FUEL
·
2014
·
IF 3.406
Wenqing Li,Liying Wang,Yu Qiao,Jian-Ying Lin,Meijun Wang,Liping Chang
Understanding the effect of the atmosphere on the release of alkali and alkaline-earth metals (AAEM) during oxy-fuel combustion is important for the development of oxy-fuel combustion technologies with reduced problems with particulate formation and corrosion. To this end, we examined the release behavior of AAEM during oxy-fuel combustion in different gas environments. A drop-tube reactor and ion chromatography were used to investigate the release rates of AAEM. Our results show that the release rates of Na and K were higher than those of Ca and Mg in all types of gas environments. Experimental conditions that favor combustion, namely, higher temperature, higher oxygen content, and longer residence time, markedly increased the release rates of Na and K, whereas changes in the release rates of Ca and Mg were much smaller. The presence of SO 2 in the atmosphere suppressed the release of AAEM via formation of sulfates, whereas the presence of H 2 O promoted it. A synergistic effect of H 2 O and SO 2 on the release of AAEM during oxy-fuel combustion was observed.
研究领域:
燃烧化学
·
能源工程
·
环境化学
·
材料腐蚀
·
颗粒物形成
✓ 已验证
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2015
·
IF 3.005
Hongwei Zhang,Qijian Niu,Ning Wang,Jun Nie,Guiping Ma
In this research a thermo-sensitive drug loaded core–shell fibers were prepared by UV photo-polymerization combined with electrospinning technology. The biodegradable polymer polylactic acid (PLA) was used as the core with electrospinning and the N-isopropylacrylamide (NIPAM) was selected to be shell of the fibers via UV photo-polymerization, respectively. Combretastatin A4 (CA4) was used as the model drug loaded in PLA (core structure) to test the thermo-sensitivity of the core–shell fibers. SEM was performed to observe the morphology of the fibers. TEM was carried out to confirm the core–shell structure of the fibers. Furthermore, XPS and FTIR results demonstrated that the core–shell structure had been fabricated as designed. Water contact angle (WCA) test indicated that the fibers show different wettability when the temperature was below or above the lower critical solution temperature (LCST). Moreover, in vitro drug release test was conducted to explore the difference of the drug release when the temperature was at 25 °C and 40 °C. The cell culture studies showed that the prepared core–shell structure nanofibers have a potential application in the biomedical fields as tissue engineering.
研究领域:
生物材料
·
药物递送
·
组织工程
·
高分子科学
·
纳米医学
✓ 已验证
DOI
高影响因子
JOURNAL OF MICROENCAPSULATION
·
2019
·
IF 2.04
Zhaoying Wu,Mengqing Zhao,Wei Zhang,Zhao Yang,Shuxin Xu,Qing Shang
The purpose of this study was to investigate the influences of drying methods on the risperidone (RIS) release profiles of RIS-loaded PLGA microspheres. These microspheres were fabricated with an O/W emulsion solvent evaporation method. The wet microspheres were dried with freeze drying and vacuum drying methods. The microspheres were mono-dispersed spheres with an average diameter of 100 μm. Studies found that drying methods had great influence on the porosity, morphology, and release profiles of RIS-loaded PLGA microspheres. Specifically, the freeze-dried microspheres had higher porosity (78.46 ± 1.64%) than those vacuum-dried ones (52.45 ± 2.68%), and they showed higher RIS release rates (p < 0.05). In the accelerated release tests (45 °C), these microspheres dried under the pressures of 700 mmHg and 200 mmHg gave faster release rates than those ones dried under the pressure of 450 mmHg. Importantly, the accelerated release test (45 °C) had a high correlation with the real-time test (37 °C) (R2 > 0.99). These studies exhibited a significance in the precise preparation of RIS-loaded PLGA microspheres.
