ACS Biomaterials Science & Engineering
·
2026
·
IF 6
An Boyuan,Zeng Qin,Zhang Lichao,Li Zhanrong,Zhang Xiuqiang,Li Jingguo
Tissue trauma or chemical injury can compromise tissue integrity and trigger an inflammatory response, which can severely hinder the tissue repair process, particularly in patients with diabetes. Existing wound repair methods struggle to strike a balance between efficacy and cost. We develop a novel natural-based nano-cellulose membrane (LOBCC) by combining lignin-based carbon dots, modified cellulose nanocrystals, and a pure cellulose matrix. The low cost of the all-natural polymer matrix, combined with the introduction of antioxidant carbon dots and the antioxidant properties of cellulose nanocrystals, positions LOBCC as a viable alternative strategy for tissue repair.
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高影响因子
Metabolites
·
2026
·Vol. 16
·期 8
·543
·
IF 4.5
Yan Yan,Jiaying Liu,Yingjian Deng,Yu Tao,Xinxin Li,Chenhui Du,Kun Yang,Ruiping Zhang
Objectives:Insomnia is a highly prevalent sleep disorder involving complex neurochem-ical dysregulation; however, the spatial distribution of neurotransmitters and small-molecule metabolites across distinct brain microregions in the insomniac state re-mains poorly characterized. This study aimed to map region-specific metabolic perturba-tions in situ in a p-chlorophenylalanine (PCPA)-induced insomnia rat model using opti-mized matrix-assisted laser desorption/ionization mass spectrometry imaging (MAL-DI-MSI) integrated with targeted metabolomics validation.Methods:On-tissue chemical derivatization MALDI-MSI was optimized using α-cyano-4-hydroxycinnamic acid (CHCA) as the matrix on a Bruker tims TOF flex mass spectrometer. The rats received PCPA (400 mg/kg, intraperitoneal) for three days to establish the insomnia model. Metabolite identifi-cation was conducted using MetaboScape® software (2020b) and the Human Metabolome Database. Ultra-performance liquid chromatography–tandem mass spectrometry was em-ployed to quantify nine key neurotransmitters and metabolites across six brain microre-gions. Key synthetic enzyme expression was evaluated by immunofluorescence and West-ern blotting analyses.Results:TMP-TFB-derived brain slices clearly showed the distribu-tion of neurotransmitters in brain microregions. MALDI-MSI demonstrated that the spatial distribution and abundance of eight neurotransmitters were disturbed in brains of PCPA-induced insomniac rats. A total of 346 metabolites were characterized across six brain microregions (cerebellum, cortex, hippocampus, brainstem, hypothalamus, and stri-atum), with principal coordinate analysis revealing clear metabolic separation between control and insomniac rats. PCPA treatment markedly disrupted tryptophan and tyrosine metabolism, evidenced by decreased 5-HT, 5-HTP, and 5-HIAA, alongside region-specific alterations in DA, NE, HVA, and Ach. Additionally, GABA levels decreased in the hippo-campus, striatum, and hypothalamus, whereas glutamate increased throughout the brain. Targeted metabolomics validated the MSI findings, and Bland–Altman analysis confirmed good consistency between the two analytical platforms. PCPA further disturbed the meta-bolic enzymes MAOA, DDC, and TPH2 within the Trp-5-HTP-5-HT-5-HIAA metabolic pathway in the brainstem and TYH and DBA within the tyrosine-DA-NE metabolic pathway in the striatum.Conclusions:This study demonstrates that region-specific altera-tions in tryptophan and tyrosine metabolism pathways provide mechanistic insights into insomnia pathogenesis and potential therapeutic targets.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Tang Xiaolu,Li Quan,Yang Yue,Wu Meilin,Liu Qingqing,Mo Zhihong
Protein-rich foods release biogenic amines (BAs) during prolonged storage, and these compounds serve as key biomarkers of food spoilage. Current separation-based methods for detecting BAs in food require sophisticated instrumentation and laborious sample pretreatment procedures. The array-sensing strategy, which mimics biological olfaction, provides a simple and rapid approach for the simultaneous detection of multiple BAs without the need for separation. Here, we constructed a multidimensional fluorescent sensor array using porphyrin-functionalized carbon dots (P-CDs) and their composites with metal ions (M-P-CDs), thereby incorporating the excitation wavelength as an additional signal dimension. This design reduces the number of physical sensors required while maintaining high discrimination capability, thereby overcoming a key limitation of conventional sensor arrays that depend solely on increasing the number of sensors. With the support of chemometric and machine learning methods, the sensor array successfully discriminated among ten BAs. We achieved quantitative detection of putrescine, histamine, and tyramine, determining their limits of detection (LODs) to be 2.37, 2.96, and 1.55 mg/L, respectively. The sensor array exhibited excellent stability (i.e., no significant fluorescence change over 30 days) and high selectivity against common interfering substances. Validation experiments on milk samples demonstrated the array’s ability to reliably discriminate specimens at different spoilage stages. This work establishes a novel multidimensional array-sensing strategy for detecting BAs, an approach that holds great potential for food safety applications. Graphical
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ACS Applied Polymer Materials
·
2026
·
IF 5.2
Zhao Di,Dong Kai,Xie Anran,Pang Yang,Mu Tong,Zhao Chengji
Balancing mechanical strength and dynamic adaptability
remains
a critical challenge for biobased epoxy vitrimers, which often suffer
from compromised strength upon incorporating dynamic covalent bonds.
