TALANTA
·
2025
·
IF 6.1
Xiwang Hou,Tianhao Chen,Chunyan Wang,Fanyu Liu,Minggang Zhao,Ye Ma
The concentration range of uric acid (UA) varies significantly across different biological fluids, and therefore, highly sensitive and wide-range detection of UA is of great importance for the early diagnosis of UA-related diseases. Surface-enhanced Raman spectroscopy (SERS) offers high sensitivity and molecular fingerprint specificity; however, challenges remain regarding its signal uniformity and detection range. In this work, a uniform and stable two-dimensional metasurface is constructed via liquid–liquid interface (LLI) self-assembly of silver nanoparticles (NPs) functionalized with bis (p-sulfonatophenyl) phenylphosphine di-potassium salt (BSPP). UA is catalytically oxidized by uricase, which in turn oxidizes the BSPP ligands on the NP surface, inducing microstructural changes in the metasurface, which led to a decrease in the BSPP signal in the SERS mode at low UA concentrations and a reduction in reflectance in the reflectance mode at high UA concentrations. Using this dual-mode strategy, a detection limit (LOD) of 3.22 ± 0.10 nM for UA and a dynamic range of 0.100–1500 μM are achieved. The strategy enables rapid NPs assembly and complementary linear ranges, offering a versatile approach with potential for extension to diverse analytes and portable point-of-care applications, highlighting its potential significance for the early diagnosis of UA–related diseases.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Shuang Feng,Dongqi Yue,Liangjiu Bai,Hou Chen,Wenxiang Wang,Huawei Yang,Lixia Yang,Donglei Wei
Wearable flexible sensors face the challenge of maintaining stable performance and state in low-temperature environments. In this work, a nano-reinforced material (CNCs/PDA/ZP) composed of ZP and PDA-coated polysaccharide material CNCs was designed. By introducing the modified nanomaterial CNCs/PDA/ZP and PDX into double-network hydrogels composed of PAA and CG, nanocomposite hydrogels were prepared. The hydrogels exhibit excellent antifreeze properties (−35 °C), along with high sensitivity (GF = 2.97) and a rapid response time (229.2 ms). Its strain sensor can detect human motion within a wide temperature range, and it also has good biocompatibility. This achievement not only expands the environmental adaptability of hydrogels but also paves a new way for the practical application of biocompatible flexible electronic devices.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Xinyu Luo,Dejin Lin,Jingqi Wang,Yihao Zhang,Xinru Liu,Sineng Gao,Da Chen
High-performance and on-site detection of pesticide glyphosate (GLY) residue is particularly urgent and challenging. Herein, dual-emission nitrogen-doped carbon dots (N-CDs) synthesized from tris-hydroxymethyl-aminomethane and resorcinol are successfully developed as a ratiometric fluorescence sensor. Upon adding GLY, the fluorescence intensity of N-CDs at 425 nm is quickly quenched via aggregation-caused quenching and photoinduced electron transfer, leading to the complexation process of N-CDs with GLY. While the fluorescence intensity of N-CDs at 525 nm with little change can be served as the reference signal. This distinct ratiometric fluorescence sensor achieves the detection limit and quantification limit as low as 24 nM and 80 nM with a wide linear range of 0.024–30 μM, respectively. Moreover, a smartphone-integrated lateral flow visual sensing platform is established for GLY detection by capturing and identifying the parameters of color variations. This platform represents a potential for the quantitative monitoring of GLY residue in food and the environment.
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ACS Sustainable Chemistry & Engineering
·
2026
·
IF 7.6
Runtian Miao,Xingyu Fan,Ning Zhang,Minjuan Gao,Yaling Mao,Yueqin Li
Hydrogel-based zinc–ion batteries (ZIBs) stand out as promising flexible energy storage devices, benefiting from their synergistic advantages of high theoretical specific capacity, reliable safety performance, and cost-effectiveness. However, conventional hydrogel-based ZIBs are plagued by inadequate ionic conductivity and structural instability at subzero temperatures, which consequently lead to sluggish Zn-ion migration kinetics and severe capacity decay. Herein, we introduced zwitterionic proline (PL) as an antifreezing additive into cross-linked polyacrylamide/carboxymethyl chitosan (PAM/CMCS) to address the above-mentioned challenges. PL can reduce hydrogen bonds between free water, thus endowing the hydrogel electrolyte (HE) with good antifreezing and antidrying performance, interfacial adhesive, high ionic conductivity (30.20 ± 0.47 mS/cm), and enhanced interfacial adhesion. Notably, the PL additive facilitates more uniform zinc deposition in the PAM/CMCS/PL electrolyte relative to the bare PAM/CMCS electrolyte and the ZnSO4 aqueous electrolyte. Accordingly, the PAM/CMCS/PL HE confers outstanding long-term cycling stability on the Zn//Zn symmetric cell. The asymmetrical Zn//MXene@PANI flexible ZIBs can deliver a specific capacity of 154.8 mAh/g at 0.5 A/g and maintain 84.9% capacity with an excellent Coulombic efficiency above 99% after 500 cycles. This flexible ZIB can withstand severe deformations and operate normally at low temperatures (75.2 mAh/g at 1.0 A/g, even at −30 °C). High-performance flexible ZIBs with outstanding low-temperature tolerance are successfully fabricated in this work, providing insightful references for advancing multifunctional flexible energy storage systems and wearable electronics.
