CELL RESEARCH
·
2017
·Vol. 28
·期 1
·48-68
·
IF 15.606
Xu Xingxing,Li Chuanyin,Gao Xiaobo,Xia Kun,Guo Hui,Li Yali,Hao Zijian,Zhang Lei,Gao Daming,Xu Chenfan,Xu Huatai,Xiong Zhi-Qi,Qiu Zilong,Mei Ling,Xie Xiaoduo,Ruan Kangcheng,Hu Ronggui
The autism spectrum disorders (ASDs) are a collection of human neurological disorders with heterogeneous etiologies. Hyperactivity of E3 ubiquitin (Ub) ligase UBE3A, stemming from 15q11-q13 copy number variations, accounts for 1%-3% of ASD cases worldwide, but the underlying mechanisms remain incompletely characterized. Here we report that the functionality of ALDH1A2, the rate-limiting enzyme of retinoic acid (RA) synthesis, is negatively regulated by UBE3A in a ubiquitylation-dependent manner. Excessive UBE3A dosage was found to impair RA-mediated neuronal homeostatic synaptic plasticity. ASD-like symptoms were recapitulated in mice by overexpressing UBE3A in the prefrontal cortex or by administration of an ALDH1A antagonist, whereas RA supplements significantly alleviated excessive UBE3A dosage-induced ASD-like phenotypes. By identifying reduced RA signaling as an underlying mechanism in ASD phenotypes linked to UBE3A hyperactivities, our findings introduce a new vista of ASD etiology and facilitate a mode of therapeutic development against this increasingly prevalent disease.
✓ 已验证
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2022
·
IF 11.357
Dashi Lei,Chunli Gou,Chunli Wang,Juanqin Xue,Zhongshen Zhang,Weizhen Liu,Zhang Lin,Jing Zhang
The reduced chromite ore processing residue (rCOPR) deposited in environments is susceptible to surrounding factors and causes reoccurrence of Cr(VI). However, the impact of natural sunlight on the stability of rCOPR is still unexplored. Herein, we investigated the dissolution and transformation behaviors of Cr(III)–Fe(III) hydroxide, a typical Cr(III)-containing component in rCOPR, under visible light. At acidic conditions, the release rate of Cr(III) under illumination markedly increased, up to 7 times higher than that in the dark, yet no Cr(VI) was produced. While at basic conditions, only Cr(VI) was obtained by photo-oxidation, with an oxidation rate of ∼7 times higher than that by δ-MnO2 under dark conditions at pH 10, but no reactive oxygen species was generated. X-ray absorption near-edge structure and density functional theory analyses reveal that coexisting Fe in the solid plays a critical role in the pH-dependent release and transformation of Cr(III), where photogenerated Fe(II) accelerates Cr(III) produced at acidic conditions. Meanwhile, at basic conditions, the production of intermediate Cr(III)–Fe(III) clusters by light leads to the oxidation of Cr(III) into Cr(VI) through the nonradical “metal-to-metal charge transfer” mechanism. Our study provides a new insight into Cr(VI) reoccurrence in rCOPR and helps in predicting its environmental risk in nature.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2017
·
IF 2.714
Shuang Li,Te Wei,Guojuan Ren,Fang Chai,Hongbo Wu,Fengyu Qu
A simple and highly practical colorimetric method has been proposed for detection of chromium ions (Cr 3+ and Cr 6+ ) synchronously by sodium hyaluronate functionalized gold nanoparticles (SH-AuNPs). The SH-AuNPs were synthesized and characterized by UV–vis spectra and transmission electron microscopy (TEM). The colorimetric response of Cr 3+ and Cr 6+ can be performed simultaneously by the same probe SH-AuNPs, based on the property of special localized surface plasmon resonance (LSPR). The interaction between chromium ions and sodium hyaluronate causes rapid aggregation of the SH–AuNPs conjugates and a concurrent color conversion from wine red to blue gray which is clearly detectable by the naked eye. By using SH-AuNPs as colorimetric probe, the color change with 3 μM Cr 3+ , 1 μM Cr 6+ , or 10 μM mixed chromium ions can be recognized easily by naked eye with highly selectivity. The detection limit calculated by the linear relationship of LSPR were at 0.78 nM (for Cr 3+ ), 2.90 nM (Cr 6+ ) and 0.69 nM (mixed chromium ions) respectively, which were all below the guideline value set by World Health Organization (0.962 μM). The practical applicability of the SH-AuNPs was also verified by the detection of chromium ions in natural lake water samples.