研究领域:
药学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2013
·Vol. 4
·期 5
·2550-2556
·
IF 2.562
Liuting Zhang,Xuezhang Xiao,Xiulin Fan,Shouquan Li,Hongwei Ge,Qidong Wang,Lixin Chen
A simple approach to dramatically enhance the dehydrogenation properties of sodium borohydride is achieved by ball milling NaBH4 with fluorographite (FGi). It was found that the ball-milled NaBH4–FGi composite starts to release hydrogen without impurity gas at a lower temperature of 125 °C, and obtains a hydrogen desorption capacity of ca. 4.8 wt% below 130 °C in seconds, which is improved markedly compared to the ball-milled pristine NaBH4. The significant thermodynamic and kinetic improvement of the NaBH4–FGi composite can be ascribed to the reaction between NaBH4 and FGi as well as the formation of micro-scale NaBH4. Moreover, since the dehydrogenation process of NaBH4–FGi composite is exothermal, the fully reverse reaction is not feasible. In-depth investigations show that the partial rehydrogenation is due to the formation of Na2B12H12 and another new borohydride.
研究领域:
材料科学
·
能源化学
·
纳米科技
·
物理化学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2024
·
IF 8.1
Chengguo Yan,Jiaguang Zheng,Ao Xia,Qingbo Zhang,Meiling Lv,Zhenxuan Ma,Chao Su,Zhendong Yao
Among conventional hydrogen storage materials , LiBH 4 has been regarded as one of the best hydrogen transporters due to its relatively large hydrogen capacities. However, because of its extraordinarily high dehydrogenation temperatures, LiBH 4 was not suitable for hydrogen storage due to its stable thermodynamic features. Herein, we present a novel approach to LiBH 4 that uses solid-state multi-hydroxyl mannitol as a reactant, regulating hydrogen release below 69.9 °C. More than 7 wt% H 2 could be released with ultra-fast rates at 140 °C from the LiBH 4 -mannitol composite. XRD , FTIR , and SEM tests revealed that the reaction between mannitol (H δ+ ) and LiBH 4 (H δ− ) to produce hydrogen was accompanied by the generation of large amounts of heat in situ, which further promoted the decomposition of LiBH 4 for hydrogen production , exceeding the theoretical dehydrogenation amount of H δ+ - H δ− reaction. This work indicates possibilities for the development of fast and easy high-capacity hydrogen generation systems based on complex hydrides.
研究领域:
材料科学
·
无机化学
·
能源化学
·
氢能源存储
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 3
·1551-1561
·
IF 3.069
Long Meng,Yunan Wu,Kai Pan,Ye Zhu,Xiaojie Li,Wei Wei,Xiaoya Liu
Nickel-titanium alloy (NiTi alloy) has recently received an increasing amount of attention. However, the release of toxic nickel ions and the threat of implant infections has limited its clinical applications. Thus, we report a promising copolymer coating with excellent nickel ion (Ni2+) inhibition release, cytocompatibility, and antimicrobial properties to solve these safety issues involving NiTi alloy implantation. Quaternized copolymers poly (7-hydroxy-4-methylcoumarin methacrylate-co-2-hydroxyethyl methacrylate-co-2-(dimethylamino)ethyl methacrylate) (PCHD-Q) with many hydroxyl and tertiary amine groups were first synthesized, self-assembled into nanoparticles, and then deposited on NiTi substrate through electrodeposition. After UV irradiation, scanning electron microscopy (SEM) images revealed that homogeneous, continuous, and dense coatings were obtained. The coatings showed good improvement of protective behavior for the NiTi alloy in an in vitro environment and could significantly decrease the release of Ni2+ through physical barriers and physical adsorption, which could obviously reduce cytotoxicity inducing by Ni2+. According to in vitro cell viability and antibacterial tests, the quaternized coating materials not only provided a relatively stable biointerface for cell adhesion, spreading and growth, but also obtained excellent antimicrobial activity for the bare NiTi alloy against S. aureus and E. coli. These results suggested that our coatings materials have the potential for improving the safety and success rate of NiTi-based implantations.
