计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
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概述
Megestrol Acetate是一种人工合成的孕酮，抑制HegG2，IC50为260μM。
Information
Megestrol acetate (BDH1298, SC10363) is a syntheticprogestogen, used to treat breast cancer and loss of appetite.
In vitro
Megestrol acetate inhibits the expression of cytoplasmic aromatase through nuclear C/EBPβ in reperfusion injury-induced ischemic rat hippocampus. Megestrol acetate significantly increases the proliferation, migration, and adipogenic differentiation of adipose-derived stem cells (ASCs) in a dose-dependent manner. Megestrol acetate also upregulates genes downstream of glucocorticoid receptor (GR) in ASCs.
In vivo
Megestrol acetate significantly decreases the circulating concentrations of estradiol (E2) and testosterone (T) in female fish or 11-ketotestosterone (11-KT) in male fish. Megestrol acetate exposure significantly downregulates the transcription of certain genes along the hypothalamic-pituitary-gonadal (HPG) axis. Megestrol acetate produces a progressive deterioration in glucose tolerance, with a significant increase in mean fasting plasma glucose concentrations and decrease in mean plasma glucose clearance rates after 6 months and 12 months of treatment in cats. Megestrol acetate also produces a progressive decrease in both resting plasma cortisol concentrations and cortisol concentrations after ACTH stimulation in cats. Megestrol acetate (50 mg/kg/day) for 9 days significantly increases food and water intake compared with untreated controls. Megestrol acetate (50 mg/kg/day) significantly (90-140%) increases in neuropeptide Y concentrations in the arcuate nucleus (where neuropeptide Y is synthesized), in the lateral hypothalamic area (through which arcuate neurones project) and in the medial preoptic area, ventromedial nucleus and dorsomedial nucleus in rats.
Cell Data
cell lines：HCT116, MDA-MB-231, SNU-5, and MKN45 cells
Concentrations：
Incubation Time：
Powder Purity:≥99%
规格
英文别名
(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
规格或纯度
10mM in DMSO
英文名称
Megestrol Acetate
生化机理
醋酸甲地孕酮（BDH1298，SC10363）是一种合成孕激素，用于治疗乳腺癌和食欲不振。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
激动剂
作用机制
孕酮受体激动剂
名称和识别符
EC号
209-864-5
分子类型
小分子
Isomeric SMILES
CC1=C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)OC(=O)C)C)[C@@]4(C1=CC(=O)CC4)C
分子量
384.52
Beilstein号
8(4)2431
Reaxy-Rn
3489305
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3489305&ln=
高级数据
关联靶点（人）
NR3C1
Tclin
糖皮质激素受体(Glucocorticoid receptor)
(2 活性数据)
化学和物理性质
溶解性
Solubility (25°C) In vitro
比旋光度
11° (C=2,CHCl3)
熔点
218 °C
安全和危险性（GHS）
信号词
警告
危险声明
H351: 怀疑会致癌
H373: 长期或反复接触可能对器官造成伤害
RTECS
TU4075000
Merck Index
5805
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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危险品化学品经营许可证（带存储）