NL-103 is an inhibitor of histone deacetylases ( HDACs ) and Hedgehog , with the IC 50 values of 21.3 nM, 57 nM, 74 nM, and 680 nM for HDAC1 , HDAC2 , HDAC3 , and HDAC6 , respectively. NL-103 can downregulate the expression of Gli2. NL-103 can be used in anti-cancer research.