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224,000+ 科研产品 · 三重ISO认证 · 每个产品均提供COA和SDS · 现货产品当日发货

Mdivi-1

Name: Mdivi-1
SKU: M407882
Availability: InStock

CAS: 338967-87-6 货号: M407882 分子式: C₁₅H₁₀Cl₂N₂O₂S 分子量: 353.23 EC号: 686-925-6

5篇引用文献 COA

有货

级别和纯度: 10mM in DMSO

储存条件

-80℃储存

运输条件

特低温运输

规格

库存

价格

数量

1ml

M407882-1ml

现货

¥340.90

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概述规格名称和识别符技术文档高级数据质检证书（CoA,COO,BSE/TSE 和分析图谱) 化学和物理性质安全和危险性（GHS）此产品的引用文献溶液计算器常见问题

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为什么选择此级别

，适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-80℃储存。特低温运输。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 5 篇同行评审文献引用。

概述

产品介绍：
线粒体分裂抑制剂1（Mdivi-1）是喹唑啉酮衍生物，具有细胞渗透性。能穿越血脑屏障，在心、脑缺血再灌注损伤中引发保护功能。

产品应用：
胚胎胸主动脉A7r5细胞，抑制细胞迁移和增殖；研究少突胶质前体细胞（OPC）中线粒体网络重塑和活性氧（ROS）产生；诱导肺成纤维细胞的线粒体损伤.

Information

Mdivi-1 Mdivi-1 (Mitochondrial division inhibitor 1) is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. Mdivi-1 attenuates mitophagy and enhan
In vitro

Mdivi-1 is a cell-permeable quinazolinone compound that inhibits yeast (Dnm1) and mammalian (Drp1) division DRPs (dynamin-related GTPases) and effectively induces mitochondrial fusion into net-like structures in a reversible manner. Cell-free studies indicate that mdivi-1 blocks Dnm1 ATPase activity (IC50<10 μM) and self-assembly by an allosteric modulation-based mechanism. Mdivi-1 is shown to effectively suppress STS- as well as C8-Bid-induced MOMP (Mitochondrial Outer Membrane Permeabilization) in HeLa cultures and in cell-free murine liver mitochondria preparations, respectively, as assessed by cytochrome C release. In cells, mdivi-1 retards apoptosis by inhibiting mitochondrial outer membrane permeabilization. In principle, mivi-1 represents a class of therapeutics for stroke, myocardial infarction, and neurodegenerative diseases.

In vivo

Drp1 and GFAP protein expression is significantly increased in the early neurodegenerative events of ischemic mouse retina. Mdivi-1 treatment blocks apoptotic cell death in ischemic retina, and significantly increases RGC survival at 2 weeks after ischemia. In the normal mouse retina, Drp1 is expressed in the ganglion cell layer (GCL) as well as the inner plexiform layer, the inner nuclear layer (INL), and the outer plexiform layer (OPL). In the GCL, Drp1 immunoreactivity is strong in RGCs. While Drp1 protein expression is increased in the GCL of vehicle-treated ischemic retina at 12 hours. Mdivi-1 treatment does not change this increase of Drp1 protein expression but significantly decreased GFAP protein expression.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥97%