| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M408331-1ml |
1ml |
现货  |
|
| 英文别名 | AHR 85 | 3-(2-methoxyphenoxy)-1,2-propanediol-1-carbamate |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Methocarbamol |
| 生化机理 | 甲氧卡巴摩尔（AHR 85）是一种碳酸酐酶抑制剂，用作治疗骨骼肌痉挛的中枢性肌肉松弛剂。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 碳酸酐酶 I 抑制剂 |
| 产品介绍 |
Methocarbamol 是一种中枢性肌肉松弛剂，用于治疗骨骼肌肉痉挛。 应用
美索巴莫是一种中枢肌肉松弛剂，可阻断 Nav1.4 肌肉通道，可逆地影响电压依赖性的 Nav1.4 通道失活，具有用于肌肉痉挛和疼痛综合症研究的潜力。
Information Methocarbamol Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms. Methocarbamol is metabolized via dealkylation and hydroxylation followed by conjugation to form both glucuronides and sulfates. In vivo Methocarbamol results in a median terminal half-life, mean transit time, mean absorption time, and apparent oral clearance of 2.89 hours, 2.67 hours, 0.410 hours, and 16.5 mL/min/kg in the horse. Methocarbamol is rapidly absorbed and extensively metabolized after oral administration to horses as indicated by a short absorption time and modest systemic bioavailability of 54.4% in the horse. Methocarbamol is a centrally acting muscle relaxant available in both IV and oral forms in cats. Methocarbamol (100 mg/kg) does not change the heart rate, cardiac output, mean pulmonary arterial blood pressure, systolic, diastolic and mean aortic blood pressure, respiratory rate and arterial blood gases, but mild to moderate depression is observed in five of eight horses administered i.v. Methocarbamol, and in all horses administered oral Methocarbamol. Plasma Methocarbamol concentration declines very rapidly during the initial or rapid disposition phase after i.v. administration; the terminal elimination half-life ranged from 59 minutes to 90 minutes in horse. Peak plasma Methocarbamol concentrations following oral administration occur within 15 to 45 minutes in horse. cell lines： Concentrations： Incubation Time： Powder Purity:≥99% |
| ALogP | 0.916 |
|---|---|
| hba_count | 4 |
| HBD Count | 2 |
| Rotatable Bond | 7 |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | COC1=C(OCC(O)COC(N)=O)C=CC=C1 |
| 分子量 | 241.24 |
| Reaxy-Rn | 1884446 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1884446&ln= |
| DMSO(mg / mL) Max Solubility | 48 |
|---|---|
| DMSO(mM) Max Solubility | 198.97 |
| Water(mg / mL) Max Solubility | 2 |
| Water(mM) Max Solubility | 8.29 |
| Reaxy-Rn | 1884446 |
|---|---|
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1884446&ln= |
| Concentration(Compounding value) | 9-11（mmol/L） |
|---|---|
| Record the entire process by video | Conform |
首页
400-620-6333