✓ 已验证
产品关联
DOI
高影响因子
POWDER TECHNOLOGY
·
2024
·
IF 4.5
Yuxiao Xue,Deqing Zhu,Jian Pan,Gen Li,Xuewei Lv
In this paper, two types of Ni-Cr bearing composite burdens including SP1 (79% Ni-bearing sinter and 21% Cr-bearing oxide pellets) and SP2 (84% Ni-bearing sinter and 16% Cr-bearing pre-reduced pellets) were used for the more efficient preparation of high-Cr ferronickel . Based on the metallurgical performance characterization, thermodynamic analysis and smelting parameters optimization, the qualified high-Cr ferronickel were prepared by the utilization of the Ni-Cr bearing composite burdens. The recovery rates of iron, chromium and nickel exceed 95%, 90% and 98% whereas their grades are 85.56–85.88%, 7.82–8.02% and 1.59–1.62%, respectively. Compared with SP1, SP2 possesses lower smelting duration, which indicates the appropriate proportioning of Cr-bearing pre-reduced pellets is beneficial for the smelting process. The obtained high-Cr ferronickel consisting of (Fe, Cr) 3 C and (Fe, Cr) 7 C 3 can be used as a low-cost substitute for the conventional raw materials of 200 or 300 series of stainless steel .
✓ 已验证
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2020
·
IF 3.232
Qiulan Li,Dezhi Yang,Yaling Yang
The study presents a spectrofluorimetric method for the determination of Cr(III) based on 2,3-diaminophenazine (DAP) as fluorescent nano sensor. With the peroxidase-mimicking activity of copper-doped carbon dots (Cu-CDs), colorless o -phenylenediamine (OPD) was oxidized to fluorescent DAP in the presence of H 2 O 2 via generation of hydroxyl radicals . The Cr(III) was found to decrease the fluorescent intensity of the Cu-CDs-mediated OPD oxidation system. Cr(VI) species were reduced to Cr(III) by employing 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonate) (ABTS) as the reductant, and a novel spectrofluorimetric method for the highly sensitive detection of speciation Cr(VI) and Cr(III) was developed. The Cu-CDs nanozyme was prepared from ethylenediaminetetraacetic acid copper disodium salt (Na 2 [Cu (EDTA)]) by one-step pyrolysis method. Under optimal conditions, the fluorescence intensity of DAP is linearly proportional to the Cr(III) ion concentration in the range of 5 × 10 −6 to 1.5 × 10 −4 mol L −1 and the detection limit is 1.2 × 10 −7 mol L −1 . The method has a good anti-interference performance against some metal ions , such as, Hg 2+ , Co 2+ , Cu 2+ , Mg 2+ , Ba 2+ , K + , Mn 2+ , Ni 2+ , Al 3+ , and Fe 3+ . The proposed method was successfully applied in the determination of Cr(VI) and Cr(III) in water samples.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF SUPERCRITICAL FLUIDS
·
2022
·
IF 4.514
Jianqiao Yang,Shuzhong Wang,Jiahuan Wang,Jinlong Wang,Baoquan Zhang,Lu Liu,Wei Liu,Yanhui Li,Donghai Xu
In this study, the erosion-corrosion experiment of Ni based alloys in high-temperature and high-pressure supercritical water environment was performed. SiO 2 and Al 2 O 3 particles with the average diameter of 30 µm and 50 µm were used as erodent. The special designed specimens were fixed on a blade impeller , and the erosion tests were performed in a high pressure autoclave with a magnetic stirrer system. Results show that the basic corrosion mechanism is not changed by the erosion process. A Cr-rich inner oxide layer and a Fe/Ni rich outer oxide layer were formed on the alloy surface. However, the oxidation rates of the alloys were affected by the erosion process. Parts of the outer Fe and Ni oxides were removed by the erodent particles during the tests. The inner Cr oxide layer still exists owing to the self-healing ability of the Cr 2 O 3 layer, acting as a barrier to resist further corrosion of the alloys. The factors that affect the degree of erosion and the erosion-corrosion mechanism in SCW environment is analyzed.