Herein, a network regulation strategy is proposed to address this
limitation through the rational design of cross-linking architecture
in imine-based epoxy resins. A bioderived aromatic epoxy monomer (VTEP)
was synthesized from vanillin and tyramine, followed by curing with
diamine agents of varied structures to systematically tune network
stiffness and cross-link density. Among the resulting systems, the
epoxy vitrimer cured with m -xylylenediamine (VTEP/MXDA)
possesses a high effective cross-link density of 2394 mol m –3 and exhibits a favorable combination of high mechanical strength
(tensile strength, Young’s modulus, and elongation at break
are 83.56 MPa, 2.35 GPa, and 9.68%, respectively), elevated glass
transition temperature (172 ° C), and appreciable dynamic behavior.
The enhanced performance is attributed to the incorporation of rigid
aromatic segments, which reinforce network integrity while preserving
the exchangeable imine linkages. As a result, the VTEP/MXDA vitrimer
demonstrates rapid stress relaxation, self-healing capability, and
reprocessability. In contrast to conventional methods that rely on
strong acids for imine bond hydrolysis, the vitrimer can achieve efficient
degradation in a 2 M acetic acid solution under mild conditions, facilitating
the recovery of carbon fibers with well-preserved morphology and mechanical
properties from the corresponding carbon fiber-reinforced polymer
composites. This work provides a feasible strategy for developing
biobased epoxy resins with superior mechanical strength as well as
favorable dynamic properties and offers insights into the design of
recyclable carbon fiber-reinforced polymer composites.
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ACS Sustainable Chemistry & Engineering
·
2026
·Vol. 14
·期 30
·13777-13787
·
IF 7.6
Liu Jupen,Wang Rongzheng,Zhu Shunfeng,Bao Siyu,Wang Qian,Pang Xiangchao,Lu Zhe,Yu You
Microgels exhibit excellent toughening capabilities for the construction of strong and resilient hydrogels; however, their fabrication often involves complex procedures, sophisticated architectures, or biocompatibility-compromising metal catalysts. To address these limitations, we develop a metal-free orthogonal photochemical strategy that employs organic riboflavin to prepare porous double-network microgels for the fabrication of tough and printable hydrogels. This metal-free system demonstrates photochemical performance comparable to that of conventional ruthenium-based catalysts. Under light irradiation, riboflavin rapidly and orthogonally triggers free-radical polymerization of vinyl monomers and covalent crosslinking via phenolic coupling, while simultaneously enabling controlled Ca 2+ release for ionic crosslinking (within several tens of seconds). The resulting microgels possess a synergistic architecture comprising a double-network structure, which imparts exceptional energy dissipation, and an internal porous structure that enhances entanglements. When incorporated as reinforcing fillers into the hydrogel matrix, these microgels endow the bulk hydrogels with superior mechanical performance, achieving a fracture energy of ∼500 J m –2 and a toughness of ∼380 kJ m –3 . Furthermore, they confer pronounced shear-thinning characteristics and rapid self-recovery to the precursor inks. As a result, high-fidelity 3D printing of intricate architectures with feature sizes down to ∼100 μm is readily achieved, as demonstrated by a customizable pressure sensor array capable of discriminating both applied loads and object shapes. This work offers a biocompatible, efficient, and versatile strategy for preparing advanced microgel tougheners and bulk hydrogels, paving the way toward printable, tough hydrogels for a broad range of applications.
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ACS Food Science & Technology
·
2026
·
IF 3
Jiayi Chen,Dandan Zhang,Lu Liu,Xiaoli Wu,Meihan Guo,Hong Yan Zou,Xi Yang
Herein, a cost-effective, naked-eye-readable platform for on-site biogenic amines (BAs) detection and shrimp freshness monitoring was developed based on a ratiometric fluorescent CDs–RhB hybrid nanosystem that was constructed by integrating carbon dots (CDs) with rhodamine B (RhB). Biogenic amines induced a significant enhancement in the green fluorescence emission of CDs, while the red fluorescence emission of RhB remained unchanged, enabling an instant self-calibration during detection. Loaded on filter paper to form disposable test strips, the nanosystem enabled a visible color transition from orange to green with increasing BAs concentration. Readable via a smartphone RGB app, the paper-based assay showed a linear response of 5.0–250 μM with a limit of detection (LOD) of 3.56 μM using histamine as the model analyte. Validated through on-site shrimp quality evaluation, the paper-based sensor established a reliable “nanoprobe–paper–phone” strategy, facilitating on-site and quantitative freshness assessment in real-world demand scenarios.
