zhang,Yue Huang,Hua Zheng,Xiaohong Cheng,Xinrui Miao
4,6-Diamino-1,3,5-triazine (DT) derivatives typically exhibit excellent liquid crystal properties, attracting numerous researchers interested in enhancing their performance. In this paper, two DT molecules (DT−10 and DT−12) are employed to elucidate the effects of their backbone length and number of branches in the tail chains on self-assembled nanostructures using scanning tunneling microscopy (STM) at the 1-octanoic acid/highly ordered pyrolytic graphite interface, compared to our previous report (2TDT−n,n= 10,12,16,18). DT−10 features a short backbone and a trialkoxy chain tail, whereas DT−12 possesses a long backbone and bifurcated chain tails. STM results reveal that DT−10 assembles into a cross-shaped nanostructure with DT head groups arranged in a head-to-head configuration stabilized by a pair of N–H···N hydrogen bindings (HBs). In contrast, DT−12 assembles into a two-row linear pattern, where DT head groups exhibit a side-by-side arrangement mediated by a pair of N–H···N HBs. Comparison with our previous findings indicates that although variations in backbone length and tail chain branching can modulate the nanostructural features of DT derivatives, the chain length of DT molecules emerges as a pivotal factor governing their assembly architecture.
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DALTON TRANSACTIONS
·
2025
·
IF 3.3
Yuan Xu,Ya-Tao Hu,Jiaping Cao,Dixin Lin,Qiqi Zhong,Yi Wang,Hongdong Shi,Qianling Zhang
To address the challenges associated with low cellular uptake efficiency of metal-based anticancer agents and the suboptimal therapeutic efficacy of photodynamic therapy (PDT), a series of polypyridyl ruthenium(II) complexes (Ru Cn) with tunable carbon chain lengths were rationally designed and synthesized through the incorporation of fatty acid moieties, which confer enhanced lipid solubility and membrane-targeting capabilities. Among these, the octadecanoic acid-modified ruthenium complex (Ru-C18) exhibited superior anticancer activity. Cytotoxicity assays demonstrated that Ru-C18 displayed sub-molar cytotoxic potency under light irradiation. Co-localization studies confirmed its preferential accumulation in lysosomes after cellular internalization. Upon light activation, Ru-C18 efficiently generated singlet oxygen and induced hallmark features of pyroptosis, including plasma membrane blebbing, cellular swelling, and Gasdermin-dependent membrane pore formation. Consequently, Ru-C18 significantly suppressed tumor cell proliferation via activation of the pyroptotic pathway. These findings offer new insights into the rational design of highly effective and selectively targeted photodynamic anticancer agents.
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PubMed
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Dongting Huang,Huixin You,Lirong Chen,Yongjing Liu,Hua Li
This study extends the development of a Graphene oxide@Zirconium-based metal-organic framework@Deep eutectic solvents (GO@MOF-808@DESs) through hydrothermal self-assembly using zirconium chloride and 1,3,5-benzenetricarboxylic acid (H 3 BTC), subsequently functionalized with four carbon-tailored fatty acid-based deep eutectic solvents (DESs) via ultrasonic impregnation. Comprehensive characterization of GO@MOF-808@DES confirmed the successful surface modification via DES. A dispersive micro-solid phase extraction(D-μSPE) method was established employing GO@MOF-808@DESs as an adsorbent for efficient removal of residual entacapone (ETCP) and tolcapone (TCP) from water. Optimization of the D-μSPE method revealed optimal conditions at pH 9.0, with a sample volume of 40 mL, an adsorbent dosage of 20 mg, and an adsorption time of 60 min. Under these conditions, the method achieved a significant adsorption capacity of 86.50 ± 4.79 mg/g for ETCP and 126.21 ± 2.72 mg/g for TCP. Mechanistic investigation revealed chemically dominated adsorption kinetics through pseudo-second-order modeling and Langmuir isotherm fitting. Concurrently, density functional theory (DFT) studies demonstrated that the synergistic effect between carboxyl-mediated hydrogen bonding and hydrophobic interactions led to enhanced adsorption performance. The engineered GO@MOF-808@DESs based D-μSPE method demonstrated superior performance in removing ETCP and TCP from river water matrices, achieving 99.67 % and 99.24 %, respectively. Meanwhile, a sensitive and reliable method for trace-level monitoring of ETCP and TCP residues in environmental waters was successfully proposed, employing GO@MOF-808@DESs-based D-μSPE coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS). This study presents a robust strategy for fabricating high-performance GO@MOF-808@DESs composite materials, demonstrating significant potential for practical applications.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2025
