| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M421306-1ml |
1ml |
现货  |
|
| 别名 | 2-(2-氨基-1H-苯并咪唑-1-基)-8-甲氧基-N-(苯甲基)-4-喹唑啉胺 |
|---|---|
| 英文别名 | BCP25527 | NCGC00347064-07 | SCHEMBL12134616 | KSC-206-032 | Tris(beta-Methoxyethoxy)vinylsilane | AC-36234 | NCGC00347064-04 | SMR002239184 | MLS003568129 | CID-49830258 | 2-(2-amino-1H-1,3-benzodiazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine | 2-(2-am |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | ML 240 |
| 生化机理 | ATP竞争性p97 ATPase抑制剂（VCP，IC50 = 110 nM）。在NCI-60癌细胞系中表现出抗增殖活性，并在多个结肠癌细胞中快速诱导execution子手胱天蛋白酶3和7。促进LC3-II的积累并损害自噬体的成熟。还损害内质网相关的降解（ERAD）通路。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Application ML240 has been used as an inhibitor of D2 ATPase activity of valosin-containing protein. |
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 2-(2-aminobenzimidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine |
| INCHI | InChI=1S/C23H20N6O/c1-30-19-13-7-10-16-20(19)27-23(28-21(16)25-14-15-8-3-2-4-9-15)29-18-12-6-5-11-17(18)26-22(29)24/h2-13H,14H2,1H3,(H2,24,26)(H,25,27,28) |
| InChi Key | NHAMBLRUUJAFOY-UHFFFAOYSA-N |
| Canonical SMILES | COC1=CC=CC2=C1N=C(N=C2NCC3=CC=CC=C3)N4C5=CC=CC=C5N=C4N |
| Isomeric SMILES | COC1=CC=CC2=C1N=C(N=C2NCC3=CC=CC=C3)N4C5=CC=CC=C5N=C4N |
| 分子量 | 396.44 |
| Reaxy-Rn | 24899602 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24899602&ln= |
| 分子量 | 396.400 g/mol |
|---|---|
| XLogP3 | 4.500 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 6 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 396.17 Da |
| 单同位素质量Monoisotopic Mass | 396.17 Da |
| 拓扑极表面积Topological Polar Surface Area | 90.900 Ų |
| 重原子数Heavy Atom Count | 30 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 558.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| Reaxy-Rn | 24899602 |
|---|---|
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24899602&ln= |
| Concentration(Compounding value) | 9.0-11.0(mmol/L) |
|---|---|
| Appearance(Colorless Transparent Liquid) | Pass |
| Record the entire process by video | Conform |
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