NOX4-IN-1 (Compound 14m) is the inhibitor for NADPH oxidase 4 ( NOX4 ), and blocks the generation of ROS. NOX4-IN-1 inhibits TGF-β1/Smad signaling pathway, decreases the expression of fibrosis-related proteins. NOX4-IN-1 inhibits the cell migration of NRK-49F.