MACROMOLECULAR BIOSCIENCE
·
2020
·Vol. 20
·期 12
·2000185
·
IF 3.416
Hanjiao Hu,Xingtang Liang,Shuangshuang Wang,Zhijun Xu,Junbo Li,Haixu Chen,Dongyue Su,Yanzhen Yin,Zuqiang Huang,Xin Huang
The pollution of antibiotics in aquaculture environment is increasingly serious, and excessive antibiotics will kill the probiotics in aquaculture feed. How to improve the viability of probiotics in the antibiotics-contaminated environment is of significance. In this study, a new strategy for protecting Saccharomyces cerevisiae cells in situ against antibiotics is constructed based on cell surface engineering technology by putting on wearable protective layers for cells. The protective layer is constructed around cellular surface via the self-assembly of coacervate microdroplets that consist of carboxymethyl chitosan and carboxyl dextran. Without affecting the cell viability, the protective layer can grasp ciprofloxacin and decrease the contact of ciprofloxacin to cells and consequently improve the survival rate of cells when exposing to ciprofloxacin. This work highlights a facile strategy to establish removable artificial cell wall by biodegradable polysaccharides for improving the productivity of probiotics in antibiotic environments.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2022
·
IF 4.326
Keda Zhi,Chao Yang,Yu Zheng,Runnan Zhang,Omojayogbe Toyosi E,Hong Wu,Zhongyi Jiang
Electro-Fenton is a widely used electrochemical advanced oxidation process for the treatment of refractory organic pollutants, in which O2 input is required to generate hydrogen peroxide. The aeration mode directly affects the dissolution and stability of O2 bubbles in the solution, thus the rate of degradation. Herein, membrane aeration was introduced to the electro-Fenton degradation of ciprofloxacin in which O2 was dispersed into the liquid phase in the form of microbubbles through the ceramic membrane. Microbubbles can greatly improve the gas–liquid mass transfer efficiency of unit volume O2 to obtain an ultrahigh concentration of dissolved O2 up to 46 mg/L, thus improving the reaction rate. The effects of aeration mode, applied current, membrane aperture, aeration rate, and ciprofloxacin concentration on degradation rate were studied. Compared with the conventional electro-Fenton process using plastic pipe aeration, the membrane aeration-enhanced electro-Fenton (MAEF) system achieved a significant improvement in the degradation rate, and the reaction time required to achieve a 97% degradation ratio was remarkably reduced from 4 h to 10 min. Membrane aeration is an efficient approach to facilitating heterogeneous catalysis reactions involving the gas phase.
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ENVIRONMENTAL RESEARCH
·
2023
·
IF 8.3
Yue Wang,Weihao Ning,Shengnan Li,Changfei Gao,Rong Cui,Wanqian Guo,Jo-Shu Chang,Shih-Hsin Ho
The wide use of antibiotics in aquaculture has triggered global ecological security issue. Microalgal bioremediation is a promising strategy for antibiotics elimination due to carbon recovery, detoxification and various ecological advantages. However, a lack of understanding with respect to the corresponding regulation mechanism towards antibiotic stress may limit its practical applicability. The microalga Scenedesmus obliquus was shown to be capable of effectively eliminating ciprofloxacin (CIP), which is a common antibiotic used in aquaculture. However, the corresponding transcriptional alterations require further investigation and verification at the metabolomic level. Thus, this study uncovered the metabolomic profiles and detailed toxic and defense mechanisms towards CIP in S. obliquus using untargeted metabolomics. The enhanced oligosaccharide/polyol/lipid transport, up-regulation of carbohydrate and arachidonic acid metabolic pathways and increased energy production via EMP metabolism were observed as defense mechanisms of microalgal cells to xenobiotic CIP. The toxic metabolic responses included: (1) down-regulation of parts of mineral and organic transporters; (2) electrons competition between antibiotic and NAD during intracellular CIP degradation; and (3) suppressed expression of the hem gene in chlorophyll biosynthesis. This study describes the metabolic profile of microalgae during CIP elimination and reveals the key pathways from the perspective of metabolism, thereby providing information on the precise regulation of antibiotic bioremediation via microalgae.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2018