·
IF 6.6
Wenchao Liu,Yize Yin,Lijuan Wang,Chung Lim Law,Linlin Li,Weiwei Cao,Xu Duan,Guangyue Ren
This study examined how fatty acids of varying chain lengths influence the microwave freeze-drying (MFD) properties and cross-linking interactions in wheat starch-fatty acid complexes. The study revealed that fatty acids with extended carbon chains decreased the initial water content in wheat starch-fatty acid blends, thereby reducing the drying time. Long-chain complexes maintained a more stable freeze-drying rate with changes in experimental power compared to short-chain ones. When microwave power was raised from 0.5 to 2.5 W/g, the enthalpy shifts (ΔH) in melting peaks for starch-fatty acid complexes varied significantly: butyric acid blends showed a change of 176.71 J/g, octanoic acid 714.06 J/g, and myristic acid 1102.02 J/g. XRD revealed reductions in relative crystallinity by 12.87 %, 19.38 %, and 27.00 %. Raman spectroscopy showed peak width increases at 480 cm −1 of 8.22, 8.49, and 10.43, respectively. The extent to which wheat starch-fatty acid complexes were affected during MFD increased with the chain length of the fatty acids.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Qiuting Cai,Xinyang Wang,Yifeng Feng,Guochao Lu,Qingli Cao,Dingshuo Zhang,Yun Gao,Meiyi Zhu,Baodan Zhao,Haiping He,Dawei Di,Zhizhen Ye,Xingliang Dai
One of the challenges associated with implementing amplified spontaneous emission (ASE) is the significant occurrence of Auger recombination, particularly in the quantum-confined blue emitters. It is well known that quantum confinement exacerbates Auger recombination, while there has been limited exploration of the impact of deep-level defects on Auger recombination. A comprehensive understanding of the influence of defects on multi-body recombination is paramount. This study investigates from a mechanistic perspective how defect-mediated Auger recombination suppresses amplified spontaneous emission. Two representative blue-emissive CsPb(Br x Cl 1-x ) 3 nanocrystals with different deep-level defect states were taken as model systems. We employ time-resolved and temperature-dependent optical characterizations to demonstrate that deep-level defects in the perovskite nanocrystals induce charge separation states because of the ultrafast capture of charge carriers. This process leads to the formation of a charged exciton state and contributes to the Auger recombination under confined conditions, thereby significantly increasing the threshold for population inversion. Leveraging the insight, we achieved pure blue ASE with a record low threshold of 25 μJ cm −2 under a lower deep-level defect density condition. The results highlight the critical role of deep-level defects in Auger recombination, becoming imperative insights for advancing high-performance blue ASE.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Kaige Zhang,Yanrong Chen,Jing Wang,Rong Guo,Guifen Zhu
A novel supramolecular deep eutectic solvent based ferrofluid for vortex-assisted liquid-liquid microextraction (SUPRADES-FF-VA-LLME) method was developed firstly for extraction of Alkylphenols (APs) from water and beverage samples. In this method, the SUPRADES composed of hydroxyethyl-β-cyclodextrin, thymol and caprylic acid was firstly designed, synthesized and then used as carrier liquid for ferrofluid. The influencing parameters were screened by a plackett-burman design and optimized by a central composite design. Under optimal conditions, the linear range of 4-heptylphenol, 4-octylphenol and 4-nonylphenol was 0.3–400, 0.2–400 and 5–400 μg L −1 , respectively, with R 2 ≥ 0.9990. And the limit of detection and the quantification of this method were 0.05–1.5 μg L −1 and 0.2–5 μg L −1 , respectively. Both intra-day and inter-day precision ( n = 5) were ≤2.1 %, and the enrichment factor were 22–24. After microextraction, phase separation was quickly completed with the help of an external magnet, without the need of centrifugation equipment, greatly simplifying the operation steps and shortening the extraction time (∼2 min). Additionally, due to the introduction of hydroxyethyl-β-cyclodextrin, the encapsulation effect between its hydrophobic cavity and APs significantly enhances its molecular recognition ability, the method modification resulting in 19–29 % increase in extraction efficiency. Extraction mechanism was also studied by density functional theory. Combined with high performance liquid chromatography-fluorescence, this method was used for determination of APs in environmental water and beverages with spiked recovery of 98.4–102.4 %. The SUPRADES-FF-VA-LLME provides a new technique for the selective separation of pollutants, which is expected to be widely used in the field of food analysis and environmental monitoring.
