Materials Science & Engineering C-Materials for Biological Applications
·
2019
·
IF 4.959
Wanling Cai,Mengyu Guo,Xiulan Weng,Wei Zhang,Zuliang Chen
Since Fe 3 O 4 nanoparticles synthesized by plant extracts possess good bio-compatibility and superparamagnetic properties, the possibility of these could be used as a carrier in drug delivery. In this work, doxorubicin hydrochloride (DOX), an anti-cancer drug, loaded on glutaric anhydride-functionalized magnetic nanoparticles (Fe 3 O 4 @SiO 2 -Glu) was investigated at varying pH values for effective drug delivery. Various factors affecting the adsorption of DOX onto the Fe 3 O 4 @SiO 2 -Glu were examined, where the adsorption efficiency of DOX reached 92% at a concentration of 20 mg/L employing 10 mg of Fe 3 O 4 @SiO 2 -Glu at 303 K in pH 7.4. However, the adsorption efficiency of DOX was decreased to 18% at acidic pH value down to 3.0, implicating that the drug releasing process was controlled by pH. Adsorption kinetics was fitting to pseudo-second-order and the isothermal adsorption conformed to Freundlich isotherm. The morphology and surface composition of the synthesized Fe 3 O 4 @SiO 2 -Glu were characterized by SEM, TEM , and N 2 adsorption/desorption isotherms, revealing that the specific surface area being 62.6 m 2 /g and the size ranging from ~30 to 50 nm. The zeta potential results indicated that Fe 3 O 4 @SiO 2 -Glu were negatively charged in various pH from 3 to 8.5. Characterizations by FTIR and UV–Vis techniques suggested that the DOX was absorbed and it can be delivered by Fe 3 O 4 @SiO 2 -Glu.
研究领域:
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2012
·
IF 3.35
Anning Wang,Hui Gao,Yanfang Sun,Yu-long Sun,Ying-Wei Yang,Guolin Wu,Yinong Wang,Yunge Fan,Jianbiao Ma
A series of temperature- and pH-responsive polyurethanes based on hexamethylene diisocyanate (HDI) and 4,4′-diphenylmethane diisocyanate (MDI) were synthesized by a coupling reaction with bis-1,4-(hydroxyethyl) piperazine (HEP), N -methyldiethanolamine (MDEA) and N -butyldiethanolamine (BDEA), respectively. The chemical structure , molecular weight, thermal property and crystallization properties were characterized by Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and X-ray diffraction (XRD) spectroscopy. The resulting polyurethanes were then used to prepare nanoparticles either by direct dispersion method or dialysis method. Their pH and temperature responsibilities were evaluated by optical transmittance and size measurement in aqueous media. Interestingly, HDI-based and MDI-based polyurethanes exhibited different pH and temperature responsive properties. Nanoparticles based on HDI-HEP and HDI-MDEA were temperature-responsive, while MDI-based biomaterials were not. All of them showed pH-sensitive behavior. The possible responsive mechanism was investigated by 1 H NMR spectroscopy. The cytotoxicity of the polyurethanes was evaluated using methylthiazoletetrazolium (MTT) assay in vitro . It was shown that the HDI-based polyurethanes were non-toxic, and could be applied to doxorubicin (DOX) encapsulation. The experimental results indicated that DOX could be efficiently encapsulated into polyurethane nanoparticles and uptaken by Huh-7 cells. The loaded DOX molecules could be released from the drug-loaded polyurethane nanoparticles upon pH and temperature changes, responsively.
研究领域:
生物材料学
·
药剂学
·
肿瘤学
·
高分子科学
·
纳米医学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Yawei Shi,Guobin Song,Anqi Li,Jun Wang,Haonan Wang,Ya Sun,Guanghui Ding
A series of composite aerogels with different precursor mass ratios were prepared from graphene oxide (GO) and chitosan (CS) by conducting the crosslinking step after lyophilization, the method of which was recently found beneficial to enhance the adsorptive properties of aerogels . The composite aerogels were then employed for the adsorption of methyl orange (MO) and methylene blue (MB) from water, and the one prepared at GO:CS= 1:2 (w/w) was selected as the optimal compromising the adsorption and mechanical properties. The maximum adsorption amounts of MO and MB were calculated to be 543.4 and 110.9 mg/g at 25 °C. Especially, the effects of pH on adsorption of MO and MB in both single and binary systems were investigated in detail. The aerogel possessed pH-responsive feature for single dye adsorption, tending to adsorb MO at low pH while to adsorb MB at high pH. In the binary system, the pH-responsive feature remained and selective adsorption was observed at low initial dye concentration. In contrast, synergistic adsorption occurred instead at high initial concentration, and MB and MO could be efficiently removed simultaneously in the whole pH range of 3–11.