研究领域:
材料科学
·
生物医学工程
·
表面涂层技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF SOILS AND SEDIMENTS
·
2016
·Vol. 17
·期 2
·536-542
·
IF 2.206
Zhang Jinyang,Li Chuxian,Wang Dingyong,Zhang Cheng,Liang Li,Zhou Xiong
Purpose The environmental safety of both nano-TiO 2 particles and mercury (Hg) pollution has been of widespread concern. Soils and sediments were the main receiving environments of nano-TiO 2 and Hg. There was a strong association between nano-TiO 2 with Hg compounds. Very limited research has been carried out on the impact of nano-TiO 2 on the environmental behavior of Hg in sediments. The objective of this study was to investigate the effects of nano-TiO 2 on the release and transformation of Hg in sediments. Materials and methods Two types of TiO 2 nanoparticles were employed. Sediment samples were collected in the water level fluctuating zone of the Three Gorges Reservoir, China. Sediment samples spiked with HgCl 2 solution were taken as Hg-contaminated sediments. The flooding experiments were conducted using capped borosilicate glass bottles containing 300 ml TiO 2 suspensions (0.2 g L −1 and 0.4 g L −1 ) and 30 g original or Hg-contaminated sediment samples outdoors. All experiments were conducted in triplicate. Water samples were collected at determined interval times over a 60-day period. Sediments were collected on the 60th day. Total Hg (THg) and methylmercury (MHg) in both water and sediment samples and Hg speciation just in sediment samples were determined. A series of control samples without TiO 2 addition were also prepared. Results and discussion The results showed that nano-TiO 2 particles at high content (4 g kg −1 ) promoted the release of Hg in sediments, and the anatase particles showed a stronger effect. Methyl Hg concentrations in waters of nano-TiO 2 treatments significantly decreased by the 10th day. The effect of nano-TiO 2 greatly depended on anatase and rutile particles. After that, methyl Hg concentrations had no significant difference between nano-TiO 2 treatments and the control, except 2 g kg −1 rutile treatment by the 20th day. The changes of Hg speciation in sediments demonstrated that nano-TiO 2 inhibited the transformation of Hg-bound organic matter into the oxidated state, especially upon 2 g kg −1 rutile treatment. This was consistent with the lower MHg concentrations in the 2 g kg −1 rutile treatment. Conclusions Both anatase and rutile nano-TiO 2 were found to affect the release of Hg in sediment. Nano-TiO 2 promoted THg release in sediments and posed an increased risk of Hg contamination in waters, especially for anatase particles. Moreover, nano-TiO 2 inhibited the methylation process of Hg in sediments at the initial stage of flooding and could affect the transformation of Hg speciation in sediments, especially for low-content rutile particles.
研究领域:
环境科学
·
地球化学
·
水体生态学
·
污染控制
·
环境毒理学
✓ 已验证
DOI
高影响因子
DRUG DELIVERY
·
2019
·
IF 3.829
Jin Li,Tongjie Cheng,Qiang Tian,Ying Cheng,Lixia Zhao,Xingzhen Zhang,Yi Qu
As a leading cause of vision impairment of the retina, macular edema (ME) has one of the highest clinical demands for treatment. Current treatment of ME relies heavily on invasive techniques resulting in complications and poor patient compliance. To enhance the efficiency of triamcinolone acetonide as eye drop to the posterior segment of the eye, we developed and characterized a novel formulation, namely, triamcinolone acetonide chitosan-coated liposomes (TA-CHL), prepared by the calcium acetate gradient method with some modifications. TA-CHL provided the mean particle size of 135.46 ± 4.49 nm and high entrapment efficiency (90.66 ± 3.21%), exhibited a sustained release profile, excellent physical stability, and no significant toxicity on cornea, conjunctiva, and retina. Optical coherence tomography system (OCT) was used to detect pharmacokinetics of CHL in vivo, indicating that CHL had good potency for drug delivery. Cellular uptake experiments showed CHL had the higher transduction efficiency into HCEC and ARPE-19 than liposomes. TA-CHL was shown to be potentially effective eye drop to contribute to the posterior segment of the eye.
