LANGMUIR
·
2025
·
IF 3.9
Chen-Zheng Yan,Zhi-Yang Zhang,Chun-Yan Li,Song-Hai Wu,Yong Liu,Xu Han
Although the slippery liquid-infused porous surfaces (SLIPSs) exhibit highly antifouling performance against various working liquids, the loss of lubricant always deteriorates their long-term durability. Herein, a spongy composite of polyvinylidene difluoride (PVDF) and hydrangea-type perfluorooctyltrimethoxysilane (POTS)-modified mesoporous silica nanoparticles (MSNs) has been successfully prepared via the spraying method and used as the substrate for SLIPSs, which exhibits satisfactory storage and lock capacities for lubricant to enhance its durable antifouling performances. After infusing perfluoropolyether (PFPE) into the spongy substrate, a stable POTS-MSNs@PVDF@PFPE is prepared, which exhibits high amphiphobic performances (WSA of 1.68 ± 1.13° and OSA of 5.99 ± 1.34°) and high repellence to various working liquids, indicating its high antifouling performance. The long freezing time of 121.50 s and the low ice-adhesion strength of 25.67 kPa also indicate its high anti-icing performances. Furthermore, the high stability of POTS-MSNs@PVDF@PFPE after various thermal, chemical, and mechanical testing indicates its satisfactory durability. Actually, the abundant micropores of POTS-MSNs@PVDF provide adequate space for locking PFPE, thus prolonging its antifouling performances. This study provides an insight into the development of SLIPSs capable of maintaining long-term antifouling performance in harsh environments.
研究领域:
材料科学
·
表面工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CONTROL
·
2024
·
IF 5.6
Zhumiao Ye,Haidu Yuan,Jianhao Zhang,Wenjing Yan,Changrui Xing
Fresh pork is easily contaminated by microorganisms, leading to spoilage. Dielectric barrier discharge (DBD) cold plasma technology has shown significant advantages in the preservation of meat. However, severe lipid oxidation of pork resulting from DBD treatment greatly limits its development. Herein, the antibacterial D@MSNs-P/PCL nanofiber membranes were prepared by modification polycaprolactone (PCL) with pre-reported nanomaterials (D@MSNs-P) through electrostatic spinning. Compared with the PCL membranes, the D@MSNs-P/PCL membranes showed better water stability, lower water vapor transmission rate, stronger hydrophobicity, and potent antibacterial activity. The D@MSNs-P/PCL membranes can be used for wrapping fresh pork before treatment with DBD plasma, which can not only improve the antibacterial efficiency but effectively inhibit the lipid oxidation and color change of fresh pork, extending the shelf life for 2 days. The developed D@MSNs-P/PCL membranes can also be used alone to preserve other fresh meat or oily food, with a wide range of application prospects.
研究领域:
食品科学
·
材料科学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2016
·
IF 3.902
Yaqing Jin,Nengpan Zhang,Chunlin Li,Kefeng Pu,Chen Ding,Yimin Zhu
A dual-functional delivery system, based on mesoporous silica nanoparticles (MSNs) with the integration of Magnetic Resonance (MR) imaging and therapeutic peptide delivery, is reported in this paper. A lipid bilayer is attached onto the surface of the nanoparticles, following the doping of Gadolinium (Gd), a paramagnetic lanthanide ion. The liposome-coated GdMSNs exhibit improved colloidal stability, better biocompatibility and more efficient cellular uptake. The Gd renders the nano carrier a potential T1 contrast agent, confirmed by the MR imaging. A pro-apoptotic peptide, KLA (HGGKLAKLAKKLAKLAK), is encapsulated into the GdMSNs-LP and enters into the cells successfully to induce mitochondrial swelling and apoptosis, while it is nontoxic outside the cells. The synthesis procedure is convenient and free of toxic organic reagents. The nanosystem we construct may contribute to a promising theranostic platform for therapeutic peptide delivery in cancer treatment.
