NW 1028 is a potent VCP/p97 inhibitor. NW 1028 targets the ND1L domain of p97 and inhibits the degradation of a p97-dependent reporter. NW 1028 has good binding affinity with K d values of 100 and 285 nM for ND1L and full length p97 , respectively. NW 1028 has the function of regulating the mitotic spindle of cells.