研究领域:
材料科学
·
腐蚀科学
·
高温高压环境材料行为
·
表面工程
·
能源材料
✓ 已验证
DOI
高影响因子
Journal of Cleaner Production
·
2022
·
IF 11.072
Lu Zhang,Jianhao Qiu,Dingliang Dai,Yichen Zhou,Xi Liu,Jianfeng Yao
MIL-101(Cr)@ZnIn 2 S 4 hierarchical heterojunction was delicately designed and fabricated through the in-situ growth of ZnIn 2 S 4 on MIL-101 and electrostatic self-assembly. It is affirmed that the Cr–S interface bonding between MIL-101 and ZnIn 2 S 4 in their composite was established based on the characterization results of X-ray photoelectron spectroscopy, Raman and zeta potential . Thus, a high-speed channel for charges transfer is offered due to the Cr–S bond, intimate interface contact and hierarchical structure of MIL-101@ZnIn 2 S 4 , which largely inhibits the recombination of photo-induced charge carriers and promises a remarkable photocatalytic activity . Choosing visible-light-driven reduction of Cr(VI) as a model, the optimal MIL-101@ZnIn 2 S 4 sample can reduce 95% of Cr(VI) within 30 min, corresponding to a rate constant of 0.107 min −1 , which is 2.9-fold compared with blank ZnIn 2 S 4 counterpart (MIL-101 has a negligible performance). Additionally, a conspicuous apparent quantum yield of 9.7% can be achieved at a wavelength of 420 nm. Eventually, to reinforce the practicability of MIL-101@ZnIn 2 S 4 , the composite powders were manufactured as aerogels utilizing bacterial cellulose as a substrate. The MIL-101@ZnIn 2 S 4 aerogel still exerts an enviable performance for photocatalytic reduction of Cr(VI) and stability. This work could inspire the material design and environmental remediation based on MOFs.
✓ 已验证
产品关联
DOI
高影响因子
Processes
·
2024
·Vol. 12
·期 5
·905
·
IF 2.8
Tianji Liu,Huawei Guo,Qing Yu,Yajun Wang,Huan Liu,Yanan Zeng,Yitong Wang,Chunyu Liu,Junguo Li
In this study,Chlorella pyrenoidosawas cultured with different concentrations of Cr(III) and Cr(VI), and the changes in biomass, lipid content, protein content and total sugar content ofChlorella pyrenoidosaunder different culture conditions were detected. The effects of Cr(III) and Cr(VI) on the intracellular antioxidant system and related key enzymes of lipid synthesis were analyzed. The results showed that appropriate Cr(III) and Cr(VI) concentrations could makeChlorella pyrenoidosaregulate the contents of SOD, POD, ASA, CAT and GSH in cells, improve the enzyme activity of ACC and promote lipid synthesis. The aim was to investigate the mechanism of lipid synthesis by analyzing the distribution of Cr(III) and Cr(VI) in algal cells. The lipid content ofChlorella pyrenoidosareached its highest level at 50.43 wt% and 38.00 wt% when both Cr(III) and Cr(VI) concentrations in the culture environment were 0.5 mg/L. These values were 1.37 and 1.03 times higher than the control group, respectively. The addition of appropriate Cr(III) and Cr(VI) concentrations can increase ME enzyme activity and decrease PEPC enzyme activity, shorten the biomass accumulation cycle and prolong the lipid synthesis cycle.
✓ 已验证
产品关联
DOI
高影响因子
OPTICAL MATERIALS
·
2016
·
IF 2.183
Pande Zhang,Benxue Jiang,Jintai Fan,Xiaojian Mao,Long Zhang
Cr and Nd co-doped laser ceramics, as the potential gain materials in inertial confinement fusion (ICF), have been widely investigated. And the study on valence states of chromium ions is important. The effects of sintering additives and annealing atmosphere on the valence state of chromium were studied in detail, and the results shown that the Cr valence states were demonstrated to be Cr 2+ and Cr 3+ ions in HIP-sintered Cr(0.2 at.%), Nd(0.8 at.%): LuAG laser ceramics. And the intensity of the near-infrared absorption band caused by Cr 2+ ions was attenuated with the decreasing SiO 2 concentration and increasing MgO amount. The near-infrared absorption could be eliminated by annealing in air. And the transformation of valence states of Cr ions in the Cr,Nd:LuAG ceramics were also confirmed by electron paramagnetic resonance and X-ray photoelectron spectroscopy.
