Mycothiazole is an inhibitor for mitochondrial electron transport chain ( ETC ) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 ( IC 50 is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1 , to extend the lifespan of C. elegans.