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ACS Applied Polymer Materials
·
2026
·
IF 4.7
Ruiyu Yuan,Yin Lu,Weichen Sheng,Kan Zhang
The severity of fire accidents and sustainable development concerns have made people increasingly aware of the importance of producing flame-retardant materials using biomass resources. Herein, we successfully synthesized an asymmetric biobisbenzoxazine monomer with a single diethyl phosphite-substituted oxazine ring (ST-fa-DEP) based on natural, renewable salicylaldehyde, tyramine, and furfurylamine. The structural characterization of ST-fa-DEP was performed using Fourier-transform infrared (FT-IR) and nuclear magnetic resonance (NMR) spectroscopies as well as high-resolution mass spectrometry (HR-MS), which confirms the successful inheritance of the single diethyl phosphite into the oxazine ring substituted bisbenzoxazine monomer. The ring-opening polymerization behavior of ST-fa-DEP was examined by using differential scanning calorimetry (DSC) and in situ FT-IR analysis. In addition, the resulting polybenzoxazine, poly(ST-fa-DEP), showed excellent thermal performance and flame retardancy with a Td10 of 413 °C, a Yc of 62.5,% and an HRC value of 53 J·g–1·K–1. Moreover, we used ST-fa-DEP as a property modifier for enhancing the comprehensive properties of the well-commercialized bisbenzoxazine resin (PH-ddm). Notably, the glass transition temperature of the resulting thermoset increased to 290 °C, and a V-0 rating in UL-94 testing was also achieved by adding only 3 wt % ST-fa-DEP in PH-ddm, which breaks the trade-off between the thermal stability and flame retardancy of other reported flame-retardant polybenzoxazines. The results obtained in the current work provide molecular-level insights into the structure–property relationship of polybenzoxazines as well as an angle for the design of highly thermal stable and intrinsically flame-retardant biothermosets.
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POLYMER DEGRADATION AND STABILITY
·
2025
·
IF 7.4
Haoxin Niu,Haojie Shi,Yu Li,Hao-Ran Jiang,Xin Wang,Yuan Hu
The three-dimensional cross-linking network endows epoxy thermosets with outstanding application performance, rendering epoxy thermosets indispensable in the field of materials. It also makes epoxy thermosets insoluble and immiscible. Moreover, epoxy thermosets are derived mainly from non-renewable fossil resources, causing an environmental crisis. In addition, epoxy thermosets are flammable and pose a significant fire hazard. To address these problems, three Schiff base curing agents were prepared in this work by utilizing p-hydroxybenzaldehyde, vanillin and syringaldehyde. Three structurally distinct curing agents were utilized to prepare epoxy vitrimers incorporating dynamic imine bonds. The epoxy vitrimers exhibited outstanding mechanical properties. The incorporation of the Schiff base structure into the cross-linking network greatly enhanced the fire safety of the epoxy vitrimers. The epoxy vitrimers demonstrated excellent chemical resistance and can be degraded selectively in an acetone solution of hydrochloric acid. In addition, the epoxy vitrimers demonstrated excellent shape memory properties and significant stress relaxation. This work provides a novel strategy for the preparation of intrinsically flame-retardant bio-based epoxy vitrimers and innovatively investigates the influence of methoxy groups on the properties of epoxy vitrimers.
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BIOCHEMICAL PHARMACOLOGY
·
2025
·
IF 5.6
Meimei Zhao,Ziteng Yu,Xinyi Zhao,Ruijiao Zhu,Mengcong Li,Lu Yu,Ziwei Song,Jiangwei Lv
Lipotoxicity is increasingly recognized as a potential cause of metabolic syndrome, yet effective treatments are still lacking. Boletus edulis ( B. edulis ) Bull: Fr., is a classical mushroom used in traditional Chinese medicine. Polysaccharides, its primary pharmacological components, are widely known to offer various health benefits, but their anti-lipotoxicity properties remain poorly understood. This study aimed to investigate a natural B. edulis Bull: Fr. polysaccharide (BP) for its effectiveness and underlying molecular mechanisms in mitigating hepatic lipotoxicity. In vitro , BP enhanced glucose uptake and reduced lipid accumulation and oxidative stress in Oleic acid (OA)-treated LO2 cells. It downregulated receptor for advanced glycation end-products (RAGE) expression, inhibited mitogen-activated protein kinase (MAPK) activation, and normalized key proteins involved in glucose and lipid metabolism, thereby alleviating OA-induced lipotoxicity. In vivo , high-fat diet-fed mice injected with BP exhibited similar metabolic improvements, with the reversal of RAGE/reactive oxygen species (ROS)/MAPK signaling in liver tissue, further supporting the molecular mechanisms observed in vitro in modulating lipotoxicity. Collectively, these findings underscore BP as a potent bioactive preparation with significant pharmacological potential in alleviating hepatic lipotoxicity.