研究领域:
纳米技术
·
生物医学工程
·
癌症研究
·
材料科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Acta Pharmaceutica Sinica B
·
2023
·
IF 14.5
Yue Zhang,Jingwen Gao,Na Li,Peng Xu,Shimeng Qu,Jinqian Cheng,Mingrui Wang,Xueru Li,Yaheng Song,Fan Xiao,Xinyu Yang,Jihong Liu,Hao Hong,Ronghao Mu,Xiaotian Li,Youmei Wang,Hui Xu,Yuan Xie,Tianming Gao,Guangji Wang,Jiye Aa
Studies have suggested that the nucleus accumbens (NAc) is implicated in the pathophysiology of major depression; however, the regulatory strategy that targets the NAc to achieve an exclusive and outstanding anti-depression benefit has not been elucidated. Here, we identified a specific reduction of cyclic adenosine monophosphate (cAMP) in the subset of dopamine D1 receptor medium spiny neurons (D1-MSNs) in the NAc that promoted stress susceptibility, while the stimulation of cAMP production in NAc D1-MSNs efficiently rescued depression-like behaviors. Ketamine treatment enhanced cAMP both in D1-MSNs and dopamine D2 receptor medium spiny neurons (D2-MSNs) of depressed mice, however, the rapid antidepressant effect of ketamine solely depended on elevating cAMP in NAc D1-MSNs. We discovered that a higher dose of crocin markedly increased cAMP in the NAc and consistently relieved depression 24 h after oral administration, but not a lower dose. The fast onset property of crocin was verified through multicenter studies. Moreover, crocin specifically targeted at D1-MSN cAMP signaling in the NAc to relieve depression and had no effect on D2-MSN. These findings characterize a new strategy to achieve an exclusive and outstanding anti-depression benefit by elevating cAMP in D1-MSNs in the NAc, and provide a potential rapid antidepressant drug candidate, crocin.
研究领域:
神经科学
·
药理学
·
精神病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Yi-Fan Gao,Rui Zou,Guang-Feng Chen,Bo-Mei Liu,Yong Zhang,Ju Jiao,Ka-Leung Wong,Jing Wang
Featured with excellent biocompatibility and background-free biomedical imaging, near infrared persistent luminescence (NIR-PersL) nanomaterials synthesized by mesoporous silica nanoparticles (MSNs) template have captured increasing attentions to be as a tumor theranostic nanoplatform. Unfortunately, many researches in the past decades have mainly focused on bioimaging performance of NIR-PersL nanomaterials themselves but not synergistically on tailoring the pore volume of the MSNs to optimize the drug loading/releasing performance, which greatly limits their potential application in tumor theranostics. In this work, we propose a tailorable large-pore mesoporous-silica-assisted synthesis strategy to synthesize a series of ZnGa 2 O 4 :Cr 3+ /Sn 4+ @MSNs (ZGOCS@MSNs) NIR-PersL nanospheres as nanoplatform. The ZGOCS@MSNs possess average diameters of ~ 80 nm. More interestingly, the mass ratio of ZGOCS to MSNs (MRZM) increases with the increasing of pore sizes of MSNs and the NIR-PersL performances of ZGOCS@MSNs enhance with the increase of MRZM, suggesting that MRZM plays an important role in optimizing NIR-PersL performance of the nanospheres. In vitro and in vivo NIR-PersL imaging further confirm the MRZM-dependent performance enhancement in NIR-PersL nanospheres. More importantly, the employment of large pore MSNs maintains the mesoporous structure of NIR-PersL nanospheres and the residual pore volume of ZnGa 2 O 4 :Cr 3+ /Sn 4+ @MSNs is high enough and available for efficient drug loading/releasing. Benefited from excellent rechargeable tumor NIR-PersL imaging ability and large residual cavities, ZGOCS@MSNs show high dose (~53%) of loading DOX and exhibit outstanding cancer cell killing efficiency, implying the MRZM also plays an important role in optimizing the drug loading/releasing performance of the nanospheres. In summary, the as-synthesized high performance ZnGa 2 O 4 :Cr 3+ /Sn 4+ @MSNs bi-functional nanoplatform showcases its great potential for imaging-guided cancer chemotherapy. We expect our work could take the development of NIR-PersL-based theranostic nanoplatforms a step forward.