研究领域:
环境科学
·
材料科学
·
化学工程
·
水处理
·
吸附技术
✓ 已验证
DOI
高影响因子
IRANIAN POLYMER JOURNAL
·
2019
·Vol. 28
·期 2
·157-166
·
IF 1.707
Zhang Guangyan,Zhou Jun,Wang Peng
A novel cross-linkable polyaspartamide derivative-containing cinnamoyl pendant groups, P(HPA-Az)-CA, was designed and synthesized in this study. Chemical structures of the obtained polymers were confirmed by FTIR, UV, and 1 H NMR techniques. The transmittance measurement results showed that the prepared polymer P(HPA-Az)-CA displayed temperature and pH dual stimuli-responsive behaviors. The cloud point of P(HPA-Az)-CA could be tuned just by adjusting the introduced percentage of hydrophobic moieties or the pH of polymer aqueous solution. The effect of pH on the cloud point of P(HPA-Az)-CA was investigated by zeta potential, and the results showed that it may be related to the weakened electrostatic repulsion caused by decreased zeta potential with pH decreasing. Diamines (ethylenediamine or cystamine) were adopted to prepare cross-linked micelles using the mixture of P(HPA-Az)-CA aqueous solution and diamines just by one-step heating method. The cross-linked micelles were stable, even when the environmental temperature was below the cloud point of P(HPA-Az)-CA. The cross-linking mechanism between the diamines and α,β-unsaturated carbonyl moieties of P(HPA-Az)-CA was confirmed by 1 H NMR. In addition, the micelles cross-linked with cystamine could be disrupted in the presence of 10 mM glutathione. According to the results, the obtained polyaspartamide derivative P(HPA-Az)-CA may be a potential for facilitating drug loading.
研究领域:
高分子化学
·
药物传递系统
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2013
·Vol. 3
·期 45
·23133-23138
·
IF 2.562
Yang Wang,Yun Xiao,Hangyu Zhou,Wei Chen,Ruikang Tang
A novel versatile system combining chemotherapy and photothermal therapy for cancer cells using CuS NCs is reported. CuS NCs were synthesized by a solid–liquid reaction between Cu2O nanocubes and thiourea. While the hollow nanocage can be used to load anticancer drugs for chemotherapy, the CuS can convert NIR light into heat for photothermal therapy. More importantly, CuS NCs display exceptionally high drug loading capacity of DOX with 500 wt% and release of DOX is pH-controllable, which is a spontaneous process under intracellular conditions. Compared with chemotherapy or photothermal therapy alone, the combination of chemotherapy and phototherapy can significantly improve the therapeutic efficacy. This improvement strategy using multifunctional nanomaterials may be particularly useful in biomedical applications.
研究领域:
肿瘤学
·
纳米医学
·
药物递送
·
转化医学
·
生物材料
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2014
·
IF 3.916
Jiachang Huang,Li Zhou
The hydrolyzed peach gum polysaccharide (HPGP) prepared at acidic condition is investigated as an anionic polyelectrolyte for the first time. A hydrolysis mechanism is proposed by monitoring the hydrolysis efficiency and morphological change of crude peach gum, and the intrinsic viscosity of resulted HPGP as a function of hydrolysis time. Fourier transform infrared (FTIR) spectroscopy and ζ-potential measurements reveal that HPGP with multiple carboxylic groups is negatively charged in water in the pH range 3–11. The HPGP exhibits remarkable pH and ionic strength responsiveness, as proven by dynamic light scattering (DLS) and atomic force microscopy (AFM) measurements. Moreover, the layer-by-layer (LbL) self-assembly experiments further confirmed that the HPGP can be utilized as an anionic polyelectrolyte . Considering the facile availability, favorable compatibility and intriguing functionality of HPGP, this study opens up enormous opportunities for the large-scale utilization of peach gum resource.