·
IF 4.61
Muhammad Zaheer Afzal,Xue-Fei Sun,Jun Liu,Chao Song,Shu-Guang Wang,Asif Javed
Biochar is effective in water treatment but it is hard to retrieve or separate biochar powder from aqueous solutions. In this study, the removal of ciprofloxacin from aqueous solutions was investigated using chitosan/biochar hydrogel beads (CBHB). The results showed that the adsorption rate was almost independent of the temperature and occurred at the homogeneous sites of adsorbent thus obeying the Langmuir model. The equilibrium time was varying for different initial concentrations and found to be 48 h for maximum one. The maximum sorption was found to be >76 mg/g of adsorbent out of 160 mg/L as initial concentration. Adsorption obeyed the second-order mechanism with leading role of intra-particle diffusion and outer diffusion. Adsorption capacity decreased from 34.90 mg/g to 15.77 mg/g in the presence of 0.01 N Na 3 PO 4 whereas other electrolytes such as NaCl, Na 2 SO 4 , NaNO 3 with same concentration did not affect the sorption capacity. However, increased concentration of NaCl reduced the sorption capacity to some extent. CBHB showed a mixed mechanism by removing CIP through π-π electron donor-acceptor (EDA) interaction, hydrogen bonding and hydrophobic interaction. The reformation of CBHB with methanol and ethanol instead of water decreased its sorption capacity to 32.69 mg/g and 29.29 mg/g. Adsorption decreased by little after every regeneration of CBHB and was still >64 ± 0.68% (25.73 mg/g) after 6th regeneration. The efficacy of CBHB for CIP removal proved that CBHB is an economical and sustainable adsorbent.
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Results in Chemistry
·
2025
·
IF 4.2
Shaoming Zeng,Xiaofang Lai,Hai Li,Rongtao Ji,Duan Zhao,Jikang Jian
The common water contaminant ciprofloxacin (CIP) poses a significant threat to the health of both aquatic species and humans. Current iron-sulfide-based catalysts, predominantly nanoparticles, face limitations including aqueous instability, narrow pH adaptability, and agglomeration. To overcome these bottlenecks, we developed a new iron-sulfide-based catalyst. This study used FeS micro-flakes to degrade CIP. The degradation efficiency and reusability of FeS micro-flakes were evaluated under different conditions. The results indicate that FeS micro-flakes can achieve a removal efficiency of over 99 % within 10 min at pH 6, a temperature of 30 °C, a FeS dosage of 0.8 g/L, and an H 2 O 2 concentration of 10 mmol/L. even after five cycles, the removal efficiency of FeS remained above 99 %. The hydroxyl radical (HO·) was identified as the primary reactive oxygen species (ROS) by chemical quenching experiments and electron paramagnetic resonance (EPR). These results demonstrate the exceptional performance and reusability of the FeS heterogeneous Fenton catalyst
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APPLIED CLAY SCIENCE
·
2019
·
IF 3.89
Mi Wu,Shifeng Zhao,Ruisen Jing,Yifei Shao,Xijuan Liu,Fengzhu Lv,Xinxin Hu,Qian Zhang,Zilin Meng,Aiju Liu
As antibiotics continue to be released into soils, it poses a potential threat to human and animal health. The migration-transformation of contaminants in soils is strongly affected by adsorption on clay. Tetracycline (TC) and ciprofloxacin (CIP) which are extensively used have been attracted attention recently. Based on adsorption kinetics, isotherm, FT-IR, XRD and molecular simulation, the intercalation and environmental behavior of TC or CIP by montmorillonite (Mt) as single or mixed substance were studied and the adsorption mechanism was also proved. In the mixed system, the relationship between TC and CIP was a competition, but no preferential adsorption. The interaction between antibiotics in interlayer and the adsorption energies were simulated and calculated by molecular simulation to reveal the experimental results.