研究领域:
材料科学
·
生物医学工程
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
MOLECULAR PHARMACEUTICS
·
2020
·
IF 4.321
Lan Cui,Xiayi Feng,Wentao Liu,Hao Liu,Qian Qin,Shuangxia Wu,Suqin He,Xinchang Pang,Dong Men,Chengshen Zhu
The surface charge of nanocarriers inevitably affects drug delivery efficiency; however, the cancer cell specificity, anti-inflammatory effects, and charge-reversal points remain to be further addressed in biomedical applications. The aim of this study was to comprehensively assess the cancer cell specificity of DOX-loaded mesoporous silica-chitosan oligosaccharide-carboxymethyl chitosan nanoparticles (DOX@MSNs-COS-CMC) in MCF-7 and HeLa cells, inhibit the production of inflammatory cytokines, and improve the drug accumulation in the tumor site. Intracellular results reveal that the retention time prolonged to 48 h in both HeLa and MCF-7 cells at pH 7.4. However, DOX@MSNs-COS-CMC exhibited a cell type-dependent cytotoxicity and enhanced intracellular uptake in HeLa cells at pH 6.5, due to the clathrin-mediated endocytosis and macropinocytosis in HeLa cells in comparison with the vesicular transport in MCF-7 cells. Moreover, Pearson’s correlation coefficient value significantly decreased to 0.25 after 8 h, prompting endosomal escape and drug delivery into the HeLa nucleus. After the treatment of MSNs-COS-CMC at 200 μg/mL, the inflammatory cytokines IL-6 and TNF-α level decreased by 70% and 80%, respectively. Tumor inhibition of DOX@MSNs-COS-CMC was 0.4 times higher than free DOX, alleviating cardiotoxicity and inflammation in the HeLa xenograft tumor model. Charge-reversible DOX@MSNs-COS-CMC could be a possible candidate for clinical therapy of cervical carcinoma.
研究领域:
药理学
·
肿瘤学
·
生物医学工程
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
Current Drug Delivery
·
2022
·Vol. 20
·期 10
·1559-1568
·
IF 3.758
Yang Qingyun,Zhao Chuncao,Yang Jian,Zhao Jingyi,Feng Yi,Liu Minchen,Zhang Jiquan
Background: Rhodojaponin III (RJ-III), a characteristic diterpene of Rhododendron molle G. Don, has a wide range of pharmacological activities including anti-inflammatory, antihypertensive, and analgesic effects. However, further research and development have been limited because
of its intense acute toxicity and poor pharmacokinetic profile. Objective: In this study, we propose the construction of folic acid–conjugated mesoporous silica nanoparticles (FA-MSNs) as carriers to deliver RJ-III in an attempt to reduce acute toxicity and improve biomedical applications
by prolonging drug release and targeting delivery. Methods: FA-MSNs were synthesized and characterized. RJ-III was then loaded into FA-MSNs (RJIII@ FA-MSNs), and the in vitro drug release profile was assessed. Subsequently, the RJ-III@FAMSNs’ cytotoxicity and targeting efficiency
were explored in lipopolysaccharide-activated RAW 264.7 cells, and their acute toxicity was investigated in mice. Results: Spherical FA-MSNs were approximately 122 nm in size. Importantly, the RJ-III@FA-MSNs showed prolonged RJ-III release in vitro. Moreover, in lipopolysaccharide-activated
RAW 264.7 cells, RJ-III@FA-MSNs not only reduced the cytotoxicity of RJ-III (P < 0.01), but also showed a good targeting effect from the results of cellular uptake. Additionally, the acute toxicity results demonstrated that RJ-III@FA-MSNs improved the LD50 value of RJ-III
in mice by intraperitoneal injection 10-fold. Conclusion: This is the first study to use FA-MSNs as carriers of RJ-III to reduce the acute toxicity of RJ-III. The results confirm the potential for targeted delivery of RJ-III in inflammatory cells to enhance efficacy, as well as providing
data for future investigations on anti-inflammatory activity.
