MACROMOLECULAR RAPID COMMUNICATIONS
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2017
·Vol. 38
·期 4
·1600551
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IF 4.265
Shi-Lei Dong,Lu Han,Cai-Xia Du,Xiao-Yu Wang,Lu-Hai Li,Yen Wei
Electroactive hydrogel scaffolds are fabricated by the 3D-printing technique using composites of 30% Pluronic F127 and aniline tetramer-grafted-polyethylenimine (AT-PEI) copolymers with various contents from 2.5% to 10%. The synthesized AT-PEI copolymers can self-assemble into nanoparticles with the diameter of ≈50 nm and display excellent electroactivity due to AT conjugation. The copolymers are then homogeneously distributed into 30% Pluronic F127 solution by virtue of the thermosensitivity of F127, denoted as F/AT-PEI composites. Macroscopic photographs of latticed scaffolds elucidate their excellent printability of F/AT-PEI hydrogels for the 3D-printing technique. The conductivities of the printed F/AT-PEI scaffolds are all higher than 2.0 × 10 −3 S cm −1 , which are significantly improved compared with that of F127 scaffold with only 0.94 × 10 −3 S cm −1 . Thus, the F/AT-PEI scaffolds can be considered as candidates for application in electrical stimulation of tissue regeneration such as repair of muscle and cardiac nerve tissue.
研究领域:
生物材料
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组织工程
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再生医学
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高分子化学
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生物医学工程
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JOURNAL OF NANOPARTICLE RESEARCH
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2018
·Vol. 20
·期 10
·1-11
·
IF 2.127
Feng Runliang,Deng Peizong,Zhou Feilong,Feng Sijia,Song Zhimei
To overcome honokiol’s poor water solubility and investigate its antifungal activity and pharmacokinetic property, Pluronic® F-127 (F127)-cyclodextrin conjugate was synthesized and employed to prepare honokiol-loaded micelles through emulsion-solvent evaporation method. The drug-loaded micelles were obtained with 92.30 ± 3.28% of encapsulation efficiency being higher than that obtained from F127 due to additional cyclodextrin inclusion. Fourier transformation infrared spectrometry and diffraction scanning calorimetry analysis tests demonstrated that honokiol was successfully encapsulated into the conjugate micelles in the amorphous or solid solution state because of their interactions. Meanwhile, in vitro antifungal activity experiment indicated that the MIC 90 of drug-loaded micelles was 64 μg/mL, showing the same antifungal activity as pure honokiol although it obviously retarded honokiol’s release. In vivo pharmacokinetic results confirmed that in vivo area under curve and apparent distribution volume of honokiol in drug-loaded micelles were 2- and 1.69-folds higher than that for pure honokiol, with its obvious prolonged mean retention time and half-life period, respectively. The clearance rate of honokiol was also shortened about 2-fold in comparison with pure honokiol when encapsulated into the micelles. These results suggest that the developed F127-cyclodextrin micellar formulation is a promising drug delivery system for antifungal drugs.
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MATERIALS SCIENCE FORUM
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2020
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IF 0
Chuan Jun Xia,Ping Deng Ming,Ya Song Hu,Cong Cong Zhan,An Duo Zhou,He Yi Mao,Xia Huang
In the present study, oligopeptide (TEA) and modified Pluronic F127 (M-Pluronic F127) with different mass fraction composited by intermolecular forces. And the oligopeptide/M-Pluronic F127 composite membranes were prepared and investigated. The structural parameters of the membranes were characterized by fourier transform-infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) measurements. It was found that there had strong interaction between TEA and M-Pluronic F127 and the composite films with different proportions had different surface morphology and thermal stability. The characteristics of the membranes were related to the significant changes of the self-assembly behavior of the TEA modified by M-Pluronic F127.
