3-Methylthienyl-carbonyl-JNJ-7706621 is a potent and selective inhibitor of cyclin-dependent kinase ( CDK ) , with IC 50 s of 6.4 nM and 2 nM for CDK1/cyclin B and CDK2/cyclin A , respectively. 3-Methylthienyl-carbonyl-JNJ-7706621 also shows potent inhibition of GSK-3 ( IC 50 =0.041 μM) and modest potency against CDK4 , VEGF-R2 , and FGF-R2 ( IC 50 =0.11, 0.13, 0.22 μM, respectively). 3-Methylthienyl-carbonyl-JNJ-7706621 can be used for the research of cancer.