研究领域:
药剂学
·
眼科医学
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2011
·Vol. 36
·期 14
·8203-8208
·
IF 4.057
Z.G. Zhang,H. Wang,M. Zhu
The major challenge of complex hydride for hydrogen storage is to release hydrogen at a moderate temperature with rapid kinetics. This paper reports a new composite system (NaBH 4 /ZnF 2 ) to generate hydrogen at a low temperature below 100 °C. The NaBH 4 and ZnF 2 mixture was prepared by a mechanical milling in a 2:1 M ratio. Dehydrogenation of the mixture during a heating process shows that the initial dehydrogenation temperature was below 100 °C with favorable kinetics. The structural analysis confirmed the formation of NaBF 4 and Zn in the reaction products. The study concerning the reaction mechanism reveals that ZnF 2 plays a role of reagent rather than catalyst. The produced intermediate of NaZnF 3 , however, affects the decomposition of the emitted B 2 H 6 . This work suggests that the extension of the decomposition mechanism of NaBH 4 /ZnF 2 composite system would favor the development of new catalysts for complex hydride systems.
研究领域:
材料科学
·
能源化学
·
无机化学
·
储氢技术
·
纳米催化
✓ 已验证
DOI
高影响因子
RSC Advances
·
2013
·Vol. 3
·期 45
·23133-23138
·
IF 2.562
Yang Wang,Yun Xiao,Hangyu Zhou,Wei Chen,Ruikang Tang
A novel versatile system combining chemotherapy and photothermal therapy for cancer cells using CuS NCs is reported. CuS NCs were synthesized by a solid–liquid reaction between Cu2O nanocubes and thiourea. While the hollow nanocage can be used to load anticancer drugs for chemotherapy, the CuS can convert NIR light into heat for photothermal therapy. More importantly, CuS NCs display exceptionally high drug loading capacity of DOX with 500 wt% and release of DOX is pH-controllable, which is a spontaneous process under intracellular conditions. Compared with chemotherapy or photothermal therapy alone, the combination of chemotherapy and phototherapy can significantly improve the therapeutic efficacy. This improvement strategy using multifunctional nanomaterials may be particularly useful in biomedical applications.
研究领域:
肿瘤学
·
纳米医学
·
药物递送
·
转化医学
·
生物材料
✓ 已验证
DOI
高影响因子
Asian Journal of Pharmaceutical Sciences
·
2017
·Vol. 12
·期 6
·580-585
·
IF 0
Shijie Wei,Jingbo Ren,Ning Li,Wuzhen Huo,Chongkai Gao
An LCC delivery system for Fenofibrate (Fen) was developed to improve its poorly oral bioavailability. Fen-LCC preparation methods were screened, and the prepared Fen-LCC was then characterized by a polarizing microscope and transmission electron microscopy (TEM). The spray drying technique was selected to dry and solidify particles into powder. The in vitro release of Fen-LCC was measured and in vivo pharmacokinetic experiments were carried out on rats after oral administration. Particles prepared through the high-temperature input method exhibited structural characteristics of LCC, and re-dissolved particles maintained the same features. The LCC delivery system can significantly improve in vitro release outcomes. After oral administration, AUCs of the suspension and LCC systems were measured at 131.6853 µg⋅h/ml and 1435.72893 µg⋅h/ml, respectively. The spray drying process presented here better maintains cubic structures, and the LCC system significantly improves bioavailability levels.
研究领域:
药剂学
·
药物递送系统
·
纳米医学
·
药代动力学
·
药物代谢
✓ 已验证
DOI
ELECTROCHIMICA ACTA
·
2019
·
IF 5.383
Tao Zhang,Zhiyuan Ling
Architecture construction of electrode is one key factor for hydrogen generation from electrochemical water splitting. To enhance the efficiency of oxygen evolution reaction (OER) at high current density , the architecture construction must be designed skillfully to prevent the surface blanketed by gas bubbles. In this work, we developed a three-level hierarchical surface with cluster-like nickel (Ni) nanowire array. The contact angle measurement indicates the surface having excellent hydrophilicity . The OER performance characterization reveals that after the surface is loaded with NiFe-based catalyst the Ni nanowire array electrode can deliver 500 mA cm −2 at an overpotential of 297 mV in 1 M KOH solution and can survive for over 24 h under 500 mA cm −2 operation. All the results demonstrate that the cluster-like nanowire array is beneficial for the spatial pathway separation for electrolyte supply and gas bubbles departure and the enhancement of OER efficiency.
研究领域:
材料科学
·
电化学
·
能源材料
·
纳米技术
·
催化化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）