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COMPUTERS AND ELECTRONICS IN AGRICULTURE
·
2026
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IF 10.3
Liru Yan,Bianxiang Zhang,Wei Zhou,Chao Feng,Caihong Zhang,Yan Zhang,Shaomin Shuang,Lihong Shi
Highly-intelligent user-friendly sensing strategies are becoming desperately demanded and indispensable in under-developed nations and resources-insufficient areas. Herein, an intelligent sensing platform has been successfully established incorporating smartphone with machine vision and deep learning function, 3D-printed handheld device, and paper microfluidic chip stained with tri-emission ratiometric-fluorescence (FL) carbon dots (TCDs). The intelligent system can quantify zinc ion (Zn 2+ ) and ethylenediaminetetraacetic acid (EDTA) only through a single-step operation on smartphone. TCDs, engendering bright blue and cyan FL as well as weak red one at 370 nm excitation, were prepared hydrothermally using tartaric acid and alizarin carmine. As-prepared TCDs exhibit continuous FL color transformation from blue to purple to blue with the addition of Zn 2+ and EDTA. Subsequently, TCDs-based paper chip is explored to enable field-portable sequential discrimination of Zn 2+ and EDTA. Intriguingly, the proposed sensor is utilized for fast and intelligent quantification of Zn 2+ and EDTA in soil filtrate, plant sap and tap water with a low detection limit of 3.8 μM and 7.9 μM, as well as wide linear correlations of 0–280 µM and 0–560 µM, respectively. It is eagerly anticipated that our methodologies will become the strong impetus for new round of technological transformation for analyte assay.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2026
·
IF 7.1
Guohua Teng,Min Zhou,Initizar Anwar,Yang Liu,Fuyi Li,Yanxu Chang,Yidan Wang,Yuefei Wang,Fei Tian
Flavonoids in Scutellaria Radix ( SR ) exhibit significant pharmacological activities, yet conventional extraction methods often suffer from low efficiency and poor selectivity. Here, a green and effective strategy was developed using deep eutectic solvent (DES)-functionalized magnetic nanoparticles for selective flavonoid enrichment. Forty-eight DESs were screened, and levulinic acid/L-proline (2:1) was identified as the optimal system. The selected DES was employed to synthesize Fe 3 O 4 @SiO 2 @DES, which demonstrated high specificity and adsorption performance in magnetic solid-phase extraction. Under optimized conditions, adsorption efficiencies for four representative flavonoids ranged from 0.770 ± 0.01 to 0.983 ± 0.002, with desorption recoveries of 0.551 ± 0.003 to 0.919 ± 0.019. The method showed excellent linearity (R 2 ≥ 0.9998) and low limits of detection and quantification (0.01-0.35 μg mL −1 and 0.03-0.98 μg mL −1 , respectively). Moreover, the adsorbent retained high adsorption efficiency after six reuse cycles, demonstrating stability and reusability. This work provides a sustainable and selective approach for flavonoid enrichment from SR and highlights the potential of DES-functionalized magnetic nanomaterials as an eco-friendly alternative to conventional organic solvent-based extraction.
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DYES AND PIGMENTS
·
2026
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IF 3.9
Shen Zhang,Zhuo Wang
In consideration of the potential threat, the establishment of efficient approach for fluazinam determination is necessary. Based on the superior property of carbon dots and biomass, sulfur doped biomass-based carbon dots (SBCDs) were constructed using a simple hydrothermal approach, in which peanuts were applied as carbon sources with the addition of methionine. The well-dispersed SBCDs displayed optimal emission wavelength of 435 nm under the excitation wavelength of 364 nm. Owing to the detection principle of fluorescence quenching through static quenching and inner filter effects, the SBCDs were used to detect fluazinam with a broad linear range of 0-100 μM and a detection limit of 0.026 μM. Additionally, the SBCDs also exhibited temperature sensing with a wide linear range of 15-95 °C. Moreover, the as-prepared SBCDs were effectively used for the determination of fluazinam in tap water and orange juice samples. The SBCDs displayed tremendous potential for the sensing of fluazinam and temperature.