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Journal of Water Process Engineering
·
2026
·
IF 6.6
Jie Zhao,Hongyang Wang,Zhisheng Jia,Ruopu Bai,Chaofan Song,Huixuan Zhang
The addition of CuS could enhance the catalytic activity of FeOCl. • The FeOCl/CuS/PMS can completely degrade ciprofloxacin within 4 min. • The FeOCl/CuS/PMS could work efficiently at pH 3–9. • FeOCl/CuS/PMS system contained reactive species (·OH, SO 4 ·- and O 2 ·- ). FeOCl serves as an effective iron-based catalyst in peroxymonosulfate (PMS) activation for antibiotic removal. However, its catalytic efficiency is hindered by the sluggish redox cycling between Fe 3+ and Fe 2+ . To overcome this limitation, a composite catalyst of FeOCl/CuS was synthesized to enhance catalytic activity. At an optimal mass ratio of FeCl 3 ·6H 2 O to CuS of 1:2, the FeOCl/CuS system achieved complete degradation of ciprofloxacin (CIP) within 4 min. Notably, the catalyst exhibited high degradation efficiency across a broad pH range, demonstrating strong environmental adaptability. Although common co-existing anions and humic acid exerted inhibitory effects on CIP degradation to varying extents, the system remained robust under complex water matrices. Radical quenching experiments and electron paramagnetic resonance (EPR) analyses confirmed that hydroxyl radicals (·OH), sulfate radicals (SO 4 ·- ), and superoxide anions (O 2 ·- ) were the dominant reactive species responsible for pollutant degradation. The incorporation of CuS significantly accelerated the Fe 3+ /Fe 2+ redox cycle, thereby improving PMS activation efficiency. Reaction pathway analysis revealed that CIP was degraded via two primary routes, generating 16 intermediate products, the majority of which showed reduced ecotoxicity compared to the parent compound. Furthermore, the FeOCl/CuS catalyst maintained excellent stability and reusability, retaining over 93% CIP degradation efficiency after four consecutive cycles. These results collectively highlight the promising potential of the FeOCl/CuS/PMS system for practical wastewater treatment applications.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 7
·6814
·
IF 5.6
Huimin Miao,Panyong Wang,Yingge Cong,Wenfei Dong,Li Li
Nowadays, bacterial infections are attracting great attention for the research and development of new antimicrobial agents. As one of the quinolones, ciprofloxacin (CI) has a broad-spectrum, strong antibacterial effect. However, the clinical use of ciprofloxacin is limited by drug resistance. Ciprofloxacin carbon dots (CCDs) with enhanced antibacterial activity and copper-doped ciprofloxacin carbon dots (Cu-CCDs) were synthesized by a simple hydrothermal method. The results of structural analysis and antibacterial experiments show that CCDs and Cu-CCDs have effective antibacterial properties by retaining the active groups of ciprofloxacin (-COOH, C-N, and C-F), and Cu-CCDs doped with copper have a better antibacterial effect. In addition, experiments have shown that Cu-CCDs show excellent antibacterial activity againstE. coliandS. aureusand have good biocompatibility, which indicates that they have great prospects in clinical applications. Therefore, novel modified copper CCDs with broad-spectrum antibacterial activity, which can be used as antibacterial nanomaterials for potential applications in the field of antibacterial drugs, were synthesized in this study.Keywords:nanomaterials;fluorescent;carbon dots;antibacterial;ciprofloxacin
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Yuwei Li,Chengfeng Zhou,Xiaohan Zhang,Bin Hui
Developing high-performance and low-cost heterogeneous catalyst is an urgent need to activate peroxymonosulfate (PMS) towards organic pollutants degradation. Herein, a novel block catalyst comprising of iron oxide nanosheets and wood carbon (FeO X @WC) is proposed to enhance PMS activation for ciprofloxacin (CIP) degradation. The resultant FeO X @WC achieved the removal rate of 86.6% in 10 min. This hardwood-derived catalyst remained the excellent degradation performance in a wide pH range of 2.0–11.0 and the co-existence of other organic pollutants. Inspired by water circulation pathway in tree, a flowthrough degradation device was constructed via using the hardwood-derived carbon block with large vessel channels and small fiber tracheids channels in diameter. The removal rate reached 75.4% in 17 min for mass pollution solution (450 mL), suggesting the good degradation ability in practical application. Quenching experiments, electron paramagnetic resonance and electrochemical analysis reveal that non-radical pathways including singlet oxygen and electron transfer occupy the dominant effect. Nine intermediates were identified and three kinds of degradation pathways were proposed. This work provides a charcoal-based block catalyst to enhance the degradation efficiency towards aqueous CIP pollutants.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2019
