Microcystins (MCs) are hepatotoxic cyclic heptapeptides, produced by various cyanobacterial species. MC’s cause adverse effects on freshwater systems with algae blooms.

Microcystin WR contains tryptophane (W) in position 2 and arginine (R) in position 4.Microcystins are potent inhibitors of protein phosphatase types 1 and 2A (IC50 value of MC-WR for inhibiting PP2A = 0.18 nM). No effects on protein kinases are known. MCs are known to be hepatic tumor promoters in experimental animal models.

Product introduction：

Microcystins (MCs) are hepatotoxic cyclic heptapeptides, produced by various cyanobacterial species. MC’s cause adverse effects on freshwater systems with algae blooms.

规格

别名

生物毒素, 蓝藻毒素, 藻华毒素

英文别名

Microcystin-WR | Microcystin WR | MC-WR | (5R,8S,11R,12S,15S,18S,19S,22R)-15-[3-(diaminomethylideneamino)propyl]-8-(1H-indol-3-ylmethyl)-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,5,12,19-tetramethyl-2-methylidene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptazacyclo | 3-L-Tryptophan-5-L-argininecyanoginosin 展开

规格或纯度

10ug/ml in methanol

英文名称

Microcystin-WR

储存条件

-20°C储存

运输条件

超低温运输

名称和识别符

分子类型

小分子

IUPAC Name

(5R,8S,11R,12S,15S,18S,19S,22R)-15-[3-(diaminomethylideneamino)propyl]-8-(1H-indol-3-ylmethyl)-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,5,12,19-tetramethyl-2-methylidene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptazacyclopentacosane-11,22-dicarboxylic acid

INCHI

1S/C54H73N11O12/c1-29(25-30(2)43(77-8)26-35-15-10-9-11-16-35)20-21-38-31(3)46(67)62-41(52(73)74)22-23-44(66)65(7)34(6)49(70)59-33(5)48(69)63-42(27-36-28-58-39-18-13-12-17-37(36)39)51(72)64-45(53(75)76)32(4)47(68)61-40(50(71)60-38)19-14-24-57-54(55)56/h9-13,15-18,20-21,25,28,30-33,38,40-43,45,58H,6,14,19,22-24,26-27H2,1-5,7-8H3,(H,59,70)(H,60,71)(H,61,68)(H,62,67)(H,63,69)(H,64,72)(H,73,74)(H,75,76)(H4,55,56,57)/b21-20+,29-25+/t30-,31-,32-,33+,38-,40-,41+,42-,43-,45+/m0/s1

InChi Key

UGNOHFGJSOFQHC-ZISXDMAXSA-N

Smiles

CC1C(NC(=O)C(NC(=O)C(C(NC(=O)C(NC(=O)C(NC(=O)C(=C)N(C(=O)CCC(NC1=O)C(=O)O)C)C)CC2=CNC3=CC=CC=C32)C(=O)O)C)CCCN=C(N)N)C=CC(=CC(C)C(CC4=CC=CC=C4)OC)C

Isomeric SMILES

C[C@H]1[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(=C)N(C(=O)CC[C@@H](NC1=O)C(=O)O)C)C)CC2=CNC3=CC=CC=C32)C(=O)O)C)CCCN=C(N)N)/C=C/C(=C/[C@H](C)[C@H](CC4=CC=CC=C4)OC)/C

PubChem CID

101619976

分子量

1068.22