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JOURNAL OF THE INDIAN CHEMICAL SOCIETY
·
2026
·Vol. 103
·期 3
·102446
·
IF 3.4
Boshen Wang,Jihong Fu,Jun Tang,Haipeng Zhang,Junli Yu,Qichao Wu,Mengdie Li
Sunflower seed meal is a rich source of chlorogenic acid (CGA). In this work, the conductor-like screening model for realistic solvation (COSMO-RS) was used to assist in identifying the optimal natural deep eutectic solvents (NADESs) for the extraction of CGA from the sunflower seed meal. A total of 20 hydrogen bond donors (HBDs) and 10 hydrogen bond acceptors (HBAs) at different molar ratios resulting in 600 NADESs were screened via the COSMO-RS model by calculating the infinite dilution activity coefficients of CGA. The results showed that the solvent composed of choline chloride (ChCl) and urea at a molar ratio of 2:1 had the highest extraction rate of 25.92 mg g −1 for CGA. Additionally, ChCl-Urea (2:1) was chosen as the solvent in response surface methodology (RSM) to optimize the microwave assisted NADES extraction parameters, including liquid-solid ratio, microwave power, temperature and irradiation time, yielding a CGA content of 26.39 mg g −1 . Furthermore, the antioxidant activities of the CGA extract using NADES were determined, which exhibited better DPPH, ABTS radicals scavenging abilities and ferric reducing antioxidant power (FRAP). Therefore, COSMO-RS and RSM can serve as effective techniques for screening NADESs and optimizing extraction processes, thereby expanding the application potential of NADES in extracting various bioactive compounds.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Rui Hu,Da-Wen Sun,You Tian,Liang Xu,Libin Sun
As a new cryoprotectant, natural deep eutectic solvents (NADESs) have been shown to achieve efficient and safe cryoprotection through excellent thermodynamic characteristics and strong recrystallisation inhibition ability. To further discover the cryoprotection mechanism of NADESs, the transcriptomics of yeast cells cryopreserved by different NADESs were examined. Notably, the PG cryoprotected yeast cells showed the highest viability (Q4: 81.39%) and the earliest regrowth peak (~ 6 h), indicating superior recovery performance. Transcriptomic analysis suggests that NADESs significantly modulate yeast cryotolerance. Differentially expressed genes (DEGs) were predominantly enriched in carbohydrate, amino acid, and fatty acid metabolism. Specifically, key genes involved in glycolysis, such as PCK1 , FBA1 , and ENO1 , were significantly regulated. Furthermore, the up-regulation of osmotic pressure-related genes ( STL1 , FPS1 ) in GF-cryopreserved yeast is consistent with observed osmotic changes. This suggests that proline-containing NADESs may help modulate osmotic pressure, thereby mitigating osmotic damage. Overall, this study supports a more comprehensive understanding of the cryopreservation mechanisms of emerging NADESs. Importantly, while these results support a role for NADES-induced shifts in glycolysis and osmoadaptation, the causality will be further validated in future work using HOG1 Δ, STL1 Δ, and FPS1 Δ strains, as well as pharmacologic MAPK inhibition.