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INTERNATIONAL JOURNAL OF FOOD PROPERTIES
·
2026
·
IF 3.9
Nian Cao,Yubo Yang,Xiaoling Xiong,Bohan Zhang,Ping Xiang,Fan Yang
This pioneering study investigated the effects of sip volume on sensory perception and drinking comfort during the consumption of Jiangxiangxing Baijiu (JB). Six sip volumes (6, 9, 12, 15, 18, and 20 mL) were tested with 30 participants (15 males and 15 females). Results revealed gender-specific preferences: females tended to prefer sip volumes of 9–12 mL, while males were more likely to favor 18 mL. Using Temporal Dominance of Sensation (TDS) and Check-All-That-Apply (CATA) methods, it was found that oral sensations of sweetness and sauce flavor, as well as post-pharyngeal sensations of “smoothness,” “mellowness,” and “lingering aftertaste,” enhanced drinking comfort. In contrast, oral sensations of spiciness and bitterness, along with post-pharyngeal sensations of “pungency,” “thinness,” “blandness,” and “momentary aftertaste,” impaired comfort. Notably, females may place greater emphasis on oral perception, whereas males could focus more on post-pharyngeal sensations. A novel flavor analysis identified 20 key compounds that influence JB perception. The insights from this research provide valuable contributions to improving the drinking experience of JB.
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Food Bioscience
·
2026
·
IF 5.9
Dancai Fan,Zijia Song,Yaya Wang,Binying Fu,Shijie Li,Shuo Wang
Accurate differentiation between dairy processing technologies such as pasteurization and ultra-high temperature sterilization is crucial for ensuring product quality, protecting consumer rights, and maintaining market order. This study identified antigen structure-sensitive antibodies and developed a high-performance sELISA detection method. By detecting antigenic changes in lactoferrin (LF) during processing, it enables the identification of milk thermal processing conditions. This antibody pair not only exhibits excellent binding affinity for native LF but also possesses processing-dependent recognition ability for heat-treated LF. While mild denaturation at 75°C reduces its recognition efficiency, it promotes the formation of stable lactose-LF complexes, thereby preserving conformation-dependent antigenicity. In contrast, combined high-temperature and pressure processing overrides the protective effect of lactose, rendering sELISA detection ineffective. Based on experimental and molecular docking results, the positive effect of lactose on LF antigenicity during thermal processing provides key support for distinguishing between pasteurization and ultra-high temperature (UHT) processing. Furthermore, validation with real samples confirms that this method can effectively differentiate pasteurized milk from UHT milk/reconstituted milk, offering technical support for industrial quality control and product authenticity verification.
