| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M408990-1ml |
1ml |
现货  |
|
| 英文别名 | CL 8490 | Acetamide, N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]- |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Methazolamide |
| 生化机理 | 美他唑胺（CL 8490）是一种碳酸酐酶抑制剂，对 hCA I、hCA II 和 bCA IV 异构体的Ki值分别为 50 nM、14 nM 和 36 nM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 碳酸酐酶 1 抑制剂；碳酸酐酶 12 抑制剂；碳酸酐酶 14 抑制剂；碳酸酐酶 4 抑制剂；碳酸酐酶 7 抑制剂 |
| 产品介绍 |
Information Methazolamide (CL 8490) is acarbonic anhydraseinhibitor withKiof 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively. Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively. Methazolamide is of strength equal to acetazolamide, another carbonic anhydrase inhibitor used to treat irregular breathing disorders. However, methazolamide differs from acetazolamide in that it fails to activate Ca2+-dependent potassium channels in skeletal muscles. In vivo Methazolamide does not impair respiratory work performance in anesthetized rabbits. cell lines：HCT116 and HT29 cells Concentrations： Incubation Time： Powder Purity:≥99% |
| Ki Data | hCAII, Ki: 14 nM |
|---|---|
| ALogP | 0.03 |
| hba_count | 5 |
| HBD Count | 1 |
| Rotatable Bond | 1 |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | CN1N=C(SC1=NC(C)=O)[S](N)(=O)=O |
| 分子量 | 236.27 |
| Reaxy-Rn | 232387 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=232387&ln= |
| 溶解性 | Solubility (25°C) In vitro DMSO: 6 mg/mL (17.36 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| DMSO(mg / mL) Max Solubility | 47 |
| DMSO(mM) Max Solubility | 198.92 |
| Water(mg / mL) Max Solubility | <1 |
| Reaxy-Rn | 232387 |
|---|---|
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=232387&ln= |
| Concentration(Compounding value) | 9-11(mmol/L) |
|---|---|
| Record the entire process by video | Conform |
| 1. Junrong Li, Yingjun Wang, Ziqi Fan, Panyang Tang, Mengting Wu, Hong Xiao, Zhenxing Zeng. (2023) Toxicity of Tetracycline and Metronidazole in Chlorella pyrenoidosa. International Journal of Environmental Research and Public Health, 20 (4): (3623). [PMID:36834317] [10.3390/ijerph20043623] |
| 2. Da Wang, Zhe Yang, Yinning He, Shiwen Dong, Feilong Dong, Zhiqiao He, Xiaohui Lu, Lizhang Wang, Shuang Song, Jun Ma. (2023) Metribuzin and metamitron degradation using catalytic ozonation over tourmaline: Kinetics, degradation pathway, and toxicity. SEPARATION AND PURIFICATION TECHNOLOGY, 309 (123028). [10.1016/j.seppur.2022.123028] |
| 3. Haojiang Wang, Wenli Hu, Qiong Zheng, Wei Bian, Zian Lin. (2017) One-pot preparation of mercaptotetrazole-silica hybrid monoliths by the thiol-ene click reaction for mixed-mode capillary liquid chromatography. JOURNAL OF SEPARATION SCIENCE, 40 (11): (2344-2354). [PMID:28374911] [10.1002/jssc.201700220] |
| 1. Junrong Li, Yingjun Wang, Ziqi Fan, Panyang Tang, Mengting Wu, Hong Xiao, Zhenxing Zeng. (2023) Toxicity of Tetracycline and Metronidazole in Chlorella pyrenoidosa. International Journal of Environmental Research and Public Health, 20 (4): (3623). [PMID:36834317] [10.3390/ijerph20043623] |
| 2. Da Wang, Zhe Yang, Yinning He, Shiwen Dong, Feilong Dong, Zhiqiao He, Xiaohui Lu, Lizhang Wang, Shuang Song, Jun Ma. (2023) Metribuzin and metamitron degradation using catalytic ozonation over tourmaline: Kinetics, degradation pathway, and toxicity. SEPARATION AND PURIFICATION TECHNOLOGY, 309 (123028). [10.1016/j.seppur.2022.123028] |
| 3. Haojiang Wang, Wenli Hu, Qiong Zheng, Wei Bian, Zian Lin. (2017) One-pot preparation of mercaptotetrazole-silica hybrid monoliths by the thiol-ene click reaction for mixed-mode capillary liquid chromatography. JOURNAL OF SEPARATION SCIENCE, 40 (11): (2344-2354). [PMID:28374911] [10.1002/jssc.201700220] |
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