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LANGMUIR
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2026
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IF 4.4
Mingze Xu,Yanwei Yang,Gai Liu,Chunyun Wang,Xu Xu,Bohan Ye,Lei Liu,Xiaoyu Wu,Shiyong Song
Pluronic F127 is widely used in micelle formulations, yet its application is limited by its poor stability and low drug loading capacity. Structural modification of F127 is therefore necessary to overcome these drawbacks. Carrier materials with intrinsic pharmacological activity can reduce metabolism-related toxicity and exert synergistic effects with loaded drugs, offering broad application prospects. Solanesol (SOL), a long-chain unsaturated polyisoprenoid, exhibits antitumor activity and favorable lipophilicity. In this study, a solanesol derivative, monosolanesyl succinate (MSS), was synthesized and conjugated via an amide bond to Pluronic F127 as a hydrophobic segment, forming a pH-sensitive therapeutic nanocarrier. The critical micelle concentration (CMC) of F127-MSS was 10-fold lower than that of F127, indicating a significantly improved stability. The resulting doxorubicin-loaded F127-MSS micelles (F127-MSS-DOX) had an average particle size of approximately 130 nm and a drug loading capacity of ∼ 6.2%, which was about 4 times higher than those of F127-DOX micelles. The F127-MSS-DOX micelles exhibited pH-responsive drug release, promoting drug accumulation at tumor sites while reducing the toxicity in normal tissues. They also demonstrated excellent dilution, plasma, and storage stability. Blank F127-MSS micelles showed inherent inhibitory effects on HepG-2 and MCF-7 cells, attributed to the pharmacological activity of MSS. Furthermore, F127-MSS-DOX micelles displayed potent antitumor activity, comparable to that of free DOX at high concentrations. In vivo studies confirmed that blank F127-MSS micelles moderately suppressed tumor growth, while F127-MSS-DOX micelles significantly inhibited tumor progression and markedly reduced the systemic toxicity of free DOX, owing to their high drug loading, superior stability, pH sensitivity, and synergistic antitumor effect. These findings highlight the great potential of F127-MSS-DOX micelles for tumor treatment.
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PubMed
高影响因子
International Journal of Nanomedicine
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2017
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IF 4.3
Yuling Liu,Sai Fu,Longfei Lin,Yuhong Cao,Xi Xie,Hua Yu,Meiwan Chen,Hui Li
Pluronic F127 (F127), an amphiphilic triblock copolymer, has been shown to have significant potential for drug delivery, as it is able to incorporate hydrophobic drugs and self-assemble into nanosize micelles. However, it suffers from dissociation upon dilution owing to the relatively high critical micelle concentration and lack of stimuli-responsive behavior. Here, we synthesized the α-tocopherol (TOC) modified F127 polymer (F127-SS-TOC) via a redox-sensitive disulfide bond between F127 and TOC, which formed stable micelles at relatively low critical micelle concentration and was sensitive to the intracellular redox environment. The particle size and zeta potential of the F127-SS-TOC micelles were 51.87±6.39 nm and -8.43±2.27 mV, respectively, and little changes in both particle size and zeta potential were observed within 7 days at room temperature. With 10 mM dithiothreitol stimulation, the F127-SS-TOC micelles rapidly dissociated followed by a significant change in size, which demonstrated a high reduction sensitivity of the micelles. In addition, the micelles showed a high hemocompatibility even at a high micelle concentration (1,000 μg/mL). Low cytotoxicity of the F127-SS-TOC micelles at concentrations ranging from 12.5 μg/mL to 200 μg/mL was also found on both Bel 7402 and L02 cells. Overall, our results demonstrated F127-SS-TOC micelles as a stable and safe aqueous formulation with a considerable potential for drug delivery.