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Food Science & Nutrition
·
2026
·Vol. 14
·期 1
·e71465
·
IF 3.8
Chenxi Zhou,Xiaohua Li,Chungen Xing,Chun Cao
Radiation‐induced intestinal injury (RIII) is a common complication in patients under radiotherapy for abdominopelvic and retroperitoneal malignancies, significantly impairing quality of life and overall survival. However, the therapeutic effect of standard enteral nutrition (EN) is limited. This study aimed to investigate the protective role and potential mechanisms of octanoic acid (OA)‐rich EN in RIII. C3H/HeN mice were randomly assigned to four groups: Sham, Radiation (RI), RI + EN and RI + OA‐rich EN to investigate the impacts of OA‐rich EN. Then mice were randomly assigned to five groups: Sham, RI, RI + OA‐rich EN, RI + OA‐rich EN + Luzindole, RI + OA‐rich EN + EX527 to examine whether OA‐rich EN alleviated RIII through the melatonin‐silent information regulator 1 (SIRT1) pathway. We evaluated the intestinal histopathology, apoptosis, tight junction protein expression and permeability. Moreover, melatonin and inflammatory cytokine levels were measured in the intestine and serum. SIRT1/Peroxisome Proliferator‐Activated Receptor Gamma Coactivator 1‐Alpha (PGC‐1α)/Peroxisome Proliferator‐Activated Receptor Gamma (PPARγ) pathway was also assessed. OA‐rich EN promoted melatonin secretion in the intestine and serum, activated the SIRT1/PGC‐1α/PPARγ pathway, markedly improved intestinal histopathology, and significantly reduced levels of inflammatory factors in intestine and serum. These beneficial effects were greater than EN alone. Furthermore, these beneficial effects were abolished when OA‐rich EN was co‐administered with either a melatonin antagonist or a SIRT1 inhibitor. This is the first confirmation that OA‐rich EN alleviated RIII by promoting melatonin secretion, which in turn activated the SIRT1/PGC‐1α/PPARγ pathway. Our findings highlight OA‐rich EN as a promising nutritional strategy to improve intestinal health and reduce treatment‐related complications in patients receiving abdominal radiotherapy. OA‐rich EN conferred superior intestinal protection compared with standard EN, achieving this through nutrient‐hormone interaction: by upregulating endogenous melatonin levels, activating the SIRT1/PGC‐1α/PPARγ pathway, thereby suppressing intestinal inflammation, enhancing the intestinal mucosal barrier function, and reducing epithelial cell apoptosis.
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JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 9
Dai Shi,Shan Luo,Jiamei Sun,Shunwen Xiao,Xianyu Sun,Yanyue Qu,Ruiyuan Zeng,Meijie Wang,Ran Chen,Youqing Tian,Yumeng Zhao,Beili Lu,Lirong Tang,Biao Huang,Hanyang Liu,Xinda You
Ionic covalent organic framework (iCOF) membranes are promising for nanofiltration, yet combining high charge density with confined pore size remains challenging because strong electrostatic repulsion disrupts ordered stacking and generates structural defects. Here, we propose a “moderately charged–highly charged–moderately charged” strategy to construct sandwich-like COF membranes (SCOFMs). By layer-by-layer assembly of TpPa-SO 3 H and TpPa-2SO 3 H nanosheets, SCOFMs with enhanced chargeability and narrowed nanopores are obtained. Increasing the outer-to-inner layer ratio from 10:0 to 7:3 raises the membrane surface charge density from −1.51 to −1.84 mC m −2 and reduces the pore diameter from 0.95 to 0.68 nm. This improvement originates from the higher chargeability and smaller pore size of TpPa-2SO 3 H, while the sandwich structure mitigates interlayer repulsion and promotes dense stacking. The synergistic Donnan exclusion and size-sieving endow SCOFM (7:3) with high rejection of 96.4 % for Na 2 SO 4 , 97.2 % for MgSO 4 , 84.4 % for NaCl, and >99 % for various antibiotics. Benefiting from this architecture, it also maintains Na 2 SO 4 rejection larger than 91 % and stable water permeance for over 50 days. This approach simultaneously narrows nanopores and enhances the membrane surface charge density, offering a promising route for high-performance nanofiltration membranes.
