Nampt-IN-10 trihydrochloride (compound 4) is a Nicotinamide Phosphoribosyltransferase ( NAMPT ) inhibitor. Nampt-IN-10 trihydrochloride shows cellular potency to A2780 and CORL23 cell lines with IC 50 values of 5 and 19 nM, respectively. Nampt-IN-10 trihydrochloride can be used as a novel non-antimitotic payload for antibody-drug conjugate (ADC).