研究领域:
高分子科学
·
生物材料
·
纳米技术
·
药物递送
·
表面化学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 39
·20208-20215
·
IF 3.708
Lei Sun,Xinge Zhang,Jinxia An,Cui Su,Qianqain Guo,Chaoxing Li
Currently, the major challenge for cancer treatment is to develop simple and smart nanocarriers that can efficiently retain the encapsulated drug during blood circulation, recognize tumor cells and quickly release the drug under stimulation. In this paper, such a pH-sensitive core–shell composite nanoparticles is prepared based on a 3-aminophenylboronic acid modified mesoporous silica nanoparticles (MSN–APBA) core coated with a lactobionic acid grafted chitosan (CS–LA) shell via boronate ester bonds. The MSN core increases drug loading capacity and stability, and lactobionic acid offers abundant diols which can form pH sensitive boronate ester bonds with APBA on MSN. Meanwhile, the lactobionic acid-conjugated shell could also efficiently target the asialoglycoprotein receptor over expressing hepatoma cells. The successful synthesis of CS–LA and MSN–APBA is confirmed by the results of TGA, TEM, DLS, FT-IR, 1H-NMR and N2 adsorption–desorption. Doxorubicin hydrochloride (DOX) is applied as a model drug and the behaviors of drug loading/release are investigated. The drug loading behavior is pH-dependent, and its drug encapsulation efficiency is near 80% and loading capacity is 13.05%. The results of cumulative in vitro release indicate that at neutral pH, the pores of the MSN are effectively capped with a polymer shell and the drug release is strongly inhibited, almost zero release. While at acidic pH, the hydrolysis of the boroester bond takes place and thus results in a rapid release of the entrapped drug. The cytotoxicity assay indicates high cell biocompatibility of this material and it is suitable as a drug carrier. When loaded with DOX, it presents distinctly cytotoxic behavior to HepG2 cells, due to the sustained release of drug. These results imply that the core–shell nanoparticles are promising platforms to construct simple and effective pH-responsive controlled drug delivery systems for cancer therapy.
研究领域:
肿瘤学
·
药剂学
·
纳米医学
·
生物材料
·
分子药理学
·
靶向治疗
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2012
·Vol. 129
·期 2
·846-852
·
IF 1.289
Hong Yu Yang,Xiu Mei Zhang,Li Jie Duan,Ming Yao Zhang,Guang Hui Gao,Hui Xuan Zhang
A series of environmental pH-responsive block copolymers PEG-polyurethane with tertiary amine groups in the main chain and free carboxyl groups in the side chain were synthesized, including poly(ethylene glycol) (PEG), 1,4-bis (hydroxyethyl) piperazine, 1,6-diisocyanato hexamethylene, and 2,2-dimethylolpropionic acid. The chemical structure, molecular weight, and pH-dependent capacity of pH-responsive PEG-polyurethane were examined by 1 H-NMR, FTIR, gel permeation chromatography (GPC), and an acid-base titration. Moreover, the fluorescent dye fluorescein isothiocyanate was conjugated with PEG-polyurethane by the similar polymerization method and the obtained polymer was measured by ultraviolet visible spectroscopy (UV-vis) and fluorescent spectroscopy. The results indicated that the pH-responsive PEG-polyurethane showed a pH-buffering phenomenon and fluorescent imaging in a range of pH values. As a result, we demonstrated its potential application for optical imaging; however, it is believed that more applications in the areas of biomedicine will be possible owing to its free carboxyl acid terminal residues in the stimuli-responsive polymer. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
研究领域:
生物材料
·
分子影像学
·
高分子化学
·
纳米医学
·
药物递送
·
生物传感器
·
转化医学
✓ 已验证
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2012
·Vol. 213
·期 20
·2192-2200
·
IF 2.361
Xiao-Hui Dai,Chun-Yan Hong,Cai-Yuan Pan
A novel double-hydrophilic block copolymer P(MEO 2 MA- co -OEGMA)- b -PAMA has been successfully synthesized by two-step RAFT polymerization. Then, the amino groups of PAMA blocks in the copolymers react with 1-pyrenecarboxaldehyde via a “Schiff-base” reaction, and the resulting copolymers are self-assembled to form spherical micelles in aqueous solution. Because the “Schiff-base” linkage is pH sensitive, the release rate of pyrene depends upon the pH of solution. Complete release is achieved at pH 1, and the control release is much faster at pH 5.5 than that at pH 7.4. With progress of pyrene release, the micelles are disassembled gradually and disappeared completely at last. This double-hydrophilic copolymer is a promising candidate of drug carrier for the aldehyde- containing hydrophobic drugs.
