计算溶液所需的质量、体积或浓度。
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 235 篇同行评审文献引用。
概述
溶于热水，略溶于乙醇，微溶于水或氯仿，极微溶于乙醇。味苦而略咸。
Information
Metronidazole Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.
In vitro
Metronidazole is relatively inactive until it is metabolized within host or microbial cells. Metronidazole is activated when it receives an electron from ferredoxin or fla vodoxin that is reduced by POR in anaerobic or microaerophilic bacteria or luminal parasites. Metronidazole damages cells by forming protein and DNA adducts. Metronidazole has activity against protozoans like Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis, for which the drug is first approved as an effective treatment. The activity of metronidazole against anaerobic bowel flora has been used for prophylaxis and treatment of patients with Crohn\'s disease who might develop an infectious complication. Metronidazole\xa0has played an important role in anaerobic-related infections.\xa0 \xa0Metronidazole\xa0has notable effectiveness in treating anaerobic brain abscesses. Metronidazole resistance tends to result from de novo mutation in the resident rdxA gene, rather than from lateral transfer of mutant rdxA (or other) genes from unrelated but Mtzr strains. Metronidazole partially inhibits growth stimulate forward mutation to rifampin resistance in rdxA(+) (Metronidazole(s)) and also in rdxA (Metronidazole(r)) H. pylori strains, and that expression of rdxA in Escherichia coli results in equivalent Mtz-induced mutation. Metronidazole leads to apoptosis-like features in growing cultures of axenic B. hominis, including key morphological and biochemical features of programmed cell death (PCD), viz. nuclear condensation and nicked DNA in nucleus, reduced cytoplasmic volume, externalization of phosphatidylserine and maintenance of plasma membrane integrity with increasing permeability.
In vivo
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
规格
英文别名
2-methyl-5-nitro-1H-imidazole-1-ethanol
规格或纯度
Moligand™, 10mM in DMSO
英文名称
Metronidazole
生化机理
甲硝唑是一种硝基咪唑类合成抗菌剂和抗原生动物剂，可用于对付原生动物。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
EC号
207-136-1
分子类型
小分子
Isomeric SMILES
CC1=NC=C(N1CCO)[N+](=O)[O-]
分子量
171.15
Beilstein号
611683
Reaxy-Rn
611683
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=611683&ln=
技术文档
高级数据
化学和物理性质
熔点
161°C
安全和危险性（GHS）
象形图
信号词
危险
危险声明
H303: 要是吞了可能有害
H351: 怀疑引起遗传缺陷
预防措施声明
P201: 使用前获取特殊说明
P202: 在阅读并理解所有安全预防措施之前，不要进行操作。
P312: 打电话给毒物中心或医生。。。如果你觉得不舒服
P380: 疏散区域。
P405: 密闭存放
P501: 将内容物/容器处理到。。。
WGK Germany
3
RTECS
NI5600000
Merck Index
6157
个人防护装备
dust mask type N95 (US),Eyeshields,Gloves
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
此产品的引用文献
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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危险品化学品经营许可证（带存储）