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ANALYTICA CHIMICA ACTA
·
2026
·
IF 6
Tongfang Chen,Jingjie Liang,Weiqing Liu,Fengxia Zhou,Chanci Qiu,Yuhui Peng,Xie Zhou
Background Glutathione (GSH), the most abundant cellular non-protein thiol and a central antioxidant, plays essential roles in regulating redox homeostasis, signal transduction, and detoxification processes. Altered GSH levels are closely associated with various pathological conditions, including neurodegenerative disorders, and liver injury . Notably, tumor tissues exhibit markedly elevated GSH concentrations (up to 4-10 times higher than in normal cells), where it promotes tumor proliferation, invasion, and chemoresistance by sustaining a reduced microenvironment, these characteristics make GSH an important biomarker and therapeutic target in oncology. Results We developed a novel "switch-on" near-infrared (NIR) fluorescence nanoprobe, Ag 2 S-CH@Cu-TCPP, for the highly sensitive and selective detection and imaging of GSH. The nanoprobe was constructed by conjugating histidine-rich CH peptides to carboxyl-capped Ag 2 S quantum dots (Ag 2 S QDs), which were then self-assembled onto two-dimensional Cu-TCPP metal-organic framework (MOF) nanosheets via coordination between Cu 2+ and imidazole groups. In this design, Cu-TCPP acts as an efficient quencher for the Ag 2 S-CH fluorescence via a fluorescence resonance energy transfer (FRET) mechanism. Upon encountering GSH, the reduction of Cu 2+ to Cu + disrupts the FRET process, leading to the recovery of the NIR fluorescence signal. This nanoprobe demonstrated a low detection limit of 5.33 μM and a wide linear range from 0.625 to 10 mM for GSH quantification, with excellent selectivity, high reproducibility, and favorable biocompatibility. We successfully applied the platform for monitoring intracellular GSH levels and distinguishing between cancer cells and normal cells based on their differential GSH expression. Significance and Novelty The "switch-on" probe demonstrates excellent biocompatibility and is applicable for cellular imaging. It enables discrimination between normal and cancer cells while supporting semi-quantitative analysis of both endogenous and exogenous GSH. This work provides a novel and reliable strategy for tumor diagnosis and advanced investigations into GSH-related biological processes.
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FOOD CHEMISTRY
·
2026
·
IF 9.8
Boyan Sun,Linqian Qin,Vasily G. Panferov,Chujun Liu,Xiaomei Wang,Jiankang Ren,Qian Ran,Sihan Wang,Haiyang Jiang
Ractopamine (RAC), a banned β-adrenergic agonist, poses severe risks to human health, necessitating rapid and ultrasensitive detection methods. This work presents a novel dual-mode immunoassay utilizing peroxidase-mimicking Au@Pt core-shell nanozymes for the colorimetric and photothermal detection of RAC. The optimized one-step synthesized Au@Pt nanoparticles (Au/Pt = 1:1) exhibited exceptional peroxidase-like activity (27.32 U/mg). After conjugation with monoclonal antibodies, the nanozymes served as immunoprobes in a one-step enzyme-linked immunosorbent assay (ELISA). The enhanced catalysis was elucidated by reactive oxygen species trapping, confirming hydroxyl radicals and singlet oxygen as key intermediates. The assay demonstrated outstanding sensitivity, with limits of detection at 5.32 pg/mL (colorimetric) and 1.03 pg/mL (photothermal), a significant improvement over conventional ELISA. Practical applicability was confirmed in spiked pork and pig urine, achieving recoveries of 86.0–113.0% (coefficient of variation<14.3%), offering a robust platform for on-site screening.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.1
Chenyan Lu,Dajie Zou,Ning Zhang,Huye Li,Yanyan Jia,Huan Wang
In this study, the hexane extract of Asters tataricus was used as the carbon source, and ethylenediamine and 4-bromophenylene diamine were selected as dopants to prepare nitrogen and bromine co-doped carbon dots (N,Br-CDs) by the hydrothermal synthesis method. The obtained fluorescent probe has a uniform particle size distribution, good water solubility and high stability, with a fluorescence quantum yield of 48.43%. Under 420 nm excitation conditions, N,Br-CDs exhibited the strongest fluorescence emission at 513 nm, indicating that the sensing system was in the “ON” state. Subsequently, TA was introduced as a quencher to induce static quenching of the N,Br-CDs system, significantly weakening the fluorescence intensity and switching the sensing system from “ON” to “OFF”. Finally, after EM was introduced into the N,Br-CDs/TA system, EM preferentially formed a complex with TA and weakened its quenching effect on the quantum dots, thereby achieving fluorescence recovery and returning the sensing system from the “OFF” state to the “ON” state. Based on the above mechanism, an “ON-OFF-ON” fluorescence sensing system with N,Br-CDs as the luminescent substrate was constructed for the sensitive detection of TA and EM. The results showed that the system exhibited good linear response to TA, with the linear ranges being 1.50–22.94 μM and 34.88–348.42 μM, respectively, and the limits of detection being 0.2168 μM and 2.1797 μM, respectively (LOD, S/N = 3). The linear range for EM was 1.93–377.08 μM, with a detection limit of 0.6693 μM. Furthermore, the sensor system was capable of quantitatively determining TA and EM in human serum, Huangshui River water, and milk matrices, demonstrating its potential for broad application in environmental monitoring and bioanalysis.
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