研究领域:
高分子化学
·
药剂学
·
纳米医学
·
生物材料
·
药物递送系统
✓ 已验证
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2016
·Vol. 217
·期 9
·1047-1056
·
IF 2.495
Liang Qiu,Chao-Ran Xu,Feng Zhong,Chun-Yan Hong,Cai-Yuan Pan
Pure cross-linked spherical micelles, nanowires, and vesicles are successfully fabricated from poly(2-hydroxypropyl methacrylate- b - p -(methacryloxyethoxy)benzaldehyde)s (PHPMA– b –PMAEBAs) through reversible addition-fragmentation chain transfer dispersion polymerization of MAEBA in methanol using PHPMA as a macro-CTA and subsequent cross-linking. The cross-linking reaction is conducted by stirring a mixture of 1,4-butanediamine and the resultant nano-objects in methanol at room temperature. For all polymerizations with feed molar ratios of MAEBA/PHPMA ranging from 75/1 to 240/1, the monomer MAEBA conversions are almost complete, and block copolymers with controlled molecular weight are obtained. The transmission electron microscopy, dynamic light scattering, and gel permeation chromatography results reveal that the following three factors significantly influence the morphology of the nano-objects: the feed molar ratio of MAEBA/PHPMA, the copolymer concentration, and the degree of polymerization of PHPMA. The cross-linked nano-objects are very stable in good solvents, the spheres and nanowires slightly decrease in size after cross-linking, whereas the vesicles slightly increase in size. The cross-linked nano-objects are stable in neutral solutions, but they dissociate in weekly acidic solutions. The loading of 1-pyrenemethylamine (PMA) into the vesicles and the unloading of PMA from the vesicles are studied.
研究领域:
高分子化学
·
纳米材料
·
药物递送
·
生物医学工程
·
胶体与界面科学
✓ 已验证
DOI
高影响因子
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
·
2021
·
IF 3.995
Jianhua Zhou,Hong Li,Yannan Li,Xiang Li
Cellulose nanocrystals (CNCs) were modified using an amphiphilic triblock copolymer [poly(2-(dimethylamino) ethyl methacrylate)- b -poly(glycidyl methacrylate)- b -poly(2,2,3,4,4,4-hexafluorobutyl acrylate) (PDMAEMA- b -PGMA- b -PHFBA)] bearing epoxy functionalities located in middle segment of PGMA, which were used to react with the hydroxyl groups on the surface of the CNCs. The triblock copolymer was synthesized via a reversible addition fragmentation chain transfer (RAFT) polymerization reaction between 2-(dimethylamino) ethyl methacrylate, glycidyl methacrylate and 2,2,3,4,4,4-hexafluorobutyl acrylate, and characterized using 1 H-NMR spectroscopy and size exclusion chromatography (SEC). The successful modification of the CNCs was demonstrated by means of FT-IR, TGA , TEM , XRD and XPS . In addition, the surface properties of the modified CNCs were studied using water contact angle and surface tension studies. When compared with the pristine CNCs, the modified CNCs exhibited a higher contact angle and lower surface tension. Good dispersion of the modified CNCs was observed in different polar solvents, such as water, THF, DMF , CHCl 3 and toluene. The modified CNCs exhibited pH responsive properties, which were measured using dynamic light scattering (DLS). In addition, the stability of Pickering emulsions stabilized by PDMAEMA- g -CNC- g -PHFBA decreased with time or increasing pH. The droplet size increased gradually upon increasing the pH. This work provides a method to design sophisticated CNC-based materials, which benefit from both the intrinsic properties of the CNCs and the new characteristics conferred by the multifunctional grafted chains.
研究领域:
高分子化学
·
纳米材料科学
·
胶体与界面化学
·
生物基功能材料
·
智能响应材料
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Zanru Guo,Hongjian Gu,Qiang Chen,Zhanfeng He,Wenyuan Xu,Jiali Zhang,Yongxin Liu,Leyan Xiong,Longzhen Zheng,Yujun Feng
Hypothesis The effective separation and recovery of oils from water is important for the protections of ecosystems and the environment. Polymeric porous monoliths have been demonstrated as attractive absorbents for oil/water separation. However, the recyclability was mainly realized by squeezing, combustion, or centrifugation, which may restrict in elastic materials, destroy the adsorbates or need special apparatus. Thus it is desirable to developing monoliths with controllable oil absorption and desorption. Experiments A series of “smart” monoliths with pH-induced switchable wettability were fabricated by high internal phase emulsion (HIPE) polymerization and epoxide ring-opening for the incorporation of amine groups. The resultant monoliths and their wettabilities were examined using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), nitrogen adsorption/desorption and contact angle analysis, respectively. The oil separation efficiency and recyclability were evaluated. Findings The monoliths with macroporous structure can undergo switchable wettability under reversible pH stimulation. As an absorbent, the monoliths not only separated and recovered organic solvents and oils (including crude oil) from aqueous mixtures through a reversible and recyclable absorption and desorption process upon alternating the pH between 7.0 and 1.0, but also continuously expulsed oils from water surfaces in a continuous manner with the aid of external driving pressures. Moreover, the monoliths also allowed the effective separation of surfactant-free and surfactant-stabilized oil-in-water emulsions with high separation efficiency.
研究领域:
环境科学
·
高分子材料
·
分离科学
·
界面化学
·
功能材料
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）