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.1
Yidan Zhang,Yuhua Lai,Yifei Ma,Lin Ge,Jinhua Liu
Since excess histamine (His) in seafood poses a significant health threat, the development of intelligent, on-site, and visual multimodal methods for detecting fish freshness has attracted widespread attention. In this study, we developed a Lewis base-induced paper-based chip coupled with smartphone RGB (Red Green Blue) recognition for the real-time colorimetric/fluorescent dual-mode detection of His in fish meat. The sensing mechanism was based on the catalytic role of His in rapidly forming a green fluorescent compound (GFC) from dopamine and 3-ethylamino-4-methylphenol. Interestingly, the introduction of 1% Tween (TW) 80 was found to significantly enhance the fluorescence signal and real-time stability of the system, achieving an exceptional detection limit of 16.67 nM for His. By immobilizing the GFC probe on Whatman 1 filter paper, a paper-based test strip for His was further developed. His quantification is achieved through RGB analysis with a smartphone, allowing visual and real-time assessment of fish meat freshness directly in the field. The developed sensor exhibits outstanding selectivity, stability, and sensitivity, and has been successfully applied to monitor His levels in fish meat samples (crucian, saury and golden pomfret) over time, providing a reliable means to prevent His poisoning. Therefore, this work presents a robust, low-cost, and user-friendly point-of-care testing platform that holds significant potential for applications in intelligent food monitoring and environmental sensing.
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高影响因子
JOURNAL OF POLYMER SCIENCE
·
2023
·Vol. 61
·期 13
·1279-1288
·
IF 3.4
Yuqi Liu,Li Yuan,Guozheng Liang,Aijuan Gu
Benzoxazine resins from benzoxazine monomers synthesized with green strategies often do not have high thermal resistance and mechanical strength. Herein, starting from renewable resources citraconic anhydride, furfurylamine and tyramine, a new benzoxazine monomer ( CT-fa ) was synthesized and purified in green solvents (ethanol and ethyl acetate), which has excellent molding processability reflected by low melting point (84.9 °C) and low curing temperature (207–245 °C). More attractively, the cured CT-fa resin ( poly(CT-fa) ) has both high glass transition temperature (281 °C) and high initial thermal decomposition temperature (407 °C), the former is higher than those of all monofunctional benzoxazine resins synthesized though green strategies in literature, and the latter is even higher than those of all benzoxazine resins synthesized by green strategies (SCI database). In addition, poly(CT-fa) also has high storage modulus (3955 MPa) and good tensile strength (51.60 MPa). These attractive properties demonstrate that poly(CT-fa) is a promising green high performance resins. Graphical
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Food Analytical Methods
·
2023
·Vol. 16
·期 5
·909-917
·
IF 2.9
Xu Yanfen,Lu Ying,Yu Jianna,Liu Wen,Jing Guoxing,Li Wenshan,Liu Wenjie
Tuna is one of the most popular fish and therefore among the most commercially valuable seafood. However, inadequate refrigeration during the whole supply chain causes serious economic loss and food poisoning. One important result of tuna spoilage is the accumulation of biogenic amines such as histamine, which can be used as a sensitive indicator for Tuna freshness. Thus, the development of rapid, sensitive, and economic analytical methods for biogenic amines in Tuna is highly desired. This research developed a method that combines high-performance liquid chromatography (HPLC) and electrospray ionization ion mobility spectrometry (ESI-IMS) to detect 7 kinds of biogenic amines including tryptamine, tyramine, spermidine, cadaverine, β-phenylethylamine, putrescine, and histamine in tuna. The limit of detections (LODs) for 7 biogenic amines are 0.01, 0.02, 0.02, 0.17, 0.03, 0.04, and 0.15 mg L −1 respectively. The linear range of histamine and spermidine is 2–100 mg kg −1 , and the linear range of other biogenic amines is 0.5–10 mg L −1 . The recoveries of biogenic amines are between 69.39 and 112.65%. Compared to the traditional HPLC-based analytical method, the proposed method does not involve any derivatization steps, which greatly decreased the sample preparation time and cost. Another advantage of the developed method is the supplementary separation to the HPLC, in which coeluted biogenic amines can clearly be separated in the ion mobility dimension. The proposed method is applied to determining the concentration of biogenic amines in tuna storage, which showed that this method can quickly and accurately monitor the changes of biogenic amines in tuna during storage.
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