研究领域:
药剂学
·
毒理学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
Materials Today Chemistry
·
2026
·
IF 7.4
Qiaozhi Miao,Lingjing Meng,Yue Yin,Yunfei Cai,Yonglong Zhang,Feiyan Yang,Chaoyu Zhang,Fang Guo,Jinfang Wu,Wenbo Wang
Stimuli-responsive active corrosion protection coatings serve as both an effective physical barrier and an active corrosion protection system for metallic substrates. However, their long-term performance is typically limited by the irreversible release of inhibitors and a restricted loading capacity, which hinders their repeated active corrosion protection capability and sustained durability. To address these limitations, we have developed a smart dual-stimuli-responsive active corrosion protection coating (denoted as MSNs-BTA@PANI/PVB) by encapsulating benzotriazole (BTA) within mesoporous silica nanocontainers (MSNs) coated with a polyaniline (PANI) shell. PANI, serving as a reversible molecular switch responsive to pH and redox conditions, enables controlled BTA release, ensuring sustained corrosion inhibition and prolonged service life. UV-vis spectroscopy revealed that in 3.5 wt% NaCl solution, minimal surface-adsorbed BTA was released from MSNs-BTA@PANI nanocontainer under pH change, whereas 0.54 mmol L − 1 release was triggered upon N 2 H 4 . After 50 days of immersion, EIS results showed that the coating containing 0.5 wt% MSNs-BTA@PANI achieved a |Z| 0.01Hz value of 1.14 × 10 5 Ω cm 2 , nearly seven times higher than that of the 0.5 wt% MSNs/PVB coating. This enhancement stems from the synergy between the physical barrier effect of MSNs and the dual-stimuli-triggered release of BTA, enabling effective localized corrosion inhibition. This work provides a reversible and controllable active protection strategy based on dual-responsive nanocontainers for designing durable intelligent corrosion protection coatings.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2021
·
IF 9.776
Zimu Li,Yao Yang,Huaxuan Wei,Xiaoting Shan,Xuanzhi Wang,Meitong Ou,Qingyun Liu,Nansha Gao,Hongzhong Chen,Lin Mei,Xiaowei Zeng
Given the difficulties of biodegradation of mesoporous silica nanoparticles (NPs), enrichment and penetration of tumor sites, and real-time monitoring of the treatment process, we developed a kind of mannose-doping doxorubicin-loading mesoporous silica nanoparticle (MSN-Man-DOX) and coated by polydopamine-Gd 3+ (PDA Gd) metal-phenolic networks, as well as modified by poly (2-Ethyl-2-Oxazoline) (PEOz), constructing a novel nanomedicine MSN-Man-DOX@PDA-Gd-PEOz. Its pH-responsive charge reversal, photothermal, biodegradation, drug release, and magnetic resonance imaging (MRI) properties were evaluated in vitro . Cellular uptake, tumor penetration, lysosomal escape properties, as well as cell safety and toxicity of the nanoplatform were investigated through cell experiments. Finally, the MRI, organ distribution, photothermal condition, and comprehensive anti-tumor therapy in vivo were evaluated comprehensively through animal experiments. Research results showed that MSN-Man-DOX@PDA-Gd-PEOz had outstanding tumor enrichment and penetration abilities, which can produce excellent treatment effects through the synergistic effect of chemotherapy and photothermal therapy (PTT) with the function of magnetic resonance imaging contrast agent for disease monitoring. Besides, after finishing the therapeutic effect MSN-Man-DOX@PDA-Gd-PEOz can be biodegraded, so it had a good prospect of clinical application.
