MRT67307 hydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC 50 s of 160 and 19 nM, respectively. MRT67307 hydrochloride also inhibits ULK1 and ULK2 with IC 50 s of 45 and 38 nM, respectively. MRT67307 hydrochloride also blocks autophagy in cells.