Myosin V-IN-1 (compound 8) is a potent and selective Myosin V inhibitor, with a K i of 6 μM. Myosin V-IN-1 shows acute inhibition of myosin V. Myosin V-IN-1 slows the actin-activated myosin V ATPase by specifically inhibiting ADP release from the actomyosin complex.
In Vitro
Myosin V-IN-1 (compound 8) shows dose-dependent reduction of the rate of steady-state actin-activated ATP hydrolysis by single-headed myosin V. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
规格
别名
肌球蛋白V-IN-1
英文名称
Myosin V-IN-1
生化机理
肌球蛋白 V-IN-1(化合物 8)是一种强效的选择性肌球蛋白 V 抑制剂,其 K i 为 6 μM。肌球蛋白 V-IN-1 通过特异性抑制肌动蛋白释放 ADP,从而减缓肌动蛋白激活的肌球蛋白 V ATP 酶的速度。