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PubMed
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Materials Science & Engineering C-Materials for Biological Applications
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2013
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IF 2.404
Yong-Yong Li,Lan Li,Hai-Qing Dong,Xiao-Jun Cai,Tian-Bin Ren
PKKKRKV (Pro-Lys-Lys-Lys-Arg-Lys-Val, PV7), a seven amino acid peptide, has emerged as one of the primary nuclear localization signals that can be targeted into cell nucleus via the nuclear import machinery. Taking advantage of chemical diversity and biological activities of this short peptide sequence, in this study, Pluronic F127 nanomicelles engineered with nuclear localized functionality were successfully developed for intracellular drug delivery. These nanomicelles with the size ~ 100 nm were self-assembled from F127 polymer that was flanked with two PV7 sequences at its both terminal ends. Hydrophobic anticancer drug doxorubicin (DOX) with inherent fluorescence was chosen as the model drug, which was found to be efficiently encapsulated into nanomicelles with the encapsulation efficiency at 72.68%. In comparison with the non-functionalized namomicelles, the microscopic observation reveals that PV7 functionalized nanomicelles display a higher cellular uptake, especially into the nucleus of HepG2 cells, due to the nuclear localization signal effects. Both cytotoxicity and apoptosis studies show that the DOX-loaded nanomicelles were more potent than drug nanomicelles without nuclear targeting functionality. It was thus concluded that PV7 functionalized nanomicelles could be a potentially alternative vehicle for nuclear targeting drug delivery.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2026
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IF 6.7
Yijie Si,Huanyu Bai,Caifu Yi,Xuebin Song,Chengliang Duan,Daliang Guo,Linxin Zhong,Zhou Sha,Jing Li,Yinchao Xu,Xin Zhang
This study reports a novel method for fabricating carbon paper (CP) self-supporting electrodes via the synergistic modification of phenolic resin with Pluronic F127 and boron-nitrogen co-doped carbon (CNB). Results demonstrated that the soft-templating effect of Pluronic F127, in conjunction with the synergistic heteroatom doping derived from urea (N) and boric acid (B), facilitated the formation of a mesopore-dominated hierarchical pore structure within the CP self-supporting electrodes. The F127-CNB@CP electrode exhibited the tensile and flexural strengths of 11.40 MPa and 633.83 MPa, which are 146% and 77% higher than those of CP electrode, respectively. It also exhibited lower in-plane and through-plane resistivities, which was attributed to attributed to improved interfacial electron transport pathways. Electrochemical tests revealed that the F127-CNB@CP electrode delivered an areal capacitance of 1589.93 mF cm −2 at a current density of 1 mA cm −2 , retains 81.4% of its capacitance at 10 mA cm −2 ，and achieves energy and power densities of 0.22 mWh cm −2 and 4.85 mW cm −2 , respectively. A symmetric supercapacitor assembled with F127-CNB@CP electrode maintains 92.8% of its initial capacitance after 30,000 cycles, delivering an energy density of 0.14 mWh cm −2 and a power density of 0.9 mW cm −2 . This work provides new insights and a theoretical basis for the design of high-performance CP based self-supporting supercapacitor electrodes.
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Progress in Natural Science-Materials International
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2023
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IF 4.7
Kaiting Cheng,Yiming Fang,Liang Bai,Feng Gui,Junchi Ma,Huimin Gao,Yadong Zhao,Xingtao Xu
In everyday life, traditional dressings such as band-aid and gauze are used for dealing with small wounds. However, these dressings have shortcomings such as pain caused by tearing, inapplicability to joints, single functionality, and adverse reactions. Therefore, there is a great need for an inexpensive, comfortable, and multi-functional wound dressing. In this study, quaternized chitosan (QCS) with a high degree of substitution (107.84 %) was successfully prepared and characterized using ultraviolet–visible (UV–vis) spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), and proton nuclear magnetic resonance ( 1 H NMR). A series of QCS/F127 thermosensitive hydrogels were prepared by physical cross-linking and used as potential wound dressings. Then the temperature sensitivity, hemostatic ability, antibacterial activity, and sustained drug release effect of the hydrogels were investigated to evaluate their multifunctionality as wound dressings. Finally, the effect of QCS concentration on hydrogel properties was explored. The results show that the composite hydrogels have significant hemostatic, antibacterial, and sustained drug release abilities, and they can be rapidly transformed into a gel state and adhere to skin upon reaching body temperature. In addition, the properties of the hydrogels can be adjusted by varying the concentration of QCS, which allows for the preparation of wound dressings that are responsive to needs. Therefore, multifunctional QCS/F127 hydrogels with temperature-response characteristics are of great clinical research value as wound dressings.
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Frontiers in Bioengineering and Biotechnology
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2021
·
IF 5.89
Xie Dengchao,Ma Panpan,Ding Xin,Yang Xiao,Duan Lian,Xiao Bo,Yi Shixiong
Colon cancer ranks as the third most common malignancy in the world. Combination chemotherapy, resorting to electrospun fibrous technology, has been considered as a promising strategy to exert synergistic effects in colon cancer treatment. Herein, we manufactured various pluronic F127 (PF127)-modified electrospun fibrous meshes with different weight ratios of camptothecin (CPT) and curcumin (CUR). The fluorescence characterization of the obtained PF127-CPT-meshes, PF127-CUR-meshes, and PF127-CPT/CUR-meshes (2:1) showed that CPT and CUR were evenly distributed within individual fibers of these meshes. Drug release experiments revealed that both types of drugs could be released from fibrous meshes simultaneously and sustainably. Importantly, these meshes exhibited strong in vitro anti-colon cancer activities, compared with the control meshes without drugs. Moreover, the combination index values of the PF127-CPT/CUR-meshes (CPT/CUR weight ratio = 5:1, 3:1, or 2:1) were <0.5 after incubation for respective 24 and 36 h, indicating the synergistic anti-colon cancer effects of CPT and CUR in fibrous meshes. Collectively, these results demonstrate that PF127-CPT/CUR-meshes can be developed as an efficient implantable system for effective synergistic treatment of colon cancer.