·
IF 6.361
Muhammad Zaheer Afzal,Rengyu Yue,Xue-Fei Sun,Chao Song,Shu-Guang Wang
In this study, humic acid coated biochar (HA-BC) and chitosan were combined to prepare an adsorbent with enhanced reactivity for the removal of ciprofloxacin (CIP). With initial CIP concentrations of 250 mg/L, the maximum adsorbed amount was 154.89 mg/g. Removal rates reached equilibrium after 12 h, obeying the pseudo second-order kinetic model . Adsorption isotherm data was better fitted to the Langmuir isotherm model. The sorption capacity of humic acid-biochar/chitosan hydrogel beads (HBCB) decreased by 11.42%, 6.66%, 9.32%, and 23.92% in the presence of NaCl , NaNO 3 , Na 2 SO 4 , and Na 3 PO 4 , respectively. A complex mechanism was found to be responsible for the adsorptive removal of CIP including, hydrogen bonding , π-π electron donor–acceptor (EDA) interactions and hydrophobic interactions. After four regeneration steps, sorption capacity remained sufficient (61.23 mg/g). These removal results indicate that HBCB is durable and effective for long term CIP removal.
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CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Chen Li,Hui Lin,Andac Armutlulu,Ruzhen Xie,Yongli Zhang,Xiaoyang Meng
In this study, ferrate (Fe(VI)) was used as catalyst to activate persulfate (PS) for the removal of ciprofloxacin (CIP) from aqueous solution. Hydroxylamine (HA) was used to accelerate the reduction and regeneration of Fe(II) from the Fe(VI) + PS system. It was found that 91.5% of 30 μM CIP was decomposed within 60 min in the PS + Fe(VI)/HA system, which is 25.9% higher than that in the PS + Fe(VI) system. In the PS + Fe(VI)/HA system, the removal of CIP increased with the decrement of initial solution pH, whereas inorganic anions (i.e. HCO 3 − , Cl − , NO 3 − ions) and humic acid had slightly inhibitory effects on CIP removal. The radical scavenging experiments and the electron paramagnetic resonance (ESR) tests confirmed that the addition of HA in the PS + Fe(VI) system can accelerate the generation of reactive oxygen species (ROS) such as sulfate radicals (SO 4 − ) and hydroxyl radicals ( OH), which played important roles for the removal of CIP in the PS + Fe(VI)/HA system. CIP degradation intermediates were also identified and the pathways were proposed. This study suggested a new approach for catalytic degradation of CIP by ferrate.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2016
·
IF 3.994
Heyu Li,Gareth R. Williams,Junzi Wu,Yao Lv,Xiaozhu Sun,Huanling Wu,Li-Min Zhu
To obtain wound dressings which could be removed easily without secondary injuries, we prepared thermoresponsive electrospun fiber mats containing poly(di(ethylene glycol) methyl ether methacrylate) (PDEGMA). Blend fibers of PDEGMA and poly( l -lactic acid-co-ε-caprolactone) (P(LLA-CL) were fabricated via electrospinning, and analogous fibers containing the antibiotic ciprofloxacin (CIF) were also prepared. Smooth cylindrical fibers were obtained, albeit with a small amount of beading visible for the ciprofloxacin-loaded fibers. X-ray diffraction showed the drug to exist in the amorphous physical form post-electrospinning. The composite fibers showed distinct thermosensitive properties and gave sustained release of CIF over more than 160 h in vitro . The fibers could promote the proliferation of fibroblasts, and by varying the temperature cells could easily be attached to and detached from the fibers. Antibacterial tests demonstrated that fibers loaded with ciprofloxacin were effective in inhibiting the growth of E. coli and S. aureus . In vivo investigations on rats indicated that the composite PDEGMA/P(LLA-CL) fibers loaded with CIF had much more potent wound healing properties than a commercial gauze and CIF-loaded fibers made solely of P(LLA-CL). These results demonstrate the potential of PDEGMA/P(LLA-CL)/ciprofloxacin fibers as advanced wound dressing materials.
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