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Sustainable Chemistry and Pharmacy
·
2026
·
IF 5.8
Jin-Yue Dong,Rong-Jie Wang,Qing Ran,Xiao-Bei Yang,Wen-Chao Han,Feng-Qi Dong,Di Chen
A novel microextraction method based on switchable natural deep eutectic solvents (SNADES) was developed for the determination of illicitly added non-steroidal anti-inflammatory drugs (NSAIDs) in herbal extracts, enabling one-step phase separation and magnetic retrieval of the extractant. The addition of ammonia solution induces the reversible transition of the hydrophobic SNADES (menthol:decanoic acid = 1:1) to a hydrophilic state, thereby significantly enhancing the extraction efficiency of the target analytes. Citric acid-modified Fe 3 O 4 composites (Fe 3 O 4 @CA) were employed to achieve rapid phase separation and efficient magnetic retrieval of the SNADES phase. After systematic optimization, the optimal conditions were established as 30 μL of SNADES, 70 mg of citric acid, 4 mg of Fe 3 O 4 , an extraction time of 4 min, and 100 μL of acetonitrile for desorption. Under the optimal conditions, four NSAIDs (flurbiprofen, diclofenac sodium, ibuprofen, and ketoprofen) exhibited good linearity over the concentration range of 0.1–20 μg/mL, with correlation coefficients (R 2 ) ≥ 0.993. The method provided relative recoveries of 93.7–109.2 % for the target analytes, with relative standard deviations (RSDs) ≤ 9.7 %. The limits of detection were in the range of 0.016–0.036 μg/mL. Spiked recovery experiments in real herbal extracts confirmed the method's accuracy (96.0–112.3 %), demonstrating that the proposed approach provides a rapid, efficient, and green sample preparation strategy for the screening of illicit synthetic drugs in herbal products.
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JOURNAL OF SEPARATION SCIENCE
·
2026
·Vol. 49
·期 8
·e70493
·
IF 3.6
Ying Shao,Xiaoyan Jiang,Mengtao Jin,Xuerong Yang,Zuguang Li,Jinsong Liu
Fluorinated liquid crystal monomers (FLCMs) are widely used in various electronic materials owing to their outstanding optoelectronic properties. However, their persistence, bioaccumulation, and toxicity, such as endocrine disruption, in the environment have rendered them emerging contaminants of significant concern. Switchable natural deep eutectic solvents (SNADESs) are prepared from natural compounds and their metabolites. These solvents possess the characteristics of green solvents while overcoming many limitations of conventional organic solvents, and have thus been widely adopted in the analysis and detection of environmental pollutants. In this study, a pH-SNADES was utilized as the extraction medium. Combined with ultrasound-assisted homogeneous liquid-liquid microextraction, a method for the extraction of FLCMs from environmental water samples was established, and the target analytes were qualitatively and quantitatively determined by gas chromatography-mass spectrometry. The results demonstrated that five of these compounds exhibited excellent linearity in the range of 0.5-500 ng mL −1 , while the other two (4-(3,4-difluorophenyl)-4'-pentyl-1,1'-bi(cyclohexyl) and 3,4,5-trifluoro-4'-(4-pentylcyclohexyl)biphenyl) showed linearity in the range of 1-500 ng mL −1 , with limits of detection ranging from 0.001 to 0.167 ng mL −1 and limits of quantification ranging from 0.003 to 0.556 ng mL −1 . Applied to real water samples, the method yielded spiked recoveries of 80.79%-125.42%, relative standard deviations of 0.09%-5.14%, and enrichment factors of 8-26, with its greenness and applicability further validated by three greenness assessment tools. The proposed method is efficient, environmentally friendly, and features mild reaction conditions and simple operation, providing technical support for the detection of FLCMs in environmental water samples.
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危险品化学品经营许可证（带存储）