✓ 已验证
DOI
高影响因子
TRANSACTIONS OF TIANJIN UNIVERSITY
·
2025
·
IF 8.5
Huang Xiaorui,Zhang Wei,Xiao Liyang,Han Chunyan,Liu Ying,Zhang Jingtong,Tan Haiwen,Yin Pengfei,Zhang Rui,Dong Cunku,Liu Hui,Du Xiwen,Yang Jing
NiFe(oxy)hydroxide (NiFeOOH) has been widely studied as a catalyst for oxygen evolution reaction (OER), but its activity is still not satisfactory. Although metal doping has been employed as a promising strategy for addressing this issue, the instability and leaching of the high-valence dopant metals remain considerable challenges. Herein, an array of Cr-doped NiFeOOH nanosheets was in situ synthesized on nickel foam via a one-step hydrothermal method. The doping of NiFeOOH with Cr was found to induce partial electron transfer from Ni and Fe to Cr atoms, thereby modulating the electronic structure of the catalyst and enhancing its intrinsic activity. Electrochemical and in situ Raman spectroscopy analyses showed that Fe active sites with lower charge density enhance the adsorption of *OH and reduce the formation energy barrier of the *OOH intermediate during OER, thereby accelerating the OER. Moreover, Fe was found to promote the transfer of additional electrons to Cr, leading to electron accumulation at Cr sites. This electron accumulation effectively prevents Cr from excessive oxidation and leaching under anode potentials, thereby maintaining the structural stability of the catalyst. The optimized Cr-doped NiFeOOH self-supported electrode exhibited a current density of 50 mA/cm 2 with an overpotential of only 239 mV and remained stable for 100 h at 600 mA/cm 2 in 1 mol/L KOH.
✓ 已验证
产品关联
DOI
高影响因子
DALTON TRANSACTIONS
·
2015
·Vol. 45
·期 20
·8347-8354
·
IF 4.197
Chen Dong,Genhua Wu,Zhuqing Wang,Wenzhi Ren,Yujie Zhang,Zheyu Shen,Tianhua Li,Aiguo Wu
A colorimetric assay is proposed for the selective detection of Cr(III) and Cr(VI) via the aggregation-induced color change of gallic acid capped gold nanoparticles (GA-AuNPs). The AuNPs are characterized using UV-vis spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS) and Fourier-transform infrared spectrometry (FT-IR). To detect Cr(III) and Cr(VI) coexisting in a sample, citrate and thiosulfate were applied to mask Cr(VI) for the detection of Cr(III), and ethylenediaminetetraacetic acid disodium salt (EDTA) was applied to mask Cr(III) for the detection of Cr(VI). At optimized experimental conditions, the selectivity of these AuNPs-based detection systems is excellent for Cr(III) and/or Cr(VI) compared with other types of metal ions. The limit of detections (LODs) of a mixture of Cr(III) and Cr(VI), Cr(III) and Cr(VI) by eye vision are 1.5, 1.5 and 2 μM, respectively, and those by UV-vis spectroscopy are 0.05, 0.1 and 0.1 μM, respectively. The minimum detectable concentrations for Cr(III) or Cr(VI) are all below the guideline value set by the US Environmental Protection Agency (EPA). The applicability of the AuNPs-based colorimetric sensor is also validated by the detection of Cr(III) and Cr(VI) in electroplating wastewater and real water samples with high recoveries.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2017
·
IF 9.446
Yaxi Zhang,Mengjiao Xu,Hao Li,Hao Ge,Zhenfeng Bian
The photocatalytic reduction efficiency of hexavalent chromium (Cr 2 O 7 2− (Cr(VI)) is suffering from high recombination of photoinduced charges, poor adsorption capacity of Cr(VI), and slow desorption of product trivalent chromium (Cr 3+ (Cr(III))) from photocatalyst surface. In this work, carbon dots (CDs) was coupled with TiO 2 mesocrystals (MT), where CDs displayed both the electron collectors and the active sites. During photoreduction of Cr(VI), the as-prepared CD/MT exhibited activity about 5.4 times higher than the pure TiO 2 mesocrystals. The positive charges on the CD/MT surface favored the selective adsorption of Cr(VI) and rapid desorption of Cr(III), which has an obvious promotion on the photocatalytic reduction of Cr(VI) and retention of photoreduction activity. Meanwhile, the CDs coupled on TiO 2 mesocrystals facilitated the separation of photogenerated charges. This work provides a simple and effective adsorption-photoreduction-desorption mechanism for the photocatalytic reduction of Cr(VI).
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）