| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M422970-1ml |
1ml |
现货  |
|
| 别名 | 富马酸单甲酯 | 反丁烯二酸一甲酯 |
|---|---|
| 英文别名 | Maleicacidmonomethylester | Sun mark sinus | FUMARIC ACID MONOMETHYL ESTER [MI] | M2413 | Methyl hydrogen fumarate | (E)-2-Butendioic acid, methyl ester | (E)-4-methoxy-4-oxobut-2-enoic acid | CHEBI:167450 | (E)-4-methoxy-4-oxobut-2-enoicacid | 4,4'-Diflo |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Monomethyl Fumarate |
| 生化机理 | 核因子（类胡萝卜素-2）样2（Nrf2）通路激活剂。在GPR109A上也表现出激动剂活性。DMF的主要代谢物。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 作用机制 | HCA 2 受体激动剂 |
| 产品介绍 |
mono-Methyl fumarate can be used as a reactant to synthesize: · Jumonji C domain-containing histone demethylases (JCHDMs) inhibitor. · (-)-Xylariamide A, a fungal metabolite. · (±)-Methoxyfumimycin ethyl ester, a potential bacterial peptide deformylase inhibitor. It is also a wide spectrum antibacterial agent with a powerful antioxidant activity. mono-Methyl fumarate can be used as a reactant to synthesize: · Jumonji C domain-containing histone demethylases (JCHDMs) inhibitor. · (-)-Xylariamide A, a fungal metabolite. · (±)-Methoxyfumimycin ethyl ester, a potential bacterial peptide deformylase inhibitor. It is also a wide spectrum antibacterial agent with a powerful antioxidant activity. |
| ALogP | 0.4 |
|---|
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | (E)-4-methoxy-4-oxobut-2-enoic acid |
| INCHI | InChI=1S/C5H6O4/c1-9-5(8)3-2-4(6)7/h2-3H,1H3,(H,6,7)/b3-2+ |
| InChi Key | NKHAVTQWNUWKEO-NSCUHMNNSA-N |
| Canonical SMILES | COC(=O)C=CC(=O)O |
| Isomeric SMILES | COC(=O)/C=C/C(=O)O |
| WGK Germany | 3 |
| 分子量 | 130.1 |
| Reaxy-Rn | 14198178 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=14198178&ln= |
| 熔点 | 145-149°C |
|---|---|
| 分子量 | 130.100 g/mol |
| XLogP3 | 0.400 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 130.027 Da |
| 单同位素质量Monoisotopic Mass | 130.027 Da |
| 拓扑极表面积Topological Polar Surface Area | 63.600 Ų |
| 重原子数Heavy Atom Count | 9 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 147.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 1 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 1 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS05 |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H318: 造成严重的眼睛损伤 |
| 预防措施声明 |
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。 P317: 寻求紧急医疗救助。 |
| WGK Germany | 3 |
| Reaxy-Rn | 14198178 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=14198178&ln= |
| 个人防护装备 | dust mask type N95 (US)， Eyeshields， Gloves |
| Concentration(Compounding value) | 9.0-11(mmol/L) |
|---|---|
| Record the entire process by video | Conform |
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