| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M424636-1ml |
1ml |
现货  |
|
| 别名 | 美替拉酮 | 2-甲基-1,2-二-3-吡啶基-1-丙酮 |
|---|---|
| 英文别名 | Su-4885 | AMY832 | Metopiron | METOPIRONE (TN) | METYRAPONE [INN] | Metroprione | Methopyrinine | metyrapone | Tox21_110323_1 | BIDD:PXR0082 | HMS3259O05 | METYRAPONE [WHO-DD] | Metyraponum | MYT | NSC25265 | NSC-25265 | HY-B1232 | EINECS 200-206-2 | Meth |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Metyrapone |
| 生化机理 | 选择性细胞色素P450抑制剂（IC 50 = 1μM）。阻断皮质醇的体内外合成。具有神经保护作用。细胞和血脑屏障通透。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
2-甲基-1,2-二-3-吡啶基-1-丙酮通过阻断脱氧皮质酮向皮质酮的转化而抑制皮质酮的生物合成。 它广泛用于肾上腺皮质相关的临床研究。 Metyrapone (NSC-25265, SU-4885) is an inhibitor of the enzyme steroid 11-beta-monooxygenase (CYP11B1) that inhibits adrenal steroid synthesis. |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 2-methyl-1,2-dipyridin-3-ylpropan-1-one |
| INCHI | InChI=1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3 |
| InChi Key | FJLBFSROUSIWMA-UHFFFAOYSA-N |
| Canonical SMILES | CC(C)(C1=CN=CC=C1)C(=O)C2=CN=CC=C2 |
| Isomeric SMILES | CC(C)(C1=CN=CC=C1)C(=O)C2=CN=CC=C2 |
| 分子量 | 226.27 |
| Reaxy-Rn | 163023 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=163023&ln= |
| 熔点 | 52-55 °C (lit.) |
|---|---|
| 分子量 | 226.270 g/mol |
| XLogP3 | 2.000 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 226.111 Da |
| 单同位素质量Monoisotopic Mass | 226.111 Da |
| 拓扑极表面积Topological Polar Surface Area | 42.900 Ų |
| 重原子数Heavy Atom Count | 17 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 275.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P330: 漱口 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| Reaxy-Rn | 163023 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=163023&ln= |
| Concentration(Compounding value) | 9-11(mmol/L) |
|---|---|
| Record the entire process by video | Conform |
| 1. Jingli Chen, Chang Liu, Mu Xu, Jiaxi Zhu, Zhongyuan Xia. (2022) Upregulation of miR-19b-3p exacerbates chronic stress-induced changes in synaptic plasticity and cognition by targeting Drebrin. NEUROPHARMACOLOGY, 207 (108951). [PMID:35041806] [10.1016/j.neuropharm.2022.108951] |
| 1. Jingli Chen, Chang Liu, Mu Xu, Jiaxi Zhu, Zhongyuan Xia. (2022) Upregulation of miR-19b-3p exacerbates chronic stress-induced changes in synaptic plasticity and cognition by targeting Drebrin. NEUROPHARMACOLOGY, 207 (108951). [PMID:35041806] [10.1016/j.neuropharm.2022.108951] |
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