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高影响因子
Polymers
·
2023
·Vol. 15
·期 4
·850
·
IF 5
Linlin Liu,Yue Zhang,Youliang Cheng,Jing Chen,Fengjuan Li
The photocatalytic degradation of organic dyes in waste water using carbon quantum dots (CQDs) remains a hot topic due to the importance of environmental protection. However, identifying suitable carbon resources and successful surface modification are still challenging. Herein, the hydrothermal method and surface modification of ammonia and thionyl chloride were applied to synthesize CQDs with different surface groups using PEO106PPO70PEO106(Pluronic F127) as a carbon source. The average particle size of the as-prepared CQDs was in the range of 2.3–3.5 nm. The unmodified CQDs had the highest relative photoluminescence intensity, while all as-prepared CQDs exhibited abnormal photoluminescence located outside the scope of the visible spectrum. Interestingly, CQDs modified with ammonia achieved a degradation rate of 99.13% (15 d) for 50 mg/L indigo carmine solution, while CQDs modified with thionyl chloride reached a degradation rate of 97.59% (15 d) for light green SF yellowish solution. Therefore, in this work, two typical organic dyes can be effectively photocatalytically degraded by as-prepared CQDs, with suitable surface modification.Keywords:carbon quantum dots;hydrothermal method;photocatalytic activity
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JOURNAL OF MICROENCAPSULATION
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2020
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IF 2.287
Ziling Li,Xiangyuan Xiong,Shengfeng Peng,Xing Chen,Wei Liu,Chengmei Liu
Aim: A novel folated pluronic F127 (FA-F127) was synthesised, so as to modify liposomes with FA group on the surface, and evaluate the effects of FA-F127 modification on the properties of the modified liposomes.Methods: FA was linked to one end of pluronic F127, via the terminal OH group, to obtain FA-F127 and the structure was characterised. FA-F127 modified curcumin liposomes (cur-FA-F127-Lps) were prepared. The physicochemical characteristics of cur-FA-F127-Lps, including morphology and particle size, were studied. The in vitro cytotoxicity of cur-FA-F127-Lps against KB cancer cells was determined by MTT tests.Results: The effects of FA-F127 modification on the average particle size, PDI, curcumin encapsulation efficiency and microstructure were not significant. Compared with nonfolated F127 liposomes (cur-F127-Lps), cur-FA-F127-Lps exhibited significantly higher cytotoxicity towards KB cells.Conclusions: Folic acid modified liposomes provide a novel strategy to improve the chemotherapeutic efficacy of hydrophobic bioactive compounds.
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高影响因子
EUROPEAN POLYMER JOURNAL
·
2019
·
IF 3.621
Li Song,Bao Zhang,Ge Gao,Chunsheng Xiao,Gao Li
Herein, Pluronic F127 (PEO 99 -PPO 65 -PEO 99 ) end functionalized with α-lipoic acid (LA) (F127-LA) was synthesized and used for preparation of “single-component, multi-responsive” hydrogels through the photo cross-linking of LA components. The F127-LA hydrogels not only possessed thermo- and reduction- double responsiveness, but also demonstrated self-healing properties under UV irradiation due to the existence of dynamic disulfide bonds. The rheological and mechanical properties of the hydrogels can be adjusted by their concentration. The F127-LA hydrogels presented a swelling ratio decrease from 25 °C to 37 °C due to a lower critical solution temperature (LCST)-type thermo-responsive volume phase transition. The bovine serum albumin (BSA) was loaded into F127-LA hydrogels, and their drug release behavior can be regulated by surrounding temperature and reducing agent concentration. The volume shrinkage of the hydrogels promoted the sustained release of BSA above volume phase transition temperature. Cytocompatibility assay of L929 mouse fibroblasts showed that cellular metabolic activity were merely affected by F127-LA, even at concentrations up to 1000 mg L −1 . This study thus provided a very promising route for the preparation of multifunctional hydrogels.
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