研究领域:
纳米医学
·
肿瘤学
·
材料科学
✓ 已验证
DOI
高影响因子
NANOTECHNOLOGY
·
2024
·Vol. 35
·期 12
·125601
·
IF 2.9
Xia Pu,Wanling Cai,Huayao Chen,Fujie Yang,Xiaomei Mu
The key step in preparing mesoporous silica is to remove the organic template agent, and the most common method used to achieve this goal is high-temperature calcination. However, this method has many disadvantages, one of which is that it reduces the silanol density on the surface of mesoporous silica, which affects its subsequent modification. Ionic liquids (ILs) are often used as extractants. In this work, the 1-butyl-3-methylimidazolium chloride ([C4mim]Cl) IL is considered, and the effects of its concentration, reaction temperature, and reaction time as well as HCl concentration on the extraction rate and silanol density were investigated using an IL extraction template agent (cetyl trimethyl ammonium bromide (CTAB)). The results show that an IL concentration of 10%, a reaction temperature of 120 °C, a reaction time of 12 h, and an HCl concentration of 1% are the best reaction parameters; with these parameters, the extraction rate and the silanol density were found to be 93.19% and 2.23%, respectively. The silanol density of mesoporous silica treated by calcination is only 0.81%. A higher silanol density provides more reaction sites, so that the modified mesoporous silica treated with the IL can be loaded with more Zn ions.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2016
·
IF 3.902
Yin-Jia Cheng,Xuan Zeng,Dong-Bing Cheng,Xiao-Ding Xu,Xian-Zheng Zhang,Ren-Xi Zhuo,Feng He
Synergistic therapy involving two or more therapeutic agents with different anticancer mechanisms represents a promising approach to eradicate chemotherapy-refractory cancers. However, the preparation of a synergistic therapy platform generally involves complicated procedures to encapsulate different therapeutic agents and thereby increases the purification difficulty. In this work, we reported a simple but robust strategy to prepare a highly controllable drug delivery system (DDS) for synergistic cancer therapy. To construct this robust DDS, mesoporous silica nanoparticles (MSNs) were employed as a nanoplatform to encapsulate anticancer drug doxorubicin (DOX). After using a tumor-targeting cellular membrane-penetrating peptide (TCPP) and a mitochondria-targeting therapeutic peptide (TPP) to seal the surface pores via disulfide bonds, these newly developed MSNs can target cancer cells, penetrate cell membrane and rapidly release anticancer drug and mitochondria-targeted peptide in cytoplasm, inducing a remarkable synergistic anticancer effect. The new design concept reported here will promote the development of targeted and smart DDSs for synergistic cancer therapy.
研究领域:
生物医学工程
·
癌症治疗
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2021
·
IF 0
Xiaomei Dai,Jifang Ma,Ningning Chen,Yuanyuan Cai,Yanping He,Xiangzi Li,Feng Gao
Bacterial infections caused by biofilms are severe clinical problems, resulting in high drug resistance by limiting the penetration of antibiotics. Herein, a near-infrared (NIR)-activated chem/photodynamic/photothermal combined therapeutic agent is proposed by loading fluorescein isothiocyanate (FITC), ultrasmall copper sulfide nanoparticles (Cu2–xSNPs), and ε-polylysine (PLL) onto mesoporous silica nanoparticles (MSNs) through a layer-by-layer self-assembly approach. FITC-doped MSNs are prepared to monitor the permeability and accumulation of nanocomposites into biofilms. MSNs can also act as hosts for the synthesis of ultrasmall Cu2–xSNPs, which has effective photodynamic and photothermal ablation against bacteria under NIR light irradiation. Moreover, biodegradable PLL introduced can not only enhance adhesion toward the bacterial surface to increase the effectiveness of phototherapy but also damage bacteria through electrostatic interaction. As a result, the prepared nanocomposites could not only penetrate biofilms but also ablate biofilms through combined chem/photodynamic/photothermal effects under NIR light irradiation. Furthermore, the nanocomposites could treat bacterial infections in vivo with negligible tissue toxicity. Overall, the finely designed nanocomposites are anticipated to display promising applications in imaging-guided chem/photodynamic/photothermal combined therapy for bacterial infections.
研究领域:
医学
·
纳米生物学
·
感染病学
✓ 已验证
产品关联
DOI
PubMed
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