计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
干燥,-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Mavorixafor trihydrochloride (AMD-070 trihydrochloride) is a potent, selective and orally available CXCR4 antagonist, with an IC 50 value of 13 nM against CXCR4 125 I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC 50 of 1 and 9 nM, respectively.
In Vitro
Mavorixafor (AMD-070) is a potent and orally available CXCR4 antagonist, with an IC 50 value of 13 nM against CXCR4 125 I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC 50 of 1 and 9 nM, respectively. Mavorixafor (AMD-070) shows no effect on other chemokine receptors (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2). Mavorixafor (AMD-070) (6.6 µM) significantly suppresses the anchorage-dependent growth, the migration and matrigel invasion of the B88-SDF-1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Mavorixafor (AMD-070) (2 mg/kg, p.o.) significantly reduces the number of metastatic lung nodules in mice, and lowers the expression of human Alu DNA in mice, without body weight loss. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Assay
Cells are seeded on a 96-well plate at 5 × 10 3 cells/well in DMEM containing 10% FCS. Twenty-four hours later, the cells are treated with or without 2 µM Mavorixafor (AMD-070) or 6.6 µM AMD-070 . After 24 or 48 h , the number of cells is quantified by an assay using MTT. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal administration
Mice BALB/c nude mice are maintained under pathogen-free conditions. The experiments are initiated when the mice are 8 weeks of age. Briefly, the cells are inoculated into the blood vessels of nude mice ( 1× 10 6 ). These mice are sacrificed at day 49. The presence or absence of distant metastases is confirmed by hematoxylin and eosin (H&E) staining. For experimental chemotherapy, the mice are treated by the daily oral administration of 0.2 mL of saline for a vehicle or the same volume of Mavorixafor (AMD-070) (2 mg/kg) . aladdin has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:125 I-SDF-CXCR4 13 nM (IC 50 ) HIV-1 (NL4.3 strain) 1 nM (IC 50 , in MT-4 cells) HIV-1 (NL4.3 strain) 9 nM (IC 50 , in PBMCs) HIV-1 (NL4.3 strain) 3 nM (IC90, in MT-4 cells) HIV-1 (NL4.3 strain) 26 nM (IC90, in PBMCs)
规格
别名
马沃利沙福三盐酸盐
规格或纯度
10mM in DMSO
英文名称
Mavorixafor trihydrochloride
生化机理
Mavorixafor trihydrochloride（AMD-070 trihydrochloride）是一种强效、选择性和口服型 CXCR4 拮抗剂，对 CXCR4 125 I-SDF 结合的 IC 50 值为 13 nM，还能抑制 T 型 HIV-1 （NL4.3 株）在 MT-4 中的复制。
储存条件
干燥,-80℃储存
运输条件
特低温运输
作用类型
抑制剂
名称和识别符
分子类型
小分子
Isomeric SMILES
C1C[C@@H](C2=C(C1)C=CC=N2)N(CCCCN)CC3=NC4=CC=CC=C4N3.Cl.Cl.Cl
PubChem CID
分子量
458.86
技术文档
高级数据
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品应如何储存？
请于?80 °C、干燥条件下保存。请与干燥剂一同密封保存，本品对湿气敏感。
本产品如何运输？
本产品采用干冰配冷袋冷冻运输。收货后请立即拆包，并按上述储存条件保存；处理干冰时请戴隔热手套并保持通风。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 2309699-17-8，分子式为 C21H30Cl3N5，